专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007022511A3 LISTERIA-INDUCED IMMUNORECRUITMENT AND ACTIVATION, AND METHODS OF USE THEREOF 审中-公开
标题翻译：李斯特菌诱导的免疫分泌和激活及其使用方法
公开(公告)号：WO2007022511A3
公开(公告)日：2007-09-13
申请号：PCT/US2006032648
申请日：2006-08-21
申请人： CERUS CORP , UNIV JOHNS HOPKINS , PARDOLL DREW M , SCHULICK RICHARD D , BAHJAT KEITH S , BROCKSTEDT DIRK G , DUBENSKY THOMAS W JR , GIEDLIN MARTIN A , JAIN AJAY , YOSHIMURA KIYOSHI
发明人： PARDOLL DREW M , SCHULICK RICHARD D , BAHJAT KEITH S , BROCKSTEDT DIRK G , DUBENSKY THOMAS W JR , GIEDLIN MARTIN A , JAIN AJAY , YOSHIMURA KIYOSHI
IPC分类号： A61K35/74 , A61P31/00 , A61P35/00 , A61P37/02
CPC分类号： A61K39/0011 , A61K31/675 , A61K35/13 , A61K35/74 , A61K38/193 , A61K2039/505 , A61K2039/522 , A61K2039/55522 , A61K2039/55544 , C07K16/2812 , C07K16/2815 , C12N1/36 , A61K2300/00 , A61K38/00
摘要： Provided are reagents and methods for administering an attenuated bacterium for use in treating a cancerous or infectious condition. Reagents and methods for administering an attenuated bacterium for use in inducing an immune response against a tumor, cancer cell, or infective agent are further provided. Also provided are methods of diagnosis and kits.
摘要翻译：提供了用于施用用于治疗癌症或感染症状的减毒细菌的试剂和方法。还提供了用于施用减毒细菌的试剂和方法，所述减毒细菌用于诱导针对肿瘤，癌细胞或感染剂的免疫应答。还提供了诊断和试剂盒的方法。

2. 发明申请

WO1994028504A1 A MACHINE-LEARNING APPROACH TO MODELING BIOLOGICAL ACTIVITY FOR MOLECULAR DESIGN AND TO MODELING OTHER CHARACTERISTICS 审中-公开
标题翻译：建立分子生物学活动的机器学习方法和模拟其他特征
公开(公告)号：WO1994028504A1
公开(公告)日：1994-12-08
申请号：PCT/US1994005877
申请日：1994-05-20
申请人： ARRIS PHARMACEUTICAL , CHAPMAN, David , CRITCHLOW, Roger , DIETTERICH, Tom , JAIN, Ajay, N. , LATHROP, Rick , PEREZ, Tomas, Lozano
发明人： ARRIS PHARMACEUTICAL
IPC分类号： G06F15/60
CPC分类号： C07K1/00 , G06F19/704 , G06F19/706 , G06F19/707 , Y10S706/92
摘要： Explicit representation of molecular shape of molecules is combined with neural network learning methods to provide models with high predictive ability that generalize to different chemical classes where structurally diverse molecules exhibiting similar surface characteristics are treated as similar. A new machine-learning methodology is disclosed that can accept multiple representations of objects (100) and construct models (102-114) that predict characteristics of those objects (116). An extension of this methodology can be applied in cases where the representations of the objects are determined by a set of adjustable parameters. An iterative process applies intermediate models to generate new representations of the objects by adjusting parameters (108) and repeatedly retrains the models to obtain better predictive models. This method can be applied to molecules because each molecule can have many orientations and conformations, or representations, that are determined by a set of translation, rotation, and torsion angle parameters.
摘要翻译：分子分子形状的显式表示与神经网络学习方法相结合，以提供具有高预测能力的模型，将其泛化为不同的化学类别，其中表现出相似表面特征的结构多样的分子被认为是相似的。公开了一种新的机器学习方法，其可以接受对象（100）的多个表示并且构造预测那些对象（116）的特征的模型（102-114）。在通过一组可调参数确定对象的表示的情况下，可以应用该方法的扩展。迭代过程通过调整参数（108）并重复地重新模拟模型以获得更好的预测模型，应用中间模型来生成对象的新表示。该方法可以应用于分子，因为每个分子可以具有由一组平移，旋转和扭转角参数确定的许多取向和构象或表示。

