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1. 发明申请

WO2014142946A1 A PROKARYOTIC-TYPE ISOCITRATE DEHYDROGENASE AND ITS APPLICATION FOR IMPROVING NITROGEN UTILIZATION IN TRANSGENIC PLANTS 审中-公开
标题翻译：原始类型分离脱氢酶及其在转基因植物中提高氮素利用的应用
公开(公告)号：WO2014142946A1
公开(公告)日：2014-09-18
申请号：PCT/US2013/031913
申请日：2013-03-15
申请人： IOWA CORN PROMOTION BOARD , MCLAREN, James , VANDE BERG, Brian
发明人： MCLAREN, James , VANDE BERG, Brian
IPC分类号： A01H5/00
CPC分类号： C12N15/8273 , C12N9/0006 , C12N15/8261 , C12N15/8271 , Y02A40/146
摘要： The present invention relates to transgenic plants that have increased nitrogen use efficiency, stress tolerance, and/or alleviating a limitation such that yield is increased, or a combination of these and that have been transformed using a novel vector construct including a synthetic isocitrate dehydrogenase ( icdh) gene that modulates nitrogen use in plants. The invention also relates to stacking the icdh gene with other exogenous or heterologous genes that modulate nitrogen use in the plant, including a N-acetylglutamate kinase gene. The invention also relates to methods of expressing in plants the nucleic acid molecules corresponding to the nucleic acid sequences that modulate nitrogen use in plants or are modulated by nitrogen conditions.
摘要翻译：本发明涉及具有增加的氮利用效率，胁迫耐受性和/或减轻使得产量增加的限制的这些转基因植物，或者使用包含合成的异柠檬酸脱氢酶的新型载体构建体 icdh）基因，调节植物中的氮使用。本发明还涉及将icdh基因与在植物中调节氮使用的其它外源或异源基因堆叠，包括N-乙酰谷氨酸激酶基因。本发明还涉及在植物中表达对应于调节植物中氮利用或由氮条件调节的核酸序列的核酸分子的方法。

2. 发明申请

WO2009126852A1 DIANHYDROSUGAR PRODUCTION PROCESS 审中-公开
标题翻译：二氢生产工艺
公开(公告)号：WO2009126852A1
公开(公告)日：2009-10-15
申请号：PCT/US2009/040142
申请日：2009-04-10
申请人： IOWA CORN PROMOTION BOARD , SCHRECK, David , BRADFORD, Marion , CLINTON, Nye , ARBURY, Paul
发明人： SCHRECK, David , BRADFORD, Marion , CLINTON, Nye , ARBURY, Paul
IPC分类号： C07D315/00
CPC分类号： C07D493/04
摘要： An enhanced process for the production of a dianhydrosugar, such as isosorbide, from the corresponding sugar alcohol is described. The sugar alcohol is combined with an acid catalyst and reacted at elevated temperatures and at atmospheric pressure, eliminating the need for a vacuum. High selectivity and yields are achieved.
摘要翻译：描述了用于从相应的糖醇生产二脱水菌糖如异山梨醇的增强方法。糖醇与酸催化剂结合，并在升高的温度和大气压下反应，消除了对真空的需要。实现了高选择性和收率。

3. 发明申请

WO2011056769A1 PLANTS WITH IMPROVED NITROGEN UTILIZATION AND STRESS TOLERANCE 审中-公开
标题翻译：具有改善氮肥利用和耐压性的植物
公开(公告)号：WO2011056769A1
公开(公告)日：2011-05-12
申请号：PCT/US2010/055053
申请日：2010-11-02
申请人： IOWA CORN PROMOTION BOARD , MCLAREN, James , DUCK, Nicholas , HAMMER, Philip , VANDE BERG, Brian , SCHOUTEN, Laura
发明人： MCLAREN, James , DUCK, Nicholas , HAMMER, Philip , VANDE BERG, Brian , SCHOUTEN, Laura
IPC分类号： A01H5/00 , C12N15/82
CPC分类号： C12N15/8271 , C12N9/1217 , C12N15/8261 , Y02A40/146
摘要： The present invention relates to transgenic plants that have increased nitrogen use efficiency, stress tolerance, and/or alleviating a limitation such that yield is increased, or a combination of these and that have been transformed using a novel vector construct including a synthetic N-acetyl glutamate kinase (NAGK) gene that modulates nitrogen use in plants. The invention also includes the overexpression and enzymatic characterization of an arginine- insensitive NAGK isolated from a bacterial strain that improves stress tolerance and nitrogen uptake, metabolism or both. In various embodiments, the vector construct includes one or more nucleic acid sequences including SEQ ID NO: 1. The invention also relates to isolated vectors for transforming plants and to antibodies used for detecting transformed plants. The invention also relates to methods of expressing in plants the nucleic acid molecules corresponding to the nucleic acid sequences that modulate nitrogen use in plants or are modulated by nitrogen conditions.
摘要翻译：本发明涉及具有增加的氮利用效率，胁迫耐受性和/或减轻使得产量提高的限制的这些转基因植物或其组合，并且已经使用包含合成N-乙酰基的新载体构建体谷氨酸激酶（NAGK）基因，调节植物中的氮利用。本发明还包括从细菌菌株分离的精氨酸不敏感的NAGK的过表达和酶学表征，其改善胁迫耐受性和氮摄取，代谢或两者。在各种实施方案中，载体构建体包括一个或多个包括SEQ ID NO：1的核酸序列。本发明还涉及用于转化植物的分离的载体和用于检测转化植物的抗体。本发明还涉及在植物中表达对应于调节植物中氮利用或由氮条件调节的核酸序列的核酸分子的方法。

