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1. 发明申请

WO2018145023A1 METHOD OF PREDICTING RESPONSE TO IMMUNOTHERAPY 审中-公开
公开(公告)号：WO2018145023A1
公开(公告)日：2018-08-09
申请号：PCT/US2018/016896
申请日：2018-02-05
申请人： NOVARTIS AG , BORDEAUX, Jennifer , DAKAPPAGARI, Naveen , KIM, Ju Young
发明人： BORDEAUX, Jennifer , DAKAPPAGARI, Naveen , KIM, Ju Young
IPC分类号： A61K35/15 , A61K39/395 , G01N33/50
摘要： The invention relates, in part, to methods of predicting a likelihood that a cancer patient will respond positively to immunotherapy. The methods include scoring a sample containing tumor tissue from a cancer patient, wherein the score is representative of a spatial proximity between at least one pair of cells, a first member of the at least one pair of cells expressing a first biomarker and a second member of the at least one pair of cells expressing a second biomarker that is different from the first biomarker, and deriving a value for % biomarker positivity (PBP) for all cells or optionally, one or more subsets thereof, present in a field of view of a tissue sample from the cancer patient.

2. 发明申请

WO2016164731A2 CD20 THERAPIES, CD22 THERAPIES, AND COMBINATION THERAPIES WITH A CD19 CHIMERIC ANTIGEN RECEPTOR (CAR) - EXPRESSING CELL 审中-公开
标题翻译： CD20治疗方案，CD22治疗方案和与CD19基因抗体受体（CAR） - 表达细胞的联合治疗
公开(公告)号：WO2016164731A2
公开(公告)日：2016-10-13
申请号：PCT/US2016/026655
申请日：2016-04-08
申请人： NOVARTIS AG , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , BITTER, Hans , BORDEAUX, Jennifer, Mary , BRANNETTI, Barbara , BROGDON, Jennifer , DAKAPPAGARI, Naveen, Kumar , GILL, Saar , HIGHFILL, Steven , HUANG, Lu , JUNE, Carl, H. , KIM, Ju, Young , LEI, Ming , LI, Na , LOWE, Andreas , ORLANDO, Elena , RUELLA, Marco , TRAN, Thai , ZHANG, Jimin , ZHOU, Li
发明人： BITTER, Hans , BORDEAUX, Jennifer, Mary , BRANNETTI, Barbara , BROGDON, Jennifer , DAKAPPAGARI, Naveen, Kumar , GILL, Saar , HIGHFILL, Steven , HUANG, Lu , JUNE, Carl, H. , KIM, Ju, Young , LEI, Ming , LI, Na , LOWE, Andreas , ORLANDO, Elena , RUELLA, Marco , TRAN, Thai , ZHANG, Jimin , ZHOU, Li
IPC分类号： C07K14/725 , C07K16/28 , C12N5/0783
CPC分类号： C07K14/70596 , A61K38/00 , A61K39/0011 , A61K45/06 , A61K2039/5156 , A61K2039/5158 , A61K2039/70 , C07K14/7051 , C07K16/2803 , C07K16/2866 , C07K2317/24 , C07K2317/622 , C07K2319/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with one or more B-cell inhibitors, e.g., inhibitors of one or more of CD1O, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, or CD79a. The disclosure additionally features novel antigen binding domains and CAR molecules directed to CD20 and CD22, and uses, e.g., as monotherapies or in combination therapies. The invention also provides kits and compositions described herein.
摘要翻译：本发明提供了用于治疗与CD19表达相关的疾病的组合物和方法，例如通过与一种或多种B细胞抑制剂组合施用包含本文所述的CD19 CAR的重组T细胞，例如一种或多种 CD1O，CD20，CD22，CD34，CD123，FLT-3，ROR1，CD79b，CD179b或CD79a。本公开另外具有指向CD20和CD22的新型抗原结合结构域和CAR分子，并且例如用作单一疗法或联合治疗。本发明还提供了本文所述的试剂盒和组合物。

