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1. 发明申请

WO2014055800A1 A FAMILY OF SYNTHETIC POLYNUCLEOTIDE-BINDING PEPTIDES AND USES THEREOF 审中-公开
标题翻译：合成多核苷酸结合肽的家族及其用途
公开(公告)号：WO2014055800A1
公开(公告)日：2014-04-10
申请号：PCT/US2013/063330
申请日：2013-10-03
申请人： EASTERN VIRGINIA MEDICAL SCHOOL , JOHNSON, Edward, M. , DANIEL, Dianne, C.
发明人： JOHNSON, Edward, M. , DANIEL, Dianne, C.
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/00
摘要： The present invention provides novel synthetic peptides (including the TZIP peptide) as oncogenic and genetic modulators, including genetics of viruses, as well as methods of making and using the same. These peptides are useful for inhibiting the proliferation of cancer cells characterized as having amplified c- MYC genes. The invention provides methods for the therapeutic uses of the peptides in the treatment of various cancers including small cell lung carcinoma, prostate cancer, lymphoma, brain tumors, colon cancer, bladder cancer, AML, malignant melanoma, mesothelioma, and cancers of head and neck. The peptides are also useful in the treatment of, and prevention of transmission of, HIV and treatment of expanded nucleotide repeat diseases, including certain currently untreatable and debilitating diseases.
摘要翻译：本发明提供新颖的合成肽（包括TZIP肽）作为致癌和遗传调节剂，包括病毒遗传学，以及制备和使用它们的方法。这些肽可用于抑制特征为具有扩增的c-MYC基因的癌细胞的增殖。本发明提供了肽在治疗各种癌症，包括小细胞肺癌，前列腺癌，淋巴瘤，脑肿瘤，结肠癌，膀胱癌，AML，恶性黑素瘤，间皮瘤和头颈癌的治疗用途方面。。这些肽也可用于治疗和预防HIV的传播和治疗扩大的核苷酸重复疾病，包括某些目前无法治愈和衰弱的疾病。

2. 发明申请

WO2007000635A1 AN UNDERWATER LIGHT 审中-公开
标题翻译：水下灯
公开(公告)号：WO2007000635A1
公开(公告)日：2007-01-04
申请号：PCT/IB2006/001648
申请日：2006-06-20
申请人： OPTO ENHANCED TECHNOLOGIES (PTY) LTD , CAROTO, Leslie, Pereira, Gonçalves , JOHNSON, Edward, Beryman
发明人： CAROTO, Leslie, Pereira, Gonçalves , JOHNSON, Edward, Beryman
IPC分类号： F21S8/00 , F21V29/00
CPC分类号： F21S8/00 , F21V29/00 , F21W2131/401 , F21Y2115/10
摘要： An underwater light (10) comprising a housing (12) and a plurality of light sources (14) extending through the housing so that when the underwater light is in use, the at least one light source is in contact with the water. The light sources may be light-emitting diodes (LED) .
摘要翻译：一种水下灯（10），包括壳体（12）和延伸穿过壳体的多个光源（14），使得当使用水中的光时，至少一个光源与水接触。光源可以是发光二极管（LED）。

3. 发明申请

WO2006050614A1 PRINTABLE SUBSTRATE, PROCESSES AND COMPOSITIONS FOR PREPARATION THEREOF 审中-公开
标题翻译：可印制基材，其制备方法和组合物
公开(公告)号：WO2006050614A1
公开(公告)日：2006-05-18
申请号：PCT/CA2005/001734
申请日：2005-11-15
申请人： DOMTAR INC. , ISP INVESTMENTS INC. , 3M INNOVATIVE PROPERTIES COMPANY , NADEAU, Lawrence N. , WADDELL, William , HOOD, David K. , JOHNSON, Edward , KITCHEN, Jonathan P. , SARKAR, Manisha , EVANS, Dwight L. , GRATTON, Richard
发明人： NADEAU, Lawrence N. , WADDELL, William , HOOD, David K. , JOHNSON, Edward , KITCHEN, Jonathan P. , SARKAR, Manisha , EVANS, Dwight L. , GRATTON, Richard
IPC分类号： C08L39/04 , C08L33/26 , C08L33/12 , C08L1/02 , G03C5/08 , G03B27/00 , B41J2/01
CPC分类号： G03C1/79 , B41M5/506 , B41M5/52 , B41M5/5227 , B41M5/5236 , B41M5/5254 , C08L1/00 , C08L1/02 , C08L1/28 , C08L1/284 , C08L33/14 , C08L33/26 , C08L67/00 , C08L2205/02 , C09D133/26 , C09D139/04 , D21H19/44 , D21H19/58 , D21H19/60 , D21H19/82 , D21H25/14 , G03G7/0046 , Y10T428/14 , C08L2666/02 , C08L2666/26 , C08L2666/04
摘要： The present invention relates to a composition comprising a crosslinkable resin comprising lactam groups; a DMAPMA / HEMA copolymer copolymer; and a cellulose based water absorbent polymer. The invention also relates to a photographic paper comprising a base paper; and a layer derived from the composition as defined in the present invention. Processes for preparing such a photographic paper are also provided.
摘要翻译：本发明涉及包含含有内酰胺基团的交联性树脂的组合物; DMAPMA / HEMA共聚物共聚物; 和纤维素类吸水性聚合物。本发明还涉及一种包含原纸的相纸; 以及衍生自本发明中定义的组合物的层。还提供了制备这种照相纸的方法。

