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1. 发明申请

WO2010056653A3 BACILLUS SUBTILISIN COMPRISING ONE OR MORE COMBINABLE MUTATIONS 审中-公开
标题翻译：包含一个或多个可组合的突变体的BACILLUS SUBTILISIN
公开(公告)号：WO2010056653A3
公开(公告)日：2010-09-16
申请号：PCT/US2009063837
申请日：2009-11-10
申请人： DANISCO US INC , CASCAO-PEREIRA LUIS G , ESTELL DAVID A , KELLIS JR JAMES T
发明人： CASCAO-PEREIRA LUIS G , ESTELL DAVID A , KELLIS JR JAMES T
IPC分类号： C11D3/386 , C12N9/54 , C12N15/09
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38609 , C11D3/38618 , C11D3/38663 , C11D3/38681 , C12N15/52 , C12Y304/21062
摘要： The present invention provides engineered protease variants. In particular, the protease variants comprise combinable mutations at selected surface positions that affect the charge and/or hydrophobicity of the enzyme to enhance at least one desired property of the resulting variant enzyme in a chosen application. Compositions comprising the protease variants, and methods for using the same are also provided.
摘要翻译：本发明提供工程蛋白酶变体。特别地，蛋白酶变体在选定的表面位置包含影响酶的电荷和/或疏水性的可组合突变，以在所选择的应用中增强所得变体酶的至少一种所需性质。还提供了包含蛋白酶变体的组合物及其使用方法。

2. 发明申请

WO2009149200A3 COMPOSITIONS AND METHODS COMPRISING VARIANT MICROBIAL PROTEASES 审中-公开
标题翻译：包含变异微生物蛋白质的组合物和方法
公开(公告)号：WO2009149200A3
公开(公告)日：2010-07-29
申请号：PCT/US2009046156
申请日：2009-06-03
申请人： DANISCO US INC , BASLER JOSHUA R , CASCAO-PEREIRA LUIS G , ESTELL DAVID A , KELLIS JR JAMES T
发明人： BASLER JOSHUA R , CASCAO-PEREIRA LUIS G , ESTELL DAVID A , KELLIS JR JAMES T
IPC分类号： C12N9/54 , A23K1/165
CPC分类号： C12N9/54 , A23K20/189 , C11D3/386 , C11D3/38681 , C11D11/0017 , C12N9/52 , C12Y304/21062
摘要： The present invention provides methods for protein engineering. Specifically, the invention provides methods utilizing site evaluation libraries to design libraries that optimize two or more properties of a protein. The present invention also provides variant subtilisins suitable for various uses.
摘要翻译：本发明提供蛋白质工程方法。具体地说，本发明提供了使用位点评估库来设计优化蛋白质的两个或多个性质的文库的方法。本发明还提供适用于各种用途的变体枯草杆菌蛋白酶。

3. 发明申请

WO2017210295A1 PROTEASE VARIANTS AND USES THEREOF 审中-公开
标题翻译：蛋白酶变体及其用途
公开(公告)号：WO2017210295A1
公开(公告)日：2017-12-07
申请号：PCT/US2017/035217
申请日：2017-05-31
申请人： DANISCO US INC. , MARQUEZ, David , STONER, Michael , KELLIS, Jr., James T. , GARSKE, Adam
发明人： MARQUEZ, David , STONER, Michael , KELLIS, Jr., James T. , GARSKE, Adam , BASLER, Joshua Roy , AUGUSTYN, Katherine , CHANDRASEKARAN, Priyanka , SCOTCHER, Miles Christopher , BABE, Lilia Maria , BOTT, Richard R. , ESTELL, David A. , VOGTENTANZ, Gudrun , PRICELIUS, Sina , YAO, Jian
IPC分类号： C12N15/52 , C12N9/54 , C11D3/386
摘要： Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
摘要翻译：本文公开了一种或多种枯草杆菌蛋白酶变体，编码其的核酸以及与其生产和使用有关的组合物和方法，包括比较具有改进的稳定性和/或污垢去除的一种或多种枯草杆菌蛋白酶变体到一个或多个参考枯草杆菌蛋白酶。

