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1. 发明申请

WO2010071692A2 METHODS FOR ENHANCED PROPAGATION OF CELLS 审中-公开
标题翻译：用于增强细胞传播的方法
公开(公告)号：WO2010071692A2
公开(公告)日：2010-06-24
申请号：PCT/US2009047522
申请日：2009-06-16
申请人： INNOVATIVE BIOTHERAPIES INC , NEPHRION INC , WESTOVER ANGELA J , SZCZYPKA MARK , TZIAMPAZIS EVANGELOS
发明人： WESTOVER ANGELA J , SZCZYPKA MARK , TZIAMPAZIS EVANGELOS
IPC分类号： C12N5/071 , A61K35/23 , A61P13/00
CPC分类号： C12N5/0687 , C12N2501/385
摘要： The present invention relates generally to methods for the isolation and propagation of cells. For example, embodiments of the present invention relate to isolation and propagation methods for the manufacture of a large number of cells for use, for example, in biotherapeutic devices, such as devices for renal replacement therapy for the treatment of acute renal failure (ARF), acute tubular necrosis (ATN), multi-organ failure (MOF), sepsis, cardiorenal syndrome (CRS) and end-stage renal disease (ESRD).
摘要翻译：本发明一般涉及细胞分离和繁殖的方法。例如，本发明的实施方案涉及用于制造用于例如生物治疗装置的大量细胞的分离和繁殖方法，例如用于治疗急性肾功能衰竭（ARF）的肾替代疗法的装置，，急性肾小管坏死（ATN），多器官衰竭（MOF），败血症，心肾综合征（CRS）和终末期肾病（ESRD）。

2. 发明申请

WO2010019643A3 AN EXTRACORPOREAL CELL-BASED THERAPEUTIC DEVICE AND DELIVERY SYSTEM 审中-公开
标题翻译：一种基于提取物细胞的治疗装置和递送系统
公开(公告)号：WO2010019643A3
公开(公告)日：2010-06-10
申请号：PCT/US2009053516
申请日：2009-08-12
申请人： INNOVATIVE BIOTHERAPIES INC , HUMES H DAVID , BUFFINGTON DEBORAH , HAGEMAN GRETCHEN
发明人： HUMES H DAVID , BUFFINGTON DEBORAH , HAGEMAN GRETCHEN
IPC分类号： A61M37/00 , A61K9/00
CPC分类号： A61M1/3687 , A61K35/12 , A61K35/22 , A61M1/3689
摘要： Extracorporeal cell-based therapeutic devices and delivery systems are disclosed which provide a method for therapeutic delivery of biologically active molecules produced by living cells in response to a dynamic physiologic environment. One embodiment includes long hollow fibers in which a layer of cells are grown within the intraluminal volume or within a double hollow-filled chamber. Another embodiment includes a wafer or a series of wafers providing a substrate onto which cells are grown. The wafer(s) are inserted into a device. A device may deliver a pre-selected molecule, for example, a hormone, into a mammal's systemic circulation and/or may deliver a member of different cell products. The device is adapted to secure viable cells which produce and secrete the pre-selected molecule into blood or fluid. The invention also provides a minimally invasive method for percutaneously introducing into a preselected blood vessel or body cavity the device of the invention.
摘要翻译：公开了基于体外细胞的治疗装置和递送系统，其提供了响应动态生理环境治疗性递送由活细胞产生的生物活性分子的方法。一个实施方案包括长中空纤维，其中一层细胞在管腔内容积内或在双重中空填充腔室内生长。另一个实施例包括提供在其上生长细胞的基底的晶片或一系列晶片。晶片被插入装置中。装置可将预先选择的分子（例如激素）递送到哺乳动物的体循环中和/或递送不同细胞产物的成员。该装置适于确保产生并分泌预选分子到血液或流体中的活细胞。本发明还提供了一种微创方法，用于将本发明的装置经皮导入预选的血管或体腔。

3. 发明申请

WO2010071692A3 METHODS FOR PROPAGATION OF RENAL PRECURSOR CELLS 审中-公开
公开(公告)号：WO2010071692A3
公开(公告)日：2010-06-24
申请号：PCT/US2009/047522
申请日：2009-06-16
申请人： INNOVATIVE BIOTHERAPIES, INC. , CYTOPHERX, INC. , WESTOVER, Angela, J. , SZCZYPKA, Mark , TZIAMPAZIS, Evangelos
发明人： WESTOVER, Angela, J. , SZCZYPKA, Mark , TZIAMPAZIS, Evangelos
IPC分类号： C12N5/071 , C12N5/06
摘要： The present invention relates generally to methods for the isolation and propagation of cells. For example, embodiments of the present invention relate to isolation and propagation methods for the manufacture of a large number of cells for use, for example, in biotherapeutic devices, such as devices for renal replacement therapy for the treatment of acute renal failure (ARF), acute tubular necrosis (ATN), multi-organ failure (MOF), sepsis, cardiorenal syndrome (CRS) and end-stage renal disease (ESRD).

