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1. 发明申请

WO2007014379A3 A LIPIDIC EXTRACT FROM LEPIDIUM MEYNII AND ITS EFFECT ON THE LIBIDO 审中-公开
标题翻译：一种甘草提取物的脂提取物及其对利比多的影响
公开(公告)号：WO2007014379A3
公开(公告)日：2007-05-24
申请号：PCT/US2006029720
申请日：2006-07-26
申请人： NATUREX , ZHENG QUN YI , ZHENG BO LIN , HE KAN
发明人： ZHENG QUN YI , ZHENG BO LIN , HE KAN
IPC分类号： A61K36/31 , A61P15/10
CPC分类号： A61K36/31 , A61K31/165 , A61K31/198 , A61K31/26 , A61K31/56 , A61K2300/00
摘要： The present invention relates to compositions containing particular components that can be obtained from a plant which can have pharmaceutical applications. More particularly, the plant genus is Lepidium and the composition may contain in the range of between about .3% and .7% of benzyl isothiocyanate, b) between about .06% and about .02% of Lepidium sterol component, c) between about 1% and about 2% of a Lepidium fatty acid component, and d) about .006% to .6% or more total macamide/macaenes component as standardized with excipients.
摘要翻译：本发明涉及含有可从具有药物应用的植物获得的特定组分的组合物。更特别的是，植物属是Lepidium，组合物可含有约0.3％至0.7％的异硫氰酸苄酯，b）约0.06％至约0.02％的Lepidium甾醇组分，c）约1％至约2％的Lepidium脂肪酸组分，和d）用赋形剂标准化的总计macamide / macaenes组分约0.006％至0.6％或更多。

2. 发明申请

WO0051548A3 COMPOSITIONS AND METHODS FOR THEIR PREPARATION FROM LEPIDIUM 审中-公开
标题翻译：用于制备LEPIDIUM的组合物和方法
公开(公告)号：WO0051548A3
公开(公告)日：2001-11-15
申请号：PCT/US0005607
申请日：2000-03-03
申请人： PURE WORLD BOTAN INC , ZHENG BO LIN , KIM CALVIN HYUNGCHAN , WOLTHOFF STEPHEN , HE KAN , ROGERS LINGLING , SHAO YU , ZHENG QUN YI
发明人： ZHENG BO LIN , KIM CALVIN HYUNGCHAN , WOLTHOFF STEPHEN , HE KAN , ROGERS LINGLING , SHAO YU , ZHENG QUN YI
IPC分类号： A61K20060101 , A61K6/00 , A61K31/16 , A61K36/31 , C07C231/00 , C07C233/00 , C07C235/02 , A61K35/78
CPC分类号： A61K36/31
摘要： The invention relates to compositions that can be isolated from Lepidium plant material and to methods for their isolation. The compositions are useful for treating and preventing cancer and sexual dysfunction.
摘要翻译：本发明涉及可从Lepidium植物材料中分离的组合物及其分离方法。该组合物可用于治疗和预防癌症和性功能障碍。

3. 发明申请

WO2012116050A2 PHOSPHORUS CONTAINING COMPOUNDS AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：含有蛋白质的化合物作为蛋白激酶抑制剂
公开(公告)号：WO2012116050A2
公开(公告)日：2012-08-30
申请号：PCT/US2012/026083
申请日：2012-02-22
申请人： ETERNITY BIOSCIENCE INC. , HU, Baihua , HE, Kan , ZHANG, Minsheng
发明人： HU, Baihua , HE, Kan , ZHANG, Minsheng
IPC分类号： A61K31/675 , C07F9/58 , C07F9/6558 , C07F9/6509 , A61P35/00
CPC分类号： C07F9/582 , C07F9/588 , C07F9/650964 , C07F9/65583
摘要： The present invention relates to compounds represented by formula (I), which can modulate the activity of protein kinases. The invention also relates to a composition containing a compound of formula (I), and a method for synthesizing and using such compound for preventing or treating ALK or cMet mediated disorders or conditions.
摘要翻译：本发明涉及可以调节蛋白激酶活性的由式（I）表示的化合物。本发明还涉及包含式（I）化合物的组合物，以及用于合成和使用该化合物以预防或治疗ALK或cMet介导的病症或病症的方法。

