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1. 发明申请

WO2015106164A1 LXR AGONISTS AND USES THEREOF 审中-公开
标题翻译： LXR激素及其用途
公开(公告)号：WO2015106164A1
公开(公告)日：2015-07-16
申请号：PCT/US2015/010909
申请日：2015-01-09
申请人： RGENIX, INC. , MARTINEZ, Eduardo, J. , KAISER, Bernd , TAVAZOIE, Sohail, F. , KURTH, Isabel , GONSALVES, Foster, Casimir , DARST, David, M., Jr. , TAVAZOIE, Masoud, Fakhr
发明人： MARTINEZ, Eduardo, J. , KAISER, Bernd , TAVAZOIE, Sohail, F. , KURTH, Isabel , GONSALVES, Foster, Casimir , DARST, David, M., Jr. , TAVAZOIE, Masoud, Fakhr
IPC分类号： A61K31/145
CPC分类号： C07F9/657172 , A61K31/138 , A61K31/145 , A61K31/165 , A61K31/195 , A61K31/24 , A61K31/357 , A61K31/366 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/661 , A61K31/675 , A61K45/06 , C07B59/004 , C07B2200/05 , C07C217/18 , C07C217/20 , C07C217/22 , C07C217/58 , C07C259/06 , C07C311/51 , C07C317/04 , C07C317/14 , C07C317/22 , C07C317/46 , C07C323/09 , C07C323/32 , C07C2101/14 , C07C2601/14 , C07D205/04 , C07D207/48 , C07D209/48 , C07D211/42 , C07D211/96 , C07D311/76 , C07D317/46 , C07F9/09 , C07F9/094 , C07F9/12 , C07F9/304 , C07F9/65744 , A61K2300/00
摘要： This invention features compounds that modulate the activity of liver X receptors, pharmaceutical compositions including the compounds of the invention, and methods of utilizing those compositions for modulating the activity of liver X receptors in the treatment of cancer.
摘要翻译：本发明的特征在于调节肝X受体活性的化合物，包括本发明化合物的药物组合物，以及利用这些组合物调节肝脏X受体在癌症治疗中的活性的方法。

2. 发明申请

WO2019015796A1 EINZELDOSIS-PULVERINHALATOR 审中-公开
公开(公告)号：WO2019015796A1
公开(公告)日：2019-01-24
申请号：PCT/EP2018/000313
申请日：2018-06-22
申请人： BELLER, Klaus-Dieter , KAISER, Bernd
发明人： BELLER, Klaus-Dieter , KAISER, Bernd
IPC分类号： A61M15/08 , A61M15/00
摘要： Die vorliegende Erfindung stellt einen Einzeldosis-Pulverinhalator (10) zur nasalen Applikation bereit, der ein flaches Inhalatorgehäuse aufweist, das aus zwei flächigen, entlang einer Verbindungsebene (E) miteinander verbundenen Gehäuseteilen (1, 2) besteht. In diesen sind eine Medikamentenkammer (11) mit zumindest einer Pulveraufnahmemulde (11'), eine Lufteinlassöffnung (14) und einen durch eine Wandung (7) begrenzten Luftkanal, der sich von der Lufteinlassöffnung (14) über die Medikamentenkammer (11) zu einer Auslassöffnung (12) erstreckt, ausgeformt. Erfindungsgemäß liegt die Lufteinlassöffnung (14) nicht auf einer von der Auslassöffnung (12) abgewandten Seite vor, wobei der Luftkanal eine Richtungsänderung einer Luftströmung durch die Lufteinlassöffnung (14) in Bezug zu der Auslassöffnung (12) bereitstellt. Der Auslassabschnitt (13) des Luftkanals zwischen der Medikamentenkammer (11) und der Auslassöffnung (12) weist mehr als eine Windung (6) auf. Ferner ist an die Auslassöffnung (12) ein Nasenstück (4) angeformt, das zur Aufnahme in nur ein Nasenloch oder zur Aufnahme in beide Nasenlöcher ausgebildet ist.

