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1. 发明申请

WO2010131249A2 PROSTHETIC DEVICES COATED WITH HEATED CROSS-LINKED FIBRIN 审中-公开
标题翻译：涂有加热交联纤维的预制装置
公开(公告)号：WO2010131249A2
公开(公告)日：2010-11-18
申请号：PCT/IL2010/000379
申请日：2010-05-12
申请人： HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , GORODETSKY, Raphael
发明人： GORODETSKY, Raphael
IPC分类号： A61L27/34 , A61L27/36
CPC分类号： A61L27/34 , A61L31/10 , C08L89/00
摘要： The present invention relates to methods of coating prosthetic devices with dried fibrin. Particularly, the present invention relates to methods of coating the surface of prosthetic devices with fibrin and drying the fibrin-coated prosthetic devices at moderately-high temperatures for extended periods of time under low atmospheric pressure to obtain prosthetic devices coated with stable cross-linked fibrin capable of binding cells and thereby capable of integrating into tissues.
摘要翻译：本发明涉及用干燥的纤维蛋白涂覆假体装置的方法。特别地，本发明涉及用纤维蛋白涂覆假体装置的表面的方法，并且在低温大气压下将中等高温干燥纤维蛋白涂覆的假体装置延长的时间段以获得涂覆有稳定的交联纤维蛋白的假体装置能够结合细胞，从而能够整合到组织中。

2. 发明申请

WO2010131249A3 PROSTHETIC DEVICES COATED WITH HEATED CROSS-LINKED FIBRIN 审中-公开
标题翻译：涂有加热交联纤维的预制装置
公开(公告)号：WO2010131249A3
公开(公告)日：2011-04-14
申请号：PCT/IL2010000379
申请日：2010-05-12
申请人： HADASIT MED RES SERVICE , GORODETSKY RAPHAEL
发明人： GORODETSKY RAPHAEL
IPC分类号： A61L27/34 , A61L27/36
CPC分类号： A61L27/34 , A61L31/10 , C08L89/00
摘要： The present invention relates to methods of coating prosthetic devices with dried fibrin. Particularly, the present invention relates to methods of coating the surface of prosthetic devices with fibrin and drying the fibrin-coated prosthetic devices at moderately-high temperatures for extended periods of time under low atmospheric pressure to obtain prosthetic devices coated with stable cross-linked fibrin capable of binding cells and thereby capable of integrating into tissues.
摘要翻译：本发明涉及用干燥的纤维蛋白涂覆假体装置的方法。特别地，本发明涉及用纤维蛋白涂覆假体装置的表面并在低温大气压下在适度高温下干燥纤维蛋白涂覆的假体装置延长的时间的方法，以获得涂覆有稳定的交联纤维蛋白的假体装置能够结合细胞，从而能够整合到组织中。

3. 发明申请

WO2009093250A2 TARGETING OF INNATE IMMUNE RESPONSE TO TUMOR SITE 审中-公开
标题翻译：针对肿瘤部位的免疫免疫应答
公开(公告)号：WO2009093250A2
公开(公告)日：2009-07-30
申请号：PCT/IL2009000097
申请日：2009-01-25
申请人： GAVISH GALILEE BIO APPL LTD , HADASIT MED RES SERVICE , PITCOVSKI JACOB , SHAHAR EHUD , GORODETSKY RAPHAEL
发明人： PITCOVSKI JACOB , SHAHAR EHUD , GORODETSKY RAPHAEL
IPC分类号： A61K47/48 , A61P35/00
CPC分类号： A61K47/48584 , A61K9/485 , A61K9/5052 , A61K9/5073 , A61K39/00 , A61K39/38 , A61K39/385 , A61K47/6807 , A61K47/6855 , A61K47/6921 , C07K16/32 , C07K2317/24 , C07K2317/40
摘要： The invention provides microparticles or nanoparticles for treatment of tumors comprising: (i) a targeting agent to the tumor or the tumor environment; and (ii) at least one inducer that stimulates a desired immune response in the tumor environment, leading to tumor apoptosis, wherein components (i) and (ii) are non-covalently or covalently attached to the surface of said microparticles or nanoparticles. The targeting agent is an agent that recognizes and binds to an antigen, a receptor or other molecules found on the surface of tumor cells or in the tumor environment and are preferably antibodies.
摘要翻译：本发明提供用于治疗肿瘤的微粒或纳米颗粒，包括：（i）肿瘤或肿瘤环境的靶向剂; 和（ii）刺激肿瘤环境中期望的免疫应答的至少一种诱导剂，导致肿瘤细胞凋亡，其中组分（i）和（ii）非共价或共价连接到所述微粒或纳米颗粒的表面。靶向剂是识别和结合到在肿瘤细胞表面或肿瘤环境中发现的抗原，受体或其他分子的试剂，优选为抗体。

