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1. 发明申请

WO2008030282A3 RECOMBINANT VACCINE AGAINST BLUETONGUE VIRUS 审中-公开
标题翻译：重组疫苗对BLUETONGUE病毒
公开(公告)号：WO2008030282A3
公开(公告)日：2009-12-17
申请号：PCT/US2007012709
申请日：2007-05-30
申请人： MERIAL LTD , UNIV CALIFORNIA , AUDONNET JEAN CHRISTOPHE FRANC , KARACA KEMAL , YAO JIANSHENG , MACLACHLAN NIGEL JAMES
发明人： AUDONNET JEAN CHRISTOPHE FRANCIS , KARACA KEMAL , YAO JIANSHENG , MACLACHLAN NIGEL JAMES
IPC分类号： C07K14/14 , A61K39/42 , C12N15/863 , G01N33/569
CPC分类号： C07K14/005 , A61K2039/5256 , C12N15/86 , C12N2710/24043 , C12N2720/12122 , C12N2720/12134 , G01N33/56983 , G01N33/6854
摘要： The present invention relates to an immunogenic or vaccine composition to induce an immune response or protective immune response against Orbiviruses, more specifically bluetongue virus (BTV) in an animal susceptible to BTV infection. The composition may include a pharmaceutically or veterinarily acceptable vehicle or excipient, and a vector. The vector may contain heterologous nucleic acid molecule(s), expresses in vivo in the animal BTV antigen, immunogen or epitope thereof, e.g., BTV VP2; BTV VP2 and VP5; BTV VP2 and VP5 and VP3 and/or VP7. The composition can contain an adjuvant, such as carbomer. Methods for making and using such a composition, including prime-boost regimes and including as to differential diagnosis, are also contemplated.
摘要翻译：本发明涉及一种免疫原性或疫苗组合物，用于在易感BTV感染的动物中诱导针对罗非鱼病毒的免疫应答或保护性免疫应答，更具体地说是Bluetong病毒（BTV）。组合物可以包括药学上或兽医学上可接受的载体或赋形剂和载体。载体可以含有异源核酸分子，在体内在动物BTV抗原，免疫原或其表位例如BTV VP2中表达; BTV VP2和VP5; BTV VP2和VP5以及VP3和/或VP7。组合物可以含有佐剂，如卡波姆。还考虑制备和使用这种组合物的方法，包括初始 - 加强方案和包括鉴别诊断。

2. 发明申请

WO2007024947A3 CANINE INFLUENZA VACCINES 审中-公开
标题翻译：犬流感疫苗
公开(公告)号：WO2007024947A3
公开(公告)日：2007-05-31
申请号：PCT/US2006032914
申请日：2006-08-23
申请人： MERIAL LTD , MINKE JULES MAARTEN , KARACA KEMAL , YAO JIANSHENG
发明人： MINKE JULES MAARTEN , KARACA KEMAL , YAO JIANSHENG
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/552 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , C07K14/005 , C12N2710/24043 , C12N2760/16122 , C12N2760/16134
摘要： The present invention encompasses influenza vaccines, in particular canine influenza vaccines. The vaccine may be a recombinant poxvirus vaccine or an inactivated vaccine. The invention also encompasses recombinant poxvirus vectors encoding and expressing influenza antigens, epitopes or immunogens which can be used to protect animals, in particular dogs, against influenza.
摘要翻译：本发明包括流感疫苗，特别是犬流感疫苗。疫苗可以是重组痘病毒疫苗或灭活疫苗。本发明还包括编码和表达流感抗原，表位或免疫原的重组痘病毒载体，所述流感病毒抗原，表位或免疫原可用于保护动物，特别是狗，以防止流感。

3. 发明申请

WO2009097291A2 CANINE INFLUENZA VACCINES 审中-公开
标题翻译：犬流感疫苗
公开(公告)号：WO2009097291A2
公开(公告)日：2009-08-06
申请号：PCT/US2009/032154
申请日：2009-01-27
申请人： MERIAL LIMITED , MINKE, Jules, Maarten , KARACA, Kemal , YAO, Jiansheng
发明人： MINKE, Jules, Maarten , KARACA, Kemal , YAO, Jiansheng
IPC分类号： A61K39/00 , A61P37/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/552 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , C07K14/005 , C12N2710/24043 , C12N2760/16122 , C12N2760/16134
摘要： The present invention encompasses influenza vaccines, in particular canine influenza vaccines. The vaccine may be a recombinant poxvirus vaccine or an inactivated vaccine. The invention also encompasses recombinant poxvirus vectors encoding and expressing influenza antigens, epitopes or immunogens which can be used to protect animals, in particular dogs, against influenza.
摘要翻译：本发明包括流感疫苗，特别是犬流感疫苗。疫苗可以是重组痘病毒疫苗或灭活疫苗。本发明还包括编码和表达流感抗原，表位或免疫原的重组痘病毒载体，其可用于保护动物，特别是狗免受流感。