4. 发明申请

WO2022066160A1 CONTINUOUS PROCESSES FOR THE SELECTIVE CONVERSION OF ALDOHEXOSE-YIELDING CARBOHYDRATE TO ETHYLENE GLYCOL USING LOW CONCENTRATIONS OF RETRO-ALDOL CATALYST 审中-公开
公开(公告)号：WO2022066160A1
公开(公告)日：2022-03-31
申请号：PCT/US2020/052579
申请日：2020-09-24
申请人： IOWA CORN PROMOTION BOARD
发明人： SCHRECK, David James , BUNNING, Donald , KAPICAK, Lou , ALBIN, Brooke , NUNLEY, Mark , BRADFORD, Michael
IPC分类号： C07C29/09 , C07C29/10 , C07C29/12
摘要： Retro-aldol processes are disclosed that use very low concentrations of retro-aldol catalyst in combination with hydrogenation catalyst of certain activities, sizes and spatial dispersions to obtain the high selectivities to ethylene glycol.

5. 发明申请

WO2017210614A1 CONTINUOUS PROCESSES FOR THE HIGHLY SELECTIVE CONVERSION OF ALDOHEXOSE-YIELDING CARBOHYDRATE TO ETHYLENE GLYCOL 审中-公开
标题翻译：将选择性生物降解碳水化合物转化为乙二醇的连续方法
公开(公告)号：WO2017210614A1
公开(公告)日：2017-12-07
申请号：PCT/US2017/035769
申请日：2017-06-02
申请人： IOWA CORN PROMOTION BOARD
发明人： SCHRECK, David James , CHRISMAN, Ray , ALBIN, Brooke , CLINTON, Nye , BRADFORD, Marion
IPC分类号： B01J23/889 , C07C29/141
摘要： Continuous processes for making ethylene glycol form aldohexose-yielding carbohydrates are disclosed which enhance the selectivity to ethylene glycol.
摘要翻译：公开了提高乙二醇选择性的连续方法，用于制备乙二醇形式的产生己醛糖的碳水化合物。

6. 发明申请

WO2008051608A2 PLANTS WITH IMPROVED NITROGEN UTILIZATION AND STRESS TOLERANCE 审中-公开
标题翻译：具有改善氮肥利用和耐压性的植物
公开(公告)号：WO2008051608A2
公开(公告)日：2008-05-02
申请号：PCT/US2007/022698
申请日：2007-10-27
申请人： IOWA CORN PROMOTION BOARD , MCLAREN, James , DUCK, Nicholas , VANDE BERG, Brian , SCHAWALDER, Alissa , BEILINSON, Vadim , HINSON, Jill
发明人： MCLAREN, James , DUCK, Nicholas , VANDE BERG, Brian , SCHAWALDER, Alissa , BEILINSON, Vadim , HINSON, Jill
IPC分类号： A01H5/00
CPC分类号： C12N15/8271 , C12N15/8216 , C12N15/8261 , Y02A40/146
摘要： The present invention relates to transgenic plants that have increased nitrogen use efficiency, stress tolerance, or both and that have been transformed using a novel vector construct including nucleic acid sequences that modulate nitrogen use in plants. In various embodiments, the vector construct includes one or more nucleic acid sequences selected from the group consisting of SEQ ID NO: 2, 4, 7, 9, 11, 13, 15, 17, 22, 24, 26, 28, 30, 32, 34, 36, or 38. The invention also relates to isolated vectors for transforming plants and to antibodies used for detecting transformed plants. The invention also relates to methods of expressing in plants the nucleic acid molecules corresponding to the nucleic acid sequences that modulate nitrogen use in plants or are modulated by nitrogen conditions.
摘要翻译：本发明涉及具有增加的氮利用效率，胁迫耐受性或两者的转基因植物，并且已经使用包含调节植物中氮利用的核酸序列的新型载体构建体进行了转化。在各种实施方案中，载体构建体包含一个或多个选自SEQ ID NO： 32,34,36或38.本发明还涉及用于转化植物的分离载体和用于检测转化植物的抗体。本发明还涉及在植物中表达对应于调节植物中氮利用或由氮条件调节的核酸序列的核酸分子的方法。

7. 发明申请

WO2021061969A1 METHODS FOR OPERATING CONTINUOUS, UNMODULATED, MULTIPLE CATALYTIC STEP PROCESSES 审中-公开
公开(公告)号：WO2021061969A1
公开(公告)日：2021-04-01
申请号：PCT/US2020/052474
申请日：2020-09-24
申请人： IOWA CORN PROMOTION BOARD
发明人： CHRISMAN, Ray , BUNNING, Donald , NUNLEY, Mark , ALBIN, Brooke , BRADFORD, Michael , SCHRECK, David James , KAPICAK, Louis, A.
IPC分类号： C07C67/465 , C10M105/36 , C07C57/02
摘要： Control methods are disclosed for continuous, unmodulated, multiple catalytic conversion step processes using at least two catalysts, a first catalyst and a second catalyst, that accommodate changes in the performance of each catalyst and the relative performances of the catalysts. In the methods, certain process parameters are used in a manner that is indicative of changes in catalyst performance, and the control methods provide for adjustment of at least one of: the absolute amount of catalytically active species and relative amounts of each of the first catalyst and second catalyst and at least one of the rate of feed or concentration of the raw material to the reaction zone.

