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1. 发明申请

WO2007148321A2 IRREVERSIBLE COOLNESS INDICATOR 审中-公开
标题翻译：不可逆的冷却指示器
公开(公告)号：WO2007148321A2
公开(公告)日：2007-12-27
申请号：PCT/IL2007/000719
申请日：2007-06-14
申请人： TIMESTRIP UK LIMITED , KAGAN, Michael , MIRSKY, Vladimir , WOLFBEIS, Otto
发明人： KAGAN, Michael , MIRSKY, Vladimir , WOLFBEIS, Otto
IPC分类号： G01K3/00 , G01K11/06
CPC分类号： G01K3/005 , B82Y15/00 , G01N31/229
摘要： The invention provides a temperature-threshold indicator device 10 comprising a sealed housing 12 having at least one surface 14 which is transparent and containing a suspension of inorganic nanoparticles 18 suspended in a liquid medium wherein the suspension undergoes an irreversible detectible change in optical characteristics upon freezing of the liquid medium due to aggregation of the nanoparticles, and wherein the device is provided with means for association thereof with a product whereby the temperature-threshold indicator device 10 serves to determine whether the product has been exposed to an environment of predetermined coldness..
摘要翻译：本发明提供了一种温度阈值指示装置10，其包括具有透明的至少一个表面14的密封壳体12，该表面14包含悬浮在液体介质中的无机纳米颗粒悬浮液，其中悬浮液在冷冻时经历光学特性的不可逆的可检测变化的液体介质，并且其中所述装置设置有用于与产品相关联的装置，由此温度阈值指示器装置10用于确定产品是否已经暴露于预定的冷度的环境中。

2. 发明申请

WO2008107871B1 ADVERTISING DEVICE WITH HIDDEN IMAGES OR INDICIA 审中-公开
标题翻译：广告设备与隐藏的图像或印度
公开(公告)号：WO2008107871B1
公开(公告)日：2008-10-23
申请号：PCT/IL2008000264
申请日：2008-03-02
申请人： TIMESTRIP UK LTD , KAGAN MICHAEL , RABINOWITZ AVI , MAGEN EREZ , ISBITSKY REUBEN , FREEDMAN PAUL
发明人： KAGAN MICHAEL , RABINOWITZ AVI , MAGEN EREZ , ISBITSKY REUBEN , FREEDMAN PAUL
IPC分类号： G04F1/06 , G04F1/00
CPC分类号： G04F1/005 , G04F1/06
摘要： The invention provides an advertising device provided with a first area containing advertising indicia and a second area provided with a plurality of indicia display areas, wherein each indicia display areas is associated with indicia activation means undergoing activation at predetermined elapses times relative to each other and wherein the display of all of the indicia in their designated indicia display areas provide a predetermined unitary message and wherein each of the predetermined elapsed times is at leas one hour in duration.
摘要翻译：本发明提供了一种广告设备，其具有包含广告标记的第一区域和设置有多个标记显示区域的第二区域，其中每个标记显示区域与在相对于彼此预定经过时间进行激活的标记激活装置相关联，并且其中在其指定的标记显示区域中的所有标记的显示提供预定的单一消息，并且其中预定经过时间中的每一个在持续时间为1小时。

3. 发明申请

WO2007053245A2 METHODS AND COMPOSITION TO GENERATE UNIQUE SEQUENCE DNA PROBES, IABELING OF DNA PROBES AND THE USE OF THESE PROBES 审中-公开
标题翻译：生成单一序列DNA探针的方法和组合，DNA探针的标识和这些探针的使用
公开(公告)号：WO2007053245A2
公开(公告)日：2007-05-10
申请号：PCT/US2006/036656
申请日：2006-09-20
申请人： IMMUNIVEST CORPORATION , CONNELLY, Mark, Carle , FOULK, Brad , KAGAN, Michael, T. , SWENNENHUIS, Joost, F. , TERSTAPPEN, Leon, W.M.M. , TIBBE, Arjan, G.J. , VERRANT, John, A.
发明人： CONNELLY, Mark, Carle , FOULK, Brad , KAGAN, Michael, T. , SWENNENHUIS, Joost, F. , TERSTAPPEN, Leon, W.M.M. , TIBBE, Arjan, G.J. , VERRANT, John, A.
IPC分类号： G06T7/20 , G01N33/567 , C12M1/34
CPC分类号： C12Q1/6886 , C12Q1/34 , C12Q1/6811 , C12Q1/6876 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2533/101 , C12Q2531/113 , C12Q2521/301 , C12Q2563/131 , C12Q2563/103
摘要： The invention relates generally to the field of identification of DNA sequences, genes or chromosomes. Methods and composition to obtain Unique Sequence DNA probes are provided. Composition comprises of any double stranded DNA containing Unique Sequences from which the repetitive sequences are eliminated according to the method described in this invention. The invention also relates to the preservation of cells that have been identified after immunomagnetic selection and fluorescent labeling in order to further interrogate the cells of interest. Furthermore the invention relates to genetic analysis of cells that have been identified after immunomagnetic selection and fluorescent labeling.
摘要翻译：本发明一般涉及DNA序列，基因或染色体的鉴定领域。提供了获得独特序列DNA探针的方法和组成。组合物包含根据本发明描述的方法从其中排除重复序列的任何含有唯一序列的双链DNA。本发明还涉及在免疫磁性选择和荧光标记之后鉴定的细胞的保存以进一步询问感兴趣的细胞。此外，本发明涉及在免疫磁性选择和荧光标记之后鉴定的细胞的遗传分析。

