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1. 发明申请

WO2005080324A1 SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES 审中-公开
标题翻译：用于治疗疾病的磺酰胺衍生物
公开(公告)号：WO2005080324A1
公开(公告)日：2005-09-01
申请号：PCT/IB2005/000112
申请日：2005-01-12
申请人： PFIZER LIMITED , PFIZER INC. , BROWN, Alan, Daniel , JAMES, Kim , LANE, Charlotte, Alice, Louise , MOSES, Ian, Brian , THOMSON, Nicholas, Murray
发明人： BROWN, Alan, Daniel , JAMES, Kim , LANE, Charlotte, Alice, Louise , MOSES, Ian, Brian , THOMSON, Nicholas, Murray
IPC分类号： C07C311/08
CPC分类号： C07C311/08 , C07C323/42 , C07C2601/14 , C07C2602/08 , C07D295/03
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译：本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。

2. 发明申请

WO2005080313A2 SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES 审中-公开
标题翻译：用于治疗疾病的磺酰胺衍生物
公开(公告)号：WO2005080313A2
公开(公告)日：2005-09-01
申请号：PCT/IB2005000086
申请日：2005-01-12
申请人： PFIZER LTD , BROWN ALAN DANIEL , BUNNAGE MARK EDWARD , GLOSSOP PAUL ALAN , JAMES KIM , LANE CHARLOTTE ALICE LOUISE , LEWTHWAITE RUSSELL ANDREW , MOSES IAN BRIAN , PRICE DAVID ANTHONY , THOMSON NICHOLAS MURRAY , PFIZER
发明人： BROWN ALAN DANIEL , BUNNAGE MARK EDWARD , GLOSSOP PAUL ALAN , JAMES KIM , LANE CHARLOTTE ALICE LOUISE , LEWTHWAITE RUSSELL ANDREW , MOSES IAN BRIAN , PRICE DAVID ANTHONY , THOMSON NICHOLAS MURRAY
IPC分类号： C07C311/08 , C07D217/06 , C07C217/00
CPC分类号： C07C311/08 , A61K31/18 , A61K31/352 , A61K31/522 , C07C2602/08 , C07D217/06
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译：本发明涉及式（1）的化合物和制备含有这些衍生物的组合物和其用途的方法。根据本发明的化合物可用于多种疾病，病症和病症，特别是炎性，变应性和呼吸系统疾病，病症和病症。

