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1. 发明申请

WO1995005806A1 MICROPARTICLES, PROCESSES FOR THEIR PREPARATION AND THEIR USE FOR THE PREPARATION OF MEDICAMENTS 审中-公开
标题翻译：微生物，其制备方法及其用于制备药物的用途
公开(公告)号：WO1995005806A1
公开(公告)日：1995-03-02
申请号：PCT/EP1994002749
申请日：1994-08-18
申请人： HENNING BERLIN ANLAGEN GMBH , LAHR, Wolfgang
发明人： HENNING BERLIN ANLAGEN GMBH
IPC分类号： A61K09/16
CPC分类号： A61K9/1694 , A61K9/1635
摘要： Microparticles in the form of particles of a coagulum of an aqueous poly(meth)acrylate dispersion containing one or more useful substances which are slightly soluble or insoluble in water can be prepared by preparing a suspension of one or more useful substances which are slightly soluble or insoluble in an aqueous medium, in particular pharmaceutical active substances, in the aqueous phase of an aqueous poly(meth)acrylate dispersion and carrying out controlled coagulation of the poly(meth)acrylate particles of the dispersion, preferably by adding a solution of a strong electrolyte.
摘要翻译：含有一种或多种微溶于水或不溶于水的有用物质的含聚（甲基）丙烯酸酯水溶液的凝结物颗粒形式的微粒可以通过制备一种或多种微溶或在聚（甲基）丙烯酸酯水分散体的水相中不溶于水性介质，特别是药物活性物质，并进行分散体的聚（甲基）丙烯酸酯颗粒的受控凝结，优选通过加入强的电解质。

2. 发明申请

WO1995006258A1 METHOD FOR THE DETERMINATION OF AN ANALYTE AND ITS USE FOR THE DETERMINATION OF ANTI-TSH RECEPTOR AUTOANTIBODIES IN A PATIENT SERUM 审中-公开
标题翻译：用于测定分析物的方法及其用于测定患者血清中抗TSH受体自身抗体的方法
公开(公告)号：WO1995006258A1
公开(公告)日：1995-03-02
申请号：PCT/EP1994002748
申请日：1994-08-18
申请人： HENNING BERLIN ANLAGEN GMBH , BERGMANN, Andreas , STRUCK, Joachim , KORNFELD, Shaul
发明人： HENNING BERLIN ANLAGEN GMBH
IPC分类号： G01N33/74
CPC分类号： G01N33/54306 , G01N33/564 , G01N33/78 , G01N2800/24
摘要： Method for the determination of an analyte in a volume of a fluid sample, in particular of anti-TSH receptor autoantibodies in a patient serum, in which one or more determination reagent(s) which contains or which contain a) a predetermined amount of a binder (B) for the analyte (A) and b) a predetermined amount of a competitor (K) which is likewise bound by the binder (B), in such a way that the extent of its binding to the binder (B) is correlated with the simultaneous presence of the analyte (A) and/or its amount in the sample, the competitor (K) being labelled, or being capable of being labelled, with a label which permits its qualitative and/or quantitative determination, is or are added to the sample with the formation of a liquid reaction mixture, wherein c) the liquid reaction mixture is reacted simultaneously or subsequently with a solid phase to which a substance (Imm) for the selective immobilization of the amount of competitor (K) not bound to the binder (B) is bound, and optionally with a labelled reactant (Label) for the immobilized competitor (K), and after a quantitative separation of the solid phase from the liquid reaction mixture, the amount of the competitor (K) bound to the solid phase is determined in a manner known per se by means of physical and/or chemical detection of the label bound to said competitor, and the determined amount of said competitor (K) is correlated with the presence and/or amount of the analyte (A) in the original sample.
摘要翻译：用于测定流体样品体积，特别是患者血清中抗TSH受体自身抗体的分析物的方法，其中一种或多种测定试剂含有或含有a）预定量的用于分析物（A）的粘合剂（B）和b）预定量的同样由粘合剂（B）结合的竞争剂（K），使得其与粘合剂（B）的结合程度为与分析物（A）的同时存在和/或其在样品中的量，被标记的竞争剂（K）或能够被标记的允许其定性和/或定量测定的标记是或被添加到样品中，形成液体反应混合物，其中c）液体反应混合物同时或随后与固相反应，物质（Imm）用于选择性地固定竞争剂（K）的量不与粘合剂（B）结合，o 用固定化的竞争剂（K）的标记反应物（Label）分批，并且在从液体反应混合物定量分离固相之后，以已知的方式测定与固相结合的竞争剂（K）的量本身通过物理和/或化学检测与所述竞争者结合的标签，并且确定的所述竞争者（K）的量与原始样品中分析物（A）的存在和/或量相关。

3. 发明申请

WO1995002824A1 METHOD AND KIT FOR THE QUANTITATIVE DETERMINATION OF HUMAN THYROID PEROXIDASE 审中-公开
标题翻译：人THYROID过氧化物定量测定的方法和工具包
公开(公告)号：WO1995002824A1
公开(公告)日：1995-01-26
申请号：PCT/EP1994001771
申请日：1994-05-31
申请人： HENNING BERLIN ANLAGEN GMBH , WECKERMANN, Renate , BERGMANN, Andreas
发明人： HENNING BERLIN ANLAGEN GMBH
IPC分类号： G01N33/573
CPC分类号： G01N33/573 , G01N33/564 , G01N33/57488 , G01N2333/08
摘要： Method for the quantitative determination of human thyroid peroxidase (hTPO) in biological fluids, culture media, tissue extracts and fluids containing highly purified natural hTPO or recombinant hTPO, in which the determination is carried out as a sandwich assay known per se, using a first monoclonal antibody against hTPO and at least one further monoclonal antibody against hTPO (MAB1, MAB2), of which the former (MAB1) recognises hTPO in a region which is sensitive to denaturing and is involved in the binding of the autoantibodies against hTPO and in enzyme inhibition, while the one or more further antibodies (MAB2) recognises hTPO in a region whose binding properties are not essentially impaired by denaturing of hTPO.
摘要翻译：用于定量测定生物流体，培养基，组织提取物和含有高度纯化的天然hTPO或重组hTPO的液体中的人类甲状腺过氧化物酶（hTPO）的方法，其中测定作为本身已知的夹心测定，使用第一针对hTPO的单克隆抗体和至少一种针对hTPO（MAB1，MAB2）的另外的单克隆抗体，其前者（MAB1）在对变性敏感并参与自身抗体与hTPO和酶结合的区域中识别hTPO 而一个或多个其他抗体（MAB2）在其结合特性基本上不受hTPO变性影响的区域中识别hTPO。

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