3. 发明申请

WO2010044572A3 METHOD AND APPARATUS FOR CHECKING INSULATION OF POUCH ELECTRIC CELL AND PROBE FOR THE SAME 审中-公开
标题翻译：检测电极电极绝缘的方法和装置及其相关探针
公开(公告)号：WO2010044572A3
公开(公告)日：2012-08-30
申请号：PCT/KR2009005816
申请日：2009-10-12
申请人： LG CHEMICAL LTD , LEE JU-SEOK , PARK HEY-WOONG , KIM JU-YOUNG , NAMGOONG JOHN E
发明人： LEE JU-SEOK , PARK HEY-WOONG , KIM JU-YOUNG , NAMGOONG JOHN E
IPC分类号： G01R31/36 , G01R1/067 , G01R31/12
CPC分类号： G01R1/06788 , G01R31/1263 , G01R31/3627
摘要： To check insulation of a pouch electric cell, probes are contacted to an electrode of a pouch electric cell and an aluminum layer of a pouch of the pouch electric cell, respectively, and then an electric characteristic value between the probes is measured. The probe contacted with the aluminum layer has a contact portion made of conductive elastic material. Also, insulation of the pouch electric cell is determined by comparing the measured electric characteristic value with a reference value. Thus, physical characteristics of an outer periphery of a flexible pouch may be sufficiently exhibited in measuring or checking insulation of a pouch electric cell such as insulation resistance, thereby improving reliability of electric contact and minimizing physical damage or deformation of the pouch electric cell.
摘要翻译：为了检查袋电池的绝缘，将探针分别与袋电池的电极和袋电池的袋的铝层接触，然后测量探针之间的电特性值。与铝层接触的探针具有由导电弹性材料制成的接触部分。此外，通过将测量的电特性值与参考值进行比较来确定袋电池的绝缘。因此，可以在测量或检查诸如绝缘电阻的袋电池的绝缘性方面充分发挥柔性袋的外周的物理特性，从而提高电接触的可靠性并使袋电池的物理损坏或变形最小化。

4. 发明申请

WO2011052950A2 PHARMACEUTICAL COMPOSITION COMPRISING INDOLE COMPOUND 审中-公开
标题翻译：包含吲哚化合物的药物组合物
公开(公告)号：WO2011052950A2
公开(公告)日：2011-05-05
申请号：PCT/KR2010/007344
申请日：2010-10-25
申请人： LG LIFE SCIENCES LTD. , KIM, Soon Ha , KIM, Hyoung Jin , PARK, Heui Sul , GU, Seon Yeong , KWAK, Hyo Shin , PARK, Du Hee , KIM, Hyo Soo , CHO, Hyun Jai , KIM, Ji Hyun , KIM, Ju Young , PARK, Kwang Min
发明人： KIM, Soon Ha , KIM, Hyoung Jin , PARK, Heui Sul , GU, Seon Yeong , KWAK, Hyo Shin , PARK, Du Hee , KIM, Hyo Soo , CHO, Hyun Jai , KIM, Ji Hyun , KIM, Ju Young , PARK, Kwang Min
IPC分类号： A61K31/404 , A61P29/00 , A61P19/02 , A61P7/08 , A61P19/10
CPC分类号： A61K31/541 , A61K8/492 , A61K31/404 , A61K31/4184 , A61K31/427 , A61K31/496 , A61K31/497 , A61K2800/522 , A61Q19/00 , C07D413/04 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to a pharmaceutical composition comprising a compound of formula (1), (2) or (3) as defined in the specification for the prevention or treatment of diseases associated with oxidative stress, mitochondria dysfunction, hypoxic injury, necrosis and/or ischemic reperfusion injury, and a cosmetic composition comprising an indole compound having an antioxidant effect.
摘要翻译：本发明涉及药物组合物，其包含如说明书中定义的式（1），（2）或（3）化合物，其用于预防或治疗与氧化应激，线粒体功能障碍，缺氧损伤，坏死和/ 或缺血再灌注损伤，以及包含具有抗氧化作用的吲哚化合物的化妆品组合物。