4. 发明申请

WO2008153935A2 METHODS FOR IMPROVING PROTEIN PROPERTIES 审中-公开
标题翻译：改善蛋白质性质的方法
公开(公告)号：WO2008153935A2
公开(公告)日：2008-12-18
申请号：PCT/US2008007114
申请日：2008-06-06
申请人： DANISCO US INC GENENCOR DIV , AEHLE WOLFGANG , CASCAO-PEREIRA LUIS GUSTAVO , KELLIS JR JAMES T , SHAW ANDREW
发明人： AEHLE WOLFGANG , CASCAO-PEREIRA LUIS GUSTAVO , KELLIS JAMES T JR , SHAW ANDREW
IPC分类号： C07K14/435
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38681 , C12N9/2411 , C12N9/2417 , C12N15/1034 , C12Y302/01001 , C12Y304/21062
摘要： The present invention provides methods for engineering proteins to optimize their performance under certain environmental conditions of interest. In some embodiments, the present invention provides methods for engineering enzymes to optimize their catalytic activity under particular environmental conditions. In some preferred embodiments, the present invention provides methods for engineering enzymes to optimize their catalytic activity and/or stability under adverse environmental conditions. In some preferred embodiments, the present invention provides methods for engineering enzymes to optimize their storage stability, particularly under adverse environmental conditions. In some preferred embodiments, the present invention provides methods for altering the net surface charge and/or surface charge distribution of enzymes (e.g., metalloproteases) to obtain enzyme variants that demonstrate improved performance and/or stability in detergent formulations as compared to the starting or parent enzyme.
摘要翻译：本发明提供了在某些感兴趣的环境条件下工程化蛋白质以优化其性能的方法。在一些实施方案中，本发明提供了工程化酶以在特定环境条件下优化其催化活性的方法。在一些优选实施方案中，本发明提供了工程化酶以在不利的环境条件下优化其催化活性和/或稳定性的方法。在一些优选的实施方案中，本发明提供了工程化酶优化其储存稳定性的方法，特别是在不利的环境条件下。在一些优选的实施方案中，本发明提供了用于改变酶（例如金属蛋白酶）的净表面电荷和/或表面电荷分布以获得酶变体的方法，所述酶变体与洗涤剂配方相比起始或以后可以改善洗涤剂配方的性能和/或稳定性亲本酶。

5. 发明申请

WO2012151534A1 COMPOSITIONS AND METHODS COMPRISING SERINE PROTEASE VARIANTS 审中-公开
标题翻译：包含丝氨酸蛋白酶变体的组合物和方法
公开(公告)号：WO2012151534A1
公开(公告)日：2012-11-08
申请号：PCT/US2012/036608
申请日：2012-05-04
申请人： DANISCO US INC. , THE PROCTER & GAMBLE COMPANY , AMIN, Neelam S. , AUGUSTYN, Katherine , BASLER, Joshua R. , CASCAO-PEREIRA, Luis G. , COLLIER, Katherine D. , CONCAR, Edward M. , ESTELL, David A. , KELLIS, JR., James T. , MAGENNIS, Euan John , PISARCHIK, Alexander , POULOSE, Ayrookaran J. , SOUTER, Philip Frank , WARD, Glenn Steven , YAO, Jian
发明人： AMIN, Neelam S. , AUGUSTYN, Katherine , BASLER, Joshua R. , CASCAO-PEREIRA, Luis G. , COLLIER, Katherine D. , CONCAR, Edward M. , ESTELL, David A. , KELLIS, JR., James T. , MAGENNIS, Euan John , PISARCHIK, Alexander , POULOSE, Ayrookaran J. , SOUTER, Philip Frank , WARD, Glenn Steven , YAO, Jian
IPC分类号： C12N9/54 , C12N15/57
CPC分类号： C12N9/54 , C11D3/386
摘要： The present invention provides serine protease variants, more specifically subtilisin variants produced there from. Specifically, the present invention provides serine protease variants, more specifically subtilisin variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants, more specifically subtilisin variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants, more specifically subtilisin variants.
摘要翻译：本发明提供丝氨酸蛋白酶变体，更具体地是从其产生的枯草杆菌蛋白酶变体。具体而言，与参考丝氨酸蛋白酶相比，本发明提供丝氨酸蛋白酶变体，更具体地具有一个或多个取代的枯草杆菌蛋白酶变体。此外，本发明提供了包含这些丝氨酸蛋白酶变体，更具体地枯草杆菌蛋白酶变体的组合物。在一些实施方案中，本发明提供了包含这些丝氨酸蛋白酶变体，更具体地枯草杆菌蛋白酶变体中的至少一种的清洁组合物。