3. 发明申请

WO2005028480A2 5-ARYL-PYRAZOLO[4,3-D]PYRIMIDINES, PYRIDINES, AND PYRAZINES AND RELATED COMPOUNDS 审中-公开
标题翻译： 5-芳基吡唑并[4,3-D]嘧啶，吡啶和吡嗪及相关化合物
公开(公告)号：WO2005028480A2
公开(公告)日：2005-03-31
申请号：PCT/US2004/028663
申请日：2004-09-03
申请人： NEUROGEN CORPORATION , AVENTIS PHARMACEUTICALS INC. , HODGETTS, Kevin, J. , JOHN, Stanly , MOORCROFT, Neil , SHUTSKE, Greg , KAISER, Bernd , YAMAGUCHI, Yasuchika , GE, Ping , HORVATH, Raymond, F.
发明人： HODGETTS, Kevin, J. , JOHN, Stanly , MOORCROFT, Neil , SHUTSKE, Greg , KAISER, Bernd , YAMAGUCHI, Yasuchika , GE, Ping , HORVATH, Raymond, F.
IPC分类号： C07D487/00
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： 5-aryl-Pyrazolo[4,3- d ] pyrimidines, 6-aryl-Pyrazolo[3,4- d ]pyrimidines and related compounds, as well as other chemically related compounds, that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRIF receptor binding. Methods of using the compounds in receptor localization studies are given.
摘要翻译： 5-芳基 - 吡唑并[4,3-d]嘧啶，6-芳基 - 吡唑并[3,4-d 提供了充当CRF1受体的选择性调节剂的嘧啶和相关化合物以及其他化学相关化合物。这些化合物可用于治疗许多CNS和周围疾病，特别是压力，焦虑，抑郁，心血管疾病和进食障碍。还提供了治疗此类病症的方法以及包装的药物组合物。本发明化合物还可用作CRF受体定位探针，并作为CRIF受体结合测定的标准。给出了在受体定位研究中使用这些化合物的方法。

4. 发明申请

WO1989000981A1 PROCESS FOR DYEING SILICIC ACID GLASS FIBRES AND PRODUCTS SO OBTAINED 审中-公开
标题翻译：用于染色硅酸玻璃纤维和产品的方法
公开(公告)号：WO1989000981A1
公开(公告)日：1989-02-09
申请号：PCT/EP1988000687
申请日：1988-07-28
申请人： FRENZELIT-WERKE GMBH & CO. KG , SCHMIDT, Ulrich , SCHNABEL, Manfred , FÜSSMANN, Klaus , KAISER, Bernd
发明人： FRENZELIT-WERKE GMBH & CO. KG
IPC分类号： C03C25/00
CPC分类号： C03C25/00 , C03C25/475 , C03C25/66
摘要： In a process for dyeing silicic acid glass fibres or textiles made from these fibres, with organic pigments, the glass is desized, if necessary, subjected to an acid treatment, dyed, and if necessary coated with a finish preferably impermeable to steam. The acid treatment is applied until an extraction yield of 2 % maximum, preferably 1 %, is attained and, after intermediate drying if necessary, the fibres are dyed with basic acrylic dyes having a K-value of

5. 发明申请

WO2008016811A3 AMINOPIPERIDINES AND REALTED COMPOUNDS 审中-公开
标题翻译：氨基哌啶和有机化合物
公开(公告)号：WO2008016811A3
公开(公告)日：2008-10-09
申请号：PCT/US2007074282
申请日：2007-07-25
申请人： NEUROGEN CORP , GHOSH MANUKA , SEEKAMP CHRISTOPHER K , ZHANG XUECHUN , TARRANT JAMES G , LEE CHE-WAH , KAISER BERND , ZABLOCKI MARY-MARGARET , CHENARD BERTRAND L , DOLLER DARIO , YAMAGUCHI YASUCHIKA , WUSTROW DAVID J , LI GUIYING
发明人： GHOSH MANUKA , SEEKAMP CHRISTOPHER K , ZHANG XUECHUN , TARRANT JAMES G , LEE CHE-WAH , KAISER BERND , ZABLOCKI MARY-MARGARET , CHENARD BERTRAND L , DOLLER DARIO , YAMAGUCHI YASUCHIKA , WUSTROW DAVID J , LI GUIYING
IPC分类号： A61K31/4025 , A61K31/4523 , A61K31/501 , C07D401/06 , C07D407/14
CPC分类号： C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D411/12 , C07D413/12 , C07D417/12 , C07D451/04
摘要： Aminopiperidines and related compounds of the formulas are provided: in which variables are described herein. Such compounds may be used to modulate MCH receptor activity in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such Iigands for detecting MCH receptors (e.g., receptor localization studies).
摘要翻译：提供氨基哌啶和相关化学式的化合物：其中变量在本文中描述。此类化合物可用于体内或体外调节MCH受体活性，并且特别可用于治疗人类，家养伴侣动物和家畜动物中的各种代谢，摄食和性障碍。提供了用于治疗此类病症的药物组合物和方法，以及使用这些配体用于检测MCH受体的方法（例如受体定位研究）。

