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1. 发明申请

WO2010036418A2 METHOD OF INTERCEPTING INCOMING PROJECTILE 审中-公开
标题翻译：拦截投资项目的方法
公开(公告)号：WO2010036418A2
公开(公告)日：2010-04-01
申请号：PCT/US2009/046359
申请日：2009-06-05
申请人： RAYTHEON COMPANY , PATTERSON, William N. , DUPONT, James H. , LOEHR, Richard D. , KIM, Henri Y. , HALL, Garrett L. , COOK, James M.
发明人： PATTERSON, William N. , DUPONT, James H. , LOEHR, Richard D. , KIM, Henri Y. , HALL, Garrett L. , COOK, James M.
IPC分类号： F41H11/02
CPC分类号： F41H11/02 , F41F3/073 , F42B10/661 , F42B15/01 , F42B15/10
摘要： A method of defeating an incoming missile (120), such as a rocket propelled grenade, includes soft launching an interceptor missile (10), and then using pitch over motors of the interceptor missile to alter course of the missile to a desired interception direction. By launching at a relatively slow speed, such as a speed less than or equal to 40 m/sec (130 ft/sec), the interceptor missile may reach the desired interception direction within 250 milliseconds of launch. The interceptor missile may be able to cover substantially all interception directions over a hemisphere or greater extent around a launch location. For example, the interceptor missile may be launched vertically from a ground vehicle, and be capable of altering course to any above-ground trajectory within 250 milliseconds.
摘要翻译：一种击败诸如火箭推进手榴弹的进入导弹（120）的方法包括软启动拦截导弹（10），然后使用拦截导弹发动机的俯仰将导弹的过程改变为所需的拦截方向。通过以相对较慢的速度（例如小于或等于40米/秒（130英尺/秒）的速度）发射，拦截导弹可以在发射的250毫秒内达到所需的拦截方向。拦截导弹可以能够围绕发射位置覆盖半球或更大程度上的所有拦截方向。例如，拦截导弹可以从地面车辆垂直发射，并且能够在250毫秒内改变任何地面上的轨迹。

2. 发明申请

WO2009100431A1 CYSTEINE AND CYSTINE PRODRUGS TO TREAT SCHIZOPHRENIA AND REDUCE DRUG CRAVINGS 审中-公开
标题翻译： CYSTININE和CYSTINE PRODRUGS TREAT SCHIZOPHRENIA并减少药物伤口
公开(公告)号：WO2009100431A1
公开(公告)日：2009-08-13
申请号：PCT/US2009/033557
申请日：2009-02-09
申请人： MARQUETTE UNIVERSITY , UNIVERSITY OF WISCONSIN-MILWAUKEE RESEARCH FOUNDATION , COOK, James, M. , BAKER, David, A. , YIN, Wenyuan , JOHNSON, Edward, Merle, II
发明人： COOK, James, M. , BAKER, David, A. , YIN, Wenyuan , JOHNSON, Edward, Merle, II
IPC分类号： C07D241/08 , C07D487/04 , A61K31/095 , A61K31/4965 , A61K31/4985 , C07C321/14 , C07C321/16 , C07C327/26 , A61P25/18
CPC分类号： C07D241/08 , A61K9/0053 , C07C323/60 , C07C327/34 , C07D211/86 , C07D487/04 , C07K5/0606
摘要： The present invention provides cysteine and cystine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction.
摘要翻译：本发明提供了用于治疗精神分裂症和药物成瘾的半胱氨酸和胱氨酸前药。本发明还包括含有药物组合物的药物组合物和使用前药和组合物治疗精神分裂症和药物成瘾的方法。

3. 发明申请

WO2007018660A2 GABAERGIC AGENTS TO TREAT MEMORY DEFICITS 审中-公开
标题翻译：处理记忆缺陷的化学剂
公开(公告)号：WO2007018660A2
公开(公告)日：2007-02-15
申请号：PCT/US2006018721
申请日：2006-05-16
申请人： WISYS TECHNOLOGY FOUND INC , COOK JAMES M , HAN DONGMEI , CLAYTON TERRY
发明人： COOK JAMES M , HAN DONGMEI , CLAYTON TERRY
IPC分类号： C07D497/04 , A61K31/5517 , A61P25/28 , C07D487/14
CPC分类号： C07D487/04 , C07D487/14 , C07D519/00
摘要： The present invention provides molecules and methods for the prevention and/or treatment of memory deficit related conditions and/or enhancement of cognizance. In a preferred embodiment, the invention includes compounds, salts and prodrugs thereof for the prevention and/or treatment of these conditions.
摘要翻译：本发明提供了用于预防和/或治疗记忆缺陷相关病症和/或增强认知的分子和方法。在优选的实施方案中，本发明包括用于预防和/或治疗这些病症的化合物，其盐和前药。