6. 发明申请

WO2009149200A2 COMPOSITIONS AND METHODS COMPRISING VARIANT MICROBIAL PROTEASES 审中-公开
标题翻译：包含变异微生物蛋白质的组合物和方法
公开(公告)号：WO2009149200A2
公开(公告)日：2009-12-10
申请号：PCT/US2009/046156
申请日：2009-06-03
申请人： DANISCO US INC. , BASLER, Joshua R. , CASCAO-PEREIRA, Luis G. , ESTELL, David A. , KELLIS, JR., James T.
发明人： BASLER, Joshua R. , CASCAO-PEREIRA, Luis G. , ESTELL, David A. , KELLIS, JR., James T.
IPC分类号： C12N9/54 , A23K1/165
CPC分类号： C12N9/54 , A23K20/189 , C11D3/386 , C11D3/38681 , C11D11/0017 , C12N9/52 , C12Y304/21062
摘要： The present invention provides methods for protein engineering. Specifically, the invention provides methods utilizing site evaluation libraries to design libraries that optimize two or more properties of a protein. The present invention also provides variant subtilisins suitable for various uses.
摘要翻译：本发明提供蛋白质工程方法。具体地说，本发明提供了使用位点评估库来设计优化蛋白质的两个或多个性质的文库的方法。本发明还提供适用于各种用途的变体枯草杆菌蛋白酶。

7. 发明申请

WO2003091713A3 SYSTEM AND METHOD OF MEASURING MOLECULAR INTERACTIONS 审中-公开
公开(公告)号：WO2003091713A3
公开(公告)日：2003-11-06
申请号：PCT/US2003/012865
申请日：2003-04-25
申请人： BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , GENENCOR INTERNATIONAL, INC. , GAST, Alice, P. , KELLIS, JR., James, T. , KIM, Joon-Hyung , POULOSE, Ayrookaran, J. , ROBERTSON, Channing , ROY, Shaunak
发明人： GAST, Alice, P. , KELLIS, JR., James, T. , KIM, Joon-Hyung , POULOSE, Ayrookaran, J. , ROBERTSON, Channing , ROY, Shaunak
IPC分类号： G01N21/64
摘要： The present disclosure relates to a device for measuring surface plasmon resonance and fluorescence of a sample comprising a light source (205), a first detector (260), a second detector (280) and a module for calculating catalytic activity of an enzyme.

8. 发明申请

WO2011140364A1 COMPOSITIONS AND METHODS COMPRISING SUBTILISIN VARIANTS 审中-公开
标题翻译：包含色氨酸变体的组合物和方法
公开(公告)号：WO2011140364A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/035389
申请日：2011-05-05
申请人： DANISCO US INC. , THE PROCTER AND GAMBLE COMPANY , ALEKSEYEV, Viktor Yuryevich , AMIN, Neelam, S. , AUGUSTYN, Katherine , CASCAO-PEREIRA, Luis Gustavo , COLLIER, Katherine, D. , ESTELL, David, A. , KELLIS, JR., James, T. , POULOSE, Ayrookaran, J. , SOUTER, Philip Frank , WARD, Glenn Steven , YAO, Jian
发明人： ALEKSEYEV, Viktor Yuryevich , AMIN, Neelam, S. , AUGUSTYN, Katherine , CASCAO-PEREIRA, Luis Gustavo , COLLIER, Katherine, D. , ESTELL, David, A. , KELLIS, JR., James, T. , POULOSE, Ayrookaran, J. , SOUTER, Philip Frank , WARD, Glenn Steven , YAO, Jian
IPC分类号： C12N9/54 , C11D3/386 , C11D3/39
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38681
摘要： The present invention provides serine protease variants produced there from. Specifically, the present invention provides serine protease variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants.
摘要翻译：本发明提供了丝氨酸蛋白酶变体。具体地，本发明提供了与参考丝氨酸蛋白酶相比具有一个或多个取代的丝氨酸蛋白酶变体。此外，本发明提供包含这些丝氨酸蛋白酶变体的组合物。在一些实施方案中，本发明提供了包含这些丝氨酸蛋白酶变体中的至少一种的清洁组合物。