5. 发明申请

WO2010143901A2 METHOD FOR PREPARING AN ANTIMICROBIAL COTTON OF CELLULOSE MATRIX HAVING CHEMICALLY AND/OR PHYSICALLY BONDED SILVER AND ANTIMICROBIAL COTTON PREPARED THEREFROM 审中-公开
标题翻译：用于制备具有化学和/或物理粘结的银的纤维素基质的抗微生物棉和其制备的抗微生物棉的方法
公开(公告)号：WO2010143901A2
公开(公告)日：2010-12-16
申请号：PCT/KR2010003736
申请日：2010-06-10
申请人： BIOTECH LLC AG , KIM JU-YOUNG
发明人： KIM JU-YOUNG
IPC分类号： D06M11/42 , D06M11/36 , D06M11/83 , D06M14/04
CPC分类号： A61K9/00 , A61F13/00012 , A61F13/00063 , A61K33/38
摘要： There is provided a method for preparing a natural cellulose-AgO matrix having antimicrobial activity without leaching silver from the cellulose-AgO matrix. The method comprises: introducing silver ions (Ag+) into a natural cellulose matrix by dipping the natural cellulose matrix in an AgCl-dissolved NH4OH solution; and substituting hydrogen (H) of hydroxyl group (-OH) in natural cellulose with Ag+ by drying the silver ion-infused natural cellulose matrix, thus to form a natural cotton-AgO complex. The cellulose-AgO matrix prepared in the method may be useful to continuously maintain antimicrobial activity by maintaining an effective concentration of silver, which does not have cytotoxicity to human skin, and chemically bonded silver is not leached during the rehydration due to the chemical bond between the silver and the cellulose matrix.
摘要翻译：提供了一种制备具有抗菌活性的天然纤维素-GiO基质的方法，而不从纤维素-AgO基质中浸出银。该方法包括：将天然纤维素基质浸入AgCl溶解的NH 4 OH溶液中，将银离子（Ag +）引入天然纤维素基质中; 并通过干燥银离子注入的天然纤维素基质用Ag +取代天然纤维素中的羟基（-OH），从而形成天然棉AgO复合物。在该方法中制备的纤维素-GioO基质可用于通过保持对人皮肤没有细胞毒性的银的有效浓度来持续保持抗微生物活性，并且化学键合的银在再水合期间不会被浸出，这是由于化学键银和纤维素基质。

6. 发明申请

WO2010101415A3 APPARATUS AND METHOD FOR CONTROLLING A RELAY OF A HYBRID ELECTRIC VEHICLE 审中-公开
标题翻译：用于控制混合动力电动车辆的继电器的设备和方法
公开(公告)号：WO2010101415A3
公开(公告)日：2010-11-04
申请号：PCT/KR2010001335
申请日：2010-03-03
申请人： LG CHEMICAL LTD , JUNG CHANG-GI , KIM JU-YOUNG , KANG JUNG-SOO , KIM CHEOL-TAEK , KIM DO-YOUN
发明人： JUNG CHANG-GI , KIM JU-YOUNG , KANG JUNG-SOO , KIM CHEOL-TAEK , KIM DO-YOUN
IPC分类号： B60L11/18 , B60K6/20 , B60W10/00 , B60W20/00
CPC分类号： B60L3/0046 , B60K6/28 , B60L3/0069 , B60L3/04 , B60L3/12 , B60L11/1805 , B60L2240/549 , B60W2510/244 , B60W2530/14 , B60Y2400/114 , H01H47/002 , Y02T10/6278 , Y02T10/7005
摘要： The present invention relates to an apparatus and to a method for controlling a relay for use in a hybrid electric vehicle. The apparatus for controlling a relay according to the present invention controls the operation of turning off the relay which interconnects an electric driving unit and a battery pack for supplying power to the electric driving unit. The apparatus comprises: a current-measuring unit which measures the residual current flowing between the battery pack and the electric driving unit and outputs a value of the measured residual current; and a control unit which receives the value of the measured residual current and compares the received value with a reference residual current value when the relay is turned off, and controls the operation of turning on or off the relay in accordance with the result of the comparison. According to the present invention, the relay is prevented from being damaged by an overcurrent such as a surge current during the operation of turning off the relay in the hybrid electric vehicle.
摘要翻译：本发明涉及一种用于控制混合电动车辆中使用的继电器的设备和方法。根据本发明的用于控制继电器的设备控制断开连接电驱动单元和用于向电驱动单元供电的电池组的继电器的操作。该装置包括：电流测量单元，其测量在电池组与电驱动单元之间流动的剩余电流并输出测量的剩余电流的值; 以及控制单元，其接收所测量的剩余电流的值，并且在所述继电器断开时将所述接收值与参考剩余电流值进行比较，并且根据所述比较的结果来控制所述继电器的接通或断开的操作。根据本发明，防止继电器在关闭混合动力电动车辆中的继电器的操作期间被诸如浪涌电流的过电流损坏。

