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1. 发明申请

WO2007032619A1 REFLECTIVE SURFACE ATTACHED LIGHT EMITTING DEVICE 审中-公开
标题翻译：反射表面附着的发光装置
公开(公告)号：WO2007032619A1
公开(公告)日：2007-03-22
申请号：PCT/KR2006/003535
申请日：2006-09-06
申请人： KIM, Kwang Hee
发明人： KIM, Kwang Hee
IPC分类号： H01L33/00
CPC分类号： H01L25/167 , H01L33/486 , H01L33/60 , H01L2224/48091 , H01L2224/48227 , H01L2224/48247 , H01L2924/10253 , H01L2924/3025 , H01L2924/00014 , H01L2924/00
摘要： Provided is a light emitting device in which a mount portion for bonding an LED chip and a reflector for reflecting light are adhered after being separately manufactured. The light emitting device includes: a mount portion on which one or more LED chips are bonded; a wire portion which is formed to connect an n-electrode and a p-electrode of the LED chip; and a reflector which is separated from the mount portion, and is bonded with the mount portion so as to reflect light emitted from the LED chip. In addition, one or more LED chips are formed, wherein internal reflectors are respectively formed around areas where the plurality of LED chips is formed, and external reflectors are further formed out of areas where the plurality of internal reflectors is formed. Accordingly, a light emitting device package can be simply manufactured in various sizes by using a method in which a substrate bonded with a chip and a cup portion functioning as a reflector are separately formed, and thereafter the two parts are adhered to be integrated as one part. Therefore, an optical directivity of the light emitting device can be easily achieved in terms of diversity. Further, it is possible to manufacture and produce a light emitting device with high brightness in a high-variety low-volume manner.
摘要翻译：提供了一种发光装置，其中分别制造用于粘合LED芯片的安装部分和用于反射光的反射器。发光器件包括：一个或多个LED芯片接合在其上的安装部分; 形成为连接所述LED芯片的n电极和p电极的线部分; 以及与安装部分隔开并与安装部分接合以反射从LED芯片发射的光的反射器。此外，形成一个或多个LED芯片，其中在形成有多个LED芯片的区域周围分别形成内部反射器，并且在形成有多个内部反射器的区域之外进一步形成外部反射器。因此，通过使用分别形成有作为反射体的芯片和杯状部分接合的基板的方法，可以简单地制造各种尺寸的发光器件封装，此后两个部分被粘合成一体化部分。因此，在分集方面可以容易地实现发光装置的光学方向性。此外，可以以各种低容量的方式制造和制造具有高亮度的发光器件。

2. 发明申请

WO2009061131A3 NOVEL TRICYCLIC DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
公开(公告)号：WO2009061131A3
公开(公告)日：2009-05-14
申请号：PCT/KR2008/006527
申请日：2008-11-06
申请人： JE IL PHARMACEUTICAL CO., LTD. , CHOI, Jong-Hee , KIM, Myung-Hwa , KIM, Seung Hyun , PARK, Chun-Ho , JOE, Bo-Young , CHUN, Kwangwoo , OH, Byung-Kyu , RYU, Dongkyu , WON, Ran , PARK, Ji-Seon , KIM, Kwang Hee , LEE, Han-Chang , CHOI, Ji Soo
发明人： CHOI, Jong-Hee , KIM, Myung-Hwa , KIM, Seung Hyun , PARK, Chun-Ho , JOE, Bo-Young , CHUN, Kwangwoo , OH, Byung-Kyu , RYU, Dongkyu , WON, Ran , PARK, Ji-Seon , KIM, Kwang Hee , LEE, Han-Chang , CHOI, Ji Soo
IPC分类号： C07D495/04
摘要： The present invention relates to novel tricyclic derivatives having an excellent inhibitory activity on poly (ADP-ribose) polymerase, or pharmaceutically acceptable salts thereof, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The tricyclic derivatives of the present invention inhibit the activity of poly (ADP-ribose) polymerase, thereby being used for the prevention or treatment of diseases that are caused by excessive activation of PARP, in particular, neuropathic pain, neurodegenerative diseases, cardiovascular diseases, diabetic neuropathic pain, inflammatory diseases, osteoporosis, and cancer.

