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1. 发明申请

WO2004101052A2 CATHETER FOR UNIFORM DELIVERY OF MEDICATION 审中-公开
标题翻译：用于统一药物递送的导管
公开(公告)号：WO2004101052A2
公开(公告)日：2004-11-25
申请号：PCT/US2004014664
申请日：2004-05-11
申请人： I FLOW CORP , DENIEGA JOSE CASTILLO , MASSENGALE ROGER , RAKE KENNETH W , DAL PORTO JAMES
发明人： DENIEGA JOSE CASTILLO , MASSENGALE ROGER , RAKE KENNETH W , DAL PORTO JAMES
IPC分类号： A61F2/958 , A61M25/00 , A61M29/00
CPC分类号： A61M25/003 , A61M25/0032 , A61M25/007 , A61M25/10 , A61M29/00 , A61M2025/0036 , A61M2025/0057 , A61M2025/105
摘要： A catheter (250, 272) is provided for uniform distribution of fluid medication within an anatomical region. One embodiment of the catheter (272) is comprised of an elongated, proximal tube (282) defining a lumen (283) and an elongated, distal tube (280) having a closed end (284). The distal tube (280) is constructed from a bio-absorbable material and also defines a lumen (281), which communicates with the lumen (283) of the proximal tube (282). Another embodiment of the catheter (250) is comprised of an elongate tubular catheter body (254) defining a lumen (268). A distal end (262) of the lumen is closed and a portion of the catheter body (254) includes a plurality of openings (266) thereby defining an infusion section of the catheter (250). A tubular sheath (252) is constructed from a porous material and is positioned over the infusion section. The tubular sheath (252) extends at least a length of the infusion section. The tubular sheath (252) and the catheter body (254) are configured such that fluid within the lumen (268) must pass through the tubular sheath (252) to exit the catheter (250).
摘要翻译：提供导管（250,272），用于在解剖区域内均匀分布流体药物。导管（272）的一个实施例包括限定内腔（283）的细长近端管（282）和具有闭合端（284）的细长远侧管（280）。远端管（280）由生物可吸收材料构成，并且还限定与近端管（282）的内腔（283）连通的管腔（281）。导管（250）的另一实施例由限定内腔（268）的细长管状导管主体（254）组成。管腔的远端（262）是封闭的并且导管主体（254）的一部分包括多个开口（266），由此限定了导管（250）的输注部分。管状护套（252）由多孔材料制成并位于输注部分上方。管状护套（252）延伸至少一段输注部分。管状护套（252）和导管主体（254）被构造成使得腔（268）内的流体必须通过管状护套（252）以离开导管（250）。