7. 发明申请

WO2010016647A1 APPARATUS AND METHOD FOR ESTIMATING STATE OF HEALTH OF BATTERY BASED ON BATTERY VOLTAGE VARIATION PATTERN 审中-公开
标题翻译：基于电池电压变化图的电池健康状况估算方法
公开(公告)号：WO2010016647A1
公开(公告)日：2010-02-11
申请号：PCT/KR2009/001490
申请日：2009-03-24
申请人： LG CHEM, LTD. , KANG, Jung-Soo , KIM, Jee-Ho , KIM, Ju-Young , JUNG, Chang-Gi
发明人： KANG, Jung-Soo , KIM, Jee-Ho , KIM, Ju-Young , JUNG, Chang-Gi
IPC分类号： G01R31/36
CPC分类号： G01R31/3679 , G01R31/3613 , G01R31/3648
摘要： An apparatus estimates SOH of a battery based on a battery voltage variation pattern. A data storing unit obtains and stores battery voltage, current and temperature data from sensors, at each SOH estimation. A first SOC estimating unit estimates first SOC by current integration using the battery current data. A second SOC estimating unit estimates open-circuit voltage from the voltage variation pattern, and calculates and stores second SOC corresponding to the open-circuit voltage and temperature using correlations between the open-circuit voltage/temperature and SOC. A weighted mean convergence calculating unit calculates and stores convergence value for weighted mean value of ratio of the second SOC variation to the first SOC variation. A SOH estimating unit estimates capacity corresponding to the weighted mean convergence value using correlation between the weighted mean convergence value and the capacity, estimates relative ratio of the estimated capacity to an initial capacity, and stores it as SOH.
摘要翻译：设备基于电池电压变化模式估计电池的SOH。在每次SOH估计时，数据存储单元获取并存储来自传感器的电池电压，电流和温度数据。第一SOC估计单元使用电池电流数据通过电流积分来估计第一SOC。第二SOC估计单元从电压变化模式估计开路电压，并且使用开路电压/温度和SOC之间的相关性来计算和存储与开路电压和温度相对应的第二SOC。加权平均收敛计算单元计算并存储第二SOC变化率与第一SOC变量的加权平均值的收敛值。 SOH估计单元使用加权平均收敛值和容量之间的相关性来估计与加权平均收敛值相对应的容量，估计估计容量与初始容量的相对比率，并将其存储为SOH。

8. 发明申请

WO2007105883A1 METHODS FOR PRODUCING SILVER-BONDED ANTIMICROBIAL MOIST WOUND DRESSINGS AND MOIST WOUND DRESSINGS PRODUCED BY THE METHODS 审中-公开
标题翻译：方法生产银粘合抗氧化物保护膜和保湿丝
公开(公告)号：WO2007105883A1
公开(公告)日：2007-09-20
申请号：PCT/KR2007/001173
申请日：2007-03-09
申请人： KIM, Yoong-Soo , KIM, Ju-Young
发明人： KIM, Yoong-Soo , KIM, Ju-Young
IPC分类号： A61L15/18
CPC分类号： A61L15/46 , A61L15/18 , A61L15/28 , A61L2300/104 , A61L2300/404 , C08L1/26
摘要： A method for producing a silver-bonded antimicrobial moist wound dressing. A silver- containing compound is added to a 0.1-30% aqueous solution of an alkaline solvent to dissociate silver ions from the silver-containing compound, dissolving CMC in water or an organic solvent to obtain a CMC solution, the silver ion-containing solution is mixed with the CMC solution so that the hydrogen ions (H+) of the hydroxyl groups of the CMC are replaced by the silver ions to prepare a silver-CMC compound, the silver-CMC compound is dispersed and absorbed in a medium, and the medium is dried.
摘要翻译：一种制备银粘合抗菌湿润伤口敷料的方法。将含银化合物加入到0.1-30％的碱性溶剂水溶液中以从含银化合物中分离银离子，将CMC溶解在水或有机溶剂中，得到CMC溶液，含有银离子的溶液与CMC溶液混合，使得CMC的羟基的氢离子（H +）被银离子代替以制备银-CMC化合物，将银-MCC化合物分散并吸收在介质中，并且培养基被干燥。

