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1. 发明申请

WO2011053867A1 SYSTEMS AND METHODS FOR EXTRACTING LIPIDS FROM AND DEHYDRATING WET ALGAL BIOMASS 审中-公开
标题翻译：提取脂肪和去除水分生物量的系统和方法
公开(公告)号：WO2011053867A1
公开(公告)日：2011-05-05
申请号：PCT/US2010/054861
申请日：2010-10-29
申请人： AURORA ALGAE, INC. , FLEISCHER, Daniel , JUKIC, Marko , THOMPSON, Andrew , RADAELLI, Guido
发明人： FLEISCHER, Daniel , JUKIC, Marko , THOMPSON, Andrew , RADAELLI, Guido
IPC分类号： C12N1/12 , B01D12/00
CPC分类号： C11B1/10 , C11B1/106
摘要： Exemplary methods include centrifuging a wet algal biomass to increase a solid content of the wet algal biomass to between approximately 10% and 40% to result in a centrifuged algal biomass, mixing the centrifuged algal biomass with an amphiphilic solvent to result in a mixture, heating the mixture to result in a dehydrated, defatted algal biomass, separating the amphiphilic solvent from the dehydrated, defatted algal biomass to result in amphiphilic solvent, water and lipids, evaporating the amphiphilic solvent from the water and the lipids, and separating the water from the lipids. The amphiphilic solvent may be selected from a group consisting of acetone, methanol, ethanol, isopropanol, butanone, dimethyl ether, and propionaldehyde. Other exemplary methods include filtering a wet algal biomass through a membrane to increase a solid content of the wet algal biomass to between approximately 10% and 40% to result in a filtered algal biomass.
摘要翻译：示例性方法包括将湿藻类生物质离心以将湿藻类生物质的固体含量提高到约10％至40％之间，以产生离心的藻类生物质，将离心的藻类生物质与两亲溶剂混合以产生混合物，加热混合物导致脱水的脱脂藻类生物质，将两亲溶剂与脱水的脱脂藻类生物质分离以产生两亲溶剂，水和脂质，从水和脂质中蒸发出两亲溶剂，并将水从脂类。两亲溶剂可以选自丙酮，甲醇，乙醇，异丙醇，丁酮，二甲醚和丙醛。其他示例性方法包括通过膜过滤湿藻类生物质以将湿藻类生物质的固体含量增加至约10％至40％之间，以产生过滤的藻类生物质。

2. 发明申请

WO2012013325A1 PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES FOR THE SYNTHESIS OF STATINS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF 审中-公开
标题翻译：制定合理统计资料的主要中间人或药物可接受的费用的程序
公开(公告)号：WO2012013325A1
公开(公告)日：2012-02-02
申请号：PCT/EP2011/003714
申请日：2011-07-25
申请人： LEK PHARMACEUTICALS D.D. , CASAR, Zdenko , STERK, Damjan , JUKIC, Marko
发明人： CASAR, Zdenko , STERK, Damjan , JUKIC, Marko
IPC分类号： C07D215/14 , C07D239/46 , C07C49/233 , C07C49/235
CPC分类号： C07D239/42 , C07C45/68 , C07C49/807 , C07C49/86 , C07D215/12 , C07D215/14 , C07D239/46
摘要： The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.
摘要翻译：本发明涉及用于合成用于制备他汀类药物的关键中间体的商业上可行的方法，特别是罗苏伐他汀和匹伐他汀或其各自的药学上可接受的盐。提出了一种关键中间体的简单且简短的合成路线，其优点是可以使用便宜且易于获得的起始原料，可以避免常规使用的DIBAL-H作为还原剂。

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