专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2015004458A2 NOVEL METHODS AND COMPOUNDS 审中-公开
标题翻译：新方法和化合物
公开(公告)号：WO2015004458A2
公开(公告)日：2015-01-15
申请号：PCT/GB2014/052094
申请日：2014-07-09
申请人： ISOMERASE THERAPEUTICS LIMITED
发明人： GREGORY, Matthew Alan , KENDREW, Steven Gary , MOSS, Steven James , WILKINSON, Barrie
IPC分类号： C12N15/10
CPC分类号： C12P21/02 , A01N43/40 , A01N43/90 , A61K31/436 , A61K31/453 , A61K45/06 , C07D405/06 , C07D491/052 , C07D498/18 , C12N9/1029 , C12N15/1082 , C12P17/06 , C12P17/08 , C12P17/10 , C12P17/12 , C12P17/16 , C12P17/162 , C12P17/181 , C12P17/182 , C12P17/188 , C12P17/189 , C12P19/60 , C12P19/62 , C12Y203/01
摘要： A method for increasing the molecular diversity of polyketides and non-ribsomomal peptides by using recombination to efficiently increase or decrease the number of modules in the polyketide synthase or non-ribosomal peptide synthetase encoding said polyketide or peptide.
摘要翻译：通过使用重组来有效增加或减少编码所述聚酮化合物或肽的聚酮化合物合酶或非核糖体肽合成酶中的模块数目来增加聚酮化合物和非支链多肽的分子多样性的方法。

2. 发明申请

WO2013061919A1 新規化合物及びその製造法审中-公开
标题翻译：新型化合物及其生产方法
公开(公告)号：WO2013061919A1
公开(公告)日：2013-05-02
申请号：PCT/JP2012/077229
申请日：2012-10-22
申请人：学校法人立命館 , 国立大学法人静岡大学
发明人：今村　信孝 , 中川　和也 , 徳山　真治
IPC分类号： C12P17/06 , A01N43/16 , A01N63/02 , A01P3/00 , A61K31/351 , A61K35/74 , A61P31/10 , C07D309/32 , C12P1/06 , C12P15/00 , C12R1/465
CPC分类号： C07D309/30 , A01N43/16 , A01N43/90 , A01N63/02 , A61K31/351 , C07D309/32 , C07D493/14 , C12P1/06 , C12P15/00 , C12P17/06 , C12P17/162 , C12P17/181 , C12R1/465
摘要：　本発明の課題は、抗カビ物質として有用な新規化合物及びその製造法を提供することである。本発明は、式（Ｉ０）：（式中、Ｒ１は、（２）を示し、Ｒ２は、（３）を示す。）で表される化合物又はその塩、及び微生物を用いる該化合物の製造方法に関する。
摘要翻译：本发明的目的是提供：用作防霉物质的新化合物; 和该化合物的制造方法。本发明涉及：由式（I0）表示的化合物（其中R1表示式（2）表示的基团; R2表示式（3）所示的基团或其盐;以及其制备方法使用微生物。

3. 发明申请

WO2013032693A2 ISOLATED BACTERIAL STRAIN OF THE GENUS BURKHOLDERIA AND PESTICIDAL METABOLITES THEREFROM-FORMULATIONS AND USES 审中-公开
标题翻译：毛果芸豆属菌种的分离菌株及其制剂和使用的杀虫剂代谢物
公开(公告)号：WO2013032693A2
公开(公告)日：2013-03-07
申请号：PCT/US2012/050807
申请日：2012-08-14
申请人： MARRONE BIO INNOVATIONS, INC. , ASOLKAR, Ratnakar , KOIVUNEN, Marja , MARRONE, Pamela
发明人： ASOLKAR, Ratnakar , KOIVUNEN, Marja , MARRONE, Pamela
IPC分类号： C12N1/20 , C12P1/04 , C12N1/38 , A01N63/02 , A01N43/06 , A01N43/26 , A01P21/00
CPC分类号： A01N63/02 , A01N31/02 , A01N37/40 , A01N43/16 , A01N43/76 , A01N43/90 , A01N47/16 , A01N63/00 , C12P7/62 , C12P7/6436 , C12P17/02 , C12P17/14 , C12P17/16 , C12P17/162 , C12P17/187 , C12P17/188 , C12P21/00 , C12R1/00 , C12R1/01
摘要： A species of Burkholderia sp with no known pathogenicity to vertebrates but with pesticidal activity (e.g., plants, algae, arachnids, insects, fungi, weeds and nematodes) as well as methods for controlling algae using said species of Burkholderia . Also provided are natural products derived from a culture of said species and methods of controlling algae and/or arachnids using said natural products.
摘要翻译：一种对脊椎动物没有已知致病性但具有杀虫活性的伯克霍尔德氏菌属（例如植物，藻类，蜘蛛类，昆虫，真菌，杂草和线虫）以及使用所述伯克霍尔德氏菌属物种控制藻类的方法。还提供了源自所述物种的培养物的天然产物以及使用所述天然产物控制藻类和/或蛛形纲动物的方法。