4. 发明申请

WO0153324A8 NOVEL HAPTOTACTIC PEPTIDES 审中-公开
标题翻译：新型HAPTOTACTIC PEPTIDES
公开(公告)号：WO0153324A8
公开(公告)日：2002-10-10
申请号：PCT/IL0100057
申请日：2001-01-21
申请人： HADASIT MED RES SERVICE , MARX GERARD , GORODETSKY RAPHAEL
发明人： MARX GERARD , GORODETSKY RAPHAEL
IPC分类号： C12N15/09 , A61K35/12 , A61K38/00 , A61K38/36 , A61K45/00 , A61K47/48 , A61K49/00 , A61K51/00 , A61L27/00 , A61P9/00 , A61P17/02 , A61P19/08 , C07K14/75 , C07K16/36 , A61K38/08 , A61K38/10 , A61K39/00 , A61K47/00 , A61K48/00 , C07K4/00 , C07K17/00 , C12Q1/16
CPC分类号： A61K38/363 , C07K14/75
摘要： Novel peptide sequences homologous to the known fibrinogen derived haptotactic peptides, C beta and C alpha E, are disclosed. The novel peptides are derived from proteins related or unrelated to fibrinogen including a peptide adjacent to fibrinogen gamma -chain C terminus denoted pre-C gamma as well as isotypes of angiopoietin, human microfibril-associated glycoprotein (mfap) and tenascins. Novel peptides having significant homology to the known fibrinogen derived haptotactic peptides are now shown to possess cell attraction activities. Active fragments comprising shorter 8-10 mer peptides are also disclosed, and shown to elicit significant haptotactic activity from a variety of cells, such as fibroblasts, endothelial and smooth muscle cells. The homologous peptides disclosed permit delineation of consensus sequences for haptotactic activity. The peptides are useful in pharmaceutical compositions alone or in conjunction with a medical device or implant.
摘要翻译：公开了与已知纤维蛋白原衍生的触动肽Cβ和CαE同源的新型肽序列。新型肽衍生自与纤维蛋白原相关或不相关的蛋白质，包括与纤维蛋白原γ-链C末端相邻的肽，其表示为前Cγ以及血管生成素，人微纤维相关糖蛋白（mfap）和腱生蛋白的同种型。显示与已知纤维蛋白原衍生的触动肽具有显着同源性的新肽具有细胞吸引活性。还公开了包含较短8-10聚体肽的活性片段，并且显示其从多种细胞（例如成纤维细胞，内皮细胞和平滑肌细胞）引发显着的触觉活性。所公开的同源肽允许描绘触觉活性的共有序列。这些肽可单独用于药物组合物或与医疗装置或植入物结合使用。

5. 发明申请

WO2009128077A1 STABLE CELL BINDING CHIMERIC PEPTIDES 审中-公开
标题翻译：稳定细胞结合重组肽
公开(公告)号：WO2009128077A1
公开(公告)日：2009-10-22
申请号：PCT/IL2009/000420
申请日：2009-04-16
申请人： HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , GORODETSKY, Raphael
发明人： GORODETSKY, Raphael
IPC分类号： C07K14/75 , A61K38/36 , A61L27/22 , C12N15/62
CPC分类号： C07K14/75 , A61K38/00 , A61L27/22 , C07K14/515 , C07K14/78 , C07K2319/00 , C12N15/62
摘要： The present invention relates to novel family of homologous cell attachment chimeric peptides. In particular, the present invention relates to chimeric peptides, each comprising synthetic peptides comprising (a) an M-tide comprising an amino acid sequence that is at least 80% homologous to the amino acid sequence selected from the group consisting of: SEQ ID NO:1, 2 and 37; and (b) a core haptide comprising an amino acid sequence homologous to amino acid sequences at the carboxy termini of the and E chains of fibrinogen or other proteins comprising C-termini that are homologous to said fibrinogen sequences, wherein the M-tide and the core haptide originate from the same protein. The synthetic peptides are linked to one another thereby providing the chimeric peptides of the invention which does not occur in the native protein as a continuous sequence. The present invention further discloses pharmaceutical compositions comprising said chimeric peptides and uses thereof.
摘要翻译：本发明涉及同源细胞附着嵌合肽的新家族。特别地，本发明涉及嵌合肽，每个嵌合肽包含合成肽，其包含（a）含有与选自以下的氨基酸序列至少80％同源的氨基酸序列的M潮流：SEQ ID NO 1：2和37; 和（b）核心浸液，其包含与纤维蛋白原的E链的羧基末端的氨基酸序列同源的氨基酸序列或包含与所述纤维蛋白原序列同源的C末端的其它蛋白质，其中M潮和核心浸液源自相同的蛋白质。合成肽彼此连接，由此提供本发明的嵌合肽，其不以天然蛋白质的形式存在，作为连续序列。本发明还公开了包含所述嵌合肽及其用途的药物组合物。

