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1. 发明申请

WO2008109040A3 CLOSED-LOOP PACING SYSTEM FOR INTERMITTENT CARDIAC STRESS AUGMENTATION 审中-公开
标题翻译：间歇性心脏应力增强的闭环起搏系统
公开(公告)号：WO2008109040A3
公开(公告)日：2008-11-27
申请号：PCT/US2008002799
申请日：2008-03-03
申请人： CARDIAC PACEMAKERS INC , PASTORE JOSEPH M , BAYNHAM TAMARA COLETTE , HOPPER DONALD L , SHUROS ALLAN C , ARCOT-KRISHNAMURTHY SHANTHA
发明人： PASTORE JOSEPH M , BAYNHAM TAMARA COLETTE , HOPPER DONALD L , SHUROS ALLAN C , ARCOT-KRISHNAMURTHY SHANTHA
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36585
摘要： A cardiac pacing system controls the progression of a cardiac disorder such as heart failure by delivering cardiac pacing to create or augment regional stress in the heart. The cardiac pacing is delivered intermittently, such as on a periodic basis, according to a cardiac stress augmentation pacing sequence that includes alternating pacing and non-pacing periods. One or more physiological signals are monitored for closed-loop control of the cardiac pacing using baseline characteristics of the cardiac disorder, acute cardiac stress created by the cardiac pacing, and/or risk associated with the cardiac pacing.
摘要翻译：心脏起搏系统通过提供心脏起搏以在心脏中产生或增加区域性应激来控制诸如心力衰竭的心脏病的发展。根据包括交替起搏和非起搏周期的心脏应力增加起搏序列，心脏起搏例如周期性地间歇性地递送。使用心脏病症的基线特征，由心脏起搏产生的急性心脏应激和/或与心脏起搏相关的风险来监测一个或多个生理信号用于心脏起搏的闭环控制。

2. 发明申请

WO2008079840A3 RATE ADAPTIVE CARDIAC PACING SYSTEMS AND METHODS 审中-公开
标题翻译：速率自适应心脏系统和方法
公开(公告)号：WO2008079840A3
公开(公告)日：2008-09-18
申请号：PCT/US2007088042
申请日：2007-12-19
申请人： CARDIAC PACEMAKERS INC , SHUROS ALLAN CHARLES , HOPPER DONALD L , KANE MICHAEL JOHN
发明人： SHUROS ALLAN CHARLES , HOPPER DONALD L , KANE MICHAEL JOHN
IPC分类号： G06F19/00
CPC分类号： A61N1/36585 , G06F19/3418 , G06F19/3481
摘要： The invention relates to cardiac rhythm management systems, and more particularly, to rate adaptive cardiac pacing systems and methods. In an embodiment, the invention includes a method for providing rate-adaptive cardiac pacing therapy from an implantable medical device, the method including sensing a pulmonary function of a patient; determining a rate of change in the pulmonary function; sensing a cardiac function of the patient; determining a rate of change in the cardiac function; and calculating a target pacing rate based on an existing pacing rate, the rate of change in the pulmonary function, and the rate of change in the cardiac function. In an embodiment, the invention includes a method of controlling a cardiac rhythm management device in response to exertion of a patient, the method including sensing the patient's pulmonary function at a first time t 1 and at a second time t 2 ; calculating a rate of change of the pulmonary function between time t 1 and time t 2 ; sensing the patient's cardiac function at time t 3 and t 4 ; calculating a rate of change of the cardiac function between time t 3 and time t 4 ; and setting a desired pacing rate. Embodiments of the invention also include cardiac rhythm management devices.
摘要翻译：本发明涉及心律管理系统，更具体地说，涉及适应性心脏起搏系统和方法的速率。在一个实施例中，本发明包括一种用于从可植入医疗装置提供速率适应性心脏起搏治疗的方法，所述方法包括感测患者的肺功能; 确定肺功能的变化率; 感测患者的心脏功能; 确定心脏功能的变化率; 并且基于现有的起搏速率，肺功能变化率和心脏功能变化率来计算目标起搏速率。在一个实施例中，本发明包括响应于患者的运动来控制心律管理装置的方法，所述方法包括在第一时间t 1>和第二时间感测患者的肺功能 t 2 2; 计算时间t 1和时间t 2之间的肺功能的变化率; 在时间t 3和t 4处感测患者的心脏功能; 计算时间t 3 3和时间t 4之间的心脏功能的变化率; 并设置所需的起搏速率。本发明的实施例还包括心律管理装置。

