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1. 发明申请

WO2023278199A1 SYSTEMS AND METHODS FOR PERSONALIZED ULTRASOUND NEUROMODULATION 审中-公开
公开(公告)号：WO2023278199A1
公开(公告)日：2023-01-05
申请号：PCT/US2022/034295
申请日：2022-06-21
申请人： CARNEGIE MELLON UNIVERSITY , HE, Bin , YU, Kai
发明人： HE, Bin , YU, Kai
IPC分类号： A61N7/00 , A61B8/00
摘要： Disclosed herein is a system and method for implementing a personalized ultrasound neuromodulation system and methods with neural sensing of personalized electrophysiological data, guiding ultrasound targeting and dosage using such personalized data. Specific ultrasound transducer solutions are provided for various neural targets that enable the low-intensity focused ultrasound to modulate the central nervous system and peripheral nervous systems to treat a variety of neurological and mental disorders. A portable ultrasound console device, a wearable guiding apparatus and a compact solution for effectively and safely enabling point-of-care neuromodulation, e.g., home healthcare, are provided. Further methods for ultrasound waveform customization are also described to improve effectiveness of ultrasound neuromodulation.

2. 发明申请

WO2011088005A1 AN ANTI-THEFT SYSTEM AND METHOD FOR A MACHINE HAVING A COMMUNICATION DEVICE AND WORK IMPLEMENT 审中-公开
标题翻译：具有通信设备和工作实现的机器的防盗系统和方法
公开(公告)号：WO2011088005A1
公开(公告)日：2011-07-21
申请号：PCT/US2011/020747
申请日：2011-01-11
申请人： CATERPILLAR INC. , HE, Bin , HE, Jie , XU, Gang , LIANG, Baobao , SHAN, Liang , YANG, Haibin , ZHANG, Kankan
发明人： HE, Bin , HE, Jie , XU, Gang , LIANG, Baobao , SHAN, Liang , YANG, Haibin , ZHANG, Kankan
IPC分类号： G08B13/14
CPC分类号： B60R25/04 , B60R2325/308
摘要： An anti-theft system for a machine having a communication device and a work implement. The system may comprise a controller configured to verify the machine status in response to a shutdown command received by the communication device and generate a shutdown signal. The system may also comprise a shutdown device in communication with the controller and configured to disable a machine start circuit in response to the shutdown signal. The controller may be further configured to disable the work implement in response to no signal from the shutdown device.
摘要翻译：一种具有通信装置和工作装置的机器的防盗系统。系统可以包括控制器，其被配置为响应于由通信设备接收的关闭命令来验证机器状态并产生关闭信号。系统还可以包括与控制器通信的关闭装置，并且被配置为响应于关闭信号来禁用机器启动电路。控制器还可以被配置为响应于没有来自关机装置的信号来禁用工作装置。

3. 发明申请

WO2007134190A2 METHODS AND APPARATUS OF THREE DIMENSIONAL CARDIAC ELECTROPHYSIOLOGICAL IMAGING 审中-公开
标题翻译：三维心脏电生理学成像的方法与装置
公开(公告)号：WO2007134190A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/068702
申请日：2007-05-10
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , HE, Bin , LIU, Zhongming , LIU, Chenguang
发明人： HE, Bin , LIU, Zhongming , LIU, Chenguang
IPC分类号： A61B5/042
CPC分类号： A61B5/0422 , A61B5/0044 , A61B6/503 , A61B6/5247 , A61B8/0883 , A61B2018/00839 , G06F19/00 , G06K9/0057
摘要： Generating a three-dimensional representation of cardiac electrical activity within a subject's heart includes collecting, from a catheter having a distal portion that includes sensors that sense electrical activity and which catheter distal portion is positioned within a cardiac chamber of a subject, data for electrical activity sensed by the catheter distal portion while positioned within the chamber of the heart. The method also includes executing an imaging algorithm on the collected electrical activity data to generate a three-dimensional representation of cardiac electrical activity within a volume of the subject including all or a portion of the subject's heart. The method further includes displaying the imaged three-dimensional cardiac electrical activity.
摘要翻译：在受试者的心脏内产生心脏电活动的三维表示包括从具有远端部分的导管收集，所述远端部分包括感测电活动的传感器，以及哪个导管远端部分位于受试者的心室内，用于电活动由导管远端部分感测，同时位于心脏的腔室内。该方法还包括对所收集的电活动数据执行成像算法以产生包括受试者心脏的全部或一部分的受试者体积内心脏电活动的三维表示。该方法还包括显示成像的三维心脏电活动。