6. 发明申请

WO2009093250A3 TARGETING OF INNATE IMMUNE RESPONSE TO TUMOR SITE 审中-公开
公开(公告)号：WO2009093250A3
公开(公告)日：2009-07-30
申请号：PCT/IL2009/000097
申请日：2009-01-25
申请人： GAVISH-GALILEE BIO APPLICATIONS LTD , HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , PITCOVSKI, Jacob , SHAHAR, Ehud , GORODETSKY, Raphael
发明人： PITCOVSKI, Jacob , SHAHAR, Ehud , GORODETSKY, Raphael
IPC分类号： A61K47/48 , A61P35/00
摘要： The invention provides microparticles or nanoparticles for treatment of tumors comprising: (i) a targeting agent to the tumor or the tumor environment; and (ii) at least one inducer that stimulates a desired immune response in the tumor environment, leading to tumor apoptosis, wherein components (i) and (ii) are non-covalently or covalently attached to the surface of said microparticles or nanoparticles. The targeting agent is an agent that recognizes and binds to an antigen, a receptor or other molecules found on the surface of tumor cells or in the tumor environment and are preferably antibodies.

7. 发明申请

WO2009022340A1 PEPTIDES AND PHARMACEUTICAL COMPOSITIONS FOR TREATING CONNECTIVE TISSUE 审中-公开
标题翻译：用于治疗连接组织的肽和药物组合物
公开(公告)号：WO2009022340A1
公开(公告)日：2009-02-19
申请号：PCT/IL2008/001121
申请日：2008-08-14
申请人： METAMOREFIX , DAHAN, Mazal , GORODETSKY, Raphael
发明人： DAHAN, Mazal , GORODETSKY, Raphael
IPC分类号： C07K14/47 , A61K47/48 , A61K38/17
CPC分类号： C07K14/4726 , A61K47/61 , A61L27/20 , A61L27/227 , A61L27/50 , C08L5/08
摘要： The invention provides a pharmaceutical composition for sequestering cells in connective tissue. The composition includes a biocompatible scaffolding to which one or more peptides or proteins are linked. The peptides or proteins have an amino acid sequence that is a subsequence of human ficolin and are capable of binding the cells to be sequestered. The pharmaceutical composition can be used in the treatment of connective tissue, and can be used as a dermal filler.
摘要翻译：本发明提供了用于在结缔组织中隔离细胞的药物组合物。组合物包括与一个或多个肽或蛋白质连接的生物相容性支架。肽或蛋白质具有作为人ficolin的亚序列的氨基酸序列，并且能够结合被隔离的细胞。药物组合物可用于结缔组织的治疗，可用作皮肤填充剂。

8. 发明申请

WO2004041298A1 LIPOSOMAL COMPOSITION COMPRISING HAPTOTACTIC PEPTIDES 审中-公开
标题翻译：包含HAPTOTACTIC PEPTIDES的脂质组合物
公开(公告)号：WO2004041298A1
公开(公告)日：2004-05-21
申请号：PCT/IL2003/000911
申请日：2003-11-03
申请人： HAPTO BIOTECH, INC. , MARX, Gerard , GORODETSKY, Raphael
发明人： MARX, Gerard , GORODETSKY, Raphael
IPC分类号： A61K38/00
CPC分类号： A61K8/14 , A61K8/64 , A61K9/127 , A61K38/363 , A61K49/0002 , A61Q19/00
摘要： The present invention relates to liposomal composition comprising peptides characterized in that they elicit cell attachment (haptotactic) responses and are internalized by cells; more particularly the compositions comprise cell attachment peptides derived from or homologous to specific portions of the carboxy termini of fibrinogen chains, designated herein as Haptides, capable of enhancing the uptake of liposomes by cells. The present invention further relates to pharmaceutical and cosmetic compositions comprising haptotactic-peptide liposomal compositions and uses of same.
摘要翻译：本发明涉及包含肽的脂质体组合物，其特征在于它们引发细胞附着（触觉反应）反应并被细胞内化; 更具体地，组合物包含衍生自或同源于纤维蛋白原链的羧基末端（本文称为Haptides）的特异性部分的细胞附着肽，其能够增强细胞对脂质体的摄取。本发明还涉及包含触头肽脂质体组合物的药物和化妆品组合物及其用途。

