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1. 发明申请

WO2009066253A3 MULTI-MODAL SPOT GENERATOR AND MULTI-MODAL MULTI-SPOT SCANNING MICROSCOPE 审中-公开
公开(公告)号：WO2009066253A3
公开(公告)日：2009-05-28
申请号：PCT/IB2008/054861
申请日：2008-11-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , STALLINGA, Sjoerd , VOSSEN, Dirk, L. J. , BAKKER, Levinus, P. , HULSKEN, Bas
发明人： STALLINGA, Sjoerd , VOSSEN, Dirk, L. J. , BAKKER, Levinus, P. , HULSKEN, Bas
IPC分类号： G02B3/00 , G02B5/18 , G02B27/00 , G02B21/00 , G02B27/09
摘要： The invention relates to a spot generator (10) having: -an entrysurface (12) for receiving an incident light beam (20) and an exit surface (14) for transmitting the light beam, the entry surface defining an entryside (16) and the exit surface defining an exit side (18). According to the invention, the spot generator is designed to modulate the incident light beam to generate on the exit side a first plurality (22) and a second plurality (24) of separate light spots, each light spot belonging to the first plurality having a first angular spectrum and each light spot belonging to the second plurality having a second angular spectrum different than the first angular spectrum. Advantageously, the spot generator comprises a periodic binary phase structure. The invention further relates to a multi-spot scanning microscope and to a method of imaging a microscopic sample.

2. 发明申请

WO2011145016A1 AUTOFOCUS IMAGING 审中-公开
标题翻译：自动成像
公开(公告)号：WO2011145016A1
公开(公告)日：2011-11-24
申请号：PCT/IB2011/051963
申请日：2011-05-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HULSKEN, Bas , STALLINGA, Sjoerd
发明人： HULSKEN, Bas , STALLINGA, Sjoerd
IPC分类号： G02B21/24
CPC分类号： G02B21/245 , G02B21/36 , H04N3/1581 , H04N5/23212
摘要： The present invention relates to the field of digital pathology and in particular to whole slide scanners. Autofocus imaging can be performed by sampling a first number of pixels of a primary image sensor and sampling a second number of pixels of an autofocus image sensor, wherein the second number is between one quarter and three quarters of the first number. Thus, continuous autofocus for rapid light scanning may be provided based on an additional image sensor that is tilted with respect to the optical axis.
摘要翻译：本发明涉及数字病理学领域，特别涉及整个幻灯片扫描器。可以通过对主图像传感器的第一数量的像素进行采样并对自动聚焦图像传感器的第二数量的像素进行采样来执行自动聚焦成像，其中第二数量在第一数量的四分之一到四分之三之间。因此，可以基于相对于光轴倾斜的附加图像传感器来提供用于快速光扫描的连续自动对焦。

3. 发明申请

WO2011080670A1 SENSOR FOR MICROSCOPY. 审中-公开
标题翻译：传感器用于显微镜。
公开(公告)号：WO2011080670A1
公开(公告)日：2011-07-07
申请号：PCT/IB2010/056005
申请日：2010-12-22
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HULSKEN, Bas , STALLINGA, Sjoerd
发明人： HULSKEN, Bas , STALLINGA, Sjoerd
IPC分类号： G02B21/36
CPC分类号： G02B21/367 , G02B21/241 , G02B21/361
摘要： This invention pertains to a method for microscopically imaging a sample, with a digital scanner comprising a sensor including a 2D array of pixels and to a digital scanning microscope carrying out this method. It is notably provided a method for microscopically imaging a sample with a scanner comprising a sensor including a 2D array of pixels in an XY coordinate system, the axis Y being substantially perpendicular to the scan direction, wherein the scanner is arranged such that the sensor can image an oblique cross section of the sample, and wherein the method comprises the steps of: • activating a first sub-array of the 2D array of pixels, the first sub-array extending mainly along the Y axis at a first X coordinate (X1), • creating a first image by imaging a first area of the sample by means of the first sub-array of pixels. According to aspects of the invention, it is further proposed a scanner carryout this method and using the same 2D array sensor for imaging and auto-focusing purpose.
摘要翻译：本发明涉及一种用于对样品进行微观成像的方法，数字扫描器包括包含2D阵列像素的传感器和执行该方法的数字扫描显微镜。特别提供了一种用于使用扫描仪对样品进行显微成像的方法，所述扫描器包括在XY坐标系中包括像素的2D阵列的传感器，所述轴线Y基本上垂直于扫描方向，其中扫描器被布置成使得传感器可对样本的倾斜横截面进行成像，并且其中所述方法包括以下步骤：激活2D阵列的第一子阵列，所述第一子阵列主要沿着Y轴在第一X坐标（X1 ），°通过借助于第一像素子阵列对样本的第一区域进行成像而产生第一图像。根据本发明的方面，进一步提出扫描器执行该方法并使用相同的2D阵列传感器用于成像和自动聚焦目的。

