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1. 发明申请

WO2003045381A1 AMINOALKYLIMIDAZOLE DERIVATIVES AND THEIR USE IN MEDICINE 审中-公开
标题翻译：氨基甲酰咪唑衍生物及其在医学中的应用
公开(公告)号：WO2003045381A1
公开(公告)日：2003-06-05
申请号：PCT/GB2002/005329
申请日：2002-11-27
申请人： MOLECULAR SKINCARE LIMITED , TAZI-AHNINI, Rachid , WARD, Simon , CORK, Michael , DUFF, Gordon , HARRITY, Joe , BAVIK, Claes
发明人： TAZI-AHNINI, Rachid , WARD, Simon , CORK, Michael , DUFF, Gordon , HARRITY, Joe , BAVIK, Claes
IPC分类号： A61K31/4174
CPC分类号： C07D403/06 , C07D233/54
摘要： The present invention provides compounds of formula (I) wherein R 1 is selected from phenyl, quinoline, isoquinoline and anthracene whereby each of these substituents may be optionally substituted by a group selected from halogen, C 1-4 alkoxy, C 1-4 alkyl, C 1-4 dialkylamino and cyano; R 2 is selected from hydrogen and phenyl optionally substituted by a group selected from halogen, C 1-4 alkoxy, C 1-4 alkyl, C 1-4 dialkylamino and cyano; R 3 is selected from halogen, C 1-12 hydrocarbyl, phenyl optionally substituted by a group selected from halogen, C 1-4 alkoxy, C 1-4 alkyl, C 1-4 dialkylamino and cyano, and N-acyl piperazinyl; and X is selected from CO and SO 2 , with the proviso that when X is CO and R 1 and R 3 are both optionally substituted phenyl, R 2 is not hydrogen or when X is CO and R 2 and R 3 are both optionally substituted phenyl, R 1 is not hydrogen; and pharmaceutically acceptable derivatives and solvates thereof, pharmaceutical formulations containing them and their use in therapy particularly as CYP24 inhibitors.
摘要翻译：本发明提供式（I）化合物，其中R 1选自苯基，喹啉，异喹啉和蒽，其中这些取代基各自可以任选地被选自卤素，C 1-4烷氧基，C 1-4烷基，C 1-4二烷基氨基和氰基; R 2选自氢和任选被选自卤素，C 1-4烷氧基，C 1-4烷基，C 1-4二烷基氨基和氰基的基团取代的苯基; R 3选自卤素，C 1-12烃基，任选被选自卤素，C 1-4烷氧基，C 1-4烷基，C 1-4二烷基氨基和氰基的基团取代的苯基和N-酰基哌嗪基; 并且X选自CO和SO 2，条件是当X是CO且R 1和R 3都是任选取代的苯基时，R 2不是氢或当X是CO和R 2时，和R 3都是任选取代的苯基，R 1不是氢; 及其药学上可接受的衍生物和溶剂合物，含有它们的药物制剂及其在治疗中的用途，特别是作为CYP24抑制剂。

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