3. 发明申请

WO2007011565A1 MONITORING PHYSIOLOGICAL RESPONSES TO STEADY STATE ACTIVITY 审中-公开
标题翻译：监测对稳定状态活动的生理反应
公开(公告)号：WO2007011565A1
公开(公告)日：2007-01-25
申请号：PCT/US2006/026660
申请日：2006-07-07
申请人： CARDIAC PACEMAKERS, INC. , BECK, Kenneth , BAKER, Lemont , HOPPER, Donald
发明人： BECK, Kenneth , BAKER, Lemont , HOPPER, Donald
IPC分类号： A61N1/37 , A61N1/365 , A61B5/0205 , A61B5/11
CPC分类号： A61B5/0245 , A61B5/0215 , A61B5/029 , A61B5/0816 , A61B5/1116 , A61B5/145 , A61B5/686 , A61B2560/0468 , A61B2562/0219 , A61N1/36585 , A61N1/37
摘要： Systems and methods monitor physiological responses to steady state activity. In an example, a physical activity signal is detected from a human or animal subject using an implantable medical device. A different, other physiological signal is also detected from the subject using the implantable medical device. The physical activity signal is processed to define first and second time periods associated with first and second steady-state physical activity levels of the subject. A first indicator is obtained by combining data from the other physiological signal obtained during the first time period. A second indicator is obtained by combining data from the other physiological signal obtained during the second time period. The first and second indicators are used provide a resulting indicator.
摘要翻译：系统和方法监测对稳态活动的生理反应。在一个示例中，使用可植入医疗装置从人或动物受试者检测身体活动信号。使用可植入医疗装置也可以从对象检测不同的其他生理信号。处理身体活动信号以定义与受试者的第一和第二稳态身体活动水平相关联的第一和第二时间段。通过组合来自第一时间段期间获得的其他生理信号的数据获得第一指示符。通过组合来自在第二时间段期间获得的其他生理信号的数据获得第二指示符。使用第一和第二指标提供了一个结果指标。

4. 发明申请

WO2006028575A3 METHOD AND APPARATUS FOR DETECTING CARDIOPULMONARY COMORBIDITIES 审中-公开
公开(公告)号：WO2006028575A3
公开(公告)日：2006-03-16
申请号：PCT/US2005/025235
申请日：2005-07-15
申请人： CARDIAC PACEMAKERS, INC. , BROCKWAY, Marina , HOPPER, Donald , CARLSON, Gerrard, M. , KADHIRESAN, Veerichetty , BECK, Kenneth
发明人： BROCKWAY, Marina , HOPPER, Donald , CARLSON, Gerrard, M. , KADHIRESAN, Veerichetty , BECK, Kenneth
IPC分类号： G06F19/00 , A61B5/08 , A61N1/365
摘要： A system receives signals indicative of cardiopulmonary conditions sensed by a plurality of sensors and provides for monitoring and automated differential diagnosis of the cardiopulmonary conditions based on the signals. Cardiogenic pulmonary edema is detected based on one or more signals sensed by implantable sensors. If the cardiogenic pulmonary edema is not detected, obstructive pulmonary disease and restrictive pulmonary disease are each detected based on a forced vital capacity (FVC) parameter and a forced expiratory volume (FEV) parameter measured from a respiratory signal sensed by an implantable or non-implantable sensor. In one embodiment, an implantable medical device senses signals indicative of the cardiopulmonary conditions, and an external system detects the cardiopulmonary conditions based on these signals by executing an automatic detection algorithm.

