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1. 发明申请

WO1997037987A1 KETOACID ENDOTHELIN ANTAGONISTS 审中-公开
标题翻译： KETOACID内皮素拮抗剂
公开(公告)号：WO1997037987A1
公开(公告)日：1997-10-16
申请号：PCT/US1997003959
申请日：1997-03-12
申请人： WARNER-LAMBERT COMPANY , CHENG, Xue-Min , DOHERTY, Annette, Marian , HURLEY, Timothy, Robert , LOVDAHL, Michael, James , PATT, William, Chester , REPINE, Joseph, Thomas
发明人： WARNER-LAMBERT COMPANY
IPC分类号： C07D317/60
CPC分类号： C07C59/90 , C07D317/60
摘要： Novel nonpeptide antagonists of endothelin I are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating acute respiratory distress syndrome (ARDS), atherosclerosis, restenosis, Raynaud's phenomenon, chronic obstructive pulmonary diseases, mild or severe congestive heart failure, cerebral ischemia, cerebral infarction, embolic stroke, cerebral vasospasm, glaucoma, subarachnoid hemorrhage, hemorrhagic stroke, diabetes, gastric ulceration and mucosal damage, ischemic bowel disease, Chrohn's disease, essential or malignant hypertension, pulmonary hypertension, pulmonary hypertension after bypass, male penile erectile dysfunction, cancer, especially malignant hemangioendothelioma or prostate cancer, myocardial infarction or ischemia, acute or chronic renal failure, renal ischemia, radiocontrast-induced nephrotoxicity, endotoxic, septic, hemorrhagic shock, angina, preeclampsia, asthma, arrhythmias, benign prostatic hyperplasia, and elevated levels or endothelin.
摘要翻译：描述了内皮素I的新型非肽拮抗剂，以及其制备方法及其药物组合物，其可用于治疗急性呼吸窘迫综合征（ARDS），动脉粥样硬化，再狭窄，雷诺现象，慢性阻塞性肺疾病，轻度或严重充血性心力衰竭，脑缺血，脑梗死，栓塞性中风，脑血管痉挛，青光眼，蛛网膜下腔出血，出血性中风，糖尿病，胃溃疡和粘膜损伤，缺血性肠病，克罗恩病，基本或恶性高血压，肺动脉高压，肺动脉高压旁路后，男性阴茎勃起功能障碍，癌症，特别是恶性血管内皮瘤或前列腺癌，心肌梗塞或局部缺血，急性或慢性肾衰竭，肾脏缺血，放射性对照诱导的肾毒性，内毒素，败血症，出血性休克，心绞痛，先兆子痫，哮喘，心律失常，良性前列腺增生 sia和升高的水平或内皮素。

2. 发明申请

WO02078747A2 PREGABALIN LACTOSE CONJUGATES 审中-公开
标题翻译： PREGABALIN乳糖凝胶
公开(公告)号：WO02078747A2
公开(公告)日：2002-10-10
申请号：PCT/IB0200647
申请日：2002-02-25
申请人： WARNER LAMBERT CO , HURLEY TIMOTHY ROBERT , LOVDAHL MICHAEL JAMES , TOBIAS BRIAN
发明人： HURLEY TIMOTHY ROBERT , LOVDAHL MICHAEL JAMES , TOBIAS BRIAN
IPC分类号： C07H7/06 , A61K31/7056 , A61K47/48 , A61P9/10 , A61P11/00 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P29/02 , A61P43/00 , C07H19/04
CPC分类号： A61K31/7056 , A61K47/555
摘要： In accordance with the present invention, there is provided pregabalin lactose conjugate compounds. Also provided as part of the present invention is a novel method of central nervous system disorders or diseases including seizure disorders, pain, depression, anxiety, sleep disorders, consumptive disorders, psychosis, tardive dyskinesia, Huntington's disease, or Parkinson's disease in a subject by administering to the subject a pharmaceutically effective amount of a pregabalin lactose conjugate.
摘要翻译：根据本发明，提供了普瑞巴林乳糖结合物。作为本发明的一部分还提供了一种中枢神经系统疾病或疾病的新方法，包括发作障碍，疼痛，抑郁，焦虑，睡眠障碍，消耗性障碍，精神病，迟发性运动障碍，亨廷顿病或帕金森氏病向受试者施用药学有效量的普瑞巴林乳糖缀合物。

