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1. 发明申请

WO2010079919A3 METHOD FOR SCREENING MATRIX METALLOPROTEINASE 审中-公开
标题翻译：筛选基质金属蛋白酶的方法
公开(公告)号：WO2010079919A3
公开(公告)日：2010-10-21
申请号：PCT/KR2009007913
申请日：2009-12-29
申请人： KOREA RES INST OF BIOSCIENCE , SONG JAE JUN , CHOI JONG HYUN , KIM BO HYE , CHOI NACK SHICK , HAN YUN JON , LEE HYE WON , LEE SEUNG GOO , KIM JOONG SU
发明人： SONG JAE JUN , CHOI JONG HYUN , KIM BO HYE , CHOI NACK SHICK , HAN YUN JON , LEE HYE WON , LEE SEUNG GOO , KIM JOONG SU
IPC分类号： C12Q1/34 , G01N33/561
CPC分类号： C12Q1/34 , G01N33/561
摘要： The present invention relates to a method of screening and activity detection for at least two different matrix metalloproteinases and more specifically to a method wherein a sample containing enzymes is subjected to gel electrophoresis, and then the sample is subjected to electrical migration in a multi-layered substrate gel having different substrates to analyze the multi-layered substrate gel, so that at least two substrate breakdown enzymes may be simultaneously screened and their activities detected. The method for screening and enzyme activity detection of matrix metalloproteinases according to the invention has the advantage that a sample is loaded on one gel, unlike the existing method, so that at least two matrix metalloproteinases can be screened. In addition, it is also useful as it has the advantage that direct screening of an unknown enzyme from a microorganism or an environmental source is accelerated.
摘要翻译：本发明涉及对至少两种不同的基质金属蛋白酶进行筛选和活性检测的方法，更具体地涉及一种方法，其中将含有酶的样品进行凝胶电泳，然后将样品进行多层电迁移底物凝胶具有不同的底物以分析多层底物凝胶，从而可以同时筛选至少两种底物分解酶并检测它们的活性。根据本发明的用于基质金属蛋白酶筛选和酶活性检测的方法具有以下优点：与现有方法不同，将样品加载在一个凝胶上，从而可以筛选至少两种基质金属蛋白酶。此外，它也有用，因为它具有加速从微生物或环境来源直接筛选未知酶的优点。

2. 发明申请

WO2006006757A1 COMPOSITION FOR LOWERING BLOOD GLUCOSE COMPRISING HEXOSE MONOPHOSPHATE 审中-公开
标题翻译：用于降低包含HEXOSE单磷酸盐的血液葡萄糖的组合物
公开(公告)号：WO2006006757A1
公开(公告)日：2006-01-19
申请号：PCT/KR2004/003254
申请日：2004-12-10
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , LEE, Dae-Sil , KIM, Hwan-Mook , KIM, Joong-Su , LEE, Chang-Woo , PARK, Song-Kyu , BAE, Jung-Don , KIM, Doo-Il , PARK, Bo-Hyun , PARK, Jung-Eun , LEE, Myong-Lyoll , KOH, Suk-Hoon , SHIN, Hyun-Jae
发明人： LEE, Dae-Sil , KIM, Hwan-Mook , KIM, Joong-Su , LEE, Chang-Woo , PARK, Song-Kyu , BAE, Jung-Don , KIM, Doo-Il , PARK, Bo-Hyun , PARK, Jung-Eun , LEE, Myong-Lyoll , KOH, Suk-Hoon , SHIN, Hyun-Jae
IPC分类号： A61K31/715
CPC分类号： A61K31/715
摘要： Disclosed is a composition comprising a hexose monophosphate for lowering blood glucose by the action of orally administered hexose monophosphate of stimulating insulin production by the pancreatic beta cells and increasing serum insulin levels.
摘要翻译：公开了一种组合物，其包含通过口服给予的单磷酸己糖的作用降低血糖的单糖磷酸酯，其通过胰β细胞刺激胰岛素产生并增加血清胰岛素水平。