4. 发明申请

WO2005094387A2 METHOD AND APPARATUS FOR AUTOMATIC JET INJECTION OF BIRD EGGS 审中-公开
标题翻译：自动注射BIRD EGGS的方法和装置
公开(公告)号：WO2005094387A2
公开(公告)日：2005-10-13
申请号：PCT/US2005011194
申请日：2005-04-01
申请人： MERIAL LTD , KARACA KEMAL , HAYZER DAVID J , JOHNSTON JOSEPH H JR
发明人： KARACA KEMAL , HAYZER DAVID J , JOHNSTON JOSEPH H JR
IPC分类号： A01K45/00
CPC分类号： A01K45/007
摘要： An in ovo jet injection apparatus and related methods for treating live eggs. The jet injection apparatus includes one or more jet injection delivery devices configured to deliver one or more treatment substances to predetermined areas of eggs using a high pressure stream of the treatment substance(s). Multiple treatment substances can be delivered so that they are spatially and/or temporally separate. The devices and methods of the invention enable the effective use of a plurality of treatment substances, including those that are effective when used alone but can be noxious if mixed. The methods and apparatus for the jet injection of substances into embryonic chicks reduce the risk of mechanical injury to the developing birds that would be caused by injection needles. The methods and apparatus of the invention can also reduce the introduction of an infection into the chicks.
摘要翻译：一种用于处理活卵的卵内注射装置和相关方法。喷射喷射装置包括一个或多个喷射输送装置，其被配置为使用处理物质的高压流将一种或多种处理物质输送到蛋的预定区域。可以交付多种处理物质，使其在空间和/或时间上分离。本发明的装置和方法能够有效地使用多种处理物质，包括单独使用时有效的处理物质，如果混合则可能是有害的。用于将物质喷射入雏鸡的方法和装置降低了由注射针引起的对发育中的鸟类的机械损伤的风险。本发明的方法和装置还可以减少对小鸡感染的引入。

5. 发明申请

WO2008058081A9 FELINE VACCINES AGAINST AVIAN INFLUENZA 审中-公开
标题翻译： FELINE VACCINES AVAAN INFLUENZA
公开(公告)号：WO2008058081A9
公开(公告)日：2013-05-16
申请号：PCT/US2007083648
申请日：2007-11-05
申请人： MERIAL LTD , KARACA KEMAL , MINKE JULES MAARTEN
发明人： KARACA KEMAL , MINKE JULES MAARTEN
IPC分类号： A61K39/12
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/552 , A61K2039/55566 , C12N15/86 , C12N2710/24043 , C12N2710/24071 , C12N2760/16134
摘要： The present invention encompasses influenza vaccines, in particular avian influenza vaccines. The vaccine may be a recombinant poxvirus vaccine or an inactivated vaccine. The invention also encompasses recombinant poxvirus vectors encoding and expressing avian influenza antigens, epitopes or immunogens which can be used to protect animals, in particular felids, against avian influenza.
摘要翻译：本发明包括流感疫苗，特别是禽流感疫苗。疫苗可以是重组痘病毒疫苗或灭活疫苗。本发明还包括编码和表达禽流感抗原，表位或免疫原的重组痘病毒载体，其可用于保护动物，特别是猫科动物免受禽流感。

6. 发明申请

WO2009097291A3 CANINE INFLUENZA VACCINES 审中-公开
公开(公告)号：WO2009097291A3
公开(公告)日：2009-10-01
申请号：PCT/US2009032154
申请日：2009-01-27
申请人： MERIAL LTD , MINKE JULES MAARTEN , KARACA KEMAL , YAO JIANSHENG
发明人： MINKE JULES MAARTEN , KARACA KEMAL , YAO JIANSHENG
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/552 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , C07K14/005 , C12N2710/24043 , C12N2760/16122 , C12N2760/16134
摘要： The present invention encompasses influenza vaccines, in particular canine influenza vaccines. The vaccine may be a recombinant poxvirus vaccine or an inactivated vaccine. The invention also encompasses recombinant poxvirus vectors encoding and expressing influenza antigens, epitopes or immunogens which can be used to protect animals, in particular dogs, against influenza.

7. 发明申请

WO2007024947A2 CANINE INFLUENZA VACCINES 审中-公开
标题翻译：犬流感疫苗
公开(公告)号：WO2007024947A2
公开(公告)日：2007-03-01
申请号：PCT/US2006/032914
申请日：2006-08-23
申请人： MERIAL LIMITED , MINKE, Jules, Maarten , KARACA, Kemal , YAO, Jiansheng
发明人： MINKE, Jules, Maarten , KARACA, Kemal , YAO, Jiansheng
IPC分类号： A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/552 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , C07K14/005 , C12N2710/24043 , C12N2760/16122 , C12N2760/16134
摘要： The present invention encompasses influenza vaccines, in particular canine influenza vaccines. The vaccine may be a recombinant poxvirus vaccine or an inactivated vaccine. The invention also encompasses recombinant poxvirus vectors encoding and expressing influenza antigens, epitopes or immunogens which can be used to protect animals, in particular dogs, against influenza.
摘要翻译：本发明包括流感疫苗，特别是犬流感疫苗。疫苗可以是重组痘病毒疫苗或灭活疫苗。本发明还包括编码和表达流感抗原，表位或免疫原的重组痘病毒载体，其可用于保护动物，特别是狗免受流感。

