基本信息:
- 专利标题： TARGETING OF INNATE IMMUNE RESPONSE TO TUMOR SITE
- 专利标题（中）：针对肿瘤部位的免疫免疫应答
- 申请号：PCT/IL2009000097 申请日：2009-01-25
- 公开(公告)号：WO2009093250A2 公开(公告)日：2009-07-30
- 发明人： PITCOVSKI JACOB , SHAHAR EHUD , GORODETSKY RAPHAEL
- 申请人： GAVISH GALILEE BIO APPL LTD , HADASIT MED RES SERVICE , PITCOVSKI JACOB , SHAHAR EHUD , GORODETSKY RAPHAEL
- 专利权人： GAVISH GALILEE BIO APPL LTD,HADASIT MED RES SERVICE,PITCOVSKI JACOB,SHAHAR EHUD,GORODETSKY RAPHAEL
- 当前专利权人： GAVISH GALILEE BIO APPL LTD,HADASIT MED RES SERVICE,PITCOVSKI JACOB,SHAHAR EHUD,GORODETSKY RAPHAEL
- 优先权： US665908 2008-01-25
- 主分类号： A61K47/48
- IPC分类号： A61K47/48 ; A61P35/00
摘要：
The invention provides microparticles or nanoparticles for treatment of tumors comprising: (i) a targeting agent to the tumor or the tumor environment; and (ii) at least one inducer that stimulates a desired immune response in the tumor environment, leading to tumor apoptosis, wherein components (i) and (ii) are non-covalently or covalently attached to the surface of said microparticles or nanoparticles. The targeting agent is an agent that recognizes and binds to an antigen, a receptor or other molecules found on the surface of tumor cells or in the tumor environment and are preferably antibodies.
摘要（中）：
本发明提供用于治疗肿瘤的微粒或纳米颗粒，包括：（i）肿瘤或肿瘤环境的靶向剂; 和（ii）刺激肿瘤环境中期望的免疫应答的至少一种诱导剂，导致肿瘤细胞凋亡，其中组分（i）和（ii）非共价或共价连接到所述微粒或纳米颗粒的表面。 靶向剂是识别和结合到在肿瘤细胞表面或肿瘤环境中发现的抗原，受体或其他分子的试剂，优选为抗体。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K47/00 | 以所用的非有效成分为特征的医用配制品，如载体、惰性添加