5. 发明申请

WO2006028575A2 METHOD AND APPARATUS FOR DETECTING CARDIOPULMONARY COMORBIDITIES 审中-公开
标题翻译：检测心脑血管事件的方法和装置
公开(公告)号：WO2006028575A2
公开(公告)日：2006-03-16
申请号：PCT/US2005025235
申请日：2005-07-15
申请人： CARDIAC PACEMAKERS INC , BROCKWAY MARINA , HOPPER DONALD , CARLSON GERRARD M , KADHIRESAN VEERICHETTY , BECK KENNETH
发明人： BROCKWAY MARINA , HOPPER DONALD , CARLSON GERRARD M , KADHIRESAN VEERICHETTY , BECK KENNETH
IPC分类号： G06F19/00 , A61B5/08 , A61N1/365
CPC分类号： A61B5/087 , A61B5/02405 , A61B5/053 , A61B5/4878 , A61N1/3627 , A61N1/36521
摘要： A system receives signals indicative of cardiopulmonary conditions sensed by a plurality of sensors and provides for monitoring and automated differential diagnosis of the cardiopulmonary conditions based on the signals. Cardiogenic pulmonary edema is detected based on one or more signals sensed by implantable sensors. If the cardiogenic pulmonary edema is not detected, obstructive pulmonary disease and restrictive pulmonary disease are each detected based on a forced vital capacity (FVC) parameter and a forced expiratory volume (FEV) parameter measured from a respiratory signal sensed by an implantable or non-implantable sensor. In one embodiment, an implantable medical device senses signals indicative of the cardiopulmonary conditions, and an external system detects the cardiopulmonary conditions based on these signals by executing an automatic detection algorithm.
摘要翻译：系统接收指示由多个传感器感测到的心肺疾病的信号，并且基于该信号提供对心肺病状态的监测和自动鉴别诊断。基于由可植入传感器感测到的一个或多个信号来检测心源性肺水肿。如果没有检测到心源性肺水肿，则基于由可植入或非注射的肺部感测的呼吸信号测量的强制肺活量（FVC）参数和强制呼气量（FEV）参数，每个都检测到阻塞性肺疾病和限制性肺部疾病，植入式传感器。在一个实施例中，可植入医疗装置感测指示心肺病的信号，并且外部系统通过执行自动检测算法基于这些信号检测心肺病。

6. 发明申请

WO2010138388A1 VENTILATION SENSOR RATE RESPONSE NORMALIZATION AND CALCULATION 审中-公开
标题翻译：通风传感器速率响应正常化和计算
公开(公告)号：WO2010138388A1
公开(公告)日：2010-12-02
申请号：PCT/US2010/035608
申请日：2010-05-20
申请人： CARDIAC PACEMAKERS, INC. , EMERSON, Paul F. , SEIM, Gary T. , QUERIMIT, Michael A. , HOPPER, Donald L. , PITZL, Stephen R. , O'BRIEN, Daniel
发明人： EMERSON, Paul F. , SEIM, Gary T. , QUERIMIT, Michael A. , HOPPER, Donald L. , PITZL, Stephen R. , O'BRIEN, Daniel
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61N1/362 , A61N1/365 , A61N1/37
摘要： A cardiac rhythm management (CRM) device can extract ventilation information from thoracic impedance or other information, and adjust a delivery rate of the CRM therapy. A tidal volume of a patient is measured and used to adjust a ventilation rate response factor. The measured tidal volume can optionally be adjusted using a ventilation rate dependent adjustment factor. The ventilation rate response factor can also be adjusted using a maximum voluntary ventilation (MVV), an age predicted maximum heart rate, a resting heart rate, and a resting ventilation determined for the patient. In various examples, a global ventilation sensor rate response factor (for a population) can be programmed into the CRM device, and automatically tailored to be appropriate for a particular patient.
摘要翻译：心脏节律管理（CRM）设备可以从胸部阻抗或其他信息中提取通气信息，并调整CRM治疗的输送速率。测量患者的潮气量并用于调节通气率反应因子。测量的潮气量可以任选地使用通风率依赖调节因子进行调整。通气率反应因子也可以使用最大自主通气（MVV），年龄预测最大心率，静息心率和为患者确定的休息通气进行调整。在各种示例中，可将全球通气传感器速率响应因子（对于群体）编程到CRM设备中，并且被自动调整为适合于特定患者。

