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1. 发明申请

WO2015183601A1 PREDICTIVE ANALYSIS FOR MYOCARDIAL INFARCTION 审中-公开
标题翻译：心肌梗塞的预测分析
公开(公告)号：WO2015183601A1
公开(公告)日：2015-12-03
申请号：PCT/US2015/031225
申请日：2015-05-15
申请人： SCRIPPS HEALTH , JANSSEN DIAGNOSTICS, LLC , ORTHO-CLINICAL DIAGNOSTICS, INC.
发明人： TOPOL, Eric, J. , MUSE, Evan , CONNELLY, Mark , JATKOE, Timothy , WANG, Haiying
IPC分类号： G01N33/53 , G01N33/48 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158 , G06F19/20
摘要： Compositions, systems and methods for the diagnosing the risk of acute myocardial infarction are provided. The methods described herein relate to the use of biomarkers, such as gene expression profiles, and analytical tools for providing information to a health care provider or the patient, that is relevant to the cardiovascular health of the patient.
摘要翻译：提供了用于诊断急性心肌梗死风险的组合物，系统和方法。本文描述的方法涉及生物标志物的使用，例如基因表达谱，以及用于向医疗保健提供者或患者提供与患者的心血管健康相关的信息的分析工具。

2. 发明申请

WO2014152758A1 ENRICHMENT OF CIRCULATING TUMOR CELLS BY DEPLETING WHITE BLOOD CELLS 审中-公开
标题翻译：通过清除白血球细胞来循环肿瘤细胞的增殖
公开(公告)号：WO2014152758A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/027701
申请日：2014-03-14
申请人： JANSSEN DIAGNOSTICS, LLC
发明人： RAO, Galla Chandra , FOULK, Brad , SMIRNOV, Denis , NIELSEN, Karl
IPC分类号： G01N33/543 , G01N33/574 , G01N33/58 , G01N33/68
CPC分类号： G01N33/5005 , G01N33/5044 , G01N33/54313 , G01N33/54326 , G01N33/54333 , G01N33/57492 , G01N33/582 , G01N33/583 , G01N33/585 , G01N33/6854
摘要： The disclosed invention includes methods and kits for the removal of white blood cells from samples of enriched rare cells.
摘要翻译：所公开的发明包括从富集的稀有细胞的样品中除去白细胞的方法和试剂盒。

3. 发明申请

WO2017152028A1 PRESERVATION OF CELLULAR COMPONENTS FROM CELLS WITH A PRESERVATIVE 审中-公开
标题翻译：保存细胞保存细胞成分
公开(公告)号：WO2017152028A1
公开(公告)日：2017-09-08
申请号：PCT/US2017/020622
申请日：2017-03-03
申请人： JANSSEN DIAGNOSTICS, LLC
发明人： CONNELLY, Mark , RAO, Chandra Galla , SMIRNOV, Denis
IPC分类号： A01N1/00 , C12N1/06
摘要： This invention relates to a preservative solution and a method to preserve whole blood for cellular and molecular analysis.
摘要翻译：本发明涉及保存液和保存全血以进行细胞和分子分析的方法。

4. 发明申请

WO2016044260A1 COMPOSITIONS AND METHODS FOR THE CAPTURE AND CHARACTERIZATION OF CIRCULATING TUMOR CELLS 审中-公开
标题翻译：用于捕获和表征循环肿瘤细胞的组合物和方法
公开(公告)号：WO2016044260A1
公开(公告)日：2016-03-24
申请号：PCT/US2015/050164
申请日：2015-09-15
申请人： DUKE UNIVERSITY , JANSSEN DIAGNOSTICS, LLC
发明人： BOOMINATHAN, Rengasamy , CONNELLY, Mark, C. , RAO, Galla, Chandra , ZHANG, Tian , GARCIA-BLANCO, Mariano, A. , ARMSTRONG, Andrew, J.
IPC分类号： A61K39/395
CPC分类号： C07K16/2863 , C07K16/18 , C07K16/289 , G01N33/57484
摘要： This disclosure provides compositions and methods for the isolation of cells that express c-MET, and in particular circulating tumor cells that express c-MET. The methods can include contacting a biological sample including a c-MET circulating tumor cell with an unbound complex including a capture binding species linked to a solid phase for a time sufficient to allow the unbound complex to bind an extracellular binding domain of the c-MET protein to form a bound complex, and subsequently isolating the bound complex. Compositions, systems, and kits adapted for use with these methods are also provided.
摘要翻译：本公开提供了用于分离表达c-MET的细胞的组合物和方法，特别是表达c-MET的循环肿瘤细胞。所述方法可以包括将包括c-MET循环肿瘤细胞的生物样品与未结合的复合物接触，所述未结合的复合物包括与固相连接的捕获结合物质足以允许未结合的复合物结合c-MET的细胞外结合结构域蛋白质以形成结合的复合物，随后分离结合的复合物。还提供了适用于这些方法的组合物，系统和试剂盒。

5. 发明申请

WO2013123031A3 HIGHLY SENSITIVE METHOD FOR DETECTING LOW FREQUENCY MUTATIONS 审中-公开
标题翻译：用于检测低频突变的高灵敏度方法
公开(公告)号：WO2013123031A3
公开(公告)日：2015-03-12
申请号：PCT/US2013025913
申请日：2013-02-13
申请人： JANSSEN DIAGNOSTICS LLC
发明人： WANG HAIYING , JIANG YUQIU , WANG YIXIN
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6858 , C12Q2525/186 , C12Q2537/163
摘要： The disclosed edge-blocker oligonucleotide based AS-NEPB-PCR method amplifies allele specific DNA (or RNA) while dramatically blocking amplification of wild type (WT) DNA (or RNA). The AS-NEPB-PCR design allows ready modification of an existing PCR reaction setup with an edge-blocker oligonucleotide together with an allele specific primer complementary to the mutant sequence to achieve allele specific amplification. The method simplifies assay optimization procedures and achieved sensitivity sufficient to detect a signal present at 0.1% level with close to 100% specificity, which is useful in detecting SNP or genetic mutations. The method was used to detect three different genetic mutations in cancer, in KRAS, BRAF, and EGFR, with three different types of modified edge-blocker oligonucleotides (phosphate, inverted dT and amino-C7). It was possible to detect one copy of mutant DNA in 1000-copy of normal DNA background of a heterogeneous sample, and was far more sensitive than the other blocking method.
摘要翻译：所公开的基于边缘阻断剂寡核苷酸的AS-NEPB-PCR方法扩增等位基因特异性DNA（或RNA），同时显着阻断野生型（WT）DNA（或RNA）的扩增。 AS-NEPB-PCR设计允许利用边界阻断剂寡核苷酸与等位基因特异性引物与突变序列互补的等位基因特异性引物即可修改现有PCR反应设置，以实现等位基因特异性扩增。该方法简化了测定优化程序，并实现了足以检测0.1％水平的信号，具有接近100％的特异性的灵敏度，可用于检测SNP或遗传突变。该方法用于检测癌症，KRAS，BRAF和EGFR中的三种不同基因突变，其中三种不同类型的修饰的边缘阻断剂寡核苷酸（磷酸盐，反向dT和氨基-C C7）。可以在异质样品的正常DNA背景的1000拷贝中检测到一个拷贝的突变体DNA，并且比其他阻断方法更敏感。

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