2. 发明申请

WO0105210A3 CATHETER FOR UNIFORM DELIVERY OF MEDICATION 审中-公开
标题翻译：统一送达药物的导管
公开(公告)号：WO0105210A3
公开(公告)日：2001-07-19
申请号：PCT/US0019746
申请日：2000-07-19
申请人： I FLOW CORP , DENIEGA JOSE CASTILLO , MASSENGALE ROGER , RAKE KENNETH W
发明人： DENIEGA JOSE CASTILLO , MASSENGALE ROGER , RAKE KENNETH W
IPC分类号： A61M25/00 , A61M25/16
CPC分类号： A61M25/0074 , A61M25/00 , A61M25/0023 , A61M25/0043 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M2025/0037 , A61M2025/0039 , A61M2025/0057 , A61M2025/0073
摘要： The present invention provides a catheter for the delivery of fluid medication across an anatomical region. In accordance with one embodiment, the catheter comprises an elongated tube with a plurality of exit holes along an infusion section of the catheter, and an elongated flexible porous member residing within the tube and forming an annular space between the tube and the member. In accordance with other embodiments, the catheter includes a tube having a plurality of exit holes in a side wall of the tube. The exit holes may combine to form a flow-restricting orifice of the catheter. Advantageously, fluid within the catheter flows through all of the exit holes, resulting in uniform distribution of fluid within an anatomical region. In one particular embodiment, the catheter comprises a tube having elongated exit slots therein. In accordance with other embodiments, the catheter includes an elongated tubular member made of a porous membrane. The porous membrane is configured so that a fluid introduced into an open end of the tubular member will flow through side walls of the tubular member at a substantially uniform rate along a length of the tubular member. In accordance with other embodiments, the catheter includes an elongated "weeping" tubular coil spring attached to an end of, or enclosed within, a tube. Fluid within the spring and greater than or equal to a threshold pressure advantageously flows radially outward between the spring coils. Advantageously, the fluid is dispensed substantially uniformly throughout a length of the spring.
摘要翻译：本发明提供了用于输送流体药物穿过解剖区域的导管。根据一个实施例，所述导管包括细长管，所述细长管具有沿所述导管的输注部分的多个出口孔以及位于所述管内并在所述管和所述构件之间形成环形空间的细长柔性多孔构件。根据其他实施例，导管包括在管的侧壁中具有多个出口孔的管。出口孔可以结合以形成导管的流量限制孔口。有利地，导管内的流体流过所有的出口孔，导致在解剖区域内流体的均匀分布。在一个特定实施例中，导管包括其中具有细长出口槽的管。根据其他实施例，导管包括由多孔膜制成的细长管状构件。多孔膜构造成使得引入管状构件的开口端的流体将沿管状构件的长度以基本均匀的速率流过管状构件的侧壁。根据其他实施例，导管包括附接到管的一端或封闭在管内的细长的“哭泣”管状螺旋弹簧。弹簧内的流体并且大于或等于阈值压力有利地在弹簧圈之间径向向外流动。有利的是，流体在弹簧的整个长度上基本均匀地分配。

3. 发明申请

WO9920327A3 SPRING-ACTUATED INFUSION SYRINGE 审中-公开
标题翻译：刺激性输液灌肠
公开(公告)号：WO9920327A3
公开(公告)日：1999-07-01
申请号：PCT/US9822083
申请日：1998-10-19
申请人： I FLOW CORP
发明人： MCPHEE CHARLES J
IPC分类号： A61M5/145 , A61M5/31 , A61M5/315
CPC分类号： A61M5/31511 , A61M5/1454 , A61M2005/3114
摘要： A spring-actuated infusion syringe includes a housing having an open distal end, with a spring-loaded piston disposed for axial translation in the housing. The piston is biased toward the distal end of the housing. The syringe also includes a barrel for containing a liquid medicament, the barrel having a distal end having a fluid passage therethrough and an open proximal end. A plunger is disposed in the barrel for axial translation therein. The proximal end of the barrel is axially insertable into the distal end of the housing, whereby the piston enters the proximal end of the barrel and engages the plunger. In use, the barrel is filled with a medicament through the fluid flow passage, and the flow of medicament from the syringe is obstructed. The proximal end of the barrel is inserted into the distal end of the housing, whereby the piston enters the proximal end of the barrel. The plunger, immobilized by the hydrostatic pressure of the liquid in the barrel, pushes the piston proximally against its biasing force. An engagement between an annular barrel flange and an internal housing thread retains the barrel at the desired axial position within the housing. To deliver the liquid from the syringe, the obstruction is removed. The hydrostatic pressure in the barrel being relieved, the biasing force of the piston pushes the plunger distally into the barrel, displacing the liquid therefrom through the fluid flow passage.
摘要翻译：弹簧致动的输注注射器包括具有敞开的远端的壳体，弹簧加载的活塞被设置用于在壳体中轴向平移。活塞朝向壳体的远端偏置。注射器还包括用于容纳液体药物的桶，所述桶具有远端，其具有穿过其中的流体通道和敞开的近端。柱塞设置在筒体中用于在其中轴向平移。筒的近端可轴向插入壳体的远端，由此活塞进入筒的近端并接合柱塞。在使用中，筒体通过流体流动通道填充药物，并且来自注射器的药物的流动被阻塞。筒的近端插入壳体的远端，由此活塞进入筒的近端。通过筒体中液体的静水压固定的柱塞将活塞向近侧推压抵抗其偏压力。环形桶形凸缘和内部壳体螺纹之间的接合将筒保持在壳体内的期望的轴向位置。为了从注射器输送液体，阻塞被去除。桶中的流体静压力被释放，活塞的偏压力将柱塞向远侧推动进入筒体，从而将液体从其中移出流体流动通道。

