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1. 发明申请

WO0187406A9 CARTRIDGE FOR AMEDICAL IMPLANTING INSTRUMENT 审中-公开
标题翻译：医用植入式仪器盒
公开(公告)号：WO0187406A9
公开(公告)日：2003-01-03
申请号：PCT/US0115868
申请日：2001-05-17
申请人： INTEGRATED IMPLANT SYSTEMS L L , FONTAYNE DIEGO , UEDA DANIEL , KAPLAN EDWARD J , RAVINS STEVEN S , ELGIN ERNEST A III
发明人： FONTAYNE DIEGO , UEDA DANIEL , KAPLAN EDWARD J , RAVINS STEVEN S , ELGIN ERNEST A III
IPC分类号： A61M36/00 , A61M36/12 , A61M37/00 , A61N5/00 , A61N5/10
CPC分类号： A61N5/1027 , A61M37/0069 , A61N2005/101
摘要： A cartridge is configured to be inserted into a medical instrument for treating patients with radioactive seeds. The cartridge includes a rotating internal barrel that is loaded with a plurality of seeds, where the internal barrel has a plurality of conduits for accepting the seeds. As the internal barrel rotates, a seed from one of the conduits is deposited into a shuttle, and then the shuttle is fully extended so as to provide the seed to the medical instrument. The shuttle is then retracted, and the barrel is rotated to the next conduit, so as to receive a seed from that next conduit. The cartridge includes a first shield and a second shield, each having slots where the slots of the first and second shields are aligned in a first verification or calibration mode, and where the slots are not aligned in a normal, seed depositing mode. The second shield also includes a plurality of numeric indicators that indicate a current number of seeds remaining in the cartridge.
摘要翻译：药筒被配置成插入用于治疗放射性种子患者的医疗器械中。盒包括旋转的内桶，其装载有多个种子，其中内桶具有用于接收种子的多个导管。当内桶旋转时，来自其中一个导管的种子被沉积到梭子中，然后梭子被完全延伸以便将种子提供给医疗器械。然后将梭子缩回，并将筒旋转到下一个导管，以便从该下一个导管接收种子。盒包括第一屏蔽和第二屏蔽，每个具有槽，其中第一和第二屏蔽的槽在第一验证或校准模式下对准，并且其中槽不以正常的种子存放模式对准。第二屏蔽还包括指示存储在盒中的当前种子数的多个数字指示器。

2. 发明申请

WO0187414A3 GUIDE SHEATH FOR A MEDICAL INSTRUMENT 审中-公开
标题翻译：医疗器械指南
公开(公告)号：WO0187414A3
公开(公告)日：2002-01-31
申请号：PCT/US0115869
申请日：2001-05-17
申请人： INTERGRATED IMPLANT SYSTEMS L , FONTAYNE DIEGO Y , BELLOFATTO STEVEN , KAPLAN EDWARD J
发明人： FONTAYNE DIEGO Y , BELLOFATTO STEVEN , KAPLAN EDWARD J
IPC分类号： A61B17/00 , A61B17/34 , A61M36/00 , A61M36/04 , A61N5/10 , A61M36/12
CPC分类号： A61B17/3403 , A61B2017/00274 , A61B2017/3411 , A61B2018/00547 , A61N5/1007 , A61N5/1027 , A61N2005/1011 , A61N2005/1012
摘要： A grid sheath that holds a medical instrument in place in order to insert treatment seeds into a patient. The grid sheath includes a sheath unit in which the medical instrument is fitted therein, whereby the medical instrument is capable of sliding movement within the sheath unit. The grid sheath also includes at least one plate support rod, which is preferably adjustable and that is integral with a distal end of the sheath unit. The grid sheath further includes a push plate, that is integral with a distal end of the plate support rod. When the medical instrument is placed in position with respect to a grid template, the medical instrument is engaged with a needle in a hole of the grid template, and the push plate rests against a distal surface of the grid template. As the medical instrument is actuated to deposit seeds and thereby to move away from the grid template to deposit more seeds in another position within the patient, the push plate provides for registration of the medical instrument with respect to the grid template while this is occurring.
摘要翻译：将医疗器械固定在适当位置以将治疗种子插入患者体内的网格护套。栅格护套包括其中装配有医疗器械的护套单元，由此医疗器械能够在护套单元内滑动。栅格护套还包括至少一个板支撑杆，其优选是可调节的并且与护套单元的远端成一体。栅格护套还包括与板支撑杆的远端成一体的推板。当医疗器械相对于网格模板放置就位时，医疗器械与网格模板的孔中的针接合，并且推板抵靠网格模板的远侧表面。当医疗器械被致动以沉积种子并且由此移动离开格栅模板以将更多的种子放置在患者体内的另一位置时，推板提供医疗器械相对于网格模板的登记。