6. 发明申请

WO1992002757A1 HEADLAMP FOR MOTOR VEHICLES 审中-公开
标题翻译：电动汽车头灯
公开(公告)号：WO1992002757A1
公开(公告)日：1992-02-20
申请号：PCT/DE1991000517
申请日：1991-06-26
申请人： ROBERT BOSCH GMBH , STEIN, Jürgen , WÖRNER, Bernhard , DELB, Fred , WEIGOLD, Thomas , SCHMIED, Friedrich , KUSSEROW, Peter , KAISER, Bernd
发明人： ROBERT BOSCH GMBH
IPC分类号： F21M07/00
CPC分类号： F21V25/04 , B60Q1/0088 , F21S41/17 , F21S41/192 , F21V9/06 , Y10S362/802
摘要： The headlamp has a reflector (10) into which a gas discharge lamp (12) is inserted from the rear via a lamp holder (11). The gas discharge lamp (12) is powered at high voltage via a ballast (14). The rear of the gas discharge lamp (12) is covered with a protective cap (17). To the ballast is connected an electric lead (19) having a magnetically actuatable switch (21) fitted in the protective cap (17). To the lamp holder (11) is fitted a magnet (24) by which the switch (21) can be held in the on position. If the protective cap (17) is not fitted, the lack of magnetic power causes the switch (21) to go into the off position and the lead (19) is interrrupted thus preventing the gas discharge lamp (12) from being operated by the ballast (14).
摘要翻译：前照灯具有反射器（10），气体放电灯（12）经由灯座（11）从后部插入其中。气体放电灯（12）通过镇流器（14）以高电压供电。气体放电灯（12）的后部被保护盖（17）覆盖。连接有安装在保护帽（17）中的具有可启动磁性开关（21）的电引线（19）。灯座11安装有一个磁体24，开关21可通过该磁体保持在接通位置。如果未安装保护盖（17），则缺少磁力使开关（21）进入关闭位置，引线（19）被中断，从而防止气体放电灯（12）由镇流器（14）。

7. 发明申请

WO2008016811A2 AMINOPIPERIDINES AND REALTED COMPOUNDS 审中-公开
标题翻译：氨基酸和实际化合物
公开(公告)号：WO2008016811A2
公开(公告)日：2008-02-07
申请号：PCT/US2007/074282
申请日：2007-07-25
申请人： NEUROGEN CORPORATION , GHOSH, Manuka , SEEKAMP, Christopher, K. , ZHANG, Xuechun , TARRANT, James, G. , LEE, Che-Wah , KAISER, Bernd , ZABLOCKI, Mary-Margaret , CHENARD, Bertrand, L. , DOLLER, Dario , YAMAGUCHI, Yasuchika , WUSTROW, David, J. , LI, Guiying
发明人： GHOSH, Manuka , SEEKAMP, Christopher, K. , ZHANG, Xuechun , TARRANT, James, G. , LEE, Che-Wah , KAISER, Bernd , ZABLOCKI, Mary-Margaret , CHENARD, Bertrand, L. , DOLLER, Dario , YAMAGUCHI, Yasuchika , WUSTROW, David, J. , LI, Guiying
IPC分类号： C07D403/02
CPC分类号： C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D411/12 , C07D413/12 , C07D417/12 , C07D451/04
摘要： Aminopiperidines and related compounds of the formulas are provided: in which variables are described herein. Such compounds may be used to modulate MCH receptor activity in viv o or in vitro , and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such Iigands for detecting MCH receptors ( e.g. , receptor localization studies).
摘要翻译：提供了下列通式的氨基哌啶类和相关化合物：本文描述了变量。这样的化合物可用于在体内或体外调节MCH受体活性，并且特别可用于治疗人，驯养伴侣动物和家畜中的各种代谢，喂养和性障碍。还提供了用于治疗这种病症的药物组合物和方法，以及使用这些配体来检测MCH受体的方法（例如，受体定位研究）。