4. 发明申请

WO2012125521A1 QUINAZOLINEDIONES AND THEIR USE 审中-公开
标题翻译：喹诺酮类及其用途
公开(公告)号：WO2012125521A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/028698
申请日：2012-03-12
申请人： ETERNITY BIOSCIENCE INC. , LIU, Dong , ZHANG, Minsheng , HE, Kan , ZHANG, Lianshan
发明人： LIU, Dong , ZHANG, Minsheng , HE, Kan , ZHANG, Lianshan
IPC分类号： C07D239/80
CPC分类号： C07D239/96 , C07D239/80 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04 , C07D487/04
摘要： The present invention discloses compounds of formula (I), or pharmaceutically acceptable salts or prodrugs thereof, which inhibit the poly(ADP-ribose) polymerases (PARP) and therefore are useful for treating diseases, disorders, and conditions related to PARP. The present invention also discloses pharmaceutical compositions comprising a compound of formula (I), and methods of using such compounds to inhibit PARP enzymes, and to treat diseases, disorders, and conditions related to PARP.
摘要翻译：本发明公开了抑制聚（ADP-核糖）聚合酶（PARP）的式（I）化合物或其药学上可接受的盐或前药，因此可用于治疗与PARP相关的疾病，病症和病症。本发明还公开了包含式（I）化合物的药物组合物，以及使用这些化合物抑制PARP酶以及治疗与PARP有关的疾病，病症和病症的方法。

5. 发明申请

WO2007014379A2 A LIPIDIC EXTRACT FROM LEPIDIUM MEYNII AND ITS EFFECT ON THE LIBIDO 审中-公开
标题翻译： LIPIDIC提取物从LEPIDIUM MEYNII及其对LIBIDO的影响
公开(公告)号：WO2007014379A2
公开(公告)日：2007-02-01
申请号：PCT/US2006/029720
申请日：2006-07-26
申请人： NATUREX , ZHENG, Qun Yi , ZHENG, Bo Lin , HE, Kan
发明人： ZHENG, Qun Yi , ZHENG, Bo Lin , HE, Kan
CPC分类号： A61K36/31 , A61K31/165 , A61K31/198 , A61K31/26 , A61K31/56 , A61K2300/00
摘要： The present invention relates to compositions containing particular components that can be obtained from a plant which can have pharmaceutical applications. More particularly, the plant genus is Lepidium and the composition may contain in the range of between about .3% and .7% of benzyl isothiocyanate, b) between about .06% and about .02% of Lepidium sterol component, c) between about 1% and about 2% of a Lepidium fatty acid component, and d) about .006% to .6% or more total macamide/macaenes component as standardized with excipients.
摘要翻译：本发明涉及包含可以从可以具有药物应用的植物获得的特定组分的组合物。更具体地，植物属是叶菜属，组合物可以含有约0.3％至0.7％的异硫氰酸苄酯，b）约0.06％至约0.02％的Lepidium甾醇组分，c）约1％和约2％的Lepidium脂肪酸组分，以及d）用赋形剂标准化的约0.006％至.6％或更多的总的macamide / macaenes组分。

