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1. 发明申请

WO2015085191A1 SPECTROPHOTOMETER WITH VARIABLE OPTICAL PATH LENGTH CELL 审中-公开
标题翻译：具有可变光路径长度细胞的光谱仪
公开(公告)号：WO2015085191A1
公开(公告)日：2015-06-11
申请号：PCT/US2014/068831
申请日：2014-12-05
申请人： JACKSON, Donald, L. , RUSSO, Chris, J. , KLINKHAMMER, Gary, Patrick
发明人： JACKSON, Donald, L. , RUSSO, Chris, J. , KLINKHAMMER, Gary, Patrick
IPC分类号： G01N21/25 , G01N21/55 , G01N33/48
CPC分类号： G01N21/645 , G01N21/0303 , G01N21/05 , G01N21/59 , G01N21/94 , G01N33/18 , G01N2021/6482 , G01N2021/6484
摘要： A hybrid spectrophotometric instrument utilizing absorption and fluorescence observations requires different cell parameters for optimal performance. The ability to have an instrument with a variable optical path length with a single set of optical surfaces and one detector to reduce system variance is unique. A Zero Angle Photon Spectrometer with the additional hardware and software to support a variable path length instrument is described.
摘要翻译：使用吸收和荧光观察的混合分光光度仪器需要不同的电池参数以获得最佳性能。具有可变光路长度的仪器与单组光学表面和一个检测器以减少系统方差的能力是独一无二的。描述了具有附加硬件和软件以支持可变路径长度仪器的零角度光子光谱仪。

2. 发明申请

WO2005012875A3 BIOMARKERS OF CYCLIN-DEPENDENT KINASE MODULATION 审中-公开
标题翻译：循环依赖性激酶调节的生物标志物
公开(公告)号：WO2005012875A3
公开(公告)日：2007-03-15
申请号：PCT/US2004024424
申请日：2004-07-29
申请人： SQUIBB BRISTOL MYERS CO , LI MARTHA , RUPNOW BRENT A , WEBSTER KEVIN R , JACKSON DONALD G , WONG TAI W
发明人： LI MARTHA , RUPNOW BRENT A , WEBSTER KEVIN R , JACKSON DONALD G , WONG TAI W
IPC分类号： C12Q1/68 , C12M1/00 , C12M1/34 , G01N20060101
CPC分类号： C12Q1/485 , C12Q1/6886 , C12Q2600/106 , C12Q2600/16 , G01N2333/4739
摘要： Biomarkers having expression patterns that correlate with a response of cells to treatment with one or more cdk modulating agents, and uses thereof. Also provided are methods for testing or predicting whether a mammal will respond therapeutically to a method of treating cancer that comprises administering an agent that modulates cdk activity.
摘要翻译：具有与细胞对一种或多种cdk调节剂治疗反应相关的表达模式的生物标志物及其用途。还提供了用于测试或预测哺乳动物是否会治疗性治疗癌症的方法的方法，所述方法包括施用调节cdk活性的药剂。

3. 发明申请

WO0248369A3 POLYNUCLEOTIDE ENCODING A HUMAN POTASSIUM CHANNEL BETA-SUBUNIT, K+MBETA1 审中-公开
标题翻译：多核苷酸编码人类钾通道亚基，K + MBETA1
公开(公告)号：WO0248369A3
公开(公告)日：2004-02-26
申请号：PCT/US0150726
申请日：2001-11-01
申请人： SQUIBB BRISTOL MYERS CO , FEDER JOHN NATHAN , LEE LIANA M , CHEN JIAN , JACKSON DONALD , RAMANATHAN CHANDRA , SIEMERS NATHAN , CHANG HAN
发明人： FEDER JOHN NATHAN , LEE LIANA M , CHEN JIAN , JACKSON DONALD , RAMANATHAN CHANDRA , SIEMERS NATHAN , CHANG HAN
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12 , A61K38/17 , C07K16/28 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides novel polynucleotides encoding K+Mbeta1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel K+Mbeta1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码K + Mbeta1多肽的新型多核苷酸，其片段及其同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型K + Mbeta1多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

4. 发明申请

WO2002102323A3 NOVEL HUMAN HISTONE DEACETYLASES 审中-公开
公开(公告)号：WO2002102323A3
公开(公告)日：2002-12-27
申请号：PCT/US2002/019560
申请日：2002-06-14
申请人： BRISTOL-MYERS SQUIBB COMPANY , JACKSON, Donald, G. , LORENZI, Matthew, V. , ATTAR, Ricardo, M. , GOTTARDIS, Marco
发明人： JACKSON, Donald, G. , LORENZI, Matthew, V. , ATTAR, Ricardo, M. , GOTTARDIS, Marco
IPC分类号： C12N15/11
摘要： The present invention relates to newly discovered human histone deacetylases (HDACs), also referred to as histone deacetylase-like polypeptides. The polynucleotide sequences and encoded polypeptides of the novel HDACs are encompassed by the invention, as well as vectors comprising these polynucleotides and host cells comprising these vectors. The invention also relates to antibodies that bind to the disclosed HDAC polypeptides, and methods employing these antibodies. Also related are methods of screening for modulators, such as inhibitors or antagonists, or agonists. The invention also relates to diagnostic and therapeutic applications which employ the disclosed HDAC polynucleotides, polypeptides, and antibodies, and HDAC modulators. Such applications can be used with diseases and disorders associated with abnormal cell growth or proliferation, cell differentiation, and cell survival, e.g., neoplastic cell growth, and especially breast and prostate cancers or tumors.

