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1. 发明申请

WO1988007874A1 A DOSAGE UNIT FOR DOSING A NUMBER OF MEASURED QUANTITIES OF A LIQUID, SUCH AS AN INSULIN PREPARATION, FROM A CONTAINER, PREFERABLY A CARTRIDGE 审中-公开
标题翻译：用于计量液体量测量数量的剂量单位，例如胰岛素制备，来自容器，优先选择一个盒子
公开(公告)号：WO1988007874A1
公开(公告)日：1988-10-20
申请号：PCT/DK1988000064
申请日：1988-04-07
申请人： D.C.P. AF 1988 A/S , BONNICHSEN, Fritz, Frydendal , SIMON, Bernd , HOLM, Niels, Erik
发明人： D.C.P. AF 1988 A/S
IPC分类号： A61M05/315
CPC分类号： A61M5/3158 , A61M5/31551 , A61M5/31563 , A61M5/31593 , G01F11/023
摘要： A syringe, having means for adjustment of the dosage of liquid to be injected, comprises a piston rod (18) which is slidable in a cylindrical casing (1). A first ratchet means (17) is provided between the casing (1) and the piston rod (13) allowing the piston rod (13) to be displaced only in the expelling direction. The adjustment means (20) comprises an inner thread (21) in engagement with an outer thread (19) provided on the outside of the casing (1), so that the adjustment means (20) will be longitudinally displaced in relation to the casing (1), when rotated in relation thereto. One end of the adjustment means (20) forms a stop, against which a head (22) on the piston rod (13) will abut, when the rod (13) is displaced. Thus, the stroke of the piston rod (13) is limited by the adjustment means (20). A second ratchet means (32) is provided between the adjustment means (20) and the casing (1), so that the adjustment means (20) can be rotated and longitudinally displaced only in one direction relatively to the casing (1). The syringe enables precise adjustment of a desired dosage and is prevented from being inadvertently reused when empty.

2. 发明申请

WO2010020254A1 MULTILAYERED BLOOD PRODUCT 审中-公开
标题翻译：多层血液制品
公开(公告)号：WO2010020254A1
公开(公告)日：2010-02-25
申请号：PCT/DK2009/050209
申请日：2009-08-24
申请人： REAPPLIX APS , LUNDQUIST, Rasmus , HOLM, Niels, Erik
发明人： LUNDQUIST, Rasmus , HOLM, Niels, Erik
IPC分类号： A61K35/14 , A61K38/36 , A61L24/10 , B01L3/14
CPC分类号： A61K35/19 , A61K35/15 , A61K35/33 , A61K38/15 , A61K38/17 , A61K38/36 , A61K38/363 , A61L24/106 , A61L26/0042 , B04B5/04 , B04B2005/0485 , C12N5/0642 , C12N5/0644 , C12N2501/905 , A61K2300/00
摘要： A blood product (10), a method for preparing the blood product, a blood product obtainable by the method and a blood product preparing container means. The blood product comprises components from whole blood, especially fibrin, thrombocytes and leukocytes. The blood product (10) comprises a first layer (21), a second layer (22) and a third layer (23). The second layer (22) is adjacent to the first layer (21) and the third layer (23). The first layer (21) defines a first outer surface (24) of the blood product (10) and the third layer (23) defining a second outer surface (25) of the blood product (10). The first layer (21) comprises a majority of fibrin, the second layer (22) comprises a majority of thrombocytes and the third layer (23) comprises a majority of leukocytes.
摘要翻译：血液制品（10），制备血液制品的方法，通过该方法获得的血液制品和血液制品制备容器装置。血液制品包括来自全血，特别是纤维蛋白，凝血细胞和白细胞的组分。血液制品（10）包括第一层（21），第二层（22）和第三层（23）。第二层（22）与第一层（21）和第三层（23）相邻。第一层（21）限定血液制品（10）的第一外表面（24）和限定血液制品（10）的第二外表面（25）的第三层（23）。第一层（21）包含大多数纤维蛋白，第二层（22）包含大多数血小板，第三层（23）包含白细胞的大部分。

3. 发明申请

WO2007121748A3 IMPROVED FIBRIN SEALANT COMPOSITION AND ITS USE 审中-公开
公开(公告)号：WO2007121748A3
公开(公告)日：2007-11-01
申请号：PCT/DK2007/000188
申请日：2007-04-20
申请人： HOLM, Niels, Erik
发明人： HOLM, Niels, Erik
IPC分类号： A61L24/10 , A61L26/00
摘要： The wound healing process may be augmented by the addition of fibrin sealant. Dependent on the sealant composition and way of application the wound healing process and tissue regeneration may be further accelerated. The present invention provides for an improved sealant composition and its use.