4. 发明申请

WO0165863A3 WIRELESS COMMUNICATIONS SYSTEM AND METHOD 审中-公开
标题翻译：无线通信系统和方法
公开(公告)号：WO0165863A3
公开(公告)日：2002-04-18
申请号：PCT/IL0100195
申请日：2001-03-01
申请人： KAGAN MICHAEL L , KAMIEN DAVID , GAMSE IAN ELKAN , ROSE CHARLES ANTHONY
发明人： KAGAN MICHAEL L , KAMIEN DAVID , GAMSE IAN ELKAN , ROSE CHARLES ANTHONY
IPC分类号： H04L29/08 , H04W4/06 , H04W48/14 , H04H1/00
CPC分类号： H04W4/06 , H04L67/20 , H04L69/329 , H04W48/14
摘要： This invention discloses a method and a system for communicating with a user including wirelessly broadcasting content which is accessible to a multiplicity of users and which includes at least some non-audio enabling a user to select a portion of the content, responsive to a selection by the user, capturing at least part of the non-audio content, corresponding to the portion of the content selected by the user and employing at least part of the captured content to access a contact using a mobile communicator by initially establishing contact with a non product-specific communication facility and employing product-specific information contained in the non-audio content.
摘要翻译：本发明公开了一种用于与用户进行通信的方法和系统，包括无线广播内容，多个用户可访问的内容，并且包括至少一些非音频，使得用户能够选择内容的一部分，所述用户捕获所述非音频内容的至少一部分，其对应于所述用户所选择的内容的所述部分，并且使用所捕获的内容的至少一部分来使用移动通信器访问联系人，通过初始建立与非产品的联系并且使用非音频内容中包含的特定于产品的信息。

5. 发明申请

WO2014105576A1 EICOSAPENTAENOIC ACID (EPA) FORMULATIONS 审中-公开
标题翻译：安非他酮酸（EPA）配方
公开(公告)号：WO2014105576A1
公开(公告)日：2014-07-03
申请号：PCT/US2013/076178
申请日：2013-12-18
申请人： QUALITAS HEALTH, LTD. , WAIBEL, Brian J. , SCHONEMANN, Hans , KRUKONIS, Val , KAGAN, Michael
发明人： WAIBEL, Brian J. , SCHONEMANN, Hans , KRUKONIS, Val , KAGAN, Michael
IPC分类号： A61K31/202 , A61P9/00 , A61P25/00 , A61K36/05
CPC分类号： A61K31/232 , A23D9/013 , A23L33/12 , A23V2002/00 , A61K31/20 , A61K31/201 , A61K31/202 , A61K31/555 , A61K31/683 , A61K31/685 , A61K31/7032 , A61K36/05 , A61K45/06 , C11B1/10 , C11B1/104 , C11B3/00 , C11B7/00 , C11B7/0025 , C11B7/005 , A61K2300/00 , A23V2200/32 , A23V2200/322 , A23V2200/326 , A23V2250/1846 , A23V2250/1848 , A23V2250/185 , A23V2250/187 , A23V2250/2136 , A23V2250/314
摘要： Provided herein are compositions comprising eicosapentaenoic acid (EPA) and polar lipids (e.g., glycolipids and phospholipids), and which do not contain any docosahexaenoic acid (DHA) or esterified fatty acids.
摘要翻译：本文提供包含二十碳五烯酸（EPA）和极性脂质（例如糖脂和磷脂）的组合物，其不含任何二十二碳六烯酸（DHA）或酯化脂肪酸。