3. 发明申请

WO2007008037A1 NOVEL CHROMEN-2-ONE BASED HYDROXAMIC ACID DERIVATIVES HAVING ANTI-INFLAMMATORY ACTIVITY, THE PREPARATION THEREOF AND A COMPOSITION CONTAINING THE SAME FOR TREATING INFLAMMATORY DISEASE 审中-公开
标题翻译：具有抗炎活性的新型的基于2-酮基的羟基酸衍生物及其制备方法以及含有其的用于治疗炎症疾病的组合物
公开(公告)号：WO2007008037A1
公开(公告)日：2007-01-18
申请号：PCT/KR2006/002743
申请日：2006-07-12
申请人： JEIL PHARMACEUTICAL CO., LTD. , KIM, Myung Hwa , JOE, Bo Young , CHOI, Jong Hee , KIM, Kwang Hee , OH, Byung Kyu , CHUN, Kwang Woo , PARK, Chun Ho , HAN, Gyoon Hee
发明人： KIM, Myung Hwa , JOE, Bo Young , CHOI, Jong Hee , KIM, Kwang Hee , OH, Byung Kyu , CHUN, Kwang Woo , PARK, Chun Ho , HAN, Gyoon Hee
IPC分类号： C07D311/06
CPC分类号： C07D311/14 , C07D311/12 , C07D311/16 , C07D405/12
摘要： The present invention relates to novel chromen-2-one based hydroxamic acid derivatives having anti-inflammatory activity, the preparation thereof and a composition containing the same for treating inflammatory disease.
摘要翻译：本发明涉及具有抗炎活性的新型的色烯-2-酮系异羟肟酸衍生物及其制备方法以及含有此类抗炎药物的组合物。

4. 发明申请

WO2010044634A3 WHOLE-BUNCH FERMENTED LIQUOR USING DEEP OCEAN WATER, AND A PRODUCTION METHOD FOR THE SAME 审中-公开
标题翻译：使用深海水的全团发酵液及其制造方法
公开(公告)号：WO2010044634A3
公开(公告)日：2010-08-05
申请号：PCT/KR2009005962
申请日：2009-10-16
申请人： KIM KWANG HEE , UH JE SUN , LEE JONG HO
发明人： KIM KWANG HEE , UH JE SUN , LEE JONG HO
IPC分类号： C12G3/02
CPC分类号： C12G3/02
摘要： The present invention provides a production method for a whole-bunch fermented liquor, in which desalinated deep ocean water, a crude enzyme preparation and a liquidized enzyme preparation are made into a watery gruel-like form by heating while mixing, after which the mixture is cooled and subjected to protein relaxation and then a mould and yeast are incorporated into the mixture and non-desalinated deep ocean water is added and mixed in and then a multi-stage fermentation process is carried out.
摘要翻译：本发明提供一种整串发酵液的制造方法，其中将淡化的深海水，粗酶制剂和液化酶制剂在混合的同时加热制成水稀释的粥状，然后混合物冷却并进行蛋白质松弛，然后将霉菌和酵母掺入混合物中，加入未脱盐的深海水并混合，然后进行多阶段发酵过程。

5. 发明申请

WO2004113281A1 TRICYCLIC DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：三肽衍生物或药物代用品，其制剂和含有它们的药物组合物
公开(公告)号：WO2004113281A1
公开(公告)日：2004-12-29
申请号：PCT/KR2004/001518
申请日：2004-06-23
申请人： JE IL PHARMACEUTICAL CO., LTD. , KIM, Myung-Hwa , CHUN, Kwangwoo , CHOI, Jae-Won , JOE, Bo-Young , PARK, Sang-Woo , KIM, Kwang Hee , OH, Byung-Kyu , CHOI, Jong-Hee
发明人： KIM, Myung-Hwa , CHUN, Kwangwoo , CHOI, Jae-Won , JOE, Bo-Young , PARK, Sang-Woo , KIM, Kwang Hee , OH, Byung-Kyu , CHOI, Jong-Hee
IPC分类号： C07C317/30
CPC分类号： C07C323/41 , C07C381/00 , C07C2601/08 , C07C2603/34 , C07D213/81 , C07D213/82 , C07D307/68 , C07D333/38
摘要： The present invention relates to tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them. More precisely, the present invention relates to tricyclic derivatives as colchicine derivatives, pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them. Tricyclic derivatives of the present invention show very powerful cytotoxicity to cancer cell lines but were much less toxic than colchicine or taxol, confirmed through animal toxicity test. Tricyclic derivatives of the invention also decrease the volume and weight of a tumor and have a strong angiogenesis inhibiting activity in HUVEC cells. Thus, tricyclic derivatives of the present invention can effectively be used as an anticancer agent, anti-proliferation agent and an angiogenesis inhibitor.
摘要翻译：本发明涉及三环衍生物或其药学上可接受的盐，它们的制剂和含有它们的药物组合物。更准确地说，本发明涉及作为秋水仙素衍生物的三环衍生物，其药学上可接受的盐，其制备物和含有它们的药物组合物。本发明的三环衍生物对癌细胞系显示出非常强大的细胞毒性，但是通过动物毒性试验证实，它比秋水仙碱或紫杉醇毒性低得多。本发明的三环衍生物还降低了肿瘤的体积和重量，并且在HUVEC细胞中具有强的血管生成抑制活性。因此，本发明的三环衍生物可以有效地用作抗癌剂，抗增生剂和血管发生抑制剂。