3. 发明申请

WO2009050478A1 CATHETER APPARATUS 审中-公开
标题翻译：导管装置
公开(公告)号：WO2009050478A1
公开(公告)日：2009-04-23
申请号：PCT/GB2008/003522
申请日：2008-10-17
申请人： BARTS AND THE LONDON NHS TRUST , JAIN, Ajay Kumar
发明人： JAIN, Ajay Kumar
IPC分类号： A61M25/00
CPC分类号： A61M25/0074 , A61M25/0082 , A61M2025/0036
摘要： A catheter apparatus is provided with lumens for accommodating guidewires. The apparatus comprises an actuator controllable to move the distal ends of the lumens relative to each other. Accordingly, the separation of the guidewires can be controlled, enabling probing by the guidewires of different area of an occlusion in a blood vessel, such as a chronic total occlusion.
摘要翻译：导管装置设置有用于容纳导丝的腔。该装置包括可控制的致动器，用于相对于彼此移动腔的远端。因此，可以控制导线的分离，使得能够通过诸如慢性完全闭塞的血管中闭塞的不同区域的导丝来探测。

4. 发明申请

WO2006027599A8 MINIMALLY INVASIVE SURGICAL APPARATUS AND METHODS 审中-公开
标题翻译：微创外科手术和方法
公开(公告)号：WO2006027599A8
公开(公告)日：2006-05-04
申请号：PCT/GB2005003480
申请日：2005-09-08
申请人： ADVOTEK MEDICAL DEVICES LTD , DICKINSON ROBERT JULIAN , PACEY ANDREW ROBERT , ROTHMAN MARTIN TERRY , JAIN AJAY KUMAR
发明人： DICKINSON ROBERT JULIAN , PACEY ANDREW ROBERT , ROTHMAN MARTIN TERRY , JAIN AJAY KUMAR
IPC分类号： A61B17/00 , A61B17/11 , A61B17/22 , A61B17/34 , A61B19/00
CPC分类号： A61B19/5244 , A61B17/11 , A61B17/2202 , A61B17/3478 , A61B34/20 , A61B2017/00252 , A61B2017/1107 , A61B2017/1139 , A61B2017/22082 , A61B2034/2051 , A61B2034/2063 , A61B2090/3782 , A61B2090/3786 , A61B2090/3788 , A61B2090/3929 , A61F2/966
摘要： Apparatus and methods are described for performing percutaneous catheter-based interventional surgery. The apparatus comprises first and second devices that are located in adjacent body cavities, such as adjacent blood vessels, the first device being capable of transmitting a directional signal that can be received by the second device. The direction of the signal is correlated with the facility to direct therapy, such that improved accuracy in therapy placement is thereby achieved. Methods for treating patients utilising the means and apparatus are also provided.
摘要翻译：描述了用于进行经皮导管介入手术的装置和方法。该装置包括位于相邻体腔中的第一和第二装置，例如相邻的血管，第一装置能够传输可由第二装置接收的定向信号。信号的方向与用于引导治疗的设备相关联，从而实现治疗放置的改善的准确性。还提供了使用该装置和装置治疗患者的方法。

5. 发明申请

WO03065787A8 METHODS AND COMPOSITIONS FOR THE TARGETING OF A SYSTEMIC IMMUNE RESPONSE TO SPECIFIC ORGANS OR TISSUES 审中-公开
标题翻译：针对特定机构或组织的系统性免疫应答的方法和组合
公开(公告)号：WO03065787A8
公开(公告)日：2005-01-13
申请号：PCT/US0303650
申请日：2003-02-06
申请人： UNIV JOHNS HOPKINS MED , SCHULICK RICHARD D , PARDOLL DREW M , JAIN AJAY
发明人： SCHULICK RICHARD D , PARDOLL DREW M , JAIN AJAY
IPC分类号： A61K39/00 , A61P35/04 , A61K35/00 , A61K35/12 , A61K48/00 , C12N15/85 , C12N15/86
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5156 , A61K2039/53 , A61K2039/55522 , A61K2039/55594
摘要： The invention provides methods and compositions for targeting a separately generated immune response to a specific organ or tissue; e.g. one affected by cancer, using one or more agents with a tropism for the organ or tissue r that can be specifically localized to the desired organ or tissue. For example, the invention provides methods and compositions for treating liver metastases from colorectal cancer using a combination of a granulocyte/macrophage colony stimulating factor (GM-CSF) augmented tumor cell vaccination and Listeria monocytogenes (LM) infection.
摘要翻译：本发明提供用于靶向单独产生的对特定器官或组织的免疫应答的方法和组合物; 例如受癌症影响的一种，使用一种或多种具有对特异性定位于所需器官或组织的器官或组织r的向性的药剂。例如，本发明提供了使用粒细胞/巨噬细胞集落刺激因子（GM-CSF）增强的肿瘤细胞疫苗接种和单核细胞增多性李斯特菌（LM）感染的组合来治疗来自结肠直肠癌的肝转移的方法和组合物。

