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2. 发明申请

WO2003033530A2 MYCOBACTERIAL ANTIGENS EXPRESSED UNDER HIGH OXYGEN TENSION 审中-公开
标题翻译：在高氧强度下表达的肌醇生成抗体
公开(公告)号：WO2003033530A2
公开(公告)日：2003-04-24
申请号：PCT/GB2002/004647
申请日：2002-10-14
申请人： MICROBIOLOGICAL RESEARCH AUTHORITY , JAMES, Brian , BACON, Joanna , MARCH, Philip
发明人： JAMES, Brian , BACON, Joanna , MARCH, Philip
IPC分类号： C07K14/00
CPC分类号： C07K14/35 , A61K39/00 , A61K2039/505 , A61K2039/522 , A61K2039/53
摘要： A method is provided for identifying mycobacterial genes the expression of which is induced or up-regulated under continuous culture conditions defined by a dissolved oxygen tension of at least 30 % air saturation measured at 37 °C when compared with a dissolved oxygen tension of up to 10 % air saturation measured at 37 °C. The described method optionally provides for identifying mycobacterial genes that are simultaneously induced or up-regulated under continuous culture conditions that are iron-limiting. Said induced or up-regulated genes form the basis of nucleic acid vaccines, or provide targets to allow preparation of attenuated mycobacteria for vaccines against mycobacterial infections. Similarly, peptides encoded by said induced or up-regulated genes are employed in vaccines. In a further embodiment, the identified genes/peptides provide the means for identifying the presence of a mycobacterial infection in a clinical sample by nucleic acid probe or antibody detection.
摘要翻译：提供了一种鉴定分枝杆菌基因的方法，该分枝杆菌基因的表达在连续培养条件下被诱导或上调，所述连续培养条件由在37℃下测量的至少30％空气饱和度的溶解氧气压力定义，在37℃下测量10％空气饱和度。所描述的方法可选地提供鉴定在限制铁的连续培养条件下同时诱导或上调的分枝杆菌基因。所述诱导的或上调的基因构成核酸疫苗的基础，或提供靶标，以允许制备减毒分枝杆菌用于针对分枝杆菌感染的疫苗。类似地，由所述诱导或上调基因编码的肽用于疫苗。在另一个实施方案中，所鉴定的基因/肽提供了通过核酸探针或抗体检测鉴定临床样品中分枝杆菌感染的存在的方法。

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