4. 发明申请

WO1996026720A1 PHARMACEUTICAL COMPOSITIONS COMPRISING MONOAMINE OXIDASE B INHIBITORS 审中-公开
标题翻译：包含单胺氧化酶B抑制剂的药物组合物
公开(公告)号：WO1996026720A1
公开(公告)日：1996-09-06
申请号：PCT/GB1996000484
申请日：1996-03-01
申请人： R.P. SCHERER LIMITED , BREWER, Francesca, Mary , JOHNSON, Edward, Stuart , CLARKE, Anthony
发明人： R.P. SCHERER LIMITED
IPC分类号： A61K31/135
CPC分类号： A61K31/137 , A61K9/0056 , A61K9/2095 , A61K31/136
摘要： This invention relates to a pharmaceutical composition for oral administration comprising a carrier and, as an active ingredient, a monoamine oxidase B inhibitor, characterised in that the composition is formulated to promote pre-gastric absorption of said monoamine oxidase B inhibitor. A process for preparing such a composition and the use of such a composition for the treatment of Parkinson's disease, the treatment and/or prophylaxis of depression and the treatment and/or prophylaxis of Alzheimer's disease are also provided.
摘要翻译：本发明涉及用于口服给药的药物组合物，其包含载体和作为活性成分的单胺氧化酶B抑制剂，其特征在于所述组合物被配制成促进所述单胺氧化酶B抑制剂的胃前吸收。还提供了制备这种组合物的方法以及这种组合物用于治疗帕金森病，治疗和/或预防抑郁症以及治疗和/或预防阿尔茨海默病的用途。

5. 发明申请

WO1991009593A2 5-HT3 ANTAGONISTS FOR TREATMENT OF NAUSEA, BRADYCARDIA OF HYPOTENSION ASSOCIATED WITH MYOCARDIAL INSTABILITY 审中-公开
标题翻译： 5-HT3拮抗剂治疗NAUSEA，BRADYCARDIA与低密度脂蛋白胆固醇不稳定相关的HYPTECA
公开(公告)号：WO1991009593A2
公开(公告)日：1991-07-11
申请号：PCT/GB1990001996
申请日：1990-12-20
申请人： BEECHAM GROUP PLC , JOHNSON, Edward, Stewart , HAMILTON, Thomas, Conway
发明人： BEECHAM GROUP PLC
IPC分类号： A61K31/00
CPC分类号： A61K31/00
摘要： A method for the treatment and/or prophylaxis of nausea and bradycardia and/or hypotension associated with myocardial instability in mammals, such as humans, which method comprises administering to the mammal in need of such treatment and/or prophylaxis an effective and/or prophylactic amount of a 5-HT3 receptor antagonist, such as a compound of formula (I): X-A-R, or a pharmaceutically acceptable salt thereof, wherein X is a phenyl group or a monocyclic 5 or 6 membered heteroaryl group, either of which group is optionally fused to a saturated or unsaturated 5-7 membered carbocyclic or heterocyclic ring; A is a linking moiety; and R is a saturated azabicyclic moiety or an imidazolyl moiety.
摘要翻译：用于治疗和/或预防与哺乳动物（例如人）中的心肌不稳定相关的恶心和心动过缓和/或低血压的方法包括向需要这种治疗和/或预防的哺乳动物施用有效和/或预防的方法 5-HT 3受体拮抗剂的量，例如式（I）的化合物：XAR或其药学上可接受的盐，其中X为苯基或单环5或6元杂芳基，其中任一组为任选的与饱和或不饱和的5-7元碳环或杂环稠合; A是连接部分; R是饱和的氮杂双环部分或咪唑基部分。