5. 发明申请

WO2002102323A2 NOVEL HUMAN HISTONE DEACETYLASES 审中-公开
标题翻译：新人类HISTONE DEACETYLASES
公开(公告)号：WO2002102323A2
公开(公告)日：2002-12-27
申请号：PCT/US2002/019560
申请日：2002-06-14
申请人： BRISTOL-MYERS SQUIBB COMPANY , JACKSON, Donald, G. , LORENZI, Matthew, V. , ATTAR, Ricardo, M. , GOTTARDIS, Marco
发明人： JACKSON, Donald, G. , LORENZI, Matthew, V. , ATTAR, Ricardo, M. , GOTTARDIS, Marco
IPC分类号： A61K
CPC分类号： C12N9/16
摘要： The present invention relates to newly discovered human histone deacetylases (HDACs), also referred to as histone deacetylase-like polypeptides. The polynucleotide sequences and encoded polypeptides of the novel HDACs are encompassed by the invention, as well as vectors comprising these polynucleotides and host cells comprising these vectors. The invention also relates to antibodies that bind to the disclosed HDAC polypeptides, and methods employing these antibodies. Also related are methods of screening for modulators, such as inhibitors or antagonists, or agonists. The invention also relates to diagnostic and therapeutic applications which employ the disclosed HDAC polynucleotides, polypeptides, and antibodies, and HDAC modulators. Such applications can be used with diseases and disorders associated with abnormal cell growth or proliferation, cell differentiation, and cell survival, e.g., neoplastic cell growth, and especially breast and prostate cancers or tumors.
摘要翻译：本发明涉及新发现的人类组蛋白脱乙酰酶（HDAC），也称为组蛋白脱乙酰酶样多肽。本发明涵盖了新型HDAC的多核苷酸序列和编码多肽，以及包含这些多核苷酸的载体和包含这些载体的宿主细胞。本发明还涉及结合所公开的HDAC多肽的抗体，以及使用这些抗体的方法。还涉及筛选调节剂的方法，例如抑制剂或拮抗剂或激动剂。本发明还涉及使用所公开的HDAC多核苷酸，多肽和抗体以及HDAC调节剂的诊断和治疗应用。这种应用可以用于与异常细胞生长或增殖，细胞分化和细胞存活相关的疾病和病症，例如肿瘤细胞生长，特别是乳腺癌和前列腺癌或肿瘤。

6. 发明申请

WO02068587A3 POLYNUCLEOTIDE ENCODING A NOVEL HUMAN POTASSIUM CHANNEL BETA-SUBUNIT, K+BETAM3 审中-公开
标题翻译：多核苷酸编码新的人类钾通道亚磷酸盐，K + BETAM3
公开(公告)号：WO02068587A3
公开(公告)日：2003-03-27
申请号：PCT/US0203986
申请日：2002-02-07
申请人： SQUIBB BRISTOL MYERS CO , FEDER JOHN , LEE LIANA , CHEN JIAN , JACKSON DONALD G , RAMANATHAN CHANDRA , SIEMERS NATHAN , CHANG HAN , RYSECK ROLF-PETER , WATSON ANDREW J , CARROLL PAMELA
发明人： FEDER JOHN , LEE LIANA , CHEN JIAN , JACKSON DONALD G , RAMANATHAN CHANDRA , SIEMERS NATHAN , CHANG HAN , RYSECK ROLF-PETER , WATSON ANDREW J , CARROLL PAMELA
IPC分类号： C07K14/705 , C12N15/12 , A61K38/16 , C07K14/435 , C07K16/18 , C12N5/10 , C12N15/63
CPC分类号： C07K14/705
摘要： The present invention provides novel polynucleotides encoding K+betaM3 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel K+betaM3 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码K +βM3多肽的新型多核苷酸，其片段及其同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型K +βM3多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

7. 发明申请

WO2002070727A3 POLYNUCLEOTIDE ENCODING A NOVEL HUMAN POTASSIUM CHANNEL BETA-SUBUNIT, K+BETAM6, EXPRESSED HIGHLY IN THE SMALL INTESTINE 审中-公开
公开(公告)号：WO2002070727A3
公开(公告)日：2002-09-12
申请号：PCT/US2002/005674
申请日：2002-02-21
申请人： BRISTOL-MYERS SQUIBB COMPANY , FEDER, John , LEE, Liana , CHEN, Jian , JACKSON, Donald, G. , RAMANATHAN, Chandra , SIEMERS, Nathan , CHANG, Han
发明人： FEDER, John , LEE, Liana , CHEN, Jian , JACKSON, Donald, G. , RAMANATHAN, Chandra , SIEMERS, Nathan , CHANG, Han
IPC分类号： A61K31/70
摘要： The present invention provides novel polynucleotides encoding K+betaM6 polypeptides (Figure 1), fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel K+betaM6 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