4. 发明申请

WO2011158162A1 AN IMAGE PROCESSING METHOD IN MICROSCOPY 审中-公开
标题翻译：微观图像处理方法
公开(公告)号：WO2011158162A1
公开(公告)日：2011-12-22
申请号：PCT/IB2011/052546
申请日：2011-06-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , MUELLER, Dan , VOSSEN, Dirk , HULSKEN, Bas
发明人： MUELLER, Dan , VOSSEN, Dirk , HULSKEN, Bas
IPC分类号： G06T3/00
CPC分类号： G06K9/0014 , G06T3/0068 , G06T2200/24 , G06T2207/10056 , G06T2207/20016 , G06T2207/20104
摘要： The invention pertains to the field of image processing in digital pathology. It notably proposes a method for processing a first digital image, representing a sample in a region, and which image has been acquired from the sample by means of a microscopic imaging system (1) and is stored in a multi-resolution image data structure (80), comprising the steps of: - retrieving (104) a sub-region of the first digital image at a first resolution, -executing (105) a transform function on the retrieved sub-region, the transform function modifying a content of the sub-region according to at least one metric derived from a second resolution representation of the first digital image.
摘要翻译：本发明涉及数字病理学中的图像处理领域。特别提出了一种用于处理第一数字图像的方法，其表示区域中的样本，并且已经通过显微镜成像系统（1）从样本获取了哪个图像，并且被存储在多分辨率图像数据结构中 80），包括以下步骤：以第一分辨率检索（104）第一数字图像的子区域， - 对所检索的子区域执行（105）变换函数，所述变换函数修改所述第一数字图像的内容根据从第一数字图像的第二分辨率表示导出的至少一个量度的子区域。

5. 发明申请

WO2010119408A1 UP-CONCENTRATION OF ORGANIC MICROOBJECTS FOR MICROSCOPIC IMAGING 审中-公开
标题翻译：用于微观成像的有机微生物的高浓度
公开(公告)号：WO2010119408A1
公开(公告)日：2010-10-21
申请号：PCT/IB2010/051617
申请日：2010-04-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HULSKEN, Bas , KUIPER, Stein , STALLINGA, Sjoerd , ISAKSSON, Bo Joakim , PONJEE, Marc W. G. , VAN MEERBERGEN, Bart E. G. , UNAY, Zeynep S.
发明人： HULSKEN, Bas , KUIPER, Stein , STALLINGA, Sjoerd , ISAKSSON, Bo Joakim , PONJEE, Marc W. G. , VAN MEERBERGEN, Bart E. G. , UNAY, Zeynep S.
IPC分类号： G01N15/06 , G01N1/40
CPC分类号： G01N1/4077 , G01N1/4005 , G01N15/0625 , G01N15/0631
摘要： A method of analyzing a sample fluid containing organic microobjects is proposed. The method comprises the steps of: up-concentrating (S1) the microobjects by removing, in a total time T 1 , a volume V 1 of the sample fluid from the microobjects; - immersing (S2) the microobjects in a transfer fluid, or leaving the microobjects in a remaining portion of the sample fluid, the remaining portion of the sample fluid then providing the transfer fluid; filtering (S3), in a total time T 3 , a volume V 3 of the transfer fluid by a filter, thereby accumulating the microobjects on the filter; and - generating (S4) an image of the microobjects accumulated on the filter; wherein the throughput V 1 / T 1 of the step of up-concentrating (S1) is greater than the throughput V 1 / T 1 , of the step of filtering (S3). The filter may be a second filter, and the step of up-concentrating (S1) may involve: filtering the sample fluid by a first filter, thereby accumulating the microobjects on the first filter. An apparatus or system for analyzing a sample fluid containing organic microobjects is also disclosed.
摘要翻译：提出了一种分析含有机微物体样品液的方法。该方法包括以下步骤：通过在总时间T 1中除去来自微观对象的样品流体的体积V 1来上集中（S1）微观对象; - 将微量物体浸入（S2）转移流体中，或将微量物体留在样品流体的剩余部分中，然后将样品流体的剩余部分提供转移流体; 在总时间T3中过滤（S3）通过过滤器的传送流体的体积V 3，从而将微物体累积在过滤器上; 以及 - 生成（S4）累积在所述过滤器上的所述微物体的图像; 其特征在于，所述上调步骤（S1）的吞吐量V 1 / T 1大于所述滤波步骤的吞吐量V 1 / T 1（S3）。过滤器可以是第二过滤器，并且上集中（S1）的步骤可以涉及：通过第一过滤器过滤样品流体，从而将微物体累积在第一过滤器上。还公开了一种用于分析含有机微物体的样品流体的装置或系统。