4. 发明申请

WO9314797A3 PLATEN PUMP 审中-公开
标题翻译：普通泵
公开(公告)号：WO9314797A3
公开(公告)日：1993-09-30
申请号：PCT/US9300565
申请日：1993-01-22
申请人： I FLOW CORP
发明人： RAKE KENNETH W , JUDGE ORVIL L , EARHART DONALD M , MCPHEE CHARLES J
IPC分类号： A61J1/10 , A61M5/142 , A61M5/148 , A61M5/168 , A61M37/00
CPC分类号： A61M5/148
摘要： Disclosed is an infusion pump and a fluid container for expelling a fluid from the fluid container to a patient. The pump comprises a housing (12, 16) having a chamber (17) therein for receiving the fluid reservoir (18). A first wall (38) is provided on the housing for contacting the fluid reservoir, and a second wall (24) is movable from a first position distanced from the first wall to form the chamber (17) therebetween, and a second position relatively closer to the first wall (38). Advancing the movable wall from the first position to the second position expels fluid from the collapsible reservoir. Preferably, the first and second walls (24, 38) are provided with non-planar complementary surface configurations for contacting the collapsible reservoir (18). Retraction mechanisms for retracting the movable wall from the second position to the first position, and user readable indicium of the status of the dispensation cycle are also disclosed.

5. 发明申请

WO2004060453B1 PATIENT CONTROLLED DRUG ADMINISTRATION DEVICE 审中-公开
标题翻译：患者控制药物管理装置
公开(公告)号：WO2004060453B1
公开(公告)日：2004-09-02
申请号：PCT/US0341427
申请日：2003-12-26
申请人： I FLOW CORP
发明人： MABRY ERIC , RAKE KENNETH WAYNE
IPC分类号： A61M5/14 , A61M5/142
CPC分类号： A61M5/14216 , A61M5/1424 , A61M2005/1405
摘要： A patient controlled liquid drug administration device (10)comprises a reciprocating pump (12) having an inlet connectable to a source of a pressurized liquid drug, and an outlet connectable to the patient. A clamp (38) rotates between closed and open positions respectively blocking and enabling pump outflow. A plunger (48) above the pump has an end contacting a movable wall (26) of the pump and is movable between raised and lowered positions. A button (50) above the plunger moves between extended and depressed positions, and has a ledge that engages the clamp when the button is moved to the depressed position and moves the clamp to its open position. A compression spring (52)is disposed between the plunger and the button. A spring catch (60) engages a detent in the button (50) when the button is moved to its depressed position and holds the button there until released by a catch release (62) on the plunger that disengages the spring catch from the detent in the button when the plunger (48) is moved to its lowered position. A removable tab permits easy, rapid priming of the pump by holding the clamp in its open position regardless of the position of the button, and by holding the button in its depressed position regardless of the position of the plunger.
摘要翻译：患者控制的液体药物施用装置（10）包括具有可连接到加压液体药物源的入口和可连接到患者的出口的往复泵（12）。夹具（38）在闭合位置和打开位置之间旋转，分别阻塞和使泵流出。泵上方的柱塞（48）具有接触泵的可移动壁（26）的端部，并且可在升高和降低位置之间移动。柱塞上方的按钮（50）在延伸和凹陷位置之间移动，并且当按钮移动到踩下位置并且将夹具移动到其打开位置时，具有与夹具接合的凸缘。压缩弹簧（52）设置在柱塞和按钮之间。当按钮移动到其按压位置时，弹簧卡扣（60）接合按钮（50）中的止动件，并将按钮保持在那里，直到通过柱塞上的卡扣释放（62）释放，从而使弹簧卡扣与卡扣脱离当柱塞（48）移动到其降低位置时的按钮。不管按钮的位置如何，通过将夹具保持在其打开位置，并且不管柱塞的位置如何，将按钮保持在其按压位置，可拆卸的突片允许泵容易地快速启动泵。

