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1. 发明申请

WO2007125303A3 TRANSCEIVER 审中-公开
标题翻译：收发器
公开(公告)号：WO2007125303A3
公开(公告)日：2008-03-27
申请号：PCT/GB2007001492
申请日：2007-04-24
申请人： THRUVISION LTD , MANN CHRISTOPHER , GREEN LESLIE O , COOMBS DAVID JOHN
发明人： MANN CHRISTOPHER , GREEN LESLIE O , COOMBS DAVID JOHN
IPC分类号： H03D9/06
CPC分类号： H04B1/40 , H01L24/45 , H01L2224/45144 , H01L2924/00014 , H01L2924/01019 , H01L2924/01067 , H01L2924/01078 , H01L2924/01079 , H01L2924/12036 , H01L2924/19041 , H01L2924/3025 , H01P3/081 , H01L2224/48 , H01L2924/00
摘要： A transceiver capable of processing signals having wavelengths of less than 1 millimeter and/or more than 1 millimeter comprising a mixer/filter circuit coupled to an IF filter where said mixer/filter circuit is positioned within a mixer block to receive incoming signals guided into one or more feed horn openings of the mixer block by an optical arrangement. The IF filter is also disposed within the mixer block, but is positioned substantially orthogonal with respect to the mixer/filter circuit for efficient use of space.
摘要翻译：能够处理波长小于1毫米和/或大于1毫米的信号的收发器，包括耦合到IF滤波器的混频器/滤波器电路，其中所述混频器/滤波器电路位于混频器块内以接收被引导到一个或更多的通过光学布置的混合器块的进料喇叭孔。 IF滤波器也设置在混频器块内，但是相对于混频器/滤波器电路基本正交地定位，以有效地利用空间。

2. 发明申请

WO2007114979A3 GENE DISRUPTONS, COMPOSITIONS AND METHODS RELATING THERETO 审中-公开
公开(公告)号：WO2007114979A3
公开(公告)日：2007-10-11
申请号：PCT/US2007/061927
申请日：2007-02-09
申请人： GENENTECH, INC. , LEXICON PHARMACEUTICALS, INC. , BOLLINGER, Kristi Rae , HORNER, Allison Anne Byers , COMBS, Katherin, E. , CULBERTSON, Ling Ling , CUNNINGHAM, Jaime-jo , DESAUVAGE, Frederic , EDWARDS, Joel , GIRGIS, Rosemary , GREEN, Leslie , MCLAIN, Dina Rebecca , MINZE, Laurie Jeanette , MONTGOMERY, Charles, A. , PAYNE, Bobby Joe , PHILLIPS, Heidi , SHI, Zheng-zheng , SPARKS, Mary Jean , STALA, Joy, Anne , TANG, Tracy Tzu-ling , TOWNSEND, Teresa Gail , VOGEL, Peter , SEVAUX, Tracy Ellen Willis
发明人： BOLLINGER, Kristi Rae , HORNER, Allison Anne Byers , COMBS, Katherin, E. , CULBERTSON, Ling Ling , CUNNINGHAM, Jaime-jo , DESAUVAGE, Frederic , EDWARDS, Joel , GIRGIS, Rosemary , GREEN, Leslie , MCLAIN, Dina Rebecca , MINZE, Laurie Jeanette , MONTGOMERY, Charles, A. , PAYNE, Bobby Joe , PHILLIPS, Heidi , SHI, Zheng-zheng , SPARKS, Mary Jean , STALA, Joy, Anne , TANG, Tracy Tzu-ling , TOWNSEND, Teresa Gail , VOGEL, Peter , SEVAUX, Tracy Ellen Willis
IPC分类号： A01K67/027 , A61K39/395 , C07K14/47 , C07K14/515 , C07K16/18 , G01N33/50
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