4. 发明申请

WO2006122232A3 METHODS AND APPARATUS FOR IMAGING WITH MAGNETIC INDUCTION 审中-公开
标题翻译：用于磁感应成像的方法和装置
公开(公告)号：WO2006122232A3
公开(公告)日：2007-11-15
申请号：PCT/US2006018207
申请日：2006-05-10
申请人： UNIV MINNESOTA , HE BIN , XU YUAN , LI XU
发明人： HE BIN , XU YUAN , LI XU
IPC分类号： A61B5/05
CPC分类号： G01R33/4808 , A61B5/0093 , A61B8/00
摘要： An apparatus includes a magnetic energy source to provide a magnetic signal and a detector to detect an acoustic energy signal from a sample stimulated by the magnetic energy signal. A method includes applying a magnetic signal to a biological sample, detecting an acoustic signal from the sample, and processing the acoustic signal to determine the electrical impedance distribution of the sample, and identify disease in the biological sample. A method includes applying a magnetic signal to a sample, detecting a magnetic or electrical signal within the sample, and processing the magnetic or electrical signal to reconstruct electrical impedance distribution of the sample.
摘要翻译：一种装置包括提供磁信号的磁能源和用于从由磁能信号刺激的样本中检测声能信号的检测器。一种方法包括向生物样品施加磁信号，检测来自样品的声信号，以及处理声信号以确定样品的电阻抗分布，并识别生物样品中的疾病。一种方法包括对样品施加磁信号，检测样品内的磁信号或电信号，以及处理磁信号或电信号以重构样品的电阻抗分布。

5. 发明申请

WO2007124040A2 ACTIVATION AND CAUSAL INTERACTION OF BIOELECTRICAL ACTIVITY 审中-公开
标题翻译：生物活性的激活和原因相互作用
公开(公告)号：WO2007124040A2
公开(公告)日：2007-11-01
申请号：PCT/US2007/009638
申请日：2007-04-20
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , HE, Bin , DING, Lei , LAI, Yuan
发明人： HE, Bin , DING, Lei , LAI, Yuan
CPC分类号： A61B5/048 , A61B5/4094
摘要： This document discloses, among other things, ictal source analysis and causal interaction estimation which considers the structure of seizures in the space, time, and frequency domains. The dynamic causal interaction can distinguish the primary source, which initiates the ictal activity, from the secondary source, which is generated due to the ictal activity propagation.
摘要翻译：本文件公开了其中考虑空间，时间和频域缉获结构的信号源分析和因果相互作用估计。动态因果相互作用可以区分起源于动作活动的主要来源，这是由于由于传播活动而产生的次要来源。

6. 发明申请

WO2009048903A1 11 BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1 审中-公开
标题翻译： 11氢氧化钠脱氢酶1型
公开(公告)号：WO2009048903A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/079132
申请日：2008-10-08
申请人： BRISTOL-MYERS SQUIBB COMPANY , GORDON, David , BLAT, Yuval , NAYEEM, Akbar , KIRBY, Mark S. , HE, Bin
发明人： GORDON, David , BLAT, Yuval , NAYEEM, Akbar , KIRBY, Mark S. , HE, Bin
IPC分类号： C07K14/47
CPC分类号： C12Y101/01146 , C12N9/0006
摘要： The invention provides gene-targeted non-human animals comprising a genetically modified 11βHSD1 gene encodes a mutant 11βHSD1 polypeptide which is modulated by human 11βHSD1 modulating compounds. The invention further provides cells expressing mutant 11 βHSD1 and cells isolated from gene-targeted animals, which cells produce a mutant 11βHSD1. The invention further provides methods of identifying agents that modulate 11βHSD1 activity, and are useful to treat 11βHSD1 -related metabolic disorders.
摘要翻译：本发明提供基因靶向的非人动物，其包含编码由人11βHSD1调节化合物调节的突变型11βHSD1多肽的遗传修饰的11βHSD1基因。本发明还提供表达突变体11βHSD1的细胞和从基因靶向动物分离的细胞，该细胞产生突变体11βHSD1。本发明还提供鉴定调节11βHSD1活性的药剂的方法，并且可用于治疗11βHSD1相关的代谢紊乱。

7. 发明申请

WO2007124040A9 ACTIVATION AND CAUSAL INTERACTION OF BIOELECTRICAL ACTIVITY 审中-公开
标题翻译：生物活性的激活和原因相互作用
公开(公告)号：WO2007124040A9
公开(公告)日：2008-01-10
申请号：PCT/US2007009638
申请日：2007-04-20
申请人： UNIV MINNESOTA , HE BIN , DING LEI , LAI YUAN
发明人： HE BIN , DING LEI , LAI YUAN
CPC分类号： A61B5/048 , A61B5/4094
摘要： This document discloses, among other things, ictal source analysis and causal interaction estimation which considers the structure of seizures in the space, time, and frequency domains. The dynamic causal interaction can distinguish the primary source, which initiates the ictal activity, from the secondary source, which is generated due to the ictal activity propagation.
摘要翻译：本文件公开了其中考虑空间，时间和频域缉获结构的信号源分析和因果相互作用估计。动态因果相互作用可以区分起源于动作活动的主要来源，这是由于由于传播活动而产生的次要来源。