4. 发明申请

WO2003000910A2 METABOLIC CONTROLLED FERMENTATION PROCESS FOR PSEUDOMONIC ACID PRODUCTION 审中-公开
标题翻译：代谢控制发酵过程的产酸生产
公开(公告)号：WO2003000910A2
公开(公告)日：2003-01-03
申请号：PCT/US2002/020044
申请日：2002-06-21
申请人： BIOGAL GYOGYSZERGYAR RT , TEVA PHARMACEUTICALS USA, INC. , GULYAS, Eva , BALOGH, Gabor , ERDEI, Janos , SERESS, Peter
发明人： GULYAS, Eva , BALOGH, Gabor , ERDEI, Janos , SERESS, Peter
IPC分类号： C12P
CPC分类号： C12N1/20 , C12P17/162
摘要： An improved fermentation process for preparing pseudomonic acid A (mupirocin) is disclosed. The metabolically controlled fermentation process provides culturing a Pseudomonas sp. strain in a submerged medium at a temperature within about 20- 5 30°C. The pH of the fermentation medium is regulated to be at about 5.5-6.0 by feeding the fermentation medium with an assimilable carbon source, a mineral salt, or an acidic/alkali solution. Accordingly, the resulting fermentation broth contains an increased yield of highly purified pseudomonic acid A as the main component. The pseudomonic acid B as an impurity in the fermentation broth is significantly decreased.
摘要翻译：公开了用于制备假单胞菌酸A（莫匹罗星）的改进的发酵方法。代谢控制的发酵过程提供培养假单胞菌属（Pseudomonas sp。在浸没的介质中温度在约20-530℃之间。通过向发酵培养基中加入可同化的碳源，矿物盐或酸/碱溶液，将发酵培养基的pH调节至约5.5-6.0。因此，所得发酵液含有高纯度假单胞菌酸A作为主要成分的增加的产率。在发酵液中作为杂质的假单胞菌酸B显着降低。

5. 发明申请

WO1996022382A1 IMMUNOSUPPRESSANT COMPOUND AND METHOD OF PRODUCTION 审中-公开
标题翻译：免疫抑制剂和生产方法
公开(公告)号：WO1996022382A1
公开(公告)日：1996-07-25
申请号：PCT/US1996000784
申请日：1996-01-19
申请人： PHARMAGENESIS, INC. , STROBEL, Gary, A. , PLIAM, Nathan, B.
发明人： PHARMAGENESIS, INC.
IPC分类号： C12P17/06
CPC分类号： C07D407/06 , C12P17/162 , C12P17/181
摘要： Novel compounds with immunosuppressive activity are disclosed. The compound can be produced in culture by fungal species isolated from the stems of Tripterygium wilfordii. Also disclosed is a Fusarium species capable of producing the compound in culture, and methods for obtaining immunosuppressant compounds from fungal-cell culture.
摘要翻译：公开了具有免疫抑制活性的新型化合物。该化合物可以通过从雷公藤的茎分离的真菌物种在培养物中产生。还公开了能够在培养物中生产化合物的镰刀菌属物种，以及从真菌细胞培养获得免疫抑制剂化合物的方法。