8. 发明申请

WO1986001761A1 ORBITAL GRINDING MACHINE 审中-公开
标题翻译： ORBITAL研磨机
公开(公告)号：WO1986001761A1
公开(公告)日：1986-03-27
申请号：PCT/DE1985000285
申请日：1985-08-23
申请人： LICENTIA PATENT-VERWALTUNGS-GMBH , BRAUN, Roland , KAISER, Bernd , STÄMMELE, Siegfried
发明人： LICENTIA PATENT-VERWALTUNGS-GMBH
IPC分类号： B24B23/04
CPC分类号： B24B23/04 , B23Q11/0035
摘要： The orbital grinding machine has a friction plate secured to the casing by means of elastic elements. A reciprocating motion is imparted to the plate by means of a control eccentric provided with a counterweight and acting through a ball bearing, the eccentric being set in rotation by the armature shaft of the motor. In order to use the grinding machine either to rough-grind or for grind-rectification by simply changing the stroke of the eccentric, the control eccentric (9) is actuated by an eccentric pivot (7) with respect to the motor shaft (1'). The shaft (1) is angularly displaceable with respect to the control excentric and to its counterweight (13). Additionally, the shift angle between the armature shaft of the motor and the control eccentric is limited in both rotational directions by means of corresponding stops (19, 20) of the motor shaft and there is added to the counterweight of the control excentric an additional balancing weight (14) shifted by approximately 100 with respect to the counterweight.
摘要翻译：轨道磨床具有通过弹性元件固定到壳体的摩擦板。通过设置有配重并通过球轴承作用的控制偏心器向板施加往复运动，偏心轮由电动机的电枢轴旋转。为了通过简单地改变偏心轮的行程来将磨床用于粗磨或进行磨削矫正，控制偏心轮9通过相对于电动机轴（1'）的偏心枢轴（7）致动，）。轴（1）相对于控制偏心角度地位移到其对重（13）。此外，电动机的电枢轴与控制偏心轮之间的移动角度通过电动机轴的相应止动件（19,20）在两个旋转方向上受到限制，并且将附加到控制偏心的配重附加了额外的平衡重量（14）相对于配重偏移大约100°。

9. 发明申请

WO2005028480A3 5-ARYL-PYRAZOLO[4,3-D]PYRIMIDINES, PYRIDINES, AND PYRAZINES AND RELATED COMPOUNDS 审中-公开
标题翻译： 5-亚氨基 - 吡唑并[4,3-D]吡啶，吡啶和吡啶及相关化合物
公开(公告)号：WO2005028480A3
公开(公告)日：2005-06-02
申请号：PCT/US2004028663
申请日：2004-09-03
申请人： NEUROGEN CORP , AVENTIS PHARMA INC , HODGETTS KEVIN J , JOHN STANLY , MOORCROFT NEIL , SHUTSKE GREG , KAISER BERND , YAMAGUCHI YASUCHIKA , GE PING , HORVATH RAYMOND F
发明人： HODGETTS KEVIN J , JOHN STANLY , MOORCROFT NEIL , SHUTSKE GREG , KAISER BERND , YAMAGUCHI YASUCHIKA , GE PING , HORVATH RAYMOND F
IPC分类号： A61K31/519 , A61K31/53 , C07D471/04 , C07D487/02 , C07D487/04 , C07D519/00 , A61K31/437 , A61P25/18 , A61P25/22
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： 5-aryl-Pyrazolo[4,3-d] pyrimidines, 6-aryl-Pyrazolo[3,4-d]pyrimidines and related compounds, as well as other chemically related compounds, that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRIF receptor binding. Methods of using the compounds in receptor localization studies are given.
摘要翻译：提供了作为CRF 1受体的选择性调节剂的5-芳基 - 吡唑并[4,3-d]嘧啶，6-芳基 - 吡唑并[3,4-d]嘧啶和相关化合物以及其它化学相关化合物。这些化合物可用于治疗许多中枢神经系统和周围疾病，特别是压力，焦虑，抑郁，心血管疾病和进食障碍。还提供了治疗这种疾病以及包装的药物组合物的方法。本发明的化合物也可用作CRF受体定位的探针，并且作为用于CRIF受体结合的测定中的标准物。给出了在受体定位研究中使用化合物的方法。

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