6. 发明申请

WO2007122396A1 APPARATUS AND METHOD FOR MAINTAINING FLUID FLOW THROUG BODY PASSAGES 审中-公开
标题翻译：维持流体流动通道的装置和方法
公开(公告)号：WO2007122396A1
公开(公告)日：2007-11-01
申请号：PCT/GB2007/001430
申请日：2007-04-20
申请人： SITE SPECIFIC THERAPIES LTD , DICKINSON, Robert, Julian , PACEY, Andrew, Robert , ROTHMAN, Martin, Terry , JAIN, Ajay, Kumar
发明人： DICKINSON, Robert, Julian , PACEY, Andrew, Robert , ROTHMAN, Martin, Terry , JAIN, Ajay, Kumar
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/90 , A61F2002/072 , A61F2250/0018
摘要： A device (10) for maintaining fluid flow through at least one passage in a human or animal body, the device comprising two end portions (12, 14) for anchoring the device in position, and an intermediate portion (16) which allows movement of the end portions relative to each another, wherein the end portions and intermediate portion together define a pathway for fluid flow through the device. The device is particularly suitable for use in the treatment of coronary heart disease by minimally invasive surgery, and the invention extends to a method for diverting fluid flow from one passage to another.
摘要翻译：一种用于维持流体流过人体或动物体内的至少一个通道的装置（10），该装置包括用于将装置固定在适当位置的两个端部部分（12,14）和允许运动的中间部分（16）所述端部相对于彼此，其中所述端部和中间部分一起限定用于流体流过所述装置的路径。该装置特别适用于通过微创手术治疗冠心病，并且本发明延伸到用于将流体流从一个通道转向另一个通道的方法。

7. 发明申请

WO2006027599A1 MINIMALLY INVASIVE SURGICAL APPARATUS AND METHODS 审中-公开
标题翻译：微创外科手术和方法
公开(公告)号：WO2006027599A1
公开(公告)日：2006-03-16
申请号：PCT/GB2005/003480
申请日：2005-09-08
申请人： ADVOTEK MEDICAL DEVICES LTD , DICKINSON, Robert, Julian , PACEY, Andrew, Robert , ROTHMAN, Martin, Terry , JAIN, Ajay, Kumar
发明人： DICKINSON, Robert, Julian , PACEY, Andrew, Robert , ROTHMAN, Martin, Terry , JAIN, Ajay, Kumar
IPC分类号： A61B17/00 , A61B17/11
CPC分类号： A61B19/5244 , A61B17/11 , A61B17/2202 , A61B17/3478 , A61B34/20 , A61B2017/00252 , A61B2017/1107 , A61B2017/1139 , A61B2017/22082 , A61B2034/2051 , A61B2034/2063 , A61B2090/3782 , A61B2090/3786 , A61B2090/3788 , A61B2090/3929 , A61F2/966
摘要： Apparatus and methods are described for performing percutaneous catheter-based interventional surgery. The apparatus comprises first and second devices that are located in adjacent body cavities, such as adjacent food vessels, the first device being capable of transmitting a directional signal that can be received by the second device. The direction of the signal is correlated with the facility to direct therapy, such that improved accuracy in therapy placement is thereby achieved. Methods for treating patients utilising the means and apparatus are also provided.
摘要翻译：描述了用于进行经皮导管介入手术的装置和方法。该装置包括位于相邻体腔中的第一和第二装置，例如相邻的食物容器，第一装置能够传送可由第二装置接收的定向信号。信号的方向与用于引导治疗的设备相关联，从而实现治疗放置的改善的准确性。还提供了使用该装置和装置治疗患者的方法。

8. 发明申请

WO2003065787A3 METHODS AND COMPOSITIONS FOR THE TARGETING OF A SYSTEMIC IMMUNE RESPONSE TO SPECIFIC ORGANS OR TISSUES 审中-公开
公开(公告)号：WO2003065787A3
公开(公告)日：2003-08-14
申请号：PCT/US2003/003650
申请日：2003-02-06
申请人： JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , SCHULICK, Richard, D. , PARDOLL, Drew, M. , JAIN, Ajay
发明人： SCHULICK, Richard, D. , PARDOLL, Drew, M. , JAIN, Ajay
IPC分类号： A61K35/00
摘要： The invention provides methods and compositions for targeting a separately generated immune response to a specific organ or tissue; e.g. one affected by cancer, using one or more agents with a tropism for the organ or tissue r that can be specifically localized to the desired organ or tissue. For example, the invention provides methods and compositions for treating liver metastases from colorectal cancer using a combination of a granulocyte/macrophage colony stimulating factor (GM-CSF) augmented tumor cell vaccination and Listeria monocytogenes (LM) infection.