6. 发明申请

WO2011047321A1 EXTRACT OF ROSMARINUS OFFICINALIS L. LEAVES FOR PHARMACEUTICAL APPLICATIONS 审中-公开
标题翻译：罗非鱼的提取L.药物应用的叶子
公开(公告)号：WO2011047321A1
公开(公告)日：2011-04-21
申请号：PCT/US2010/052925
申请日：2010-10-15
申请人： NATUREX S.A. , HE, Kan , ROLLER, Marc , IBARRA, Alvin , BAI, Naisheng , DIKANSKY, Jacques
发明人： HE, Kan , ROLLER, Marc , IBARRA, Alvin , BAI, Naisheng
IPC分类号： A61K36/53
CPC分类号： A61K36/53
摘要： Disclosed are methods of alleviating oxidative stress, regulating blood glucose levels, and controlling pancreatic lipase activity by administering a Rosemary extract. Such methods may be useful to help body weight and body fat, prevent obesity, and treat hyperglycemia, hyperinsulinemia, cardiovascular disease and Type-2 diabetes. Preferred extracts contain 20% or 50% carnosic acid.
摘要翻译：公开了通过施用迷迭香提取物来减轻氧化应激，调节血糖水平和控制胰脂肪酶活性的方法。这些方法可用于帮助体重和身体脂肪，预防肥胖，以及治疗高血糖症，高胰岛素血症，心血管疾病和2型糖尿病。优选的提取物含有20％或50％的鼠尾草酸。

7. 发明申请

WO2009061849A1 EXTRACT OF FRAXINUS EXCELSIOR SEEDS AND THERAPEUTIC APPLICATIONS THEREFOR 审中-公开
标题翻译： FRAXINUS EXCELSIOR种子的提取及其治疗应用
公开(公告)号：WO2009061849A1
公开(公告)日：2009-05-14
申请号：PCT/US2008/082524
申请日：2008-11-05
申请人： NATUREX , BAI, Naisheng , DIKANSKY, Jacques , HE, Kan , ROLLER, Marc , BILY, Antoine , IBARRA, Alvin
发明人： HE, Kan , ROLLER, Marc , BILY, Antoine , IBARRA, Alvin
IPC分类号： A61Q9/00
CPC分类号： A61K36/63 , A61K31/7088
摘要： A Fraxinus excelsior seed extract that can be administered for therapeutic treatment of a subject, including a human, by blocking fat synthesis, activating PPAR-alpha, increasing hypoglycemic activity, reducing bodyweight, controlling fasting plasma insulin levels against hyperinsulinemia, and promoting insulin sensitivity and causing a beneficial acute insulinotropic effect. The Fraxinus excelsior seed extract includes, inter alia, an isolated compound (2S, 3E, 4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-β-D-glucopyranosyl-β-D- glucopyranosyl) oxy]-3,4-dihydro-5-(methoxycarbonyl) methyl ester, commonly called excelside A, an isolated compound (2S, 3E, 4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O- β-D-glucopyranosyl-β-D-glucopyranosyl) oxy]-3,4-dihydro-5-(methoxycarbonyl) 2-(4- hydroxyphenyl) ethyl ester, commonly called excelside B, and the compounds GI5, GI3, nuzhenide, and oleoside dimethyl ester.
摘要翻译：可以通过阻断脂肪合成，激活PPAR-α，增加降血糖活性，降低体重，控制空腹血浆胰岛素水平对抗高胰岛素血症，以及促进胰岛素敏感性以及促进胰岛素敏感性的方法，将可以用于治疗受试者包括人的Fraxinus excelsior种子提取物引起有益的急性促胰岛素作用。 Fraxinus excelsior种子提取物尤其包括分离的化合物（2S，3E，4S）2H-吡喃-4-乙酸-3-亚乙基-2 - [（6-O-β-D-吡喃葡萄糖基-β-D - 吡喃葡萄糖基）氧基] -3,4-二氢-5-（甲氧基羰基）甲酯，通常称为excelside A，分离的化合物（2S，3E，4S）2H-吡喃-4-乙酸-3-亚乙基-2- 氧基] -3,4-二氢-5-（甲氧基羰基）2-（4-羟基苯基）乙酯（通常称为excelside B）的化合物和化合物（6-O-D-D-吡喃葡萄糖基-β- GI5，GI3，nunzhenide和油脂二甲酯。