3. 发明申请

WO1997043260A1 INDOLE DERIVATIVES USEFUL AS ENDOTHELIN RECEPTOR ANTAGONISTS 审中-公开
标题翻译：内含衍生物作为内皮素受体拮抗剂有用
公开(公告)号：WO1997043260A1
公开(公告)日：1997-11-20
申请号：PCT/EP1997001882
申请日：1997-04-11
申请人： PFIZER INC. , PFIZER LIMITED , RAWSON, David, James , DACK, Kevin, Neil , DICKINSON, Roger, Peter , JAMES, Kim
发明人： PFIZER INC. , PFIZER LIMITED
IPC分类号： C07D209/18
CPC分类号： C07D405/06 , C07D209/18 , C07D405/14 , C07D409/14 , C07D413/14
摘要： Compounds of formula (I), and their pharmaceutically acceptable derivatives, wherein R and R are optional substituents and independently represent C1-6 alkyl, C2-6 alkenyl [optionally substituted by CO2H or CO2(C1-6 alkyl)], C2-6 alkynyl, halogen, C1-3 perfluoroalkyl, (CH2)mAr , (CH2)mHet , (CH2)mCONR R , (CH2)mCO2R , O(CH2)qCO2R , (CH2)mCOR , (CH2)mOR , O(CH2)pOR , (CH2)mNR R , CO2(CH2)qNR R , (CH2)mCN, S(O)nR , SO2NR R , CONH(CH2)mAr or CONH(CH2)mHet ; R represents H, C1-6 alkyl, (CH2)pNR R , SO2R , SO2NR R , (CH2)mCOR , C2-6 alkenyl, C2-6 alkynyl, (CH2)mCONR R , (CH2)mCO2R , (CH2)pCN, (CH2)pR or (CH2)pOR ; R represents H or C1-6 alkyl; R represents H or OH; R represents phenyl optionally fused to a heterocyclic ring, the group as a whole being optionally substituted; R are fully defined herein and may independently represent Ar or Het ; Z represents CO2H, CONH(tetrazol-5-yl), CONHSO2O(C1-4 alkyl), CO2Ar , CO2(C1-6 alkyl), tetrazol-5-yl, CONHSO2Ar , CONHSO2(CH2)qAr or CONHSO2(C1-6 alkyl); Ar independently represent phenyl, naphthyl, or an aromatic heterocycle, which groups are optionally fused and optionally substituted; and Het and Het independently represent a non-aromatic heterocycle which is optionally substituted; are useful in the treatment of restenosis, renal failure and pulmonary hypertension.
摘要翻译：式（I）化合物及其药学上可接受的衍生物，其中R 1和R 2是任选的取代基并且独立地表示C 1-6烷基，C 2-6烯基[任选被CO 2 H或CO 2（C 1-6烷基）]，C 2-6炔基，卤素，C 1-3全氟烷基，（CH 2）mAr 1，（CH 2）m Het 1，（CH 2）m CONR 7 R 8，（CH 2）m CO 2 R 8，，O（CH 2）q CO 2 R 8，（CH 2）m COOR 8，（CH 2）mOR 8，O（CH 2）pOR 8，（CH 2）m NR 7 R 8，CO 2 ）qNR 7 R 8，（CH 2）mCN，S（O）n R 8，SO 2 NR 7 R 8，CONH（CH 2）mAr 1或CONH（CH 2）m Het 1 ; R 3表示H，C 1-6烷基，（CH 2）p NR R 10，SO 2 R 10，SO 2 NR 9 R 10，（CH 2）m COR 10，C 2-6烯基，C 2-6炔基，（CH 2）m CONR 9 R 10，（CH 2）m CO 2 R 10，（CH 2）pCN，（CH 2）p R 10或（CH 2）pOR 10; R 4表示H或C 1-6烷基; R 5表示H或OH; R 6表示任选地与杂环稠合的苯基，该基团整体上任选被取代; R 7-10>全部定义，并且可以独立地表示Ar 2或Het 2; Z表示CO 2 H，CONH（四唑-5-基），CONHSO 2 O（C 1-4烷基），CO 2 Ar 3，CO 2（C 1-6烷基），四唑-5-基，CONHSO 2 Ar 3，CONHSO 2（CH 2）qAr 3或CONHSO 2（C 1-6烷基）; Ar <1-3>独立地表示苯基，萘基或芳族杂环，这些基团任选地稠合并任选被取代; Het 1和Het 2独立地表示任选被取代的非芳族杂环; 可用于治疗再狭窄，肾衰竭和肺动脉高压。

4. 发明申请

WO2011083387A1 HYDROCHLORIDE SALT OF BIPHENYL-2-YL-CARBAMIC ACID 1-{9-[(3-FLUORO-4-HYDROXY-BENZOYL)-METHYL-AMINO]-NONYL}-PIPERIDIN-4-YL ESTER 审中-公开
标题翻译：邻苯二甲酸二乙酯盐酸1- {9 - [（3-氟-4-羟基苯甲酰基） - 甲基] -NONYL} - 哌啶-4-基酯
公开(公告)号：WO2011083387A1
公开(公告)日：2011-07-14
申请号：PCT/IB2010/056018
申请日：2010-12-22
申请人： PFIZER LIMITED , JAMES, Kim
发明人： JAMES, Kim
IPC分类号： C07D211/46 , A61K31/4465 , A61P11/00
CPC分类号： C07D211/46
摘要： This invention relates to the hydrochloride salt of biphenyl-2-yl-carbamic acid -{9-[(3-fluoro-4-hydroxy-benzoyl)-methyl-amino]-nonyl}-piperidin-4-yl ester and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, said compound. The invention also relates to the hydrates, solvates and polymorphs of the hydrochloride salt of Biphenyl-2-yl-carbamic acid 1-{9-[(3-fluoro-4-hydroxy-benzoyl)-methyl- amino]-nonyl}-piperidin-4-yl ester.
摘要翻译：本发明涉及联苯-2-基 - 氨基甲酸 - {9 - [（3-氟-4-羟基 - 苯甲酰基） - 甲基 - 氨基] - 壬基} - 哌啶-4-基酯的盐酸盐，用于制备用于制备所述化合物的含有和用途的组合物的中间体。本发明还涉及联苯-2-基 - 氨基甲酸1- {9 - [（3-氟-4-羟基 - 苯甲酰基） - 甲基 - 氨基] - 壬基} - 酮的盐酸盐的水合物，溶剂合物和多晶型物哌啶-4-基酯。

