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    • 1. 发明申请
    • SEMICONDUCTOR BIOSENSORS
    • 半导体生物传感器
    • WO2010142773A2
    • 2010-12-16
    • PCT/EP2010/058183
    • 2010-06-10
    • HELMHOLTZ ZENTRUM MÜNCHEN DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)THALHAMMER, StefanHOFSTETTER, MarkusHOWGATE, JohnSTUTZMANN, Martin
    • THALHAMMER, StefanHOFSTETTER, MarkusHOWGATE, JohnSTUTZMANN, Martin
    • G01N27/414
    • G01T1/02G01N33/48728
    • The present invention relates to semiconductor devices, in particular to a device for monitoring a cell signal such as an electrical signal produced by living cells in response to external stimulation, optionally in real time, comprising (a) at least one discrete area comprising a high electron mobility transistor (HEMT); and (b)non-excitable cells attached to said HEMT (HEMT element). Preferably, said device, and preferably said at least one discrete area which comprises a HEMT, has a surface suitable for cell attachment or growth. Accordingly, the device can be applied in uses and methods for monitoring a cell signal such as an electrical signal produced by living cells in response to external stimulation, optionally in real time. Likewise, the device can be applied for screening compounds that reverse, protect from and/or shield cells from external stimuli which cause damage to cells. Also, kits comprising the device are an aspect of the present invention.
    • 本发明涉及半导体器件,特别涉及一种用于监测细胞信号(例如,响应于外部刺激而由活细胞产生的电信号,可选地实时地)产生的电信号的装置,包括:(a)至少一个离散的区域,包括高的 电子迁移率晶体管(HEMT); 和(b)附着于所述HEMT(HEMT元件)的不可兴奋细胞。 优选地,所述装置,优选地包括HEMT的所述至少一个离散区域具有适于细胞附着或生长的表面。 因此,该设备可以应用于可选地实时监视响应于外部刺激的由活细胞产生的电信号的细胞信号的用途和方法。 同样,该装置可用于筛选从外部刺激反向,保护和/或屏蔽细胞的化合物,从而引起细胞损伤。 而且,包括该装置的试剂盒是本发明的一个方面。
    • 5. 发明申请
    • SEMICONDUCTOR BIOSENSORS
    • 半导体生物传感器
    • WO2010142773A3
    • 2011-06-09
    • PCT/EP2010058183
    • 2010-06-10
    • HELMHOLTZ ZENTRUM MUENCHENTHALHAMMER STEFANHOFSTETTER MARKUSHOWGATE JOHNSTUTZMANN MARTIN
    • THALHAMMER STEFANHOFSTETTER MARKUSHOWGATE JOHNSTUTZMANN MARTIN
    • C12M1/34G01N27/414G01N33/487G01N33/50G01T1/24
    • G01T1/02G01N33/48728
    • The present application relates to semiconductor devices, in particular to a device for monitoring a cell signal such as an electrical signal produced by living cells in response to external stimulation, optionally in real time, comprising (a) at least one discrete area comprising a high electron mobility transistor (HEMT); and (b) non - excitable cells attached to said HEMT (HEMT element) for example, fibroblasts, HEK, CHO cell lines, keratinocytes, etc. Preferably, the HEMT is an AlGaN/GaN FET. Accordingly, the device can be applied in uses and methods for monitoring a cell signal such as an electrical signal produced by living cells in response to external stimulation, optionally in real time. Likewise, the device can be applied for screening compounds that reverse, protect from and/or shield cells from external stimuli which cause damage to cells. Also, kits comprising the device are disclosed.
    • 本申请涉及半导体器件,特别涉及一种用于监视细胞信号的装置,例如可选地实时地响应于外部刺激而由活细胞产生的电信号,包括(a)至少一个离散区域,包括高 电子迁移率晶体管(HEMT); 和(b)附着于所述HEMT(HEMT元件)例如成纤维细胞,HEK,CHO细胞系,角质形成细胞等的不可兴奋细胞。优选地,HEMT是AlGaN / GaN FET。 因此,该设备可以应用于可选地实时监视响应于外部刺激的由活细胞产生的电信号的细胞信号的用途和方法。 同样,该装置可用于筛选从外部刺激反向,保护和/或屏蔽细胞的化合物,从而引起细胞损伤。 此外,公开了包括该装置的套件。