4. 发明申请

WO1996016714A1 METHOD AND DEVICE FOR SEPARATING FIBRIN MONOMER FROM BLOOD PLASMA 审中-公开
标题翻译：用于从血浆等离子体分离纤维素单体的方法和装置
公开(公告)号：WO1996016714A1
公开(公告)日：1996-06-06
申请号：PCT/US1995015669
申请日：1995-12-01
申请人： E.R. SQUIBB AND SONS, INC. , HOLM, Niels, Erik , EDWARDSON, Peter, Andrew, David
发明人： E.R. SQUIBB AND SONS, INC.
IPC分类号： B01D21/26
CPC分类号： G01N33/491 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0449 , A61M2202/045 , B01D21/01 , B01D21/08 , B01D21/20 , B01D21/2405 , B01D21/26 , B01D21/262 , B01D2221/10 , B04B5/0442 , B04B2005/0485 , Y10T436/111666 , Y10T436/25375
摘要： A device for separating components such as fibrin monomer from blood by centrifugation about a central axis comprising a first annular chamber (70) defined by an outer cylindrical wall (72) and an inner cylindrical wall (71) both walls being concentrically accommodated about an axis of rotation, and by a top wall (73) and a bottom wall (74), where the bottom wall is formed by a piston (55) displaceable within the first chamber. The device including a second chamber (75) below the first chamber and communicating with the first chamber through a first conduit (4) and being defined by said outer cylindrical wall (72), the bottom wall (74) of the first chamber, and another bottom wall (76). The device also includes a capsule (45) accommodated in the second chamber and including a plurality of compartments for receiving respective compositions promoting the separation.
摘要翻译：用于通过围绕包括由外圆柱形壁（72）和内圆柱形壁（71）限定的第一环形室（70））的中心轴离心分离诸如纤维蛋白单体的组分与血液的装置，所述两个壁围绕轴线同心地容纳的旋转，以及顶壁（73）和底壁（74），其中底壁由在第一室内可移位的活塞（55）形成。所述装置包括在第一室下方的第二室（75），并通过第一导管（4）与第一室连通并由所述外圆筒壁（72），第一室的底壁（74）限定，以及另一个底壁（76）。该装置还包括容纳在第二室中的胶囊（45），并且包括多个隔室，用于接收促进分离的相应组合物。

5. 发明申请

WO1996016713A1 CENTRIFUGE REAGENT DELIVERY SYSTEM 审中-公开
标题翻译：离心试剂递送系统
公开(公告)号：WO1996016713A1
公开(公告)日：1996-06-06
申请号：PCT/US1995015667
申请日：1995-12-01
申请人： E.R. SQUIBB AND SONS, INC. , HOLM, Niels, Erik
发明人： E.R. SQUIBB AND SONS, INC.
IPC分类号： B01D21/26
CPC分类号： B01D21/262 , B01D21/2405 , B01D21/2427 , B01D2221/10 , B04B1/02 , B04B5/0442 , B04B2005/0485 , Y10T137/87676 , Y10T436/111666 , Y10T436/25375
摘要： A device for separating components such as fibrin monomer from blood by centrifugation about a central axis comprising a first annular chamber (70) defined by an outer cylindrical wall (72) and an inner cylindrical wall (71) both walls being concentrically accommodated about an axis of rotation, and by a top wall (73) and a bottom wall (74), where the bottom wall is formed by a piston (55) displaceable within the first chamber. The device including a second chamber (75) below the first chamber and communicating with the first chamber through a first conduit (4) and being defined by the outer cylindrical wall (72), the bottom wall (74) of the first chamber, and another bottom wall (76). The device also includes a capsule (45) accommodated in the second chamber and including a plurality of compartments for receiving respective compositions promoting the separation.
摘要翻译：一种用于通过围绕包括由外圆柱形壁（72）和内圆柱形壁（71）限定的第一环形室（70））的中心轴离心分离诸如纤维蛋白单体的组分与血液的装置，两个壁围绕轴线同心地容纳的旋转，以及顶壁（73）和底壁（74），其中底壁由可在第一室内移位的活塞（55）形成。该装置包括在第一室下方的第二室（75），并通过第一导管（4）与第一室连通并由第二室的外圆筒壁（72），第一室的底壁（74）限定，以及另一个底壁（76）。该装置还包括容纳在第二室中的胶囊（45），并且包括多个隔室，用于接收促进分离的相应组合物。