3. 发明申请

WO0187404A3 MEDICAL INSTRUMENT FOR IMPLANTING SEEDS 审中-公开
标题翻译：用于植入种子的医用仪器
公开(公告)号：WO0187404A3
公开(公告)日：2002-03-21
申请号：PCT/US0115870
申请日：2001-05-17
申请人： INTEGRATED IMPLANT SYSTEMS L L , KAPLAN EDWARD J , FONTAYNE DIEGO Y , JOACHIM ROBERT A , BELLOFATTO STEVEN , PHIPPS TROY H , ELGIN ERNEST A III
发明人： KAPLAN EDWARD J , FONTAYNE DIEGO Y , JOACHIM ROBERT A , BELLOFATTO STEVEN , PHIPPS TROY H , ELGIN ERNEST A III
IPC分类号： A61M5/32 , A61M36/00 , A61M36/04 , A61M36/12 , A61N5/00 , A61N5/10
CPC分类号： A61M37/0069 , A61M2005/3289 , A61N5/1007 , A61N5/1027 , A61N2005/1011 , A61N2005/1012
摘要： A medical instrument provides for precise indexing in order to implant seeds into seed implant locations within a patient. The medical instrument is affixed to a targeting fixture, and upon operatior actuation of a trigger, is automatically indexed from one seed implant location to a next seed implant location.
摘要翻译：医疗器械提供精确的分度，以将种子植入患者的种子植入位置。医疗器械被固定到瞄准器具上，并且在触发器的操作致动时，被自动地从一个种子植入位置索引到下一个种子植入位置。

4. 发明申请

WO2002068000A3 POLYMERIC IMAGABLE BRACHYTHERAPY SEED 审中-公开
公开(公告)号：WO2002068000A3
公开(公告)日：2002-09-06
申请号：PCT/US2001/043517
申请日：2001-11-16
申请人： MICROSPHERIX LLC , KAPLAN, Edward, J.
发明人： KAPLAN, Edward, J.
IPC分类号： A61K51/12
摘要： A brachytherapy seed that includes an imaging marker and/or a therapeutic, diagnostic or prophylactic agent such as a drug in a polymeric carrier that can be delivered to a subject upon implantation into the subject through the bore of a brachytherapy implantation needle has been developed. Because the brachytherapy seeds can be sized and shaped to fit through the bore of a brachytherapy implantation needle, they are suitable for use with brachytherapy seed implantation instruments. A drug or other therapeutically active substance or diagnostic can be included in the seed in addition to, or as an alternative to, a radioisotope. The rate of release in the implantation site can be controlled by controlling the rate of degradation and/or release at the implantation site. In the preferred embodiment, the seeds also contain a radioopaque material or other means for external imaging. Like conventional radioactive brachytherapy seeds, the seeds can be precisely implanted in many different target tissues without the need for invasive surgery. Moreover, similar to the radiation emitted from conventional brachytherapy seeds, the therapeutically active substance included within a seed can be delivered in a controlled fashion over a relatively long period of time (e.g., weeks, months, or longer periods).

5. 发明申请

WO0187406A3 CARTRIDGE FOR AMEDICAL IMPLANTING INSTRUMENT 审中-公开
标题翻译：医用植入式仪器盒
公开(公告)号：WO0187406A3
公开(公告)日：2002-03-28
申请号：PCT/US0115868
申请日：2001-05-17
申请人： INTEGRATED IMPLANT SYSTEMS L L , FONTAYNE DIEGO , UEDA DANIEL , KAPLAN EDWARD J , RAVINS STEVEN S , ELGIN ERNEST A III
发明人： FONTAYNE DIEGO , UEDA DANIEL , KAPLAN EDWARD J , RAVINS STEVEN S , ELGIN ERNEST A III
IPC分类号： A61M36/00 , A61M36/12 , A61M37/00 , A61N5/00 , A61N5/10
CPC分类号： A61N5/1027 , A61M37/0069 , A61N2005/101
摘要： A cartridge is configured to be inserted into a medical instrument for treating patients with radioactive seeds. The cartridge includes a rotating internal barrel that is loaded with a plurality of seeds, where the internal barrel has a plurality of conduits for accepting the seeds. As the internal barrel rotates, a seed from one of the conduits is deposited into a shuttle, and then the shuttle is fully extended so as to provide the seed to the medical instrument. The shuttle is then retracted, and the barrel is rotated to the next conduit, so as to receive a seed from that next conduit. The cartridge includes a first shield and a second shield, each having slots where the slots of the first and second shields are aligned in a first verification or calibration mode, and where the slots are not aligned in a normal, seed depositing mode. The second shield also includes a plurality of numeric indicators that indicate a current number of seeds remaining in the cartridge.
摘要翻译：药筒被配置成插入用于治疗放射性种子患者的医疗器械中。盒包括旋转的内桶，其装载有多个种子，其中内桶具有用于接收种子的多个导管。当内桶旋转时，来自其中一个导管的种子被沉积到梭子中，然后梭子被完全延伸以便将种子提供给医疗器械。然后将梭子缩回，并将筒旋转到下一个导管，以便从该下一个导管接收种子。盒包括第一屏蔽和第二屏蔽，每个具有槽，其中第一和第二屏蔽的槽在第一验证或校准模式下对准，并且其中槽不以正常的种子存放模式对准。第二屏蔽还包括指示存储在盒中的当前种子数的多个数字指示器。