3. 发明申请

WO2008036437A3 NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO 审中-公开
标题翻译：新的基因破坏，组合物和与其相关的方法
公开(公告)号：WO2008036437A3
公开(公告)日：2008-10-02
申请号：PCT/US2007066886
申请日：2007-04-18
申请人： GENENTECH INC , LEXICON PHARMACEUTICALS INC , BOLLINGER KRISTI RAE , DESAUVAGE FREDERIC , EDWARDS JOEL A , GIRGIS ROSEMARY , GREEN LESLIE , MINZE LAURIE JEANETTE , PAYNE BOBBY JOE , RANGEL CAROLINA , SHI ZHENG-ZHENG , SPARKS MARY JEAN , TANG TRACY TZU-LING , VOGEL PETER
发明人： BOLLINGER KRISTI RAE , DESAUVAGE FREDERIC , EDWARDS JOEL A , GIRGIS ROSEMARY , GREEN LESLIE , MINZE LAURIE JEANETTE , PAYNE BOBBY JOE , RANGEL CAROLINA , SHI ZHENG-ZHENG , SPARKS MARY JEAN , TANG TRACY TZU-LING , VOGEL PETER
IPC分类号： C12N15/85 , A61K39/395 , C07K16/00 , C12N5/00 , G01N33/50
CPC分类号： C12Q1/6883 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0375 , C07K14/705 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO286, PRO706, PRO1800, PRO4354, PRO6029, PRO9739, PRO20044, PRO28631 or PRO34128 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译：本发明涉及转基因动物，以及涉及基因功能表征的组合物和方法。具体而言，本发明提供了包含PRO286，PRO706，PRO1800，PRO4354，PRO6029，PRO9739，PRO20044，PRO28631或PRO34128基因中的破坏的转基因小鼠。这种体内研究和表征可以提供有用的用于预防，改善或矫正与基因破坏相关的疾病或功能障碍的治疗剂和/或治疗的有价值的鉴定和发现，所述疾病例如神经疾病; 心血管，内皮或血管生成疾病; 眼睛异常; 免疫性疾病; 肿瘤疾病; 骨代谢异常或病症; 脂质代谢紊乱; 或发育异常。

4. 发明申请

WO2007021423A3 GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO 审中-公开
标题翻译：基因破坏，组合物和方法相关
公开(公告)号：WO2007021423A3
公开(公告)日：2007-06-28
申请号：PCT/US2006027777
申请日：2006-07-18
申请人： GENENTECH INC , LEXICON PHARMACEUTICALS INC , HORNER ALLISON ANNE BYERS , COMBS KATHERINE E , CULBERTSON LING LING , DELMAS-MATA JUAN , DESAUVAGE FREDERIC , FAN LIANGFEN , FRANTZ GRETCHEN , GREEN LESLIE JANE , MASSEY ERIN MARIE , MCLAIN DINA REBECCA , MONTGOMERY CHARLES A , PAYNE BOBBY JOE , PEALE FRANKLIN JR , PHILLIPS HEIDI , ROHRER MICHELLE , SHI ZHENG-ZHENG , SPARKS MARY JEAN , STALA JOY , TANG TRACY TZU-LING , VOGEL PETER , WANG CHING-YUN , SEVAUX TRACY ELLEN WILLIS , XIONG WEI
发明人： HORNER ALLISON ANNE BYERS , COMBS KATHERINE E , CULBERTSON LING LING , DELMAS-MATA JUAN , DESAUVAGE FREDERIC , FAN LIANGFEN , FRANTZ GRETCHEN , GREEN LESLIE JANE , MASSEY ERIN MARIE , MCLAIN DINA REBECCA , MONTGOMERY CHARLES A , PAYNE BOBBY JOE , PEALE FRANKLIN JR , PHILLIPS HEIDI , ROHRER MICHELLE , SHI ZHENG-ZHENG , SPARKS MARY JEAN , STALA JOY , TANG TRACY TZU-LING , VOGEL PETER , WANG CHING-YUN , SEVAUX TRACY ELLEN WILLIS , XIONG WEI
IPC分类号： C12N15/85 , A01K67/027 , A61K38/00 , A61K49/00 , C12N5/06
CPC分类号： C12N15/8509 , A01K2217/075 , A01K2267/0306 , A01K2267/0362 , A01K2267/0375
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地说，本发明提供转基因小鼠，其包括在PRO226，PRO257，PRO268，PRO290，PRO36006，PRO363，PRO365，PRO382，PRO444，PRO705，PRO1071，PRO1125，PRO1134，PRO1155，PRO1281，PRO1343，PRO1379，PRO1380，PRO1387，PRO1419中的中断，PRO1433，PRO1474，PRO1550，PRO1571，PRO1572，PRO1759，PRO1904，PRO35193，PRO4341，PRO4348，PRO4369，PRO4381，PRO4407，PRO4425，PRO4985，PRO4989，PRO5737，PRO5800，PRO5993，PRO6017，PRO7174，PRO9744，PRO9821，PRO9852，PRO9873 ，PRO10196，PRO34778，PRO20233，PRO21956，PRO57290，PRO38465，PRO38683或PRO85161基因。这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱或发育异常。