9. 发明申请

WO2008153934A3 METHODS FOR IMPROVING PROTEIN PERFORMANCE 审中-公开
标题翻译：改善蛋白质性能的方法
公开(公告)号：WO2008153934A3
公开(公告)日：2009-02-05
申请号：PCT/US2008007113
申请日：2008-06-06
申请人： DANISCO US INC GENENCOR DIV , AEHLE WOLFGANG , CASCAO-PEREIRA LUIS GUSTAVO , KELLIS JR JAMES T , SHAW ANDREW
发明人： AEHLE WOLFGANG , CASCAO-PEREIRA LUIS GUSTAVO , KELLIS JR JAMES T , SHAW ANDREW
IPC分类号： C12N15/10 , C12N15/01 , C12N15/52
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38681 , C12N9/2411 , C12N9/2417 , C12N15/1034 , C12Y302/01001 , C12Y304/21062
摘要： The present invention provides methods for engineering proteins to optimize their performance under certain environmental conditions of interest. In some embodiments, the present invention provides methods for engineering enzymes to optimize their catalytic activity under particular environmental conditions. In some preferred embodiments, the present invention provides methods for altering the net surface charge and/or surface charge distribution of enzymes {e.g., metalloproteases or serine proteases) to obtain enzyme variants that demonstrate improved performance in detergent formulations as compared to the starting or parent enzyme.
摘要翻译：本发明提供了在某些感兴趣的环境条件下工程化蛋白质以优化其性能的方法。在一些实施方案中，本发明提供了工程化酶以在特定环境条件下优化其催化活性的方法。在一些优选的实施方案中，本发明提供用于改变酶（例如金属蛋白酶或丝氨酸蛋白酶）的净表面电荷和/或表面电荷分布的方法，以获得与起始或母体相比在洗涤剂配方中表现出改善的性能的酶变体酶。

10. 发明申请

WO2008153935A3 METHODS FOR IMPROVING PROTEIN PROPERTIES 审中-公开
公开(公告)号：WO2008153935A3
公开(公告)日：2008-12-18
申请号：PCT/US2008/007114
申请日：2008-06-06
申请人： DANISCO US, INC., GENENCOR DIVISION , AEHLE, Wolfgang , CASCAO-PEREIRA, Luis Gustavo , KELLIS, JR., James T. , SHAW, Andrew
发明人： AEHLE, Wolfgang , CASCAO-PEREIRA, Luis Gustavo , KELLIS, JR., James T. , SHAW, Andrew
IPC分类号： C12N15/10 , C12N15/01 , C12N15/52 , C12N9/14 , C12N15/55 , C11D3/386 , C12N1/21
摘要： The present invention provides methods for engineering proteins to optimize their performance under certain environmental conditions of interest. In some embodiments, the present invention provides methods for engineering enzymes to optimize their catalytic activity under particular environmental conditions. In some preferred embodiments, the present invention provides methods for engineering enzymes to optimize their catalytic activity and/or stability under adverse environmental conditions. In some preferred embodiments, the present invention provides methods for engineering enzymes to optimize their storage stability, particularly under adverse environmental conditions. In some preferred embodiments, the present invention provides methods for altering the net surface charge and/or surface charge distribution of enzymes (e.g., metalloproteases) to obtain enzyme variants that demonstrate improved performance and/or stability in detergent formulations as compared to the starting or parent enzyme.

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