6. 发明申请

WO2010067256A1 AUTOFOCUS FOR A MICROSCOPE SYSTEM. 审中-公开
标题翻译：自动识别系统。
公开(公告)号：WO2010067256A1
公开(公告)日：2010-06-17
申请号：PCT/IB2009/055431
申请日：2009-12-01
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KIEFT, Erik , Van DIJK, Erik , STALLINGA, Sjoerd , HULSKEN, Bas
发明人： KIEFT, Erik , Van DIJK, Erik , STALLINGA, Sjoerd , HULSKEN, Bas
IPC分类号： G02B21/24
CPC分类号： G02B21/245 , G02B21/006
摘要： A scanning microscope (10) for imaging a sample (12) comprises imaging optics (54, 56) for generating an imaging light spot (44); a scan mechanism for translating the sample (12) relative to the imaging light spot (44) in a horizontal plane, a focusing mechanism for translating the sample (12) relative to the imaging light spot (44) on a vertical axis; autofocus optics (36, 58, 60, 66, 56, 54) for generating during an autofocus interval a set of autofocus light spots (46, 47) in the sample (12), the autofocus light spots having different vertical positions; a detector (52, 53) for receiving autofocus light (40) from each of the autofocus light spots (46, 47) and for delivering a detector signal as a function of the received autofocus light (40); a controller for determining from the detector signal a vertical position of an object in the sample (12) and for causing the focusing mechanism to adapt the vertical position of the imaging light spot (44) to the vertical position of the object in the sample (12). The sample (12) may comprise a substrate layer (18), a specimen layer (16) containing organic matter (24), and a cover layer (14); the organic matter (24) being the object in the sample. In a preferred embodiment, the detector is comprises a confocal arrangement.
摘要翻译：用于对样品（12）成像的扫描显微镜（10）包括用于产生成像光点（44）的成像光学器件（54,56）。用于在水平平面中相对于成像光点（44）平移样本（12）的扫描机构，用于在垂直轴上相对于成像光点（44）平移样本（12）的聚焦机构; 自动对焦光学器件（36,58,60,66,56,54），用于在自动聚焦间隔期间在样本（12）中产生一组自动聚焦光点（46,47），所述自动聚焦光点具有不同的垂直位置; 用于从每个自动聚焦光点（46,47）接收自动聚焦光（40）并用于传送作为所接收的自动聚焦光（40）的函数的检测器信号的检测器（52,53）; 控制器，用于根据检测器信号确定样品（12）中的物体的垂直位置，并使聚焦机构使成像光点（44）的垂直位置适应样品中的物体的垂直位置（ 12）。样品（12）可以包括基底层（18），含有有机物质的试样层（16）和覆盖层（14）; 有机物（24）是样品中的物体。在优选实施例中，检测器包括共焦排列。