9. 发明申请

WO2005075164A2 SILVER-IMPREGNATED LIGNOCELLULOSE (SIL): PROCESS FOR MAKING AND USING SAME 审中-公开
标题翻译：银注射纤维素（SIL）：制备和使用它们的方法
公开(公告)号：WO2005075164A2
公开(公告)日：2005-08-18
申请号：PCT/US2005002292
申请日：2005-01-25
申请人： H20 TECHNOLOGIES L L C , KIM JU YOUNG
发明人： KIM JU YOUNG
IPC分类号： B27K3/16 , B27K3/32 , B27K3/52
CPC分类号： B27K3/15 , B27K3/0292 , C08K3/11
摘要： A process for making a silver-impregnated lignocellulose (SIL) is disclosed, comprising dissociating an AJ cation from its counterion in a hydrophilic solvent, forming an Aj polymer complex, penetrating the cation-polymer complex into a lignocellulose matrix; and irreversibly associating the cation-polymer with the lignocellulose matrix by drying the lignocellulose matrix, such that leaching will not occur upon rehydration.
摘要翻译：公开了一种制备银浸渍的木质纤维素（SIL）的方法，包括在亲水溶剂中从其抗衡离子解离AJ阳离子，形成Aj聚合物复合物，将阳离子 - 聚合物复合物穿透到木质纤维素基质中; 并通过干燥木质纤维素基质使阳离子聚合物与木质纤维素基质不可逆地缔合，使得在再水化时不会发生浸出。

10. 发明申请

WO2016164731A3 CD20 THERAPIES, CD22 THERAPIES, AND COMBINATION THERAPIES WITH A CD19 CHIMERIC ANTIGEN RECEPTOR (CAR) - EXPRESSING CELL 审中-公开
标题翻译： CD20疗法，CD22疗法和与CD19嵌合抗原接受者（CAR）的组合疗法 - 表达细胞
公开(公告)号：WO2016164731A3
公开(公告)日：2016-10-13
申请号：PCT/US2016/026655
申请日：2016-04-08
申请人： NOVARTIS AG , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , BITTER, Hans , BORDEAUX, Jennifer, Mary , BRANNETTI, Barbara , BROGDON, Jennifer , DAKAPPAGARI, Naveen, Kumar , GILL, Saar , HIGHFILL, Steven , HUANG, Lu , JUNE, Carl, H. , KIM, Ju, Young , LEI, Ming , LI, Na , LOWE, Andreas , ORLANDO, Elena , RUELLA, Marco , TRAN, Thai , ZHANG, Jimin , ZHOU, Li
发明人： BITTER, Hans , BORDEAUX, Jennifer, Mary , BRANNETTI, Barbara , BROGDON, Jennifer , DAKAPPAGARI, Naveen, Kumar , GILL, Saar , HIGHFILL, Steven , HUANG, Lu , JUNE, Carl, H. , KIM, Ju, Young , LEI, Ming , LI, Na , LOWE, Andreas , ORLANDO, Elena , RUELLA, Marco , TRAN, Thai , ZHANG, Jimin , ZHOU, Li
IPC分类号： C07K14/725 , C07K16/28 , C12N5/0783 , A61K39/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with one or more B-cell inhibitors, e.g., inhibitors of one or more of CD1O, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, or CD79a. The disclosure additionally features novel antigen binding domains and CAR molecules directed to CD20 and CD22, and uses, e.g., as monotherapies or in combination therapies. The invention also provides kits and compositions described herein.
摘要翻译：本发明提供了用于治疗与CD19表达相关的疾病的组合物和方法，例如通过给予包含本文所述的CD19CAR的重组T细胞与一种或多种B细胞抑制剂的组合，例如CD10，CD20，CD22，CD34，CD123，FLT-3，ROR1，CD79b，CD179b或CD79a中的一种或多种的抑制剂。本公开还特征在于新颖的抗原结合结构域和针对CD20和CD22的CAR分子，并且例如用作单一疗法或组合疗法。本发明还提供了本文所述的试剂盒和组合物。

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