4. 发明申请

WO2011028304A1 METHOD OF CONTROLLING MISSILE FLIGHT USING ATTITUDE CONTROL THRUSTERS 审中-公开
标题翻译：使用姿态控制雷达控制飞行器的方法
公开(公告)号：WO2011028304A1
公开(公告)日：2011-03-10
申请号：PCT/US2010/031676
申请日：2010-04-20
申请人： RAYTHEON COMPANY , KINSEY JR, Lloyd , COOK, James M.
发明人： KINSEY JR, Lloyd , COOK, James M.
IPC分类号： F42B10/66
CPC分类号： F42B10/661
摘要： A method of controlling flight of a missile includes using gyroscopes, such as pitch rate gyroscopes, to sense when a factor based on the angular rate of change of the missile exceeds a threshold value. One the threshold value is exceeded, a decision may be made to use one or more compensation thrusters to reduce the angular rate of change. The use of the compensation thrusters may correct residual angular velocities from a pitch over maneuver used to put the missile on an intended course. In addition, the compensation thrusters may be used to compensate for errors in missile heading induced after the pitch over maneuver, such as induced by misalignment of thrust provided by a main rocket motor of the missile. Multiple compensation thrusters may be used to compensate for angular changes in the pitch and yaw directions.
摘要翻译：控制导弹飞行的方法包括使用诸如俯仰速率陀螺仪的陀螺仪来感测何时基于导弹的角速度变化的因子超过阈值。超过阈值的一个，可以决定使用一个或多个补偿推进器来减小角速度变化。补偿推进器的使用可以校正用于将导弹放置在预期路线上的机动的俯仰角的剩余角速度。此外，补偿推进器可以用于补偿在机动之后引起的导弹航向的误差，例如由导弹的主火箭发动机提供的推力不对准引起的。可以使用多个补偿推进器来补偿俯仰和偏航方向上的角度变化。

5. 发明申请

WO2009137251A3 CYSTEINE AND CYSTINE BIOISOSTERES TO TREAT SCHIZOPHRENIA AND REDUCE DRUG CRAVINGS 审中-公开
公开(公告)号：WO2009137251A3
公开(公告)日：2009-11-12
申请号：PCT/US2009/040799
申请日：2009-04-16
申请人： MARQUETTE UNIVERSITY , UNIVERSITY OF WISCONSIN-MILWAUKEE RESEARCH FOUNDATION , COOK, James, M. , BAKER, David, A. , YIN, Wenyuan , JOHNSON, Edward, Merle
发明人： COOK, James, M. , BAKER, David, A. , YIN, Wenyuan , JOHNSON, Edward, Merle
IPC分类号： C07D271/06 , C07D413/12 , A61P25/18 , A61P25/30 , A61K31/4245 , C07C323/02
摘要： The present invention provides cysteine and cystine bioisosteres for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing such bioisosteres and methods of using the bioisosteres for treatment of schizophrenia and drug addiction.

6. 发明申请

WO2009137251A2 CYSTEINE AND CYSTINE BIOISOSTERES TO TREAT SCHIZOPHRENIA AND REDUCE DRUG CRAVINGS 审中-公开
标题翻译： CYSTININE和CYSTINE BIOISOSTERES TREAT SCHIZOPHRENIA并减少药物伤口
公开(公告)号：WO2009137251A2
公开(公告)日：2009-11-12
申请号：PCT/US2009040799
申请日：2009-04-16
申请人： UNIV MARQUETTE , UNIV WISCONSIN MILWAUKEE RES F , COOK JAMES M , BAKER DAVID A , YIN WENYUAN , JOHNSON EDWARD MERLE
发明人： COOK JAMES M , BAKER DAVID A , YIN WENYUAN , JOHNSON EDWARD MERLE
IPC分类号： C07D271/06 , A61K31/4245 , A61P25/18 , A61P25/30 , C07C323/02 , C07D413/12
CPC分类号： C07D271/06 , C07D413/12 , C07K5/0606
摘要： The present invention provides cysteine and cystine bioisosteres for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing such bioisosteres and methods of using the bioisosteres for treatment of schizophrenia and drug addiction.
摘要翻译：本发明提供了用于治疗精神分裂症和药物成瘾的半胱氨酸和胱氨酸生物电子等排体。本发明还包括含有这种生物电子等排体的药物组合物和使用生物电子等离子体治疗精神分裂症和药物成瘾的方法。