5. 发明申请

WO2007021423A2 NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO 审中-公开
标题翻译：新的基因破坏，组合物和方法相关
公开(公告)号：WO2007021423A2
公开(公告)日：2007-02-22
申请号：PCT/US2006/027777
申请日：2006-07-18
申请人： GENENTECH, INC. , LEXICON GENETICS INCORPORATED , BYERS-HORNER, Allison Anne , COMBS, Katherin , CULBERTSON, Ling Ling , DELMAS-MATA, Juan , DESAUVAGE, Frederic , FAN, Liangfen , FRANTZ, Gretchen , GREEN, Leslie Jane , MASSEY, Erin Marie , MCLAIN, Dina Rebecca , MONTGOMERY, Chuck , PAYNE, Bobby Joe , PEALE, Franklin, Jr. , PHILLIPS, Heidi , ROHRER, Michelle , SHI, Zheng-Zheng , SPARKS, Mary Jean , STALA, Joy , TANG, Tracy Tzu-Ling , VOGEL, Peter , WANG, Ching-Yun , WILLIS-SEVAUX, Tracy Ellen , XIONG, Wen
发明人： BYERS-HORNER, Allison Anne , COMBS, Katherin , CULBERTSON, Ling Ling , DELMAS-MATA, Juan , DESAUVAGE, Frederic , FAN, Liangfen , FRANTZ, Gretchen , GREEN, Leslie Jane , MASSEY, Erin Marie , MCLAIN, Dina Rebecca , MONTGOMERY, Chuck , PAYNE, Bobby Joe , PEALE, Franklin, Jr. , PHILLIPS, Heidi , ROHRER, Michelle , SHI, Zheng-Zheng , SPARKS, Mary Jean , STALA, Joy , TANG, Tracy Tzu-Ling , VOGEL, Peter , WANG, Ching-Yun , WILLIS-SEVAUX, Tracy Ellen , XIONG, Wen
CPC分类号： C12N15/8509 , A01K2217/075 , A01K2267/0306 , A01K2267/0362 , A01K2267/0375
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地，本发明提供转基因小鼠，其包括在PRO226，PRO257，PRO268，PRO290，PRO36006，PRO363，PRO365，PRO382，PRO444，PRO705，PRO1071，PRO1125，PRO1134，PRO1155，PRO1281，PRO1343，PRO1379，PRO1380，PRO1387，PRO1419中的中断，PRO1433，PRO1474，PRO1550，PRO1571，PRO1572，PRO1759，PRO1904，PRO35193，PRO4341，PRO4348，PRO4369，PRO4381，PRO4407，PRO4425，PRO4985，PRO4989，PRO5737，PRO5800，PRO5993，PRO6017，PRO7174，PRO9744，PRO9821，PRO9852，PRO9873 ，PRO10196，PRO34778，PRO20233，PRO21956，PRO57290，PRO38465，PRO38683或PRO85161基因。这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱或发育异常。

6. 发明申请

WO2008078112A8 ENVIRONMENTAL CONDITIONING APPARATUS, A CHAMBER FOR USE THEREOF AND A RELATED DETECTION METHOD AND APPARATUS 审中-公开
标题翻译：环境调节装置，其使用室和相关检测方法和装置
公开(公告)号：WO2008078112A8
公开(公告)日：2008-09-25
申请号：PCT/GB2007005021
申请日：2007-12-24
申请人： THRUVISION LTD , MANN CHRISTOPHER MARK , GREEN LESLIE , BERGSTEDT CLAES , HASKETT DAVID , FINN GREGORY
发明人： MANN CHRISTOPHER MARK , GREEN LESLIE , BERGSTEDT CLAES , HASKETT DAVID , FINN GREGORY
IPC分类号： G01N21/35 , G01V8/00
CPC分类号： G01N21/3581 , G01V8/005
摘要： Thermal surfaces are used to condition the environment of a subject in black body radiation imaging apparatus. The surfaces improve the image contrast in detecting concealed objects and can be built into the walls of passages and cubicles for scanning human subjects. Thermal surfaces may be warmed and/or cooled according to conditions. In one embodiment for use in imaging a body carrying a concealed object, cooled surfaces are used to immerse the body and object in a reduced level of black body radiation in the field of view of an imager, and a warmed surface is used behind the body to match the effective temperature of the body. The body and warmed surface merge to appear as a blank area, both avoiding the imaging of any anatomical detail and making the object easier to detect. An alarm or alert can be generated when an object is detected and a second, conventional camera can be used to provide a conventional visual view of the subject area to an operator which can be overlaid with a black body view of a concealed object at any time that such an object is detected.
摘要翻译：热表面用于调节黑体辐射成像装置中受试者的环境。这些表面改善了检测隐藏物体的图像对比度，并且可以被构建在用于扫描人类受试者的通道和隔间的壁中。热表面可以根据条件加热和/或冷却。在用于成像携带隐藏物体的身体的一个实施例中，使用冷却表面将身体和物体在成像器的视野中以较低的黑体辐射水平浸入，并且在身体后面使用加热表面以匹配身体的有效温度。身体和温暖的表面合并出现为空白区域，既避免了任何解剖细节的成像，并使对象更容易检测。当检测到物体时，可以产生警报或警报，并且可以使用第二传统照相机向被操作者提供主题区域的常规视觉视图，操作者可随时覆盖隐藏物体的黑色身体视图检测到这样的物体。