6. 发明申请

WO9318173A3 CD4 BINDING AGENTS AND INHIBITORS OF COLLAGENASE AND PROTEIN KINASE C 审中-公开
标题翻译： CD4。。。。。。。。。。。。。。。。。。。。
公开(公告)号：WO9318173A3
公开(公告)日：1993-10-28
申请号：PCT/GB9300511
申请日：1993-03-11
申请人： XENOVA LTD
发明人： HYLANDS PETER JOHN , WRIGLEY STEPHEN KEITH , CHANDLER GLENDA LOUISE , COLLINS MARK ANTHONY DAVID , FOX FRANCES , MOORE MICHAEL
IPC分类号： A61K31/35 , C07D493/04 , C12P1/02 , C12P17/16 , C12P17/18
CPC分类号： C07D493/04 , A61K31/35 , C12P1/02 , C12P17/162 , C12P17/181 , C12R1/80
摘要： A compound which is obtainable from Penicillium glabrum X8063 (CMI 336456) and which has a molecular formula of C27H16O12, a molecular weight of 532 and defined spectral characteristics; a compound which is obtainable from Penicillium glabrum X8063 (CMI 336456) and which has a molecular formula of C14 H10O6, a molecular weight of 274 and defined spectral characteristics; anhydrofulvic acid; and citromycetin; and pharmaceutically and veterinarily acceptable salts, esters and ethers thereof; are useful as CD4 binding agents, inhibitors of collagenase and in the case of the compound of molecular formula C27H16O12 and the compound having the molecular formula C14H10O6 inhibitors of protein kinase C.

7. 发明申请

WO1993004055A2 COMPOUNDS USED FOR THE INHIBITION OF HIV-PROTEASE 审中-公开
标题翻译：用于抑制HIV-PROTEASE的化合物
公开(公告)号：WO1993004055A2
公开(公告)日：1993-03-04
申请号：PCT/US1992005250
申请日：1992-06-29
申请人： THE UPJOHN COMPANY , DOLAK, Lester, Arthur , SEEST, Eric, Peter , CIALDELLA, Joyce, Irma , LI, Grace, P. , BOHANON, Michael, John
发明人： THE UPJOHN COMPANY
IPC分类号： C07D307/60
CPC分类号： C07D407/06 , A61K31/365 , C07C305/24 , C07D307/60 , C12P11/00 , C12P17/04 , C12P17/162
摘要： This invention relates to new compounds, known compounds and new uses for those compounds. The compounds of this invention are comprised of tetronic acid type compounds, panosialin type compounds and virustomycin type compounds that are inhibitors of HIV protease. The invention further comprises the extraction, isolation, and purification of the compounds plus a method of treating a human cell system, including a patient possibly infected with a human retrovirus (HRV), to prevent or retard the further replication of the HRV in that human cell system or patient.
摘要翻译：本发明涉及新化合物，已知化合物和这些化合物的新用途。本发明的化合物包括作为HIV蛋白酶抑制剂的四氢叶酸化合物，全唾液酸化合物类型和virustomycin类化合物。本发明还包括提取，分离和纯化化合物加上治疗人细胞系统的方法，包括可能感染人类逆转录病毒（HRV）的患者，以预防或延缓HRV在该人中的进一步复制细胞系统或患者。

8. 发明申请

WO2016198850A1 ANTI-DANDRUFF COMPOSITIONS COMPRISING A SPIROFURANONE LACTAM TETRAMIC ACID DERIVATIVE 审中-公开
标题翻译：包含螺吡喃半乳糖酸酯衍生物的抗-DDDR
公开(公告)号：WO2016198850A1
公开(公告)日：2016-12-15
申请号：PCT/GB2016/051681
申请日：2016-06-08
申请人： CRODA INTERNATIONAL PLC
发明人： KERR, Russell Greig , OVERY, David Patrick , BERRUÉ, Fabrice
IPC分类号： A61Q5/00 , A61K31/00 , A61K31/336
CPC分类号： A61K31/407 , A61K8/4973 , A61K31/336 , A61K31/4025 , A61Q5/006 , C12P17/162 , C12P17/182 , C12R1/645 , A61K2300/00
摘要： Anti-Dandruff Agents A novel anti-dandruff composition comprising spirofuranone-lactam tetramic acid or derivatives thereof, and optionally at least one biologically derivable meroterpene. The spirofuranone-lactam tetramic acid is preferably a bio-active heterospirocyclic secondary metabolite of Aspergillus, such as pseurotin A. The biologically derivable meroterpene may be selected from fumagillin, fumagillin derivative, chlovalicin, or ovalicin. Use of said agents as anti-dandruff actives in anti-dandruff compositions, particularly shampoos and conditioners is also provided. The active is particularly effective against Malassezia yeasts and Malassezia furfur which may cause dandruff. A method of obtaining the anti-dandruff actives from culturing of Peyronellaea sp. strain RKDO347 is also described.
摘要翻译：抗头皮屑剂一种新颖的抗头皮屑组合物，其包含螺呋喃酮 - 内酰胺四酸或其衍生物，以及任选的至少一种生物可衍生的富萜烯。螺呋喃酮 - 内酰胺四酸优选为曲霉属的生物活性杂环二环代谢产物，例如pseurotin A.生物学上可衍生的meroterpene可以选自夫马洁林，烟曲霉素衍生物，喹诺酮或卵圆蛋白。还提供了在去头皮屑组合物，特别是洗发剂和调理剂中使用所述药剂作为去头皮屑活性物质。活跃对马拉色霉酵母和马拉色霉糠疹特别有效，可能引起头皮屑。一种通过培养Peyronellaea sp获得抗头皮屑活性物质的方法。还描述了菌株RKDO347。