4. 发明申请

WO2010019643A9 AN EXTRACORPOREAL CELL-BASED THERAPEUTIC DEVICE AND DELIVERY SYSTEM 审中-公开
公开(公告)号：WO2010019643A9
公开(公告)日：2010-04-22
申请号：PCT/US2009053516
申请日：2009-08-12
申请人： INNOVATIVE BIOTHERAPIES INC , HUMES H DAVID , BUFFINGTON DEBORAH , HAGEMAN GRETCHEN
发明人： HUMES H DAVID , BUFFINGTON DEBORAH , HAGEMAN GRETCHEN
IPC分类号： A61M37/00 , A61K9/00
CPC分类号： A61M1/3687 , A61K35/12 , A61K35/22 , A61M1/3689
摘要： Extracorporeal cell-based therapeutic devices and delivery systems are disclosed which provide a method for therapeutic delivery of biologically active molecules produced by living cells in response to a dynamic physiologic environment. One embodiment includes long hollow fibers in which a layer of cells are grown within the intraluminal volume or within a double hollow-filled chamber. Another embodiment includes a wafer or a series of wafers providing a substrate onto which cells are grown. The wafer(s) are inserted into a device. A device may deliver a pre-selected molecule, for example, a hormone, into a mammal's systemic circulation and/or may deliver a member of different cell products. The device is adapted to secure viable cells which produce and secrete the pre-selected molecule into blood or fluid. The invention also provides a minimally invasive method for percutaneously introducing into a preselected blood vessel or body cavity the device of the invention.

5. 发明申请

WO2010019643A2 AN EXTRACORPOREAL CELL-BASED THERAPEUTIC DEVICE AND DELIVERY SYSTEM 审中-公开
标题翻译：基于细胞的细胞治疗设备和递送系统
公开(公告)号：WO2010019643A2
公开(公告)日：2010-02-18
申请号：PCT/US2009/053516
申请日：2009-08-12
申请人： INNOVATIVE BIOTHERAPIES, INC. , HUMES, H., David , BUFFINGTON, Deborah , HAGEMAN, Gretchen
发明人： HUMES, H., David , BUFFINGTON, Deborah , HAGEMAN, Gretchen
IPC分类号： A61M37/00 , A61K9/00
CPC分类号： A61M1/3687 , A61K35/12 , A61K35/22 , A61M1/3689
摘要： Extracorporeal cell-based therapeutic devices and delivery systems are disclosed which provide a method for therapeutic delivery of biologically active molecules produced by living cells in response to a dynamic physiologic environment. One embodiment includes long hollow fibers in which a layer of cells are grown within the intraluminal volume or within a double hollow-filled chamber. Another embodiment includes a wafer or a series of wafers providing a substrate onto which cells are grown. The wafer(s) are inserted into a device. A device may deliver a pre-selected molecule, for example, a hormone, into a mammal's systemic circulation and/or may deliver a member of different cell products. The device is adapted to secure viable cells which produce and secrete the pre-selected molecule into blood or fluid. The invention also provides a minimally invasive method for percutaneously introducing into a preselected blood vessel or body cavity the device of the invention.
摘要翻译：公开了基于体外细胞的治疗装置和递送系统，其提供了响应于动态生理环境而由活细胞产生的生物活性分子的治疗递送的方法。一个实施方案包括长的中空纤维，其中细胞层在腔内体积内生长或在双重中空填充的室内生长。另一个实施例包括晶片或一系列晶片，其提供生长细胞的衬底。将晶片插入设备中。装置可以将预先选择的分子例如激素递送到哺乳动物的体循环中和/或可以递送不同细胞产物的成员。该装置适于将产生和分泌预先选择的分子的活细胞固定到血液或流体中。本发明还提供了一种微创方法，用于将本发明的装置经皮引入预选的血管或体腔。

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