9. 发明申请

WO2003065787A2 TARGETING OF A SYSTEMICALLY GENERATED IMMUNE RESPONSE TO A SPECIFIC ORGAN OR TISSUE 审中-公开
标题翻译：对特定机构或组织进行系统性生成的免疫应答
公开(公告)号：WO2003065787A2
公开(公告)日：2003-08-14
申请号：PCT/US2003/003650
申请日：2003-02-06
申请人： JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , SCHULICK, Richard, D. , PARDOLL, Drew, M. , JAIN, Ajay
发明人： SCHULICK, Richard, D. , PARDOLL, Drew, M. , JAIN, Ajay
IPC分类号： A61K39/00 , A61P35/04
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5156 , A61K2039/53 , A61K2039/55522 , A61K2039/55594
摘要： The invention provides methods and compositions for targeting a separately generated immune response to a specific organ or tissue; e.g. one affected by cancer, using one or more agents with a tropism for the organ or tissue r that can be specifically localized to the desired organ or tissue. For example, the invention provides methods and compositions for treating liver metastases from colorectal cancer using a combination of a granulocyte/macrophage colony stimulating factor (GM-CSF) augmented tumor cell vaccination and Listeria monocytogenes (LM) infection.
摘要翻译：本发明提供用于靶向单独产生的对特定器官或组织的免疫应答的方法和组合物; 例如受癌症影响的一种，使用一种或多种具有对特异性定位于所需器官或组织的器官或组织r的向性的药剂。例如，本发明提供了使用粒细胞/巨噬细胞集落刺激因子（GM-CSF）增强的肿瘤细胞疫苗接种和单核细胞增多性李斯特菌（LM）感染的组合来治疗来自结肠直肠癌的肝转移的方法和组合物。

10. 发明申请

WO2018004619A1 HIGH DENSITY INTERCONNECT STRUCTURES CONFIGURED FOR MANUFACTURING AND PERFORMANCE 审中-公开
标题翻译：配置用于制造和性能的高密度互连结构
公开(公告)号：WO2018004619A1
公开(公告)日：2018-01-04
申请号：PCT/US2016/040486
申请日：2016-06-30
申请人： BRAUNISCH, Henning , AYGUN, Kemal , JAIN, Ajay , QIAN, Zhiguo
发明人： BRAUNISCH, Henning , AYGUN, Kemal , JAIN, Ajay , QIAN, Zhiguo
IPC分类号： H01L23/48 , H01L23/00 , H01L23/495 , H01L23/498 , H01L23/522
摘要： Discussed generally herein are methods and devices including or providing a high density interconnect structure. A high density interconnect structure can include a stack of alternating dielectric layers and metallization layers comprising at least three metallization layers including conductive material with low k dielectric material between the conductive material, and at least two dielectric layers including first medium k dielectric material with one or more first vias extending therethrough, the at least two dielectric layers situated between two metallization layers of the at least three metallization layers, a second medium k dielectric material directly on a top surface of the stack, a second via extending through the second medium k dielectric material, the second via electrically connected to conductive material in a metallization layer of the three or more metallization layers, and a pad over the second medium k dielectric material and electrically connected to the second via.
摘要翻译：这里通常讨论的是包括或提供高密度互连结构的方法和设备。高密度互连结构可以包括交替介电层和金属化层的叠层，所述金属化层包括至少三个金属化层，所述至少三个金属化层包括在导电材料之间具有低k介电材料的导电材料，以及至少两个介电层，包括第一介质k介电材料，所述至少两个电介质层位于所述至少三个金属化层的两个金属化层之间，第二介质k电介质材料直接位于所述堆叠的顶表面上，第二通孔延伸穿过所述第二介质k电介质所述第二通孔电连接到所述三个或更多个金属化层的金属化层中的导电材料，所述第二介质k电介质材料上方的焊盘并且电连接到所述第二通孔。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式