6. 发明申请

WO1991017778A1 AN APPARATUS FOR PREPARING A CONCENTRATE OF COAGULATION FACTORS, SUCH AS FIBRINOGEN, FROM A BLOOD SAMPLE 审中-公开
标题翻译：用于制备凝血因子浓度的装置，如来自血液样品的纤维蛋白原
公开(公告)号：WO1991017778A1
公开(公告)日：1991-11-28
申请号：PCT/DK1991000131
申请日：1991-05-14
申请人： UNES A/S , WEIS-FOGH, Ulla , HERN, Soren , HOLM, Niels, Erik
发明人： UNES A/S
IPC分类号： A61M01/36
CPC分类号： A61M1/3693 , A61M1/369 , A61M2202/0449 , C07K14/75
摘要： An apparatus for preparing a concentrate of coagulation factors, such as fibrinogen, from a blood sample, comprises a first chamber (14) for collection and separation of said blood sample so as to separate a plasma fraction, and a second chamber (15) for collection of said plasma fraction through a tubing member (22, 30) and a valve (24) and for precipitation of said concentrate. The apparatus comprises furthermore a removable syringe (36) for receiving the concentrate from the second chamber (15) through a tubing member (32). The first and the second chamber (14, 15) are partially defined by the same integrally formed solid container wall (2) and comprise a common partition. The first chamber (14) is further defined by a piston (4) displaceable both in connection with the blood sample collection and the transfer of said plasma fraction to the second chamber (15) and in connection with returning said plasma fraction to the first chamber (14) upon the precipitation of the concentrate.
摘要翻译：一种用于从血液样品制备凝血因子如纤维蛋白原的浓缩物的装置包括用于收集和分离所述血液样品以分离血浆分数的第一腔室（14）和用于通过管道构件（22,30）和阀（24）收集所述血浆部分并且用于沉淀所述浓缩物。该装置还包括用于通过管道构件（32）从第二室（15）接收浓缩物的可移除注射器（36）。第一和第二室（14,15）由同一整体形成的固体容器壁（2）部分地限定，并且包括公共隔板。第一腔室（14）由活塞（4）进一步限定，活塞（4）可以与血液样品收集和所述等离子体部分转移到第二腔室（15）并且将所述血浆部分返回到第一腔室（14）浓缩物沉淀后。

7. 发明申请

WO2012037942A1 CONTAINER FOR USE WHEN PRODUCING A MULTI-LAYERED BLOOD PRODUCT 审中-公开
标题翻译：生产多层血液产品时使用的容器
公开(公告)号：WO2012037942A1
公开(公告)日：2012-03-29
申请号：PCT/DK2011/050354
申请日：2011-09-20
申请人： REAPPLIX APS , LUNDQUIST, Rasmus , HOLM, Niels Erik
发明人： LUNDQUIST, Rasmus , HOLM, Niels Erik
IPC分类号： A61M1/36 , B01L3/14
CPC分类号： B01D21/262 , A61M1/029 , A61M1/3633 , A61M1/3693 , B01L3/50215 , B01L2200/0689 , B01L2300/044 , B01L2300/0609 , B01L2300/0672 , B01L2300/0681 , B01L2400/0409
摘要： Container to be used for preparing a multi-layered blood product by centrifugation, said container comprising a substantially cylindrical body (2) with a closed bottom (3) and a top (4) having a filling opening as well as a filter device (15), which is slidable inside the container (1). The filling opening is closed by means of a penetrable membrane (13), and the filter device (15) comprises a substantially planar mesh (16) and a supporting buoyancy body (18). In addition to this, there are means (35, 36, 39, 40, 42), for releasable fixation of the filter device (15) adjacent to the bottom (3) of the container (1).
摘要翻译：用于通过离心制备多层血液制品的容器，所述容器包括具有封闭底部（3）的基本上圆柱形的本体（2）和具有填充开口的顶部（4）以及过滤装置（15）），其可在容器（1）内滑动。所述填充开口通过可穿透膜（13）封闭，所述过滤装置（15）包括基本上平面的网（16）和支撑浮力体（18）。除此之外，还有用于与容器（1）的底部（3）相邻的过滤装置（15）的可释放固定的装置（35,36,39,40,42）。