6. 发明申请

WO2002085188A3 DEFLECTABLE IMPLANTATION DEVICE AND METHOD FOR USE 审中-公开
公开(公告)号：WO2002085188A3
公开(公告)日：2002-10-31
申请号：PCT/US2002/012654
申请日：2002-04-22
申请人： KAPLAN, Edward, J.
发明人： KAPLAN, Edward, J.
IPC分类号： A61M36/00
摘要： Apparatus (100) and methods allowing the clinician to circumvent the public arch in instances where it interferes with insertion of instrumentation (102) into the prostate or periprostatic tissue. The apparatus (100) employs needles of shape emory alloys, such as nickel-tatanium (NiTi) for the purpose of avoiding the public arch when accessing the prostate from the perineum.

7. 发明申请

WO02085188A2 DEFLECTABLE IMPLANTATION DEVICE AND METHOD FOR USE 审中-公开
标题翻译：可植入植入装置及其使用方法
公开(公告)号：WO02085188A2
公开(公告)日：2002-10-31
申请号：PCT/US0212654
申请日：2002-04-22
申请人： KAPLAN EDWARD J
发明人： KAPLAN EDWARD J
IPC分类号： A61M36/04 , A61N5/00 , A61N5/10 , A61B
CPC分类号： A61M37/0069 , A61B17/3468 , A61B2017/00867 , A61M25/0662 , A61M2205/0266 , A61N5/1007 , A61N2005/1011
摘要： Systems, apparatus, components and methods are disclosed that allow the clinician to circumvent the public arch in instances where it interferes with insertion of instrumentation into the prostate or periprostatic tissue. The systems, apparatus and components disclosed herein employ structures, such as needles and trocars, of shape emory alloys, such as nickel-tatanium (Ni-Ti) for the purpose of avoiding the public arch when accessing the prostate from the perineum.
摘要翻译：公开了系统，装置，部件和方法，其允许临床医生在妨碍将仪器插入前列腺或周围静脉组织的情况下规避公共拱。本文公开的系统，装置和组件采用诸如镍 - 钛（Ni-Ti）的形状金刚石合金的结构，例如针和套针，用于在从会阴进入前列腺时避免公共拱。

8. 发明申请

WO02068000A2 POLYMERIC IMAGABLE BRACHYTHERAPY SEED 审中-公开
标题翻译：聚合成像BRACHYTHERAPY SEED
公开(公告)号：WO02068000A2
公开(公告)日：2002-09-06
申请号：PCT/US0143517
申请日：2001-11-16
申请人： MICROSPHERIX LLC , KAPLAN EDWARD J
发明人： KAPLAN EDWARD J
IPC分类号： A61K41/00 , A61K47/48 , A61K49/04 , A61K51/12 , A61N5/10
CPC分类号： A61N5/1027 , A61K41/0038 , A61K47/6957 , A61K49/0409 , A61K51/1282 , A61N2005/1023 , A61N2005/1024
摘要： A brachytherapy seed that includes an imaging marker and/or a therapeutic, diagnostic or prophylactic agent such as a drug in a polymeric carrier that can be delivered to a subject upon implantation into the subject through the bore of a brachytherapy implantation needle has been developed. Because the brachytherapy seeds can be sized and shaped to fit through the bore of a brachytherapy implantation needle, they are suitable for use with brachytherapy seed implantation instruments. A drug or other therapeutically active substance or diagnostic can be included in the seed in addition to, or as an alternative to, a radioisotope. The rate of release in the implantation site can be controlled by controlling the rate of degradation and/or release at the implantation site. In the preferred embodiment, the seeds also contain a radioopaque material or other means for external imaging. Like conventional radioactive brachytherapy seeds, the seeds can be precisely implanted in many different target tissues without the need for invasive surgery. Moreover, similar to the radiation emitted from conventional brachytherapy seeds, the therapeutically active substance included within a seed can be delivered in a controlled fashion over a relatively long period of time (e.g., weeks, months, or longer periods).
摘要翻译：已经开发了一种近距离放射治疗种子，其包括成像标记物和/或治疗性，诊断性或预防剂，例如聚合物载体中的药物，其可以通过近距离放射治疗植入针的孔植入受试者中而被递送至受试者。因为近距离放射治疗种子的大小和形状可以通过近距离放射治疗植入针的孔适应，它们适用于近距离放射治疗种子植入器械。药物或其他治疗活性物质或诊断物可以除了放射性同位素之外或作为替代放射性同位素包括在种子中。可以通过控制植入部位的降解和/或释放速率来控制植入部位的释放速度。在优选实施例中，种子还包含不透射线材料或用于外部成像的其它装置。像常规放射性近距离放射治疗种子一样，可以将种子精确地植入许多不同的靶组织，而不需要进行侵入性手术。此外，类似于从常规近距离放射治疗种子发射的辐射，包含在种子内的治疗活性物质可以以相对长的时间段（例如，数周，数月或更长的时间）以受控的方式递送。

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