8. 发明申请

WO2015179302A1 PROCESS FOR THE CONTINUOUS PRODUCTION OF ETHYLENE GLYCOL FROM CARBOHYDRATES 审中-公开
标题翻译：从碳酸氢盐连续生产乙烯甘油的工艺
公开(公告)号：WO2015179302A1
公开(公告)日：2015-11-26
申请号：PCT/US2015/031390
申请日：2015-05-18
申请人： IOWA CORN PROMOTION BOARD
发明人： SCHRECK, David , CHRISMAN, Ray , ALBIN, Brooke , CLINTON, Nye
IPC分类号： C07C47/19 , C10G1/06 , C10G3/00
CPC分类号： C07C29/141 , B01J21/02 , B01J21/066 , B01J23/30 , B01J23/8896 , B01J23/892 , C07C29/145 , C07C45/60 , C07C45/673 , Y02P20/52 , Y02P30/20 , C07C31/202 , C07C31/205 , C07C47/127 , C07C47/19
摘要： A continuous process for converting carbohydrates to ethylene and propylene glycol. The carbohydrates are mixed with water and passed through a reactor at a temperature that hydrolyzes the carbohydrate mixture at least partially to monosaccharides. The reactor has a first zone comprising a retro-aldol catalyst and a second zone comprising a reducing catalyst. The aldose is converted in the first zone into glycolaldehyde by the retro-aldol catalyst and the glycolaldehyde, in the presence of hydrogen, is converted to ethylene glycol in the second zone of the reactor. The reaction products are removed from the reactor and the ethylene glycol is recovered. The selectivity to propylene glycol can be enhanced via feeding ketose as the carbohydrate.
摘要翻译：将碳水化合物转化为乙烯和丙二醇的连续方法。将碳水化合物与水混合并在至少部分地将糖类混合物水解成单糖的温度下通过反应器。反应器具有包含反醛缩醛催化剂的第一区和包含还原催化剂的第二区。醛糖在第一区中通过反醛醇二醇催化剂转化成乙二醇，在氢的存在下，乙二醇在反应器的第二区被转化为乙二醇。将反应产物从反应器中除去并回收乙二醇。通过加入酮糖作为碳水化合物可以提高丙二醇的选择性。

9. 发明申请

WO2008051608A8 PLANTS WITH IMPROVED NITROGEN UTILIZATION AND STRESS TOLERANCE 审中-公开
标题翻译：具有改善氮肥利用和耐压性的植物
公开(公告)号：WO2008051608A8
公开(公告)日：2008-12-11
申请号：PCT/US2007022698
申请日：2007-10-27
申请人： IOWA CORN PROMOTION BOARD , MCLAREN JAMES , DUCK NICHOLAS , VANDE BERG BRIAN , SCHAWALDER ALISSA , BEILINSON VADIM , HINSON JILL
发明人： MCLAREN JAMES , DUCK NICHOLAS , VANDE BERG BRIAN , SCHAWALDER ALISSA , BEILINSON VADIM , HINSON JILL
IPC分类号： A01H1/00 , C07H21/04 , C12N15/29
CPC分类号： C12N15/8271 , C12N15/8216 , C12N15/8261 , Y02A40/146
摘要： A method is provided for increasing nitrogen utilization efficiency in a plant comprising transforming a plant cell with an expression vector comprising a nucleic acid molecule that comprises a nucleotide sequence that encodes an amino acid sequence that is at least 95% identical to the sequence set forth in SEQ ID NO: 31; and growing from said plant cell a transformed plant in which said nucleotide sequence is expressed.

10. 发明申请

WO2021062008A1 CONTINUOUS, CARBOHYDRATE TO ETHYLENE GLYCOL PROCESSES 审中-公开
公开(公告)号：WO2021062008A1
公开(公告)日：2021-04-01
申请号：PCT/US2020/052519
申请日：2020-09-24
申请人： IOWA CORN PROMOTION BOARD
发明人： CHRISMAN, Ray , BUNNING, Donald , ALBIN, Brooke , NUNLEY, Mark , BRADFORD, Michael , SCHRECK, David James , KAPICAK, Lou
IPC分类号： B01J23/652 , C07C29/132 , C07C29/74
摘要： By this invention processes are provided for the conversion of carbohydrate to ethylene glycol by retro-aldol catalysis and sequential hydrogenation using control methods having at least one of acetol (hydroxyacetone) and a tracer as inputs.

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