9. 发明申请

WO2016089166A1 신규한 항바이러스용 조성물 및 이를 이용한 식물바이러스의 방제 방법 审中-公开
标题翻译：新型抗病毒组合物，以及使用该方法控制植物病毒的方法
公开(公告)号：WO2016089166A1
公开(公告)日：2016-06-09
申请号：PCT/KR2015/013238
申请日：2015-12-04
申请人： 서울여자대학교 산학협력단 , 고려대학교 산학협력단
发明人： 이동호 , 김재진 , 류기현 , 김범석 , 류승목
IPC分类号： A01N43/90 , A01N63/00
CPC分类号： A01N43/90 , A01N63/02 , A01N63/04 , C05G3/02 , C07D493/08 , C12P17/162 , C12R1/885
摘要： 본 발명은 트리코더마 알불루테슨스( Trichoderma albolutescenes ) 균주로부터 분리한 트리코더민 또는 트리코더민올을 유효성분으로 포함하는 항바이러스용 조성물, 식물바이러스 방제용 조성물, 및 상기 조성물을 이용한 식물바이러스의 방제 방법에 관한 것이다. 본 발명에 따른 트리코더마 알불루테슨스( Trichoderma albolutescenes ) 균주로부터 분리한 트리코테센 계열의 화합물인 트리코더민 또는 트리코더민올은 다양한 식물바이러스에 대한 항바이러스 활성을 가지고 있어, 식물바이러스 방제에 유용하게 이용될 수 있다. 또한, 본 발명은 천연물을 기반으로 한 것으로 유효성분의 대량생산이 용이하며, 식물체에 피해를 주지 않는 안전한 물질을 이용한 환경 친화적인 방제제의 개발 및 고부가가치의 농작물 생산 등, 농업 분야에서 다양하게 활용될 수 있다.
摘要翻译：本发明涉及一种抗病毒组合物，其含有从白喉木霉菌株中分离出的三唑虫或三唑虫作为活性成分; 用于控制植物病毒的组合物; 以及通过使用该组合物来控制植物病毒的方法。根据本发明，作为从木霉属白喉菌株分离的单端孢霉烯类化合物的trichodermin或trichoderminol具有针对各种植物病毒的抗病毒活性，因此可用于防治植物病毒。此外，本发明基于天然产物，可以容易地大量生产活性成分，并且可以各种应用于农业领域，例如使用对植物不造成损害的安全材料开发环境友好的控制剂，并在高价值作物的生产中。

10. 发明申请

WO2012095707A1 PROCESS FOR THE PREPARATION OF NEBIVOLOL 审中-公开
标题翻译：制备NEBIVOLOL的方法
公开(公告)号：WO2012095707A1
公开(公告)日：2012-07-19
申请号：PCT/IB2011/055385
申请日：2011-11-30
申请人： MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. , MAURO, Sandro , FATTORI, Daniela , D'ANDREA, Piero , CIPOLLONE, Amalia
发明人： MAURO, Sandro , FATTORI, Daniela , D'ANDREA, Piero , CIPOLLONE, Amalia
IPC分类号： C07D311/58
CPC分类号： C12P17/162 , C07D311/58
摘要： The present invention relates to a novel process for the synthesis of the Nebivolol product depicted in Scheme 1, comprised of a reduced number of high-yield steps, and characterized by the enzymatic resolution of the chroman ester precursor.
摘要翻译：本发明涉及一种合成方案1中描述的奈比洛尔产物的新方法，其包括减少数量的高产率步骤，并且特征在于色满酸酯前体的酶拆分。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式