7. 发明申请

WO2008078112A1 ENVIRONMENTAL CONDITIONING APPARATUS, A CHAMBER FOR USE THEREOF AND A RELATED DETECTION METHOD AND APPARATUS 审中-公开
标题翻译：环境调节装置，其使用的房间以及相关的检测方法和装置
公开(公告)号：WO2008078112A1
公开(公告)日：2008-07-03
申请号：PCT/GB2007/005021
申请日：2007-12-24
申请人： THRUVISION LIMITED , MANN, Christopher, Mark , GREEN, Leslie , BERGSTEDT, Claes , HASKETT, David , FINN, Gregory
发明人： MANN, Christopher, Mark , GREEN, Leslie , BERGSTEDT, Claes , HASKETT, David , FINN, Gregory
IPC分类号： G01N21/35 , G01V8/00
CPC分类号： G01N21/3581 , G01V8/005
摘要： Thermal surfaces are used to condition the environment of a subject in black body radiation imaging apparatus. The surfaces improve the image contrast in detecting concealed objects and can be built into the walls of passages and cubicles for scanning human subjects. Thermal surfaces may be warmed and/or cooled according to conditions. In one embodiment for use in imaging a body carrying a concealed object, cooled surfaces are used to immerse the body and object in a reduced level of black body radiation in the field of view of an imager, and a warmed surface is used behind the body to match the effective temperature of the body. The body and warmed surface merge to appear as a blank area, both avoiding the imaging of any anatomical detail and making the object easier to detect. An alarm or alert can be generated when an object is detected and a second, conventional camera can be used to provide a conventional visual view of the subject area to an operator which can be overlaid with a black body view of a concealed object at any time that such an object is detected.
摘要翻译：使用热表面来调节黑体辐射成像装置中的对象的环境。这些表面改善了检测隐藏物体时的图像对比度，并且可以嵌入通道和隔间的墙壁中，以扫描人体。热表面可根据条件加热和/或冷却。在用于对携带隐藏物体的物体进行成像的一个实施例中，冷却表面用于将物体和物体浸入成像仪视场中的黑体辐射降低水平，并且在身体后面使用加温表面以匹配身体的有效温度。身体和温暖的表面合并成一个空白区域，既避免了任何解剖细节的成像，又使物体更易于检测。当检测到物体并且可以使用第二传统相机向操作者提供传统的目标区域的视觉视图时，可以生成警报或警报，该操作者可以在任何时间用隐藏物体的黑体视图覆盖这样的对象被检测到。

8. 发明申请

WO2007125303A2 TRANSCEIVER 审中-公开
标题翻译：收发器
公开(公告)号：WO2007125303A2
公开(公告)日：2007-11-08
申请号：PCT/GB2007/001492
申请日：2007-04-24
申请人： THRUVISION LTD. , MANN, Christopher , GREEN, Leslie, O. , COOMBS, David, John
发明人： MANN, Christopher , GREEN, Leslie, O. , COOMBS, David, John
IPC分类号： H03D9/06
CPC分类号： H04B1/40 , H01L24/45 , H01L2224/45144 , H01L2924/00014 , H01L2924/01019 , H01L2924/01067 , H01L2924/01078 , H01L2924/01079 , H01L2924/12036 , H01L2924/19041 , H01L2924/3025 , H01P3/081 , H01L2224/48 , H01L2924/00
摘要： A transceiver capable of processing signals having wavelengths of less than 1 millimeter and/or more than 1 millimeter comprising a mixer/filter circuit coupled to an IF filter where said mixer/filter circuit is positioned within a mixer block to receive incoming signals guided into one or more feed horn openings of the mixer block by an optical arrangement. The IF filter is also disposed within the mixer block, but is positioned substantially orthogonal with respect to the mixer/filter circuit for efficient use of space.
摘要翻译：能够处理波长小于1毫米和/或大于1毫米的信号的收发器，包括耦合到IF滤波器的混频器/滤波器电路，其中所述混频器/滤波器电路位于混频器模块内，以接收被引导到一个或更多的通过光学装置的混合器块的进料喇叭孔。 IF滤波器也设置在混频器块内，但是相对于混频器/滤波器电路基本正交地定位，以有效地利用空间。