8. 发明申请

WO2010020247A1 MULTILAYERED BLOOD PRODUCT 审中-公开
标题翻译：多层血液制品
公开(公告)号：WO2010020247A1
公开(公告)日：2010-02-25
申请号：PCT/DK2008/000299
申请日：2008-08-22
申请人： REAPPLIX APS , LUNDQUIST, Rasmus , HOLM, Niels, Erik
发明人： LUNDQUIST, Rasmus , HOLM, Niels, Erik
IPC分类号： A61K35/14 , A61L15/64 , A61P17/02
CPC分类号： A61K35/19 , A61K35/15 , A61K35/33 , A61K38/15 , A61K38/17 , A61K38/36 , A61K38/363 , A61L24/106 , A61L26/0042 , B04B5/04 , B04B2005/0485 , C12N5/0642 , C12N5/0644 , C12N2501/905 , A61K2300/00
摘要： A blood product (10), a method for preparing the blood product, a blood product obtainable by the method and an apparatus for performing the method. The blood product comprises components from whole blood, especially fibrin, thrombocytes and leukocytes. The blood product (10) comprises a first layer (21), a second layer (22) and a third layer (23). The second layer (22) is adjacent to the first layer (21) and the third layer (23). The first layer (21) defines a first outer surface (24) of the blood product (10) and the third layer (23) defining a second outer surface (25) of the blood product (10). The first layer (21) comprises a majority of fibrin, the second layer (22) comprises a majority of thrombocytes and the third layer (23) comprises a majority of leukocytes.
摘要翻译：血液制品（10），制备血液制品的方法，通过该方法获得的血液制品和用于执行该方法的装置。血液制品包括来自全血，特别是纤维蛋白，凝血细胞和白细胞的组分。血液制品（10）包括第一层（21），第二层（22）和第三层（23）。第二层（22）与第一层（21）和第三层（23）相邻。第一层（21）限定血液制品（10）的第一外表面（24）和限定血液制品（10）的第二外表面（25）的第三层（23）。第一层（21）包含大多数纤维蛋白，第二层（22）包含大多数血小板，第三层（23）包含白细胞的大部分。

9. 发明申请

WO2007121748A2 IMPROVED FIBRIN SEALANT COMPOSITION AND ITS USE 审中-公开
标题翻译：改进的FIBRIN密封剂组合物及其用途
公开(公告)号：WO2007121748A2
公开(公告)日：2007-11-01
申请号：PCT/DK2007000188
申请日：2007-04-20
申请人： HOLM NIELS ERIK
发明人： HOLM NIELS ERIK
IPC分类号： A61L24/10 , A61L24/04 , A61L26/00 , A61L31/04
CPC分类号： A61L26/0042 , A61L24/106
摘要： The wound healing process may be augmented by the addition of fibrin sealant. Dependent on the sealant composition and way of application the wound healing process and tissue regeneration may be further accelerated. The present invention provides for an improved sealant composition and its use.
摘要翻译：通过添加纤维蛋白密封剂可以增加伤口愈合过程。根据密封剂组合物和施用方式，可以进一步加速伤口愈合过程和组织再生。本发明提供改进的密封剂组合物及其用途。

10. 发明申请

WO2002066833A1 HOSE PUMP 审中-公开
标题翻译：软管泵
公开(公告)号：WO2002066833A1
公开(公告)日：2002-08-29
申请号：PCT/DK2002/000113
申请日：2002-02-20
申请人： N.E. HOLM A/S , HOLM, Niels, Erik , LINNEBJERG, Steven
发明人： HOLM, Niels, Erik , LINNEBJERG, Steven
IPC分类号： F04B43/12
CPC分类号： F04B43/1276
摘要： A hose pump comprises a housing (1) with a circularly curving wall surface (8) and a rotatable support means (9) carrying a plurality of rollers (22, 23, 24), where said support means is adapted to press said rollers (22, 23, 24) against the circular wall surface (8) and to cause said rollers (22, 23, 24) to propel a fluid through a hose, a length of said hose being arranged between the wall surface (8) and the rollers (22, 23, 24). The support means (9) of the rollers (22, 23, 24) is connected to said rollers (22, 23, 24) by means of a displacing mechanism (15 to 18, 30 to 33) adapted to move the rollers (22, 23, 24) into a squeezing engagement with the hose length in question when the support means (9) is turned in the fluid propelling direction and to pull said rollers (22, 23, 24) out of said engagement when said support means is turned in the opposite direction.
摘要翻译：软管泵包括具有圆形弯曲壁表面（8）的壳体（1）和承载多个辊（22,23,24）的可旋转支撑装置（9），其中所述支撑装置适于将所述辊 22,23,24）抵靠所述圆形壁表面（8）并使所述辊（22,23,24）通过软管推动流体，所述软管的长度被布置在所述壁表面（8）和辊（22,23,24）。辊（22,23,24）的支撑装置（9）通过适于移动辊（22）的位移机构（15至18,30至33）连接到所述辊（22,23,24），23,24）当所述支撑装置（9）在所述流体推进方向上转动时与所述软管长度挤压接合，并且当所述支撑装置是所述支撑装置是所述支撑装置时，将所述辊（22,23,24）拉出所述接合转向相反的方向。

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