7. 发明申请

WO2006004945B1 STEREOSPECIFIC ANXIOLYTIC AND ANTICONVULSANT AGENTS WITH REDUCED MUSCLE-RELAXANT, SEDATIVE-HYPNOTIC AND ATAXIC EFFECTS 审中-公开
标题翻译：立体特异性抗焦虑剂和抗静脉剂，具有降低肌肉松弛，阻断性代谢和呼吸衰竭的作用
公开(公告)号：WO2006004945B1
公开(公告)日：2006-04-20
申请号：PCT/US2005023301
申请日：2005-06-30
申请人： WISYS TECHNOLOGY FOUND INC , COOK JAMES M , ZHOU HAO , HUANG SHENGMING , SARMA P V V S , ZHANG CHUNCHUN
发明人： COOK JAMES M , ZHOU HAO , HUANG SHENGMING , SARMA P V V S , ZHANG CHUNCHUN
IPC分类号： C07D243/16 , A61K31/5517 , A61P25/22 , C07D243/24 , C07D487/04 , C07D495/04 , C07D495/14
CPC分类号： C07D243/24 , C07D243/16 , C07D471/06 , C07D487/04 , C07D487/06
摘要： The present invention provides compositions and methods of using stereospecific benzodiazepine derivatives, their salts and prodrugs for the treatment of anxiolytic or convulsant disorders having the side effects of reduced alcohol craving in human alcoholics and a concomitant reduced sedative, hypnotic, muscle relaxant and ataxic side-effects. The invention further provides pharmaceutical compositions for treatment of anxiolytic and convulsant disorders in subjects in need thereof, comprising a compound, prodrug or a salt having a chemical structure represented by any one of Formula I-XXI and a pharmaceutically-acceptable carrier.
摘要翻译：本发明提供了使用立体特异性苯并二氮杂衍生物，它们的盐和前体药物用于治疗在人类酗酒中具有减少酒精渴求的副作用并伴随减少镇静，催眠，肌肉松弛和无毒性副作用的抗焦虑或惊厥性障碍的组合物和方法，效果。本发明进一步提供用于治疗有需要的受试者中的抗焦虑剂和惊厥剂病症的药物组合物，其包含具有由式I-XXI中任一个表示的化学结构的化合物，前药或盐以及药学上可接受的载体。

8. 发明申请

WO2006004945A1 STEREOSPECIFIC ANXIOLYTIC AND ANTICONVULSANT AGENTS WITH REDUCED MUSCLE-RELAXANT, SEDATIVE-HYPNOTIC AND ATAXIC EFFECTS 审中-公开
标题翻译：具有降低肌肉松弛作用的STEREOSPECIFIC ANXIOLYTIC AND ANTICAVULENTANT AGENTS，SEDATIVE-HYPNOTIC AND ATAXIC EFFECTS
公开(公告)号：WO2006004945A1
公开(公告)日：2006-01-12
申请号：PCT/US2005/023301
申请日：2005-06-30
申请人： WISYS TECHNOLOGY FOUNDATION, INC. , COOK, James, M. , ZHOU, Hao , HUANG, Shengming , SARMA, P.V.V.S. , ZHANG, Chunchun
发明人： COOK, James, M. , ZHOU, Hao , HUANG, Shengming , SARMA, P.V.V.S. , ZHANG, Chunchun
IPC分类号： C07D243/16
CPC分类号： C07D243/24 , C07D243/16 , C07D471/06 , C07D487/04 , C07D487/06
摘要： The present invention provides compositions and methods of using stereospecific benzodiazepine derivatives, their salts and prodrugs for the treatment of anxiolytic or convulsant disorders having the side effects of reduced alcohol craving in human alcoholics and a concomitant reduced sedative, hypnotic, muscle relaxant and ataxic side-effects. The invention further provides pharmaceutical compositions for treatment of anxiolytic and convulsant disorders in subjects in need thereof, comprising a compound, prodrug or a salt having a chemical structure represented by any one of Formula I-XXI and a pharmaceutically-acceptable carrier.
摘要翻译：本发明提供了使用立体定向苯并二氮杂衍生物，其盐和前药用于治疗在人类酒精中具有降低酒精渴求的副作用的抗焦虑或惊厥疾病的组合物和方法，以及伴随的降低镇静剂，催眠药，肌肉松弛剂和共济失调副作用的组合物和方法，效果。本发明还提供用于治疗有需要的受试者的抗焦虑和惊厥疾病的药物组合物，其包含具有由式I-XXI中任一项所示的化学结构和药学上可接受的载体的化合物，前药或盐。