7. 发明申请

WO2009094335A1 RESPIRATION AS A TRIGGER FOR THERAPY OPTIMIZATION 审中-公开
标题翻译：作为治疗优化的触发器的呼吸
公开(公告)号：WO2009094335A1
公开(公告)日：2009-07-30
申请号：PCT/US2009/031447
申请日：2009-01-20
申请人： CARDIAC PACEMAKERS, INC. , KUENZLER, Richard, O. , HOPPER, Donald , RASMUSSEN, Mary, Jane , MCCABE, Aaron , LAYTON, John
发明人： KUENZLER, Richard, O. , HOPPER, Donald , RASMUSSEN, Mary, Jane , MCCABE, Aaron , LAYTON, John
IPC分类号： A61N1/362 , A61B5/0205
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/021 , A61B5/02405 , A61B5/0816 , A61N1/36521 , A61N1/36592 , A61N1/37247 , A61N1/37258 , G06F19/00 , G06F19/3418 , G16H10/20 , G16H40/63 , G16H50/30
摘要： Changes in patient status are assessed based at least in part on respiration parameters. A user can make selections regarding alert criteria options to be used in assessing patient status. Respiration is implantably sensed and respiration data is stored by an implantable device. A respiration parameter, such as respiration rate, is measured from the respiration data. The change in patient status is assessed by comparing the respiration parameter to the configured alert criteria. If the comparison of the respiration parameter and the configured alert criteria indicates a significant change in patient status, an alert signal is generated.
摘要翻译：至少部分地基于呼吸参数来评估患者状态的变化。用户可以对用于评估患者状态的警报标准选项进行选择。呼吸被植入式感测，呼吸数据由可植入装置储存。从呼吸数据测量呼吸参数，例如呼吸速率。通过将呼吸参数与配置的警报标准进行比较来评估患者状态的变化。如果呼吸参数和配置的警报标准的比较表示患者状态的显着变化，则产生警报信号。

8. 发明申请

WO2011084635A1 PACEMAKER WITH AUTOMATIC ADAPTATION OF THE PACING RATE BASED ON INPUT FROM AN ACTIVITY SENSOR AND A MINUTE VENTILATION SENSOR 审中-公开
标题翻译：具有自动适应基于活动传感器和分钟通风传感器输入的速率的起搏器
公开(公告)号：WO2011084635A1
公开(公告)日：2011-07-14
申请号：PCT/US2010/060839
申请日：2010-12-16
申请人： CARDIAC PACEMAKERS, INC. , STAHMANN, Jeffrey E. , QUERIMIT, Michael A. , HOPPER, Donald L. , LARSON, Brian Ralph , EMERSON, Paul F. , O'BRIEN, Daniel
发明人： STAHMANN, Jeffrey E. , QUERIMIT, Michael A. , HOPPER, Donald L. , LARSON, Brian Ralph , EMERSON, Paul F. , O'BRIEN, Daniel
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61N1/36542 , A61N1/36585 , A61N1/368 , A61N1/37264
摘要： A rate adaptive pacemaker and a method for its operation in which the response factor for a minute ventilation sensor or other type of exertion level sensor is automatically set (A5) during a parameter adjustment mode that utilizes (A3) an activity level measurement to determine when the patient is at a target activity level with which is associated an appropriate target pacing rate. In a preferred embodiment, the target activity level corresponds to casual walking (e.g., 0.9 m/s at a 4% grade) with a target pacing rate selected as appropriate for that level of activity in the individual patient.
摘要翻译：速率自适应起搏器及其操作方法，其中在参数调整模式期间自动设置分钟通气传感器或其他类型的运动水平传感器的响应因子（A5），所述参数调整模式利用（A3）活动水平测量来确定何时患者处于与目标活动水平相关联的目标起搏速度。在优选实施例中，目标活动水平对应于休闲步行（例如，在4％等级为0.9m / s），其中针对个体患者中的该活动水平选择适合的目标起搏速率。