3. 发明申请

WO2012064096A2 NOVEL STRAIN OF BACILLUS SUBTILIS, AND USE THEREOF FOR PREVENTING ROOT ROT DISEASE IN PLANTS 审中-公开
标题翻译：新鲜菌丝芽孢杆菌及其用于预防植物根系疾病的用途
公开(公告)号：WO2012064096A2
公开(公告)日：2012-05-18
申请号：PCT/KR2011008496
申请日：2011-11-09
申请人： KOREA RES INST OF BIOSCIENCE , KIM YOUNG KOOK , KIM JOONG SU , KIM HYOUNG CHIN , BAE KYUNG SOOK
发明人： KIM YOUNG KOOK , KIM JOONG SU , KIM HYOUNG CHIN , BAE KYUNG SOOK
IPC分类号： C12N1/20 , A01N63/02 , C12R1/125
CPC分类号： C12R1/125 , A01N63/00
摘要： The present invention relates to a novel strain of Bacillus subtilis, and more particularly, to the B-5604 strain of Bacillus subtilis, which inhibits the growth of root rot pathogens, to a composition containing said strain or the culture medium thereof for controlling root rot pathogens, to a method for controlling ginseng root rot pathogens using said composition, and to a method for inhibiting the growth of Cylindrocarpon destructans or Fusarium solani using said strain. The microorganisms having antagonistic activity developed according to the present invention are not harmful to water and soil, and thus does not cause environmental pollution, and particularly, the microorganisms having antagonistic activity according to the present invention may not only reduce root rot pathogens in farmland in which ginseng is repeatedly cultivated or recultivated, but also alleviate root rot disease in ginseng being cultivated, thus significantly contributing to ginseng cultivation.
摘要翻译：本发明涉及一种新的枯草芽孢杆菌菌株，更具体地说，涉及一种抑制根腐病原体生长的枯草芽孢杆菌B-5604菌株，所述组合物含有所述菌株或其培养基用于控制根腐病病原体，使用所述组合物控制人参根腐病病原体的方法，以及使用所述菌株抑制茄子根腐病菌或茄病镰刀菌生长的方法。根据本发明开发的具有拮抗活性的微生物对水和土壤无害，因此不会引起环境污染，特别是根据本发明的具有拮抗活性的微生物不仅可以减少农田的根腐病原体人参多次栽培或重新种植，也可减轻人参中的根腐病，从而大大促进了人参的培育。

4. 发明申请

WO2011002237A3 METHOD FOR PREPARING GENOMIC LIBRARY DERIVED FROM SINGLE CELL OF RARE MICROORGANISMS OR NOVEL MICROORGANISMS BASED ON DOMINANT SPECIES REMOVAL TECHNOLOGY 审中-公开
标题翻译：一种基于优势种植物脱除技术制备源自单细胞微生物或新型微生物的基因组文库的方法
公开(公告)号：WO2011002237A3
公开(公告)日：2011-05-19
申请号：PCT/KR2010004273
申请日：2010-07-01
申请人： KOREA RES INST OF BIOSCIENCE , SONG JAE JUN , CHOI JONG HYUN , HAN YUN JON , KIM JOONG SU
发明人： SONG JAE JUN , CHOI JONG HYUN , HAN YUN JON , KIM JOONG SU
IPC分类号： C12N15/10 , C12Q1/02 , C12Q1/68
CPC分类号： C12N15/1086
摘要： The present invention relates to a method for preparing a genomic library derived from a single cell of rare microorganisms or novel microorganisms. More specifically, the present invention is characterized by: analyzing a community of a microorganism group from collected samples; performing FISH and first FACS process for removing a dominant microorganism group based on the analysis and performing second FACS process to sort the microorganisms into single cells; amplifying non-culturable rare microorganisms or novel microorganisms which rarely exist in an environment into a genome derived from a single cell from performing multiple displacement amplification; and constructing a gene library. The method of the prevent invention can obtain and provide a genome library of non-culturable microorganisms and novel microorganisms existing in a real environment, which are difficult to detect by a conventional method and can obtain large quantities of genes of rare and novel microorganisms. In addition, the method is useful since the method enables the identification of the origin of the obtained gene unlike the conventional method for preparing a metagenome library and a library based on diversity can be manufactured by removing a dominant microorganism existing in an environment.
摘要翻译：本发明涉及用于制备源自稀有微生物单细胞或新微生物的基因组文库的方法。更具体地说，本发明的特征在于：从收集的样品中分析微生物组的群落; 基于所述分析执行用于去除显性微生物组的FISH和第一FACS过程并且执行第二FACS过程以将所述微生物分类为单个细胞; 通过多重置换扩增，将非环境中罕见的稀有微生物或极少存在于环境中的新微生物扩增到来源于单细胞的基因组中; 并构建一个基因库。本发明的方法可以获得并提供难以用常规方法检测并且可以获得大量稀有和新型微生物基因的不可培养微生物和存在于真实环境中的新微生物的基因组文库。此外，该方法是有用的，因为该方法能够鉴定所获得的基因的起源，与制备宏基因组文库的常规方法不同，并且可以通过去除存在于环境中的显性微生物来制造基于多样性的文库。