6. 发明申请

WO9925110A9 METHOD AND APPARATUS FOR MONITORING A PATIENT 审中-公开
标题翻译：用于监测患者的方法和装置
公开(公告)号：WO9925110A9
公开(公告)日：1999-08-26
申请号：PCT/US9824083
申请日：1998-11-12
申请人： I FLOW CORP
发明人： VASKO ROBERT S , MASSENGALE ROGER
IPC分类号： A61B5/00 , G06Q50/00 , H04M11/00
CPC分类号： H04M11/002 , A61B5/0002 , G06F19/3418 , G16H40/40 , G16H40/63
摘要： A remotely programmable and accessible medical device system (10) including an interface unit (14) and a medical device (12) connected to a patient (18) is disclosed. Through a transceiver, such as a telephone (48) or computer (50), a person may obtain status reports from a remotely located medical device in audible, electronic or paper form. In addition, the person may change a protocol associated with the medical device or be alerted to a remote location of an alarm associated with the medical device.
摘要翻译：公开了一种包括连接到患者（18）的接口单元（14）和医疗设备（12）的远程可编程且可访问的医疗设备系统（10）。通过诸如电话（48）或计算机（50）的收发机，人可以从声音，电子或纸张形式的远程位置的医疗设备获得状态报告。此外，该人可以改变与医疗设备相关联的协议，或者被警告到与医疗设备相关联的警报的远程位置。

7. 发明申请

WO2007027545A2 ANTI-MICROBIAL CATHETER 审中-公开
标题翻译：抗微生物导管
公开(公告)号：WO2007027545A2
公开(公告)日：2007-03-08
申请号：PCT/US2006033375
申请日：2006-08-28
申请人： I FLOW CORP , RAKE LOIS , PORTO JAMES DAL , DENIEGA JOSE CASTILLO , MASSENGALE ROGER , FORREST KEVIN , SIMINUK MARK
发明人： PORTO JAMES DAL , DENIEGA JOSE CASTILLO , MASSENGALE ROGER , FORREST KEVIN , SIMINUK MARK , RAKE KENNETH W
IPC分类号： A61M25/00 , A61L29/02 , A61L29/10
CPC分类号： A61L27/54 , A61L29/16 , A61L2300/104 , A61L2300/404 , A61M25/0045 , A61M25/0069 , A61M25/007 , A61M25/0071 , A61M2025/0056 , A61M2025/0057
摘要： A catheter having features configured to provide a substantially uniform flow rate of a fluid exiting the catheter and also exhibits anti-microbial properties. The uniform flow rate features may include one or more of a flow restricting membrane or flow restricting component within an infusion section of the catheter. In other arrangements, exit holes defining the infusion section of the catheter may be configured to provide the desired uniform flow rate over the length of the infusion section. Furthermore, the catheter also includes anti-microbial properties to inhibit the growth of microbes on or within the catheter and, preferably, to inhibit microbe growth in an anatomical region surrounding the catheter. The desired anti-microbial properties may be provided by an anti-microbial layer, anti-microbial materials dispersed within the material from which components of the catheters are constructed, or a combination of anti-microbial layers and embedded anti-microbial materials. In some arrangements, one or more portions of the catheter may be bio-absorbable.
摘要翻译：具有被配置为提供离开导管的流体的基本均匀流速并且还具有抗微生物性质的特征的导管。均匀的流速特征可以包括在导管的输注部分内的流动限制膜或流量限制部件中的一个或多个。在其他布置中，限定导管的输注部分的出口孔可以被配置为在输注部分的长度上提供期望的均匀流速。此外，导管还包括抗微生物性质以抑制导管上或导管内的微生物的生长，并且优选地抑制在导管周围的解剖区域中的微生物生长。期望的抗微生物性质可以通过抗微生物层，分散在构成导管的组分的材料中的抗微生物材料，或抗微生物层和嵌入的抗微生物材料的组合来提供。在一些布置中，导管的一个或多个部分可以是生物可吸收的。