9. 发明申请

WO2008109040A2 CLOSED-LOOP PACING SYSTEM FOR INTERMITTENT CARDIAC STRESS AUGMENTATION 审中-公开
标题翻译：闭环控制系统用于间歇性心脏压力补偿
公开(公告)号：WO2008109040A2
公开(公告)日：2008-09-12
申请号：PCT/US2008/002799
申请日：2008-03-03
申请人： CARDIAC PACEMAKERS, INC. , PASTORE, Joseph, M. , BAYNHAM, Tamara, Colette , HOPPER, Donald, L. , SHUROS, Allan, C. , ARCOT-KRISHNAMURTHY, Shantha
发明人： PASTORE, Joseph, M. , BAYNHAM, Tamara, Colette , HOPPER, Donald, L. , SHUROS, Allan, C. , ARCOT-KRISHNAMURTHY, Shantha
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36585
摘要： A cardiac pacing system controls the progression of a cardiac disorder such as heart failure by delivering cardiac pacing to create or augment regional stress in the heart. The cardiac pacing is delivered intermittently, such as on a periodic basis, according to a cardiac stress augmentation pacing sequence that includes alternating pacing and non-pacing periods. One or more physiological signals are monitored for closed-loop control of the cardiac pacing using baseline characteristics of the cardiac disorder, acute cardiac stress created by the cardiac pacing, and/or risk associated with the cardiac pacing.
摘要翻译：心脏起搏系统通过递送心脏起搏来创建或增加心脏中的区域应力来控制心脏病症如心力衰竭的进展。根据包括交替起搏和非起搏时间段的心脏应激增加起搏序列，间歇地递送心脏起搏，例如周期性地起搏。使用心脏病症的基线特征，由心脏起搏产生的急性心脏压力和/或与心脏起搏相关的风险来监测一个或多个生理信号用于心脏起搏的闭环控制。

10. 发明申请

WO2008079840A2 RATE ADAPTIVE CARDIAC PACING SYSTEMS AND METHODS 审中-公开
标题翻译：速率自适应心脏起搏系统和方法
公开(公告)号：WO2008079840A2
公开(公告)日：2008-07-03
申请号：PCT/US2007/088042
申请日：2007-12-19
申请人： CARDIAC PACEMAKERS, INC. , SHUROS, Allan, Charles , HOPPER, Donald, L. , KANE, Michael, John
发明人： SHUROS, Allan, Charles , HOPPER, Donald, L. , KANE, Michael, John
IPC分类号： G06F19/00
CPC分类号： A61N1/36585 , G06F19/00 , G06F19/3418 , G06F19/3481
摘要： The invention relates to cardiac rhythm management systems, and more particularly, to rate adaptive cardiac pacing systems and methods. In an embodiment, the invention includes a method for providing rate-adaptive cardiac pacing therapy from an implantable medical device, the method including sensing a pulmonary function of a patient; determining a rate of change in the pulmonary function; sensing a cardiac function of the patient; determining a rate of change in the cardiac function; and calculating a target pacing rate based on an existing pacing rate, the rate of change in the pulmonary function, and the rate of change in the cardiac function. In an embodiment, the invention includes a method of controlling a cardiac rhythm management device in response to exertion of a patient, the method including sensing the patient's pulmonary function at a first time t 1 and at a second time t 2 ; calculating a rate of change of the pulmonary function between time t 1 and time t 2 ; sensing the patient's cardiac function at time t 3 and t 4 ; calculating a rate of change of the cardiac function between time t 3 and time t 4 ; and setting a desired pacing rate. Embodiments of the invention also include cardiac rhythm management devices.
摘要翻译：本发明涉及心律管理系统，并且更具体地涉及对自适应心脏起搏系统和方法进行评级。在一个实施例中，本发明包括一种用于从可植入医疗设备提供速率自适应心脏起搏治疗的方法，所述方法包括感测患者的肺功能; 确定肺功能的变化率; 感测患者的心脏功能; 确定心脏功能的变化率; 并且基于现有的起搏速率，肺功能的变化率以及心功能的变化率来计算目标起搏速率。在一个实施例中，本发明包括响应于患者的运动而控制心律管理装置的方法，该方法包括在第一时间t 1和第二时间检测患者的肺功能 t _{2 ; 计算在时间t 1和时间t 2之间的肺功能的变化率; 在时间t 3和t 4时感测患者的心脏功能; 计算在时间t 3和时间t 4之间的心脏功能的变化率; 并设定所需的起搏速率。本发明的实施例还包括心律管理装置。}

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