7. 发明申请

WO2010018514A1 METHOD AND MEANS FOR NEAR-FIELD MICROSCOPY BASED ON TRANSIENT PROBES IN A PHASE-CHANGE MATERIAL. 审中-公开
标题翻译：基于相变材料瞬态探测的近场微观方法与方法。
公开(公告)号：WO2010018514A1
公开(公告)日：2010-02-18
申请号：PCT/IB2009/053488
申请日：2009-08-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HULSKEN, Bas , STALLINGA, Sjoerd
发明人： HULSKEN, Bas , STALLINGA, Sjoerd
IPC分类号： G01Q60/18 , G02B21/34
CPC分类号： G01Q60/22 , G02B5/23 , G02B21/34
摘要： A slide for carrying a sample (38), for use with a near-field optical microscope (10), comprises a phase-change layer (36). Any region (40) of the phase-change layer is capable of reversibly assuming a first phase or a second phase independently of other regions of the phase-change layer. With regard to illumination light (44), the region's transmittance is substantially higher in the second phase than in the first phase, or the region's reflectivity is substantially higher in the second phase than in the first phase. A method of imaging a sample (38) comprises the steps of placing the sample (38) on a slide of the type described above; creating a probe region (40) in the phase-change layer (36), the probe region being surrounded by a surrounding region (42) of the phase-change layer (36), wherein the surrounding region (42) is in the first phase while the probe region (40) is in the second phase; illuminating the probe region (40) by illumination light (44), whereby illumination light is at least partially transmitted through or reflected by the probe region (40) so as to illuminate a region (50) of the sample (38); and detecting light (48) from the sample (38). A near-field optical microscope comprising a slide as described above is also disclosed.
摘要翻译：用于携带用于近场光学显微镜（10）的样品（38）的载玻片包括相变层（36）。相变层的任何区域（40）能够独立于相变层的其它区域可逆地假设第一相或第二相。对于照明光（44），第二相中的区域的透射率比第一相中的透射率明显更高，或者第二相中的区域的反射率比在第一相中显着更高。成像样品（38）的方法包括以下步骤：将样品（38）放置在上述类型的载玻片上; 在所述相变层（36）中产生探针区域（40），所述探针区域被所述相变层（36）的周围区域（42）包围，其中所述周围区域（42）处于所述第一而探针区域（40）处于第二阶段; 通过照明光（44）照射探针区域（40），由此照明光至少部分透射通过探针区域（40）或由探针区域（40）反射，以照射样品（38）的区域（50）。以及从所述样品（38）检测光（48）。还公开了包括如上所述的载玻片的近场光学显微镜。

8. 发明申请

WO2009066253A2 MULTI-MODAL SPOT GENERATOR AND MULTI-MODAL MULTI-SPOT SCANNING MICROSCOPE 审中-公开
标题翻译：多模光斑发生器和多模多光斑扫描显微镜
公开(公告)号：WO2009066253A2
公开(公告)日：2009-05-28
申请号：PCT/IB2008054861
申请日：2008-11-19
申请人： KONINKL PHILIPS ELECTRONICS NV , STALLINGA SJOERD , VOSSEN DIRK L J , BAKKER LEVINUS P , HULSKEN BAS
发明人： STALLINGA SJOERD , VOSSEN DIRK L J , BAKKER LEVINUS P , HULSKEN BAS
IPC分类号： G02B3/00 , G02B5/18 , G02B21/00 , G02B27/00 , G02B27/09
CPC分类号： G02B21/0032 , G02B27/0087 , G02B27/0905
摘要： The invention relates to a spot generator (10) having: -an entrysurface (12) for receiving an incident light beam (20) and an exit surface (14) for transmitting the light beam, the entry surface defining an entryside (16) and the exit surface defining an exit side (18). According to the invention, the spot generator is designed to modulate the incident light beam to generate on the exit side a first plurality (22) and a second plurality (24) of separate light spots, each light spot belonging to the first plurality having a first angular spectrum and each light spot belonging to the second plurality having a second angular spectrum different than the first angular spectrum. Advantageously, the spot generator comprises a periodic binary phase structure. The invention further relates to a multi-spot scanning microscope and to a method of imaging a microscopic sample.
摘要翻译：本发明涉及一种点发生器（10），其具有： - 用于接收入射光束（20）的表面（12）和用于透射光束的出射表面（14），所述入射表面限定了农庄（16）;以及出口表面限定出口侧（18）。根据本发明，点发生器被设计为调制入射光束以在出射侧产生第一多个（22）和第二多个（24）分离的光点，属于第一多个的每个光点具有第一角谱和属于第二多个谱的每个光斑具有不同于第一角谱的第二角谱。有利地，点发生器包括周期性二元相位结构。本发明还涉及一种多点扫描显微镜和一种对显微镜样品成像的方法。