6. 发明申请

WO2012103447A1 SYSTEMS, DEVICES, AND METHODS FOR ULTRA-SENSITIVE DETECTION OF MOLECULES OR PARTICLES 审中-公开
标题翻译：用于超敏感检测分子或颗粒的系统，装置和方法
公开(公告)号：WO2012103447A1
公开(公告)日：2012-08-02
申请号：PCT/US2012/022923
申请日：2012-01-27
申请人： QUANTERIX CORPORATION , FOURNIER, David , CAMPBELL, Todd , KAN, Cheuk , LAWSON, John , RIVNAK, Andrew , KAGAN, Michael , DUFFY, David, C.
发明人： FOURNIER, David , CAMPBELL, Todd , KAN, Cheuk , LAWSON, John , RIVNAK, Andrew , KAGAN, Michael , DUFFY, David, C.
IPC分类号： G01N35/00 , G01N35/10 , B29C65/00
CPC分类号： G01N35/00029 , B01L3/502761 , B01L3/5085 , B01L2200/0668 , B01L2200/0689 , B01L2300/0803 , B01L2400/043 , B01L2400/086 , G01N35/0098 , G01N35/1065 , G01N2035/00287
摘要： Described are systems, devices, and methods which related to various aspects of assays for detecting and/or determining a measure of the concentration of analyte molecules or particles in a sample fluid. In some cases, the systems employ an assay consumable comprising a plurality of assay sites. The systems, devices, and/or methods, in some cases, are automated. In some cases, the systems, devices, and/or methods relate to inserting a plurality of beads into assay sites, sealing assay sites, imaging assay sites, or the like.
摘要翻译：描述了与用于检测和/或确定样品流体中分析物分子或颗粒的浓度的测量的测定的各个方面相关的系统，装置和方法。在一些情况下，系统使用包含多个测定位点的测定消耗品。在某些情况下，系统，设备和/或方法是自动化的。在一些情况下，系统，装置和/或方法涉及将多个珠粒插入测定位点，密封测定位点，成像分析位点等。

7. 发明申请

WO2011061649A1 DYNAMICALLY-CONNECTED TRANSPORT SERVICE 审中-公开
标题翻译：动态连接运输服务
公开(公告)号：WO2011061649A1
公开(公告)日：2011-05-26
申请号：PCT/IB2010/054768
申请日：2010-10-21
申请人： MELLANOX TECHNOLOGIES LTD. , CRUPNICOFF, Diego , KAGAN, Michael , SHAHAR, Ariel , BLOCH, Noam , CHAPMAN, Hillel
发明人： CRUPNICOFF, Diego , KAGAN, Michael , SHAHAR, Ariel , BLOCH, Noam , CHAPMAN, Hillel
IPC分类号： H04L12/28
CPC分类号： H04L67/14 , H04L69/324 , H04Q2213/13389
摘要： A method of communication includes receiving, in a network interface device (26), first and second requests from an initiator process (22) running on an initiator host (24) to transmit, respectively, first and second data to first and second target processes (28, 34) running on one or more target nodes (14, 16), via a packet network (18). A single dynamically-connected initiator context is allocated for serving both the first and second requests. A first connect packet referencing the dynamically-connected (DC) initiator context is directed to the first target process so as to open a first dynamic connection with the first target process, followed by transmission of the first data over the first dynamic connection. The first dynamic connection is closed after the transmission of the first data, and a second connect packet is transmitted so as to open a second dynamic connection with the second target process, followed by transmission of the second data.
摘要翻译：一种通信方法包括在网络接口设备（26）中接收来自在发起者主机（24）上运行的发起者进程（22）的第一和第二请求，以将第一和第二数据分别发送到第一和第二目标进程（28,34）经由分组网络（18）运行在一个或多个目标节点（14,16）上。分配单个动态连接的发起者上下文用于服务第一和第二请求。引用动态连接（DC）启动器上下文的第一连接分组被引导到第一目标进程，以便打开与第一目标进程的第一动态连接，随后通过第一动态连接传输第一数据。第一动态连接在传输第一数据之后被关闭，并且传输第二连接分组以便打开与第二目标进程的第二动态连接，随后传输第二数据。