6. 发明申请

WO2009061131A2 NOVEL TRICYCLIC DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译：新型三环衍生物或其药学上可接受的盐，其制备方法和包含该组合物的药物组合物
公开(公告)号：WO2009061131A2
公开(公告)日：2009-05-14
申请号：PCT/KR2008006527
申请日：2008-11-06
申请人： JE IL PHARMACEUTICAL CO LTD , CHOI JONG-HEE , KIM MYUNG-HWA , KIM SEUNG HYUN , PARK CHUN-HO , JOE BO-YOUNG , CHUN KWANGWOO , OH BYUNG-KYU , RYU DONGKYU , WON RAN , PARK JI-SEON , KIM KWANG HEE , LEE HAN-CHANG , CHOI JI SOO
发明人： CHOI JONG-HEE , KIM MYUNG-HWA , KIM SEUNG HYUN , PARK CHUN-HO , JOE BO-YOUNG , CHUN KWANGWOO , OH BYUNG-KYU , RYU DONGKYU , WON RAN , PARK JI-SEON , KIM KWANG HEE , LEE HAN-CHANG , CHOI JI SOO
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： The present invention relates to novel tricyclic derivatives having an excellent inhibitory activity on poly (ADP-ribose) polymerase, or pharmaceutically acceptable salts thereof, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The tricyclic derivatives of the present invention inhibit the activity of poly (ADP-ribose) polymerase, thereby being used for the prevention or treatment of diseases that are caused by excessive activation of PARP, in particular, neuropathic pain, neurodegenerative diseases, cardiovascular diseases, diabetic neuropathic pain, inflammatory diseases, osteoporosis, and cancer.
摘要翻译：本发明涉及对聚（ADP-核糖）聚合酶或其药学上可接受的盐具有优异抑制活性的新型三环衍生物，其制备方法以及包含其的药物组合物。本发明的三环衍生物抑制聚（ADP-核糖）聚合酶的活性，由此用于预防或治疗由PARP的过度活化引起的疾病，特别是神经性疼痛，神经变性疾病，心血管疾病，糖尿病性神经性疼痛，炎性疾病，骨质疏松症和癌症。

7. 发明申请

WO2007102679A1 NOVEL THIENOPYRIMIDINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译：新型三硝基嘧啶衍生物或其药学上可接受的盐，其制备方法和包含其的药物组合物
公开(公告)号：WO2007102679A1
公开(公告)日：2007-09-13
申请号：PCT/KR2007/001074
申请日：2007-03-05
申请人： JE IL PHARMACEUTICAL CO., LTD. , KIM, Myung-Hwa , PARK, Chun-Ho , CHUN, Kwangwoo , OH, Byung-Kyu , JOE, Bo-Young , CHOI, Jong-Hee , KWON, Hyuk-Man , HUH, Sun-Chul , WON, Ran , KIM, Kwang Hee , KIM, Sun-Mee
发明人： KIM, Myung-Hwa , PARK, Chun-Ho , CHUN, Kwangwoo , OH, Byung-Kyu , JOE, Bo-Young , CHOI, Jong-Hee , KWON, Hyuk-Man , HUH, Sun-Chul , WON, Ran , KIM, Kwang Hee , KIM, Sun-Mee
IPC分类号： C07D495/04
CPC分类号： C07D487/04 , C07D491/04 , C07D495/04
摘要： The present invention relates to a novel thienopyrimidine derivative having an excellent anti¬ inflammatory and anti-cancer activity, or a pharmaceutically acceptable salt thereof, a process for the preparation thereof and a pharmaceutical composition comprising the same. The compound according to the present invention strongly inhibits IKB kinase-β (IKK-β) involved in the activation of a transcriptional factor, NF-κB, which is associated with inducing various immune and inflammatory diseases, whereby a composition comprising the compound is a useful therapeutic agent against inflammatory diseases, in particular, arthritis and cancer.
摘要翻译：本发明涉及具有优异的抗炎和抗癌活性的新型噻吩并嘧啶衍生物或其药学上可接受的盐，其制备方法和包含其的药物组合物。根据本发明的化合物强烈地抑制与诱导各种免疫和炎症疾病相关的转录因子NF-κB的活化的IκB激酶-β（IKK-β），由此包含该化合物的组合物是一种有用的治疗炎症性疾病的治疗剂，特别是关节炎和癌症。

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