6. 发明申请

WO2011163386A1 APPARATUS FOR AND METHOD OF PULLING A TENSILE MEMBER FROM A MEDICAL DEVICE 审中-公开
标题翻译：用于从医疗装置拉伸拉伸成员的装置和方法
公开(公告)号：WO2011163386A1
公开(公告)日：2011-12-29
申请号：PCT/US2011/041483
申请日：2011-06-22
申请人： CORDIS CORPORATION , RINCON, Cesar , KREVER, Matthew , OLSEN, Daniel , JOHNSON, Edward
发明人： RINCON, Cesar , KREVER, Matthew , OLSEN, Daniel , JOHNSON, Edward
IPC分类号： A61F2/84
CPC分类号： A61F2/95 , A61F2002/9511 , A61F2002/9517
摘要： Mechanisms for pulling a tensile member (24) a predetermined distance from a medical device (10) having an intracorporeal end and an extracorporeal end are disclosed. Such mechanisms may be safely operated using a robot, two hands, or in some embodiments, only one hand. Such mechanisms may include one or more cams, drums, or pulley- like members (34) and a lever (48), and may be physically coupled to an extracorporeal portion of the medical device.
摘要翻译：公开了从具有体内末端和体外终端的医疗装置（10）拉出预定距离的拉伸构件（24）的机构。这样的机构可以使用机器人，两只手，或在一些实施例中仅一只手来安全地操作。这种机构可包括一个或多个凸轮，滚筒或滑轮状构件（34）和杠杆（48），并且可以物理耦合到医疗装置的体外部分。

7. 发明申请

WO2009137251A3 CYSTEINE AND CYSTINE BIOISOSTERES TO TREAT SCHIZOPHRENIA AND REDUCE DRUG CRAVINGS 审中-公开
公开(公告)号：WO2009137251A3
公开(公告)日：2009-11-12
申请号：PCT/US2009/040799
申请日：2009-04-16
申请人： MARQUETTE UNIVERSITY , UNIVERSITY OF WISCONSIN-MILWAUKEE RESEARCH FOUNDATION , COOK, James, M. , BAKER, David, A. , YIN, Wenyuan , JOHNSON, Edward, Merle
发明人： COOK, James, M. , BAKER, David, A. , YIN, Wenyuan , JOHNSON, Edward, Merle
IPC分类号： C07D271/06 , C07D413/12 , A61P25/18 , A61P25/30 , A61K31/4245 , C07C323/02
摘要： The present invention provides cysteine and cystine bioisosteres for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing such bioisosteres and methods of using the bioisosteres for treatment of schizophrenia and drug addiction.

8. 发明申请

WO2006007446A3 PHOTONIC CRYSTAL EMITTER, DETECTOR, AND SENSOR 审中-公开
标题翻译：光电晶体发射器，探测器和传感器
公开(公告)号：WO2006007446A3
公开(公告)日：2009-04-02
申请号：PCT/US2005021617
申请日：2005-06-17
申请人： ION OPTICS INC , PRALLE MARTIN U , DALY JAMES T , PUSCASU IRINA , MCNEAL MARK P , JOHNSON EDWARD A
发明人： PRALLE MARTIN U , DALY JAMES T , PUSCASU IRINA , MCNEAL MARK P , JOHNSON EDWARD A
IPC分类号： H01L33/00
CPC分类号： G01J5/20 , B82Y20/00 , G01J1/02 , G01J1/0252 , G01J1/42 , G01J3/02 , G01J3/0286 , G01J3/108 , G01J5/02 , G01J5/023 , G01J5/024 , G01J5/04 , G01J5/045 , G01J5/046 , G01J5/08 , G01J5/0803 , G01J5/0853 , G01J5/0862 , G01N21/3504 , G01N2021/317 , G01N2021/3513 , G02B6/1225 , H01L27/14676
摘要： An infrared emitter, which utilizes a photonic bandgap (PBG) structure to produce electromagnetic emissions with a narrow band of wavelengths, includes a semiconductor material layer, a dielectric material layer overlaying the semiconductor material layer, and a metallic material layer having an inner side overlaying the dielectric material layer. The semiconductor material layer is capable of being coupled to an energy source for introducing energy to the semiconductor material layer. An array of holes are defined in the device in a periodic manner, wherein each hole extends at least partially through the metallic material layer. The three material layers are adapted to transfer energy from the semiconductor material layer to the outer side of the metallic material layer and emit electromagnetic energy in a narrow band of wavelengths from the outer side of the metallic material layer.
摘要翻译：利用光子带隙（PBG）结构产生具有窄波长波段的电磁发射的红外发射器包括半导体材料层，覆盖半导体材料层的电介质材料层和具有内侧重叠的金属材料层介电材料层。半导体材料层能够耦合到能量源以将能量引入到半导体材料层。定期地在器件中限定一组孔，其中每个孔至少部分地延伸通过金属材料层。三个材料层适于将能量从半导体材料层转移到金属材料层的外侧，并从金属材料层的外侧发射出窄波长的波长的电磁能。