5. 发明申请

WO2005080313A9 SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES 审中-公开
标题翻译：用于治疗疾病的磺酰胺衍生物
公开(公告)号：WO2005080313A9
公开(公告)日：2006-08-31
申请号：PCT/IB2005000086
申请日：2005-01-12
申请人： PFIZER LTD , PFIZER , BROWN ALAN DANIEL , BUNNAGE MARK EDWARD , GLOSSOP PAUL ALAN , JAMES KIM , LANE CHARLOTTE ALICE LOUISE , LEWTHWAITE RUSSELL ANDREW , MOSES IAN BRIAN , PRICE DAVID ANTHONY , THOMSON NICHOLAS MURRAY
发明人： BROWN ALAN DANIEL , BUNNAGE MARK EDWARD , GLOSSOP PAUL ALAN , JAMES KIM , LANE CHARLOTTE ALICE LOUISE , LEWTHWAITE RUSSELL ANDREW , MOSES IAN BRIAN , PRICE DAVID ANTHONY , THOMSON NICHOLAS MURRAY
IPC分类号： C07C311/08 , C07D217/06
CPC分类号： C07C311/08 , A61K31/18 , A61K31/352 , A61K31/522 , C07C2602/08 , C07D217/06
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译：本发明涉及式（1）化合物及其制备方法，含有这些衍生物的用途和用途。根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。

6. 发明申请

WO2006051375A1 L-TARTRATE SALT OF N-1-ADAMANTHYL -2-{3-[(2R)-2- ({(2R)-2-HYDROXY -2- [4-HYDROXY-3- (HYDROXYMETHYL) PHENYL]ETHYL} AMINO)PROPYL] PHENYL} ACET AMIDE 审中-公开
标题翻译： N-1-ADAMANTHYL -2- {3 - [（2R）-2-（{（2R）-2-羟基-2- [4-羟基-3-（羟甲基）苯基]乙基}氨基酸的L-十三烷酸盐）PROPYL] PHENYL} ACET AMIDE
公开(公告)号：WO2006051375A1
公开(公告)日：2006-05-18
申请号：PCT/IB2005/003314
申请日：2005-10-31
申请人： PFIZER LIMITED , PFIZER INC. , JAMES, Kim , TAYLOR, Stefan, Colin, John
发明人： JAMES, Kim , TAYLOR, Stefan, Colin, John
IPC分类号： C07C237/20 , A61K31/135 , A61P11/00
CPC分类号： C07C237/20 , C07C2603/74
摘要： This invention relates to the L-tartrate salt of N-1Adamantyl-2- {3- [(2R)-2-({(2R)-2-hydroxy-2- [4-hydroxy-3-(hydroxymethyl)phenyl] ethyl}amino)propyl} acetamide and its use as a medicament.
摘要翻译：本发明涉及N-1金刚烷基-2- {3 - [（2R）-2 - （{（2R）-2-羟基-2- [4-羟基-3-（羟甲基）苯基] 乙基}氨基）丙基}乙酰胺及其作为药物的用途。

7. 发明申请

WO2005090287A3 PHENYLETHANOLAMINE DERIVATIVES AS BETA-2 AGONISTS 审中-公开
标题翻译：苯乙醇胺衍生物作为BETA-2激动剂
公开(公告)号：WO2005090287A3
公开(公告)日：2006-02-16
申请号：PCT/IB2005000640
申请日：2005-03-10
申请人： PFIZER LTD , PFIZER , BROWN ALAN DANIEL , BUNNAGE MARK EDWARD , GLOSSOP PAUL ALAN , JAMES KIM , LANE CHARLOTTE ALICE LOUISE , LEWTHWAITE RUSSELL ANDREW , LUNN GRAHAM , PRICE DAVID ANTHONY
发明人： BROWN ALAN DANIEL , BUNNAGE MARK EDWARD , GLOSSOP PAUL ALAN , JAMES KIM , LANE CHARLOTTE ALICE LOUISE , LEWTHWAITE RUSSELL ANDREW , LUNN GRAHAM , PRICE DAVID ANTHONY
IPC分类号： A61K31/165 , A61K31/472 , C07C237/20 , C07D217/06
CPC分类号： C07D217/06
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译：本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。