3. 发明申请

WO02078747A9 PREGABALIN LACTOSE CONJUGATES 审中-公开
标题翻译： PREGABALIN乳糖凝胶
公开(公告)号：WO02078747A9
公开(公告)日：2003-12-31
申请号：PCT/IB0200647
申请日：2002-02-25
申请人： WARNER LAMBERT CO , HURLEY TIMOTHY ROBERT , LOVDAHL MICHAEL JAMES , TOBIAS BRIAN
发明人： HURLEY TIMOTHY ROBERT , LOVDAHL MICHAEL JAMES , TOBIAS BRIAN
IPC分类号： C07H7/06 , A61K31/7056 , A61K47/48 , A61P9/10 , A61P11/00 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P29/02 , A61P43/00 , C07H19/04
CPC分类号： A61K31/7056 , A61K47/555
摘要： In accordance with the present invention, there is provided pregabalin lactose conjugate compounds. Also provided as part of the present invention is a novel method of central nervous system disorders or diseases including seizure disorders, pain, depression, anxiety, sleep disorders, consumptive disorders, psychosis, tardive dyskinesia, Huntington's disease, or Parkinson's disease in a subject by administering to the subject a pharmaceutically effective amount of a pregabalin lactose conjugate.
摘要翻译：根据本发明，提供了普瑞巴林乳糖结合物。作为本发明的一部分还提供了一种中枢神经系统疾病或疾病的新方法，包括发作障碍，疼痛，抑郁，焦虑，睡眠障碍，消耗性障碍，精神病，迟发性运动障碍，亨廷顿病或帕金森氏病向受试者施用药学有效量的普瑞巴林乳糖缀合物。

4. 发明申请

WO02078747A8 PREGABALIN LACTOSE CONJUGATES 审中-公开
标题翻译： PREGABALIN乳糖共轭物
公开(公告)号：WO02078747A8
公开(公告)日：2003-12-04
申请号：PCT/IB0200647
申请日：2002-02-25
申请人： WARNER LAMBERT CO , HURLEY TIMOTHY ROBERT , LOVDAHL MICHAEL JAMES , TOBIAS BRIAN
发明人： HURLEY TIMOTHY ROBERT , LOVDAHL MICHAEL JAMES , TOBIAS BRIAN
IPC分类号： C07H7/06 , A61K31/7056 , A61K47/48 , A61P9/10 , A61P11/00 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P29/02 , A61P43/00 , C07H19/04
CPC分类号： A61K31/7056 , A61K47/555
摘要： In accordance with the present invention, there is provided pregabalin lactose conjugate compounds. Also provided as part of the present invention is a novel method of central nervous system disorders or diseases including seizure disorders, pain, depression, anxiety, sleep disorders, consumptive disorders, psychosis, tardive dyskinesia, Huntington's disease, or Parkinson's disease in a subject by administering to the subject a pharmaceutically effective amount of a pregabalin lactose conjugate.
摘要翻译：根据本发明，提供了普瑞巴林乳糖缀合物化合物。作为本发明的一部分还提供了一种中枢神经系统障碍或疾病的新方法，其包括癫痫发作障碍，疼痛，抑郁症，焦虑症，睡眠障碍，消耗性障碍，精神病，迟发性运动障碍，亨廷顿舞蹈病或帕金森病，向受试者施用药学有效量的普瑞巴林乳糖缀合物。

5. 发明申请

WO2002078747A3 PREGABALIN LACTOSE CONJUGATES 审中-公开
公开(公告)号：WO2002078747A3
公开(公告)日：2002-10-10
申请号：PCT/IB2002/000647
申请日：2002-02-25
申请人： WARNER-LAMBERT COMPANY LLC , HURLEY, Timothy, Robert , LOVDAHL, Michael, James , TOBIAS, Brian
发明人： HURLEY, Timothy, Robert , LOVDAHL, Michael, James , TOBIAS, Brian
IPC分类号： A61K47/48
摘要： In accordance with the present invention, there is provided pregabalin lactose conjugate compounds. Also provided as part of the present invention is a novel method of central nervous system disorders or diseases including seizure disorders, pain, depression, anxiety, sleep disorders, consumptive disorders, psychosis, tardive dyskinesia, Huntington's disease, or Parkinson's disease in a subject by administering to the subject a pharmaceutically effective amount of a pregabalin lactose conjugate.

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