8. 发明申请

WO2006122232A2 METHODS AND APPARATUS FOR IMAGING WITH MAGNETIC INDUCTION 审中-公开
标题翻译：用于磁感应成像的方法和装置
公开(公告)号：WO2006122232A2
公开(公告)日：2006-11-16
申请号：PCT/US2006/018207
申请日：2006-05-10
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , HE, Bin , XU, Yuan , LI, Xu
发明人： HE, Bin , XU, Yuan , LI, Xu
IPC分类号： G02B27/09
CPC分类号： G01R33/4808 , A61B5/0093 , A61B8/00
摘要： An apparatus includes a magnetic energy source to provide a magnetic signal and a detector to detect an acoustic energy signal from a sample stimulated by the magnetic energy signal. A method includes applying a magnetic signal to a biological sample, detecting an acoustic signal from the sample, and processing the acoustic signal to determine the electrical impedance distribution of the sample, and identify disease in the biological sample. A method includes applying a magnetic signal to a sample, detecting a magnetic or electrical signal within the sample, and processing the magnetic or electrical signal to reconstruct electrical impedance distribution of the sample.
摘要翻译：一种装置包括提供磁信号的磁能源和用于从由磁能信号刺激的样本中检测声能信号的检测器。一种方法包括将磁信号应用于生物样品，检测来自样品的声信号，以及处理声信号以确定样品的电阻抗分布，并识别生物样品中的疾病。一种方法包括对样品施加磁信号，检测样品内的磁信号或电信号，以及处理磁信号或电信号以重建样品的电阻抗分布。

9. 发明申请

WO2005025416A3 LOCALIZING NEURAL SOURCES IN A BRAIN 审中-公开
标题翻译：在大脑中定位神经来源
公开(公告)号：WO2005025416A3
公开(公告)日：2005-06-16
申请号：PCT/US2004029725
申请日：2004-09-10
申请人： UNIV MINNESOTA , UNIV ILLINOIS , HE BIN , XU XIAOLING , XU BOBBY
发明人： HE BIN , XU XIAOLING , XU BOBBY
IPC分类号： A61B5/04 , A61B5/0476 , G06K9/00
CPC分类号： G06K9/0057 , A61B5/04008 , A61B5/0476 , A61B5/4094
摘要： Described herein is a non-invasive determination of locations of neural activity in a brain. In particular, methods and systems have been developed that utilize a FINES algorithm for use in three-dimensional (3-D) dipole source localization to locate neural activity in a brain.
摘要翻译：本文描述了脑中神经活动的位置的非侵入式确定。具体而言，已经开发了利用FINES算法用于三维（3-D）偶极子源定位以定位脑中的神经活动的方法和系统。

10. 发明申请

WO2016061764A1 FILTRATION ASSEMBLY INCLUDING FILTRATION MODULE SECURED BY ROTATABLE RETAINING RING 审中-公开
标题翻译：过滤组件，包括可旋转保持环保护的过滤模块
公开(公告)号：WO2016061764A1
公开(公告)日：2016-04-28
申请号：PCT/CN2014/089173
申请日：2014-10-22
申请人： DOW GLOBAL TECHNOLOGIES LLC , LI, Bi'e , HE, Bin , FAN, Liangzhou
发明人： LI, Bi'e , HE, Bin , FAN, Liangzhou
IPC分类号： B01D63/04
CPC分类号： B01D63/043 , B01D2313/02 , B01D2313/025 , B01D2313/21
摘要： A filtration assembly (10) including: a vessel (12) comprising a partition plate (14) dividing the vessel (12) into a first (16) and second (18) chamber, wherein the partition plate (14) includes at least one cylindrical aperture (20) passing therethrough and comprising an outer section (22) adjacent to the second chamber (18) and at least one slot (28) extending radially outward, an inner section (24) adjacent to the first chamber (16), and a retaining groove (26) located between the inner (24) and outer (22) sections; a filter module (30) comprising: an end cap (40) including a cylindrical base (42) and a distal annular rim (44) wherein the end cap (40) is seated within the aperture (20); and a retaining ring (46) located within the retaining groove (26) and including at least one tab (48) extending radially outward in engagement with the retaining groove (26) to prevent axial removal of the retaining ring (46), wherein the retaining ring (46) is rotatable within the retaining groove (26) to permit alignment of the tab (48) with slot (28).
摘要翻译：一种过滤组件（10），包括：容器（12），包括将容器（12）分成第一（16）和第二（18）室的隔板（14），其中所述隔板（14）包括至少一个圆柱形孔（20）穿过其中并且包括邻近第二腔室（18）的外部部分（22）和径向向外延伸的至少一个狭槽（28），邻近第一腔室（16）的内部部分（24）以及位于内部（24）和外部（22）部分之间的保持槽（26）过滤器模块（30），包括：端盖（40），其包括圆柱形基部（42）和远端环形边缘（44），其中所述端盖（40）位于所述孔（20）内; 以及位于所述保持槽（26）内并且包括至少一个突出部（48）的保持环（46），所述突出部沿径向向外延伸，与所述保持槽（26）接合，以防止所述保持环（46）的轴向移除，其中保持环（46）可在保持槽（26）内旋转，以允许突片（48）与槽（28）对准。

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