9. 发明申请

WO2011161594A1 AUTOFOCUS BASED ON DIFFERENTIAL MEASUREMENTS 审中-公开
标题翻译：基于差异测量的自动对焦
公开(公告)号：WO2011161594A1
公开(公告)日：2011-12-29
申请号：PCT/IB2011/052641
申请日：2011-06-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HULSKEN, Bas
发明人： HULSKEN, Bas
IPC分类号： G02B21/24
CPC分类号： H04N5/23212 , G02B21/002 , G02B21/241 , G02B21/244 , G02B21/245 , G02B21/365 , G02B21/367 , H04N5/247
摘要： The present invention relates to the field of digital pathology and in particular to whole slide scanners. A tilted autofocus image sensor images an oblique cross-section of the slide. For focusing multiple sequential overlapping images, which have been taken by the tilted sensor, are compared. The axial position of the tissue layer can be determined from the polar error signal resulting from this differential measurement.
摘要翻译：本发明涉及数字病理学领域，特别涉及整个幻灯片扫描器。倾斜的自动对焦图像传感器成像幻灯片的斜横截面。对于聚焦由倾斜传感器拍摄的多个顺序重叠图像进行对比。组织层的轴向位置可以由该差分测量得到的极性误差信号确定。

10. 发明申请

WO2010070553A1 SCANNING MICROSCOPE. 审中-公开
标题翻译：扫描显微镜
公开(公告)号：WO2010070553A1
公开(公告)日：2010-06-24
申请号：PCT/IB2009/055659
申请日：2009-12-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , Van DIJK, Erik , HULSKEN, Bas , HEZEMANS, Cornelius , VERBERNE, Henricus
发明人： Van DIJK, Erik , HULSKEN, Bas , HEZEMANS, Cornelius , VERBERNE, Henricus
IPC分类号： G02B21/36
CPC分类号： G02B21/367 , G01D5/34746 , G02B21/245
摘要： A scanning microscope (10) comprises a stage (18) for holding a sample (20), a scan mechanism, a probing system for probing a region (24) of the sample (20), a position sensor (80, 82), and a controller. The scan mechanism is designed for translating the stage (18) between at least two axial positions. The probing system 10 comprises an optical element and a photosensor having a readout region, wherein the readout region extends in a direction (14), which is transverse to an ideal orientation (72) of the stage (18). The position sensor (80, 82) serves for measuring a transverse position (84, 86) of the stage (18) and/or of an orientation (74) of the stage (18). The controller (30) serves for adapting the probing system as a function of the measured 15 transverse position (84, 86) and/or the measured orientation (74).
摘要翻译：扫描显微镜（10）包括用于保持样品（20）的台（18），扫描机构，用于探测样品（20）的区域（24）的探测系统，位置传感器（80,82）和控制器。扫描机构设计用于在至少两个轴向位置之间平移台架（18）。探测系统10包括光学元件和具有读出区域的光电传感器，其中读出区域沿横向于平台（18）的理想取向（72）的方向（14）延伸。位置传感器（80,82）用于测量载物台（18）的横向位置（84,86）和/或载物台（18）的取向（74）。控制器（30）用于根据测量的15横向位置（84,86）和/或所测量的取向（74）来调整探测系统。

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