9. 发明申请

WO2006010133A3 TUNABLE PHOTONIC CRYSTAL 审中-公开
标题翻译：可调光子晶体
公开(公告)号：WO2006010133A3
公开(公告)日：2006-05-04
申请号：PCT/US2005024654
申请日：2005-07-08
申请人： ION OPTICS INC , PUSCASU IRINA , PRALLE MARTIN U , DALY JAMES T , MCNEAL MARK P , JOHNSON EDWARD A
发明人： PUSCASU IRINA , PRALLE MARTIN U , DALY JAMES T , MCNEAL MARK P , JOHNSON EDWARD A
IPC分类号： H01L33/00
CPC分类号： G01N21/255 , B82Y20/00 , B82Y30/00 , G01J1/42 , G01J3/108 , G01J5/20 , G01N21/3504 , H01L31/101
摘要： An infrared emitter (10), which utilizes a photonic crystal (PC) structure to produce electromagnetic emissions with a narrow band of wavelengths, includes a semiconductor material layer (12), a dielectric material layer (14) overlaying the semiconductor material layer, and a metallic material layer (16) having an inner side overlaying the dielectric material layer. The semiconductor material layer (12) is capable of being coupled to an energy source for introducing energy to the semiconductor material layer. An array of surface features (18) are defined in the device in a periodic or quasi-periodic manner. The emitter device is adapted to emit electromagnetic energy having spectral characteristics determined by parameters of the periodically distributed surface features, the parameters including shape, size, depth, distribution geometry, periodicity, material properties and defects. The emitter device may also function as a selective detector of electromagnetic radiation.
摘要翻译：利用光子晶体（PC）结构产生具有窄波长带的电磁发射的红外发射器（10）包括半导体材料层（12），覆盖半导体材料层的电介质材料层（14），以及金属材料层（16），其具有覆盖介电材料层的内侧。半导体材料层（12）能够耦合到用于将能量引入半导体材料层的能量源。表面特征（18）的阵列以周期性或准周期性方式在器件中定义。发射器件适于发射具有通过周期性分布的表面特征的参数确定的光谱特性的电磁能，参数包括形状，尺寸，深度，分布几何形状，周期性，材料性质和缺陷。发射器件还可以用作电磁辐射的选择性检测器。

10. 发明申请

WO2006010133A2 TUNABLE PHOTONIC CRYSTAL 审中-公开
标题翻译：可调光子晶体
公开(公告)号：WO2006010133A2
公开(公告)日：2006-01-26
申请号：PCT/US2005/024654
申请日：2005-07-08
申请人： ION OPTICS, INC. , PUSCASU, Irina , PRALLE, Martin, U. , DALY, James, T. , MCNEAL, Mark, P. , JOHNSON, Edward, A.
发明人： PUSCASU, Irina , PRALLE, Martin, U. , DALY, James, T. , MCNEAL, Mark, P. , JOHNSON, Edward, A.
IPC分类号： H01L21/44
CPC分类号： G01N21/255 , B82Y20/00 , B82Y30/00 , G01J1/42 , G01J3/108 , G01J5/20 , G01N21/3504 , H01L31/101
摘要： An infrared emitter, which utilizes a photonic crystal (PC) structure to produce electromagnetic emissions with a narrow band of wavelengths, includes a semiconductor material layer, a dielectric material layer overlaying the semiconductor material layer, and a metallic material layer having an inner side overlaying the dielectric material layer. The semiconductor material layer is capable of being coupled to an energy source for introducing energy to the semiconductor material layer. An array of surface features are defined in the device in a periodic manner or quasi-periodic. The emitter device is adapted to emit electromagnetic energy having spectral characteristics determined by parameters of the periodically distributed surface features, the parameters including shape, size, depth, distribution geometry, periodicity, material properties and defects.
摘要翻译：利用光子晶体（PC）结构产生具有窄波长带的电磁发射的红外发射器包括半导体材料层，覆盖半导体材料层的介电材料层和具有内侧覆盖层的金属材料层介电材料层。半导体材料层能够耦合到能量源以将能量引入到半导体材料层。表面特征的阵列以周期性或准周期性方式在器件中定义。发射器件适于发射具有通过周期性分布的表面特征的参数确定的光谱特性的电磁能，参数包括形状，尺寸，深度，分布几何形状，周期性，材料性质和缺陷。

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