8. 发明申请

WO2012116050A3 PHOSPHORUS CONTAINING COMPOUNDS AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：含有蛋白质的化合物作为蛋白激酶抑制剂
公开(公告)号：WO2012116050A3
公开(公告)日：2014-04-17
申请号：PCT/US2012026083
申请日：2012-02-22
申请人： JIANGSU HANSOH PHARMACEUTICAL CO LTD , HU BAIHUA , HE KAN , ZHANG MINSHENG
发明人： HU BAIHUA , HE KAN , ZHANG MINSHENG
IPC分类号： A61K31/4706 , A61K31/4709
CPC分类号： C07F9/582 , C07F9/588 , C07F9/650964 , C07F9/65583
摘要： The present invention relates to compounds represented by formula (I), which can modulate the activity of protein kinases. The invention also relates to a composition containing a compound of formula (I), and a method for synthesizing and using such compound for preventing or treating ALK or cMet mediated disorders or conditions.
摘要翻译：本发明涉及可以调节蛋白激酶活性的由式（I）表示的化合物。本发明还涉及包含式（I）化合物的组合物，以及用于合成和使用该化合物以预防或治疗ALK或cMet介导的病症或病症的方法。

9. 发明申请

WO2010129307A1 APPLICATION OF AMERICAN GINSENG TO ENHANCE NEUROCOGNITIVE FUNCTION 审中-公开
标题翻译：美国金森应用于增强神经元功能
公开(公告)号：WO2010129307A1
公开(公告)日：2010-11-11
申请号：PCT/US2010/032629
申请日：2010-04-27
申请人： NATUREX S.A. , SCHOLEY, Andrew , IBARRA, Alvin , HE, Kan , ROLLER, Marc , DIKANSKY, Jacques
发明人： SCHOLEY, Andrew , IBARRA, Alvin , HE, Kan , ROLLER, Marc
IPC分类号： A61K36/254 , A61K36/258
CPC分类号： A61K36/258
摘要： Disclosed are methods of enhancing neurocognitive function by administering of American Ginseng. Preferred dosages in the range of 5 to 50 mg total genosides enhance cognitive function-including, improvement of working memory (WM) performance, attentional performance (e.g., Choice Reaction Time accuracy), and calmness.
摘要翻译：公开的是通过施用美国人参来增强神经认知功能的方法。优选的剂量范围为5至50mg的总苷类增强了认知功能，包括改善工作记忆（WM）性能，注意性能（例如，选择反应时间精度）和平静度。

10. 发明申请

WO2006017157A1 WEIGHT LOSS COMPOSITION 审中-公开
标题翻译：重量损失组成
公开(公告)号：WO2006017157A1
公开(公告)日：2006-02-16
申请号：PCT/US2005/024218
申请日：2005-07-08
申请人： PURE WORLD BOTANICALS, INC. , ZHENG, Qun Yi , ZHENG, Bo Lin , HE, Kan , CUI, Bao Liang , BAI, Naisheng
发明人： ZHENG, Qun Yi , ZHENG, Bo Lin , HE, Kan , CUI, Bao Liang , BAI, Naisheng
IPC分类号： A61K35/78
CPC分类号： A61K31/375 , A23L33/105 , A23L33/30 , A61K31/198 , A61K36/185 , A61K36/48 , A61K36/484 , A61K36/704 , A61K36/75 , A61K36/82 , A61K2300/00
摘要： The present invention provides a dietary supplement and methods of using the same to promote body weight reduction and/or loss of body fat in a subject, and for the management of obesity. The supplement can further be used to reduce one or more metabolic parameters in a subject, such as blood glucose levels, blood triglyceride levels, and blood cholesterol levels.
摘要翻译：本发明提供了一种膳食补充剂及其使用方法，以促进受试者体重减轻和/或体内脂肪的丧失，以及肥胖的管理。该补充剂可进一步用于减少受试者中的一种或多种代谢参数，例如血糖水平，血液甘油三酯水平和血液胆固醇水平。

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