5. 发明申请

WO2013019050A3 NOVEL Alpha-GLYCOSYL STEVIOSIDE, AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：新型α-GLYCOSYL STEVIOSIDE及其制备方法
公开(公告)号：WO2013019050A3
公开(公告)日：2013-06-13
申请号：PCT/KR2012006070
申请日：2012-07-30
申请人： KOREA RES INST OF BIOSCIENCE , LEE WOO SONG , KIM YOUNG MIN , RHO MUN CHUAL , RYU YOUNG BAE , PARK SU JIN , KIM JOONG SU
发明人： LEE WOO SONG , KIM YOUNG MIN , RHO MUN CHUAL , RYU YOUNG BAE , PARK SU JIN , KIM JOONG SU
IPC分类号： C07H7/04 , C07H1/08 , C12N9/14 , C12P19/00
CPC分类号： C07H15/24 , A23L27/36 , C12P19/56
摘要： The present invention relates to novel alpha-glycosyl stevioside, and a preparation method thereof, and more specifically, to alpha-glycosyl stevioside, wherein glucose is connected to the 19-OH position of stevioside by an alpha-glycoside bond to be added, a method for preparing the alpha-glycosyl stevioside, a composition for alpha-glycosylation of stevioside containing sucrose and glucansucrase or a microorganism producing the same, a sweetener composition containing the alpha-glycosyl stevioside as an active ingredient, a food composition containing the alpha-glycosyl stevioside as a sweetener, and a method for enhancing the sweet taste of a plant or food containing stevioside, comprising a step of treating the plant or food containing stevioside with glucansucrase or a microorganism producing the same. Therefore, it is possible to prepare novel alpha-glycosyl stevioside in which one glucose is added to the 19-OH position in a high yield of 95% or more using the method for preparing alpha-glycosyl stevioside using glucansucrase of the present invention, thereby improving a sweet taste. Accordingly, the compound can be useful as a sweetening food additive and in the food industry containing the same and the like.
摘要翻译：本发明涉及新的α-糖基甜菊苷及其制备方法，更具体地说，涉及α-糖基甜菊苷，其中葡萄糖通过加入的α-糖苷键连接到甜菊苷的19-OH位置，用于制备α-糖基甜菊苷的方法，含有蔗糖和葡聚糖蔗糖酶的甜菊苷的α-糖基化的组合物或其制备的微生物，含有α-糖基甜菊苷作为活性成分的甜味剂组合物，含有α-糖基甜菜碱甜菊糖苷的甜菊糖苷，以及增强含有甜菊苷的植物或食品的甜味的方法，包括用葡聚糖蔗糖酶或其生产的微生物处理含有甜菊糖苷的植物或食物的步骤。因此，使用本发明的葡聚糖蔗糖酶制备α-糖基甜菊苷的方法，可以制备新的α-糖基甜菊苷，其中以95％以上的高产率将19个OH位置加入一个葡萄糖，从而改善甜味。因此，该化合物可用作甜味食品添加剂和含有相同物质的食品工业。

6. 发明申请

WO2008060112A1 COMPOSITION COMPRISING ARALIAE CORDATAE RADIX EXTRACT OR COMPOUNDS ISOLATED FROM THE SAME FOR PREVENTING OR TREATING PERIODONTITIS 审中-公开
标题翻译：包含ARALIAE CORDATAE RADIX提取物或其化合物的组合物从其分离用于预防或治疗周期性
公开(公告)号：WO2008060112A1
公开(公告)日：2008-05-22
申请号：PCT/KR2007/005741
申请日：2007-11-15
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , LEE, Dae-sil , KOH, Sukhoon , KIM, Joong Su , BAE, Jungdon , KIM, Dooil , PARK, Jung Eun , PARK, Miri , CHOI, Yongseok , PARK, Bo Hyun , KIM, Jin Sook , JANG, Dae Sik , KOOK, Joong-ki , SONG, Gyu Yong
发明人： LEE, Dae-sil , KOH, Sukhoon , KIM, Joong Su , BAE, Jungdon , KIM, Dooil , PARK, Jung Eun , PARK, Miri , CHOI, Yongseok , PARK, Bo Hyun , KIM, Jin Sook , JANG, Dae Sik , KOOK, Joong-ki , SONG, Gyu Yong
IPC分类号： A61K36/25 , A61K31/19 , A23L1/29 , A61P1/02
CPC分类号： A61K31/19 , A23L33/105 , A61K36/25
摘要： The present invention relates to a composition comprising an Araliae Cordatae Radix extract or compounds isolated from the same for preventing or treating periodontitis. The Araliae Cordatae Radix extract or compounds isolated from the extract according to the present invention has/have excellent antimicrobial and bactericidal activities against Porphyromonas endodontalis, Porphyromonas gingivalis and Prevotella intermedia, which are periodontal pathogens, thereby being used to prevent or treat periodontitis.
摘要翻译：本发明涉及包含Araliae Cordatae Radix提取物或从其分离的用于预防或治疗牙周炎的化合物的组合物。根据本发明的提取物中分离出的Araliae Cordatae Radix提取物或化合物对牙龈卟啉单胞菌属牙龈卟啉单胞菌和牙周膜间质瘤具有优异的抗菌和杀菌活性，它们是牙周病原体，因此用于预防或治疗牙周炎。

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