9. 发明申请

WO0153324A2 NOVEL HAPTOTACTIC PEPTIDES 审中-公开
标题翻译：新颖的皮肤病
公开(公告)号：WO0153324A2
公开(公告)日：2001-07-26
申请号：PCT/IL0100057
申请日：2001-01-21
申请人： HADASIT MED RES SERVICE , MARX GERARD , GORODETSKY RAPHAEL
发明人： MARX GERARD , GORODETSKY RAPHAEL
IPC分类号： C12N15/09 , A61K35/12 , A61K38/00 , A61K38/36 , A61K45/00 , A61K47/48 , A61K49/00 , A61K51/00 , A61L27/00 , A61P9/00 , A61P17/02 , A61P19/08 , C07K14/75 , C07K16/36 , C07K
CPC分类号： A61K38/363 , C07K14/75
摘要： Novel peptide sequences homologous to the known fibrinogen derived haptotactic peptides, C beta and C alpha E, are disclosed. The novel peptides are derived from proteins related or unrelated to fibrinogen including a peptide adjacent to fibrinogen gamma -chain C terminus denoted pre-C gamma as well as isotypes of angiopoietin, human microfibril-associated glycoprotein (mfap) and tenascins. Novel peptides having significant homology to the known fibrinogen derived haptotactic peptides are now shown to possess cell attraction activities. Active fragments comprising shorter 8-10 mer peptides are also disclosed, and shown to elicit significant haptotactic activity from a variety of cells, such as fibroblasts, endothelial and smooth muscle cells. The homologous peptides disclosed permit delineation of consensus sequences for haptotactic activity. The peptides are useful in pharmaceutical compositions alone or in conjunction with a medical device or implant.
摘要翻译：公开了与已知的纤维蛋白源衍生的触角肽Cβ和CαE同源的新型肽序列。新型肽衍生自与纤维蛋白原相关或不相关的蛋白质，包括与纤维蛋白原γ链C端相邻的肽，表示为前Cγ，以及血管生成素，人微纤维相关糖蛋白（mfap）和腱生蛋白的同种型。与已知的纤维蛋白原衍生的结合肽具有显着同源性的新肽现在显示具有细胞吸引活性。还公开了包含较短的8-10个mer肽的活性片段，并且显示出从各种细胞如成纤维细胞，内皮细胞和平滑肌细胞引起显着的结合活性。所公开的同源肽允许描述触发活性的共有序列。肽可单独或与医疗装置或植入物一起用于药物组合物中。

10. 发明申请

WO2009081408A3 PULVERIZED FIBRIN CLOTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译： PULVERIZED FIBRIN CLOTS和含有它们的药物组合物
公开(公告)号：WO2009081408A3
公开(公告)日：2010-05-20
申请号：PCT/IL2008001676
申请日：2008-12-25
申请人： METAMOREFIX , SHMULEWITZ ASCHER , DAHAN MAZAL , GORODETSKY RAPHAEL
发明人： SHMULEWITZ ASCHER , DAHAN MAZAL , GORODETSKY RAPHAEL
IPC分类号： A61L24/00
CPC分类号： A61L24/0031 , A61L24/0047 , Y10T428/2982
摘要： The invention provides a pulverized fibrin clot and a pharmaceutical composition comprising a pulverized fibrin clot. The pharmaceutical composition may contain the pulverized fibrin clot suspended in a gel such as cross-linked hyaluronic acid. The pharmaceutical composition may be in a form suitable for injection and may be used, for example, in the treatment of connective tissue, such as skin connective tissue. The invention also provides a method for preparing a pulverized fibrin clot as well as a method for treating connective tissue using the pharmaceutical composition of the invention.
摘要翻译：本发明提供粉碎的纤维蛋白凝块和包含粉碎的纤维蛋白凝块的药物组合物。药物组合物可以含有悬浮在凝胶如交联透明质酸中的粉碎的纤维蛋白凝块。药物组合物可以是适于注射的形式，并且可以用于例如结缔组织如皮肤结缔组织的治疗。本发明还提供了使用本发明的药物组合物制备粉碎的纤维蛋白凝块的方法以及治疗结缔组织的方法。

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