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1. 发明申请

WO2007117264A3 COMPOSITIONS AND METHODS FOR PRODUCTION OF IMMUNOGLOBULINS 审中-公开
公开(公告)号：WO2007117264A3
公开(公告)日：2007-10-18
申请号：PCT/US2006/030545
申请日：2006-08-03
申请人： FRAUNHOFER USA, INC. , YUSIBOV, Vidadi , HULL, Anna , METT, Vadim
发明人： YUSIBOV, Vidadi , HULL, Anna , METT, Vadim
IPC分类号： A61K39/395 , A61P31/04
摘要： Provided are oligonucleotides for isolating human antibody cDNAs from cells or cell lines, such as hybridomas. The invention also provides cDNAs that encode at least one provided CDR of heavy chain or a light chain of a human monoclonal antibody that binds to B. anthracis protective antigen; and cDNAs that encode at least one provided CDR of a heavy chain or a light chain of a human monoclonal antibody that binds to B. anthracis lethal factor. The invention further provides expression vectors that contain one or more cDNAs isolated according to the methods of the invention, host cells expressing one or more inventive cDNAs, and transgenic plants and animals that express one or more inventive cDNAs. In certain embodiments of the invention the expression system is a plant-based expression system. The invention further provides antibody compositions comprising one or more antibodies produced by expressing a cDNA isolated according to the methods of the invention in a suitable expression system. Additionally encompassed in the invention are kits containing one or more of provided compositions, as well as methods of production and use of provided compositions.

2. 发明申请

WO2004044161A2 EXPRESSION OF FOREIGN SEQUENCES IN PLANTS USING TRANS-ACTIVATION SYSTEM 审中-公开
标题翻译：使用转移系统表达植物外来序列
公开(公告)号：WO2004044161A2
公开(公告)日：2004-05-27
申请号：PCT/US2003/035869
申请日：2003-11-06
申请人： FRAUNHOFER USA , YUSIBOV, Vidadi , SKARJINSKAIA, Marina , METT, Vadim , HULL, Anna
发明人： YUSIBOV, Vidadi , SKARJINSKAIA, Marina , METT, Vadim , HULL, Anna
IPC分类号： C12N
CPC分类号： C12N15/8216
摘要： A transactivation system and method for producing a foreign polypeptide of interest in cells of a host plant is disclosed. The transactivation system has two components. It has genetically transformed cells of the host plant having integrated in their nuclear genome, an inactive or silenced foreign nucleic acid sequence, which is capable of encoding, upon its activation, the foreign polypeptide of interest; and a recombinant RNA viral vector capable of infecting the cells of the host plant and encoding therein a factor for activating or facilitating the expression of inactive or silenced foreign nucleic acid sequence.
摘要翻译：公开了用于在宿主植物的细胞中产生感兴趣的外源多肽的反式激活系统和方法。反式激活系统有两个组成部分。它已经遗传转化已经整合在其核基因组中的宿主植物的细胞，其是无活性或沉默的外源核酸序列，其能够在其活化时编码感兴趣的外源多肽; 以及能够感染宿主植物的细胞并在其中编码用于激活或促进无活性或沉默的外来核酸序列的表达的因子的重组RNA病毒载体。

3. 发明申请

WO2007117264A2 COMPOSITIONS AND METHODS FOR PRODUCTION OF IMMUNOGLOBULINS 审中-公开
标题翻译：用于生产免疫球蛋白的组合物和方法
公开(公告)号：WO2007117264A2
公开(公告)日：2007-10-18
申请号：PCT/US2006030545
申请日：2006-08-03
申请人： FRAUNHOFER USA INC , YUSIBOV VIDADI , HULL ANNA , METT VADIM
发明人： YUSIBOV VIDADI , HULL ANNA , METT VADIM
CPC分类号： C07K16/1278 , A61K2039/505 , C07K2317/13 , C07K2317/21 , C07K2317/565
摘要： Provided are oligonucleotides for isolating human antibody cDNAs from cells or cell lines, such as hybridomas. The invention also provides cDNAs that encode at least one provided CDR of heavy chain or a light chain of a human monoclonal antibody that binds to B. anthracis protective antigen; and cDNAs that encode at least one provided CDR of a heavy chain or a light chain of a human monoclonal antibody that binds to B. anthracis lethal factor. The invention further provides expression vectors that contain one or more cDNAs isolated according to the methods of the invention, host cells expressing one or more inventive cDNAs, and transgenic plants and animals that express one or more inventive cDNAs. In certain embodiments of the invention the expression system is a plant-based expression system. The invention further provides antibody compositions comprising one or more antibodies produced by expressing a cDNA isolated according to the methods of the invention in a suitable expression system. Additionally encompassed in the invention are kits containing one or more of provided compositions, as well as methods of production and use of provided compositions.
摘要翻译：提供了用于从细胞或细胞系如杂交瘤分离人抗体cDNA的寡核苷酸。本发明还提供了编码至少一种所提供的重链CDR或轻链的CDR结合于炭疽杆菌保护性抗原的cDNA。以及编码至少一种提供的结合于炭疽杆菌致死因子的人单克隆抗体的重链或轻链的CDR的cDNA。本发明进一步提供含有根据本发明方法分离的一种或多种cDNA的表达载体，表达一种或多种本发明cDNA的宿主细胞，以及表达一种或多种本发明cDNA的转基因植物和动物。在本发明的某些实施方案中，表达系统是基于植物的表达系统。本发明进一步提供了抗体组合物，其包含通过在合适的表达系统中表达根据本发明的方法分离的cDNA产生的一种或多种抗体。本发明另外包括含有一种或多种所提供的组合物的试剂盒，以及所提供的组合物的生产和使用方法。

4. 发明申请

WO2004044161A3 EXPRESSION OF FOREIGN SEQUENCES IN PLANTS USING TRANS-ACTIVATION SYSTEM 审中-公开
标题翻译：使用转移系统表达植物外来序列
公开(公告)号：WO2004044161A3
公开(公告)日：2005-01-13
申请号：PCT/US0335869
申请日：2003-11-06
申请人： FRAUNHOFER USA , YUSIBOV VIDADI , SKARJINSKAIA MARINA , METT VADIM , HULL ANNA
发明人： YUSIBOV VIDADI , SKARJINSKAIA MARINA , METT VADIM , HULL ANNA
IPC分类号： C12N15/82 , C12N15/83 , C12N5/10 , C12N15/09 , C12N15/63 , C12N15/64 , C12N15/66 , C12N15/67 , C12N15/87 , C12N15/90
CPC分类号： C12N15/8216
摘要： A transactivation system and method for producing a foreign polypeptide of interest in cells of a host plant is disclosed. The transactivation system has two components. It has genetically transformed cells of the host plant having integrated in their nuclear genome, an inactive or silenced foreign nucleic acid sequence, which is capable of encoding, upon its activation, the foreign polypeptide of interest; and a recombinant RNA viral vector capable of infecting the cells of the host plant and encoding therein a factor for activating or facilitating the expression of inactive or silenced foreign nucleic acid sequence.
摘要翻译：公开了用于在宿主植物的细胞中产生感兴趣的外源多肽的反式激活系统和方法。反式激活系统有两个组成部分。它已经遗传转化已经整合在其核基因组中的宿主植物的细胞，其是无活性或沉默的外源核酸序列，其能够在其活化时编码感兴趣的外源多肽; 以及能够感染宿主植物的细胞并在其中编码用于激活或促进无活性或沉默的外来核酸序列的表达的因子的重组RNA病毒载体。

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