8. 发明申请

WO2008058081A1 FELINE VACCINES AGAINST AVIAN INFLUENZA 审中-公开
标题翻译： FELINE VACCINES AVAAN INFLUENZA
公开(公告)号：WO2008058081A1
公开(公告)日：2008-05-15
申请号：PCT/US2007/083648
申请日：2007-11-05
申请人： MERIAL LIMITED , KARACA, Kemal , MINKE, Jules, Maarten
发明人： KARACA, Kemal , MINKE, Jules, Maarten
IPC分类号： A61K39/12
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/552 , A61K2039/55566 , C12N15/86 , C12N2710/24043 , C12N2710/24071 , C12N2760/16134
摘要： The present invention encompasses influenza vaccines, in particular avian influenza vaccines. The vaccine may be a recombinant poxvirus vaccine or an inactivated vaccine. The invention also encompasses recombinant poxvirus vectors encoding and expressing avian influenza antigens, epitopes or immunogens which can be used to protect animals, in particular felids, against avian influenza.
摘要翻译：本发明包括流感疫苗，特别是禽流感疫苗。疫苗可以是重组痘病毒疫苗或灭活疫苗。本发明还包括编码和表达禽流感抗原，表位或免疫原的重组痘病毒载体，其可用于保护动物，特别是猫科动物免受禽流感。

9. 发明申请

WO2008030282A2 RECOMBINANT VACCINE AGAINST BLUETONGUE VIRUS 审中-公开
标题翻译：重组疫苗对BLUETONGUE病毒
公开(公告)号：WO2008030282A2
公开(公告)日：2008-03-13
申请号：PCT/US2007/012709
申请日：2007-05-30
申请人： MERIAL LIMITED , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , AUDONNET, Jean, Christophe Francis , KARACA, Kemal , YAO, Jiansheng , MacLACHLAN, Nigel, James
发明人： AUDONNET, Jean, Christophe Francis , KARACA, Kemal , YAO, Jiansheng , MacLACHLAN, Nigel, James
CPC分类号： C07K14/005 , A61K2039/5256 , C12N15/86 , C12N2710/24043 , C12N2720/12122 , C12N2720/12134 , G01N33/56983 , G01N33/6854
摘要： The present invention relates to an immunogenic or vaccine composition to induce an immune response or protective immune response against Orbiviruses, more specifically bluetongue virus (BTV) in an animal susceptible to BTV infection. The composition may include a pharmaceutically or veterinarily acceptable vehicle or excipient, and a vector. The vector may contain heterologous nucleic acid molecule(s), expresses in vivo in the animal BTV antigen, immunogen or epitope thereof, e.g., BTV VP2; BTV VP2 and VP5; BTV VP2 and VP5 and VP3 and/or VP7. The composition can contain an adjuvant, such as carbomer. Methods for making and using such a composition, including prime-boost regimes and including as to differential diagnosis, are also contemplated.
摘要翻译：本发明涉及一种免疫原性或疫苗组合物，用于在易感BTV感染的动物中诱导针对罗非鱼病毒的免疫应答或保护性免疫应答，更具体地说是Bluetong病毒（BTV）。组合物可以包括药学上或兽医学上可接受的载体或赋形剂和载体。载体可以含有异源核酸分子，在体内在动物BTV抗原，免疫原或其表位例如BTV VP2中表达; BTV VP2和VP5; BTV VP2和VP5以及VP3和/或VP7。组合物可以含有佐剂，如卡波姆。还考虑制备和使用这种组合物的方法，包括初始 - 加强方案和包括鉴别诊断。

10. 发明申请

WO2005094387A3 METHOD AND APPARATUS FOR AUTOMATIC JET INJECTION OF BIRD EGGS 审中-公开
公开(公告)号：WO2005094387A3
公开(公告)日：2005-10-13
申请号：PCT/US2005/011194
申请日：2005-04-01
申请人： MERIAL LIMITED , KARACA, Kemal , HAYZER, David, J. , JOHNSTON, Joseph, H., Jr.
发明人： KARACA, Kemal , HAYZER, David, J. , JOHNSTON, Joseph, H., Jr.
IPC分类号： A01K45/00
摘要： An in ovo jet injection apparatus and related methods for treating live eggs. The jet injection apparatus includes one or more jet injection delivery devices configured to deliver one or more treatment substances to predetermined areas of eggs using a high pressure stream of the treatment substance(s). Multiple treatment substances can be delivered so that they are spatially and/or temporally separate. The devices and methods of the invention enable the effective use of a plurality of treatment substances, including those that are effective when used alone but can be noxious if mixed. The methods and apparatus for the jet injection of substances into embryonic chicks reduce the risk of mechanical injury to the developing birds that would be caused by injection needles. The methods and apparatus of the invention can also reduce the introduction of an infection into the chicks.

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