8. 发明申请

WO2007053245A3 METHODS AND COMPOSITION TO GENERATE UNIQUE SEQUENCE DNA PROBES, IABELING OF DNA PROBES AND THE USE OF THESE PROBES 审中-公开
标题翻译：产生独特序列DNA探针的方法和组合物，DNA探针的激发以及这些探针的使用
公开(公告)号：WO2007053245A3
公开(公告)日：2007-11-22
申请号：PCT/US2006036656
申请日：2006-09-20
申请人： IMMUNIVEST CORP , CONNELLY MARK CARLE , FOULK BRAD , KAGAN MICHAEL T , SWENNENHUIS JOOST F , TERSTAPPEN LEON W M M , TIBBE ARJAN G J , VERRANT JOHN A
发明人： CONNELLY MARK CARLE , FOULK BRAD , KAGAN MICHAEL T , SWENNENHUIS JOOST F , TERSTAPPEN LEON W M M , TIBBE ARJAN G J , VERRANT JOHN A
IPC分类号： C12P19/34 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q1/34 , C12Q1/6811 , C12Q1/6876 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2533/101 , C12Q2531/113 , C12Q2521/301 , C12Q2563/131 , C12Q2563/103
摘要： The invention relates generally to the field of identification of DNA sequences, genes or chromosomes. Methods and composition to obtain Unique Sequence DNA probes are provided. Composition comprises of any double stranded DNA containing Unique Sequences from which the repetitive sequences are eliminated according to the method described in this invention. The invention also relates to the preservation of cells that have been identified after immunomagnetic selection and fluorescent labeling in order to further interrogate the cells of interest. Furthermore the invention relates to genetic analysis of cells that have been identified after immunomagnetic selection and fluorescent labeling.
摘要翻译：本发明一般涉及DNA序列，基因或染色体的鉴定领域。提供了获得独特序列DNA探针的方法和组成。组合物包含任何含有根据本发明描述的方法消除重复序列的独特序列的双链DNA。本发明还涉及在免疫磁性选择和荧光标记后已经鉴定的细胞的保存，以便进一步询问感兴趣的细胞。此外，本发明涉及在免疫磁性选择和荧光标记后已经鉴定的细胞的遗传分析。

9. 发明申请

WO2007034473A3 ELAPSED TIME INDICATOR DEVICE 审中-公开
标题翻译： ELAPSED时间指示器设备
公开(公告)号：WO2007034473A3
公开(公告)日：2007-10-04
申请号：PCT/IL2006001067
申请日：2006-09-12
申请人： TIMESTRIP UK LTD , KAGAN MICHAEL
发明人： KAGAN MICHAEL
IPC分类号： G04F1/00
CPC分类号： G04F1/005
摘要： The invention provides an electronic printed chromatic elapsed time indicator device 10 comprising a switch 14, a power source 12 and a power driven elapsed time display 18 for indicating the elapse of a limited predetermined segment of time upon activation of the switch 14 and irrespective of the actual time of activation thereof, wherein the components are functionally interconnected and are printed on at least one substrate.
摘要翻译：本发明提供了一种电子印刷色彩流逝时间指示器装置10，其包括开关14，电源12和电力驱动的经过时间显示器18，用于指示在开关14激活时经过有限的预定时间段，并且不管其活化的实际时间，其中所述组分在功能上互连并印刷在至少一个基底上。

10. 发明申请

WO2005028663A3 OPERATOR INDEPENDENT PROGRAMMABLE SAMPLE PREPARATION AND ANALYSIS SYSTEM 审中-公开
公开(公告)号：WO2005028663A3
公开(公告)日：2005-03-31
申请号：PCT/US2004/030429
申请日：2004-09-17
申请人： IMMUNIVEST CORPORATION , BENDELE, Teresa , HARBART, Thomas , HOWARD, Dave , KAGAN, Michael , KEENE, Douglas , LAPEUS, Dave , MAYES, Jared , PAYNTER, Douglas , PROHASKA, Jerry , RUTNER, Herman
发明人： BENDELE, Teresa , HARBART, Thomas , HOWARD, Dave , KAGAN, Michael , KEENE, Douglas , LAPEUS, Dave , MAYES, Jared , PAYNTER, Douglas , PROHASKA, Jerry , RUTNER, Herman
IPC分类号： G01N21/00
摘要： The present invention provides a protocol and apparatus for enriching circulating tumor cells and other rare cells from blood, including debris and other components, from samples with high precision and at high throughput rates. This invention discloses an improved processing system from previously described semi-automated sample processing. The system further reduces operator intervention and hands-on time from prior systems. While this system has general utility in processing diverse materials, the system is configured for sample processing of biological specimens to provide an enriched fraction suitable for detection, enumeration and identification of target cells by appropriate analytical methodologies. The presence and quantities of such target cells in a sample specimen can utilized for screening and detection in disease such as cancer, assessing early stage pre-metastatic cancer, monitoring for disease remission in response to therapy and selection of more effective dose regimens or alternative therapies in case of relapse.

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