8. 发明申请

WO2004014263A2 BONE CEMENT SYRINGE 审中-公开
标题翻译：骨水泥注射器
公开(公告)号：WO2004014263A2
公开(公告)日：2004-02-19
申请号：PCT/US0324297
申请日：2003-08-05
申请人： I FLOW CORP
发明人： PORTER WILLIAM M , AURIN GARY DOUGLAS
IPC分类号： A61B17/34 , A61B17/88 , A61F2/46 , A61M5/178 , A61M5/31 , A61M5/315
CPC分类号： A61B17/8816 , A61B17/3472 , A61B17/8822 , A61F2/4601 , A61M5/1782 , A61M5/3135 , A61M5/31511 , A61M5/31586
摘要： An improved syringe for delivering a viscous liquid, especially bone cement, to a surgical site, has a barrel with a distal outlet end and an open proximal end, and a plunger movable axially within the barrel, the plunger having a shaft extending proximally from the proximal end of the barrel. The plunger shaft incorporates a reinforcing structure that provides increased torsional rigidity and improved dispersion of torsional loads, and the barrel includes an outwardly and proximally flared peripheral rim around its proximal end. The peripheral rim forms a funnel that circumscribes less than 360°, and preferably about 240° of the proximal end of the barrel, thereby defining a gap in the rim that provides direct access to the open proximal end of the barrel. The rim facilitates the filling of the barrel either by pouring a liquid into the funnel, or by filling the barrel with a highly viscous, paste-like liquid directly into the open proximal end of the barrel through the gap. The shaft is formed of a pair of flattened, elongate longitudinal members that intersect at right angles to form a shaft structure that is cruciform in cross section, wherein the reinforcing structure is provided by a truss element lattice formed between the longitudinal members.
摘要翻译：用于将粘性液体（特别是骨粘固剂）输送到外科手术部位的改进的注射器具有带有远侧出口端和开口近端的筒体，以及在筒体内可轴向移动的柱塞，所述柱塞具有从所述筒体的近侧延伸的轴枪管的近端。柱塞轴包括增强结构，其提供增加的扭转刚度并改善扭转载荷的分散，并且筒包括围绕其近端的向外和向近端扩张的外围边缘。外围边缘形成一个漏斗，该漏斗围绕枪管的近端小于360°，优选地约240°，从而在轮缘中限定了提供直接进入枪管的开口近端的间隙。边缘通过将液体倒入漏斗中或者通过将高粘度的糊状液体直接填充到筒的敞开的近端中来容纳桶的填充。轴由一对扁平的，细长的纵向构件形成，该纵向构件以直角相交，形成十字形横截面的轴结构，其中，加强结构由在纵向构件之间形成的桁架构件格架提供。

9. 发明申请

WO9925110A8 METHOD AND APPARATUS FOR MONITORING A PATIENT 审中-公开
标题翻译：监测患者的方法和设备
公开(公告)号：WO9925110A8
公开(公告)日：1999-07-15
申请号：PCT/US9824083
申请日：1998-11-12
申请人： I FLOW CORP
发明人： VASKO ROBERT S , MASSENGALE ROGER
IPC分类号： A61B5/00 , G06Q50/00 , H04M11/00
CPC分类号： H04M11/002 , A61B5/0002 , G06F19/3418 , G16H40/40 , G16H40/63
摘要： A remotely programmable and accessible medical device system (10) including an interface unit (14) and a medical device (12) connected to a patient (18) is disclosed. Through a transceiver, such as a telephone (48) or computer (50), a person may obtain status reports from a remotely located medical device in audible, electronic or paper form. In addition, the person may change a protocol associated with the medical device or be alerted to a remote location of an alarm associated with the medical device.
摘要翻译：公开了包括连接到患者（18）的接口单元（14）和医疗装置（12）的远程可编程且可访问的医疗装置系统（10）。通过诸如电话（48）或计算机（50）的收发器，人们可以从可远程定位的医疗设备以可听，电子或纸质形式获得状态报告。另外，该人可以改变与医疗设备相关联的协议或者被警告到与医疗设备相关联的警报的远程位置。

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