9. 发明申请

WO2007114979A2 NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO 审中-公开
标题翻译：新的基因破坏，组合物和方法相关
公开(公告)号：WO2007114979A2
公开(公告)日：2007-10-11
申请号：PCT/US2007061927
申请日：2007-02-09
申请人： GENENTECH INC , LEXICON PHARMACEUTICALS INC , BOLLINGER KRISTI RAE , HORNER ALLISON ANNE BYERS , COMBS KATHERIN E , CULBERTSON LING LING , CUNNINGHAM JAIME-JO , DESAUVAGE FREDERIC , EDWARDS JOEL , GIRGIS ROSEMARY , GREEN LESLIE , MCLAIN DINA REBECCA , MINZE LAURIE JEANETTE , MONTGOMERY CHARLES A , PAYNE BOBBY JOE , PHILLIPS HEIDI , SHI ZHENG-ZHENG , SPARKS MARY JEAN , STALA JOY , TANG TRACY TZU-LING , TOWNSEND TERESA GAIL , VOGEL PETER , SEVAUX TRACY ELLEN WILLIS
发明人： BOLLINGER KRISTI RAE , HORNER ALLISON ANNE BYERS , COMBS KATHERIN E , CULBERTSON LING LING , CUNNINGHAM JAIME-JO , DESAUVAGE FREDERIC , EDWARDS JOEL , GIRGIS ROSEMARY , GREEN LESLIE , MCLAIN DINA REBECCA , MINZE LAURIE JEANETTE , MONTGOMERY CHARLES A , PAYNE BOBBY JOE , PHILLIPS HEIDI , SHI ZHENG-ZHENG , SPARKS MARY JEAN , STALA JOY , TANG TRACY TZU-LING , TOWNSEND TERESA GAIL , VOGEL PETER , SEVAUX TRACY ELLEN WILLIS
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N15/8509
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地，本发明提供转基因小鼠，其包括在PRO188，PRO235，PRO266，PRO337，PRO361，PRO539，PRO698，PRO717，PRO846，PRO874，PRO98346，PRO1082，PRO1097，PRO1192，PRO1268，PRO1278，PRO1303，PRO1308，PRO1338，PRO1378中的中断，PRO1415，PRO1867，PRO1890，PRO3438，PRO19835，PRO36915，PRO36029，PRO4999，PRO5778，PRO5997，PRO6079，PRO6090，PRO7178，PRO21184，PRO7434，PRO9822，PRO9833，PRO9836，PRO9854，PRO9862，PRO10284，PRO37510，PRO35444，PRO20473，PRO21054 或PRO35246基因。这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱或发育异常。

10. 发明申请

WO2008036437A2 NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO 审中-公开
标题翻译：新的基因破坏，组合物和方法相关
公开(公告)号：WO2008036437A2
公开(公告)日：2008-03-27
申请号：PCT/US2007/066886
申请日：2007-04-18
申请人： GENENTECH, INC. , LEXICON PHARMACEUTICALS, INC. , BOLLINGER, Kristi Rae , DESAUVAGE, Frederic , EDWARDS, Joel A. , GIRGIS, Rosemary , GREEN, Leslie , MINZE, Laurie Jeanette , PAYNE, Bobby Joe , RANGEL, Carolina , SHI, Zheng-zheng , SPARKS, Mary Jean , TANG, Tracy Tzu-ling , VOGEL, Peter
发明人： BOLLINGER, Kristi Rae , DESAUVAGE, Frederic , EDWARDS, Joel A. , GIRGIS, Rosemary , GREEN, Leslie , MINZE, Laurie Jeanette , PAYNE, Bobby Joe , RANGEL, Carolina , SHI, Zheng-zheng , SPARKS, Mary Jean , TANG, Tracy Tzu-ling , VOGEL, Peter
CPC分类号： C12Q1/6883 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0375 , C07K14/705 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO286, PRO706, PRO1800, PRO4354, PRO6029, PRO9739, PRO20044, PRO28631 or PRO34128 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地说，本发明提供包含PRO286，PRO706，PRO1800，PRO4354，PRO6029，PRO9739，PRO20044，PRO28631或PRO34128基因中断的转基因小鼠。这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱或发育异常。

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