8. 发明申请

WO2005092860A1 COMPOUNDS FOR THE TREATMENT OF DISEASES 审中-公开
标题翻译：治疗疾病的化合物
公开(公告)号：WO2005092860A1
公开(公告)日：2005-10-06
申请号：PCT/IB2005/000669
申请日：2005-03-11
申请人： PFIZER LIMITED , PFIZER INC , BROWN, Alan, Daniel , BUNNAGE, Mark, Edward , GLOSSOP, Paul, Alan , JAMES, Kim , LANE, Charlotte, Alice, Louise , LEWTHWAITE, Russell, Andrew , PRICE, David, Anthony
发明人： BROWN, Alan, Daniel , BUNNAGE, Mark, Edward , GLOSSOP, Paul, Alan , JAMES, Kim , LANE, Charlotte, Alice, Louise , LEWTHWAITE, Russell, Andrew , PRICE, David, Anthony
IPC分类号： C07D213/65
CPC分类号： C07D401/12 , C07D213/65
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译：本发明涉及式（1）的化合物和用于制备用于制备含有这些衍生物的组合物和其用途的中间体的方法。根据本发明的化合物可用于许多疾病，病症和病症，特别是炎性，变应性和呼吸系统疾病，病症和病症。

9. 发明申请

WO2005092840A1 FORMAMIDE DERIVATIVES USEFUL AS ADRENOCEPTOR 审中-公开
标题翻译：甲醛衍生物有用作ADRENOCEPTOR
公开(公告)号：WO2005092840A1
公开(公告)日：2005-10-06
申请号：PCT/IB2005/000619
申请日：2005-03-10
申请人： PFIZER LIMITED , PFIZER INC. , BROWN, Alan, Daniel , BUNNAGE, Mark, Edward , GLOSSOP, Paul, Alan , JAMES, Kim , LANE, Charlotte, Alice, Louise , LEWTHWAITE, Russell, Andrew , PRICE, David, Anthony
发明人： BROWN, Alan, Daniel , BUNNAGE, Mark, Edward , GLOSSOP, Paul, Alan , JAMES, Kim , LANE, Charlotte, Alice, Louise , LEWTHWAITE, Russell, Andrew , PRICE, David, Anthony
IPC分类号： C07C233/43
CPC分类号： C07C237/20 , C07C237/30 , C07C237/32 , C07C255/60 , C07C311/37 , C07C311/46 , C07C317/32 , C07C323/32 , C07C323/41 , C07C323/42 , C07C2601/14 , C07C2602/08 , C07C2603/74 , C07D209/48 , C07D211/32 , C07D213/38 , C07D213/40 , C07D217/06 , C07D217/16 , C07D221/22 , C07D221/24 , C07D295/192 , C07D335/02
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译：本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。

10. 发明申请

WO2007107828A2 AMINE DERIVATIVES 审中-公开
标题翻译：胺衍生物
公开(公告)号：WO2007107828A2
公开(公告)日：2007-09-27
申请号：PCT/IB2007/000619
申请日：2007-03-07
申请人： PFIZER LIMITED , JAMES, Kim , JONES, Lyn, Howard , PRICE, David, Anthony
发明人： JAMES, Kim , JONES, Lyn, Howard , PRICE, David, Anthony
IPC分类号： C07C311/08 , C07C233/43 , C07D215/26 , C07D215/60 , A61K31/18 , A61P29/00
CPC分类号： C07C311/08 , C07C215/54 , C07C217/48 , C07C217/62 , C07C223/02 , C07C233/43 , C07C255/13 , C07C271/16 , C07C271/66 , C07D215/26 , C07D215/60 , C07F7/1852
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译：本发明涉及式（1）的化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。根据本发明的化合物可用于许多疾病，病症和病症，特别是炎性，过敏和呼吸道疾病，病症和病症。

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