8. 发明申请

WO2002068604A2 POLYNUCLEOTIDE ENCODING TWO NOVEL HUMAN POTASSIUM CHANNEL BETA-SUBUNITS, K+BETAM4 AND K+BETAM5 审中-公开
标题翻译：多核苷酸编码两个新人类钾通道亚基，K + BETAM4和K + BETAM5
公开(公告)号：WO2002068604A2
公开(公告)日：2002-09-06
申请号：PCT/US2002/006003
申请日：2002-02-28
申请人： BRISTOL-MYERS SQUIBB COMPANY , FEDER, John , LEE, Liana , CHEN, Jian , JACKSON, Donald, G. , RAMANATHAN, Chandra , SIEMERS, Nathan , CHANG, Han , CARROLL, Pamela
发明人： FEDER, John , LEE, Liana , CHEN, Jian , JACKSON, Donald, G. , RAMANATHAN, Chandra , SIEMERS, Nathan , CHANG, Han , CARROLL, Pamela
IPC分类号： C12N
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides novel polynucleotides encoding K+betaM4 or K+betaM5 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel K+betaM4 or K+betaM5 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码K +βM4或K +βM5多肽的新型多核苷酸，其片段及其同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型K +βM4或K +βM5多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

9. 发明申请

WO2005067667A3 BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO EPIDERMAL GROWTH FACTOR RECEPTOR MODULATORS 审中-公开
标题翻译：生物标志物和确定对生殖因子受体调节剂敏感性的方法
公开(公告)号：WO2005067667A3
公开(公告)日：2007-11-22
申请号：PCT/US2005000638
申请日：2005-01-07
申请人： SQUIBB BRISTOL MYERS CO , CLARK EDWIN A , FORD SHIRIN K , YOGANATHAN SUGANTHY , JACKSON DONALD G
发明人： CLARK EDWIN A , FORD SHIRIN K , YOGANATHAN SUGANTHY , JACKSON DONALD G
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/574 , G01N33/74
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/574 , G01N33/74 , G01N2500/00 , G01N2800/52
摘要： EGFR biomarkers useful in a method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises (a) exposing the mammal to the EGFR modulator and (b) measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in (b) compared to the level of the biomarker in a mammal that has not been exposed to the EGFR modulator indicates that the mammal will respond therapeutically to the method of treating cancer.
摘要翻译： EGFR生物标志物，其可用于鉴定将对治疗癌症治疗的治疗反应的哺乳动物的方法，包括施用EGFR调节剂，其中所述方法包括（a）将哺乳动物暴露于EGFR调节剂和（b）在哺乳动物中测量水平的至少一种生物标志物，其中在（b）中测量的至少一种生物标志物的水平的差异与尚未暴露于EGFR调节剂的哺乳动物中的生物标志物的水平相比表明哺乳动物将在治疗涉及治疗癌症的方法。

10. 发明申请

WO2005067667A2 BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO EPIDERMAL GROWTH FACTOR RECEPTOR MODULATORS 审中-公开
标题翻译：生物标记物和测定敏感性的方法，用于生物生长因子受体调节剂
公开(公告)号：WO2005067667A2
公开(公告)日：2005-07-28
申请号：PCT/US2005/000638
申请日：2005-01-07
申请人： BRISTOL-MYERS SQUIBB COMPANY , CLARK, Edwin, A. , FORD, Shirin, K. , YOGANATHAN, Suganthy , JACKSON, Donald, G.
发明人： CLARK, Edwin, A. , FORD, Shirin, K. , YOGANATHAN, Suganthy , JACKSON, Donald, G.
IPC分类号： C12Q1/68 , G01N33/574 , G01N33/74
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/574 , G01N33/74 , G01N2500/00 , G01N2800/52
摘要： EGFR biomarkers useful in a method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises (a) exposing the mammal to the EGFR modulator and (b) measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in (b) compared to the level of the biomarker in a mammal that has not been exposed to the EGFR modulator indicates that the mammal will respond therapeutically to the method of treating cancer.
摘要翻译： EGFR生物标志物可用于鉴定将对治疗癌症治疗的治疗反应的哺乳动物的方法，包括施用EGFR调节剂，其中所述方法包括（a）将哺乳动物暴露于EGFR调节剂和（b）在哺乳动物中测量水平的至少一种生物标志物，其中在（b）中测量的至少一种生物标志物水平的差异与尚未暴露于EGFR调节剂的哺乳动物中的生物标志物的水平相比表明哺乳动物将在治疗涉及治疗癌症的方法。

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