基本信息:
- 专利标题： AN EXTRACORPOREAL CELL-BASED THERAPEUTIC DEVICE AND DELIVERY SYSTEM
- 专利标题（中）：基于细胞的细胞治疗设备和递送系统
- 申请号：PCT/US2009/053516 申请日：2009-08-12
- 公开(公告)号：WO2010019643A2 公开(公告)日：2010-02-18
- 发明人： HUMES, H., David , BUFFINGTON, Deborah , HAGEMAN, Gretchen
- 申请人： INNOVATIVE BIOTHERAPIES, INC. , HUMES, H., David , BUFFINGTON, Deborah , HAGEMAN, Gretchen
- 申请人地址： 401 West Morgan Road Ann Arbor, MI 48108 US
- 专利权人： INNOVATIVE BIOTHERAPIES, INC.,HUMES, H., David,BUFFINGTON, Deborah,HAGEMAN, Gretchen
- 当前专利权人： INNOVATIVE BIOTHERAPIES, INC.,HUMES, H., David,BUFFINGTON, Deborah,HAGEMAN, Gretchen
- 当前专利权人地址： 401 West Morgan Road Ann Arbor, MI 48108 US
- 代理机构： CURRIE, Matthew, T. et al.
- 优先权： US61/189,119 20080815
- 主分类号： A61M37/00
- IPC分类号： A61M37/00 ; A61K9/00
摘要：
Extracorporeal cell-based therapeutic devices and delivery systems are disclosed which provide a method for therapeutic delivery of biologically active molecules produced by living cells in response to a dynamic physiologic environment. One embodiment includes long hollow fibers in which a layer of cells are grown within the intraluminal volume or within a double hollow-filled chamber. Another embodiment includes a wafer or a series of wafers providing a substrate onto which cells are grown. The wafer(s) are inserted into a device. A device may deliver a pre-selected molecule, for example, a hormone, into a mammal's systemic circulation and/or may deliver a member of different cell products. The device is adapted to secure viable cells which produce and secrete the pre-selected molecule into blood or fluid. The invention also provides a minimally invasive method for percutaneously introducing into a preselected blood vessel or body cavity the device of the invention.
摘要（中）：
公开了基于体外细胞的治疗装置和递送系统，其提供了响应于动态生理环境而由活细胞产生的生物活性分子的治疗递送的方法。 一个实施方案包括长的中空纤维，其中细胞层在腔内体积内生长或在双重中空填充的室内生长。 另一个实施例包括晶片或一系列晶片，其提供生长细胞的衬底。 将晶片插入设备中。 装置可以将预先选择的分子例如激素递送到哺乳动物的体循环中和/或可以递送不同细胞产物的成员。 该装置适于将产生和分泌预先选择的分子的活细胞固定到血液或流体中。 本发明还提供了一种微创方法，用于将本发明的装置经皮引入预选的血管或体腔。