9. 发明申请

WO2010036418A3 METHOD OF INTERCEPTING INCOMING PROJECTILE 审中-公开
标题翻译：截取入侵项目的方法
公开(公告)号：WO2010036418A3
公开(公告)日：2010-06-10
申请号：PCT/US2009046359
申请日：2009-06-05
申请人： RAYTHEON CO , PATTERSON WILLIAM N , DUPONT JAMES H , LOEHR RICHARD D , KIM HENRI Y , HALL GARRETT L , COOK JAMES M
发明人： PATTERSON WILLIAM N , DUPONT JAMES H , LOEHR RICHARD D , KIM HENRI Y , HALL GARRETT L , COOK JAMES M
IPC分类号： F41H11/02 , F41F3/073 , F41H5/007 , F42B10/66 , F42B15/01 , F42B15/10
CPC分类号： F41H11/02 , F41F3/073 , F42B10/661 , F42B15/01 , F42B15/10
摘要： A method of defeating an incoming missile (120), such as a rocket propelled grenade, includes soft launching an interceptor missile (10), and then using pitch over motors of the interceptor missile to alter course of the missile to a desired interception direction. By launching at a relatively slow speed, such as a speed less than or equal to 40 m/sec (130 ft/sec), the interceptor missile may reach the desired interception direction within 250 milliseconds of launch. The interceptor missile may be able to cover substantially all interception directions over a hemisphere or greater extent around a launch location. For example, the interceptor missile may be launched vertically from a ground vehicle, and be capable of altering course to any above-ground trajectory within 250 milliseconds.
摘要翻译：一种击败诸如火箭推进式榴弹的输入导弹（120）的方法包括软式发射拦截导弹（10），然后使用拦截导弹的发动机上的俯仰来改变导弹的航向至期望的拦截方向。通过以相对较低的速度启动，例如小于或等于40米/秒（130英尺/秒）的速度，拦截导弹可以在发射250毫秒内达到期望的拦截方向。拦截导弹可能能够覆盖围绕发射位置的半球或更大范围内的基本上所有拦截方向。例如，拦截导弹可以从地面车辆垂直发射，并且能够在250毫秒内改变航向到任何地面轨迹。

10. 发明申请

WO2009143445A1 AZA-BETA-CARBOLINES AND METHODS OF USING SAME 审中-公开
标题翻译： AZA-BETA-CARBOLINES及其使用方法
公开(公告)号：WO2009143445A1
公开(公告)日：2009-11-26
申请号：PCT/US2009/045014
申请日：2009-05-22
申请人： THE UWM RESEARCH FOUNDATION, INC , COOK, James, M. , VAN LINN, Michael, L. , YIN, Wenyuan
发明人： COOK, James, M. , VAN LINN, Michael, L. , YIN, Wenyuan
IPC分类号： C07D471/04 , A61K31/437 , A61P25/32
CPC分类号： C07D471/04
摘要： Provided are compounds having the general structure according to Formula (I). Further provided are pharmaceutical compositions comprising these compounds. The invention still further provides methods of treating alcoholism, methods of reducing alcohol intake, methods of treating anhedonia, and methods of treating anxiety using theses compounds or the compositions containing them.
摘要翻译：提供具有根据式（I）的通式结构的化合物。还提供了包含这些化合物的药物组合物。本发明还提供了使用这些化合物或含有它们的组合物治疗酒精中毒的方法，降低酒精摄取的方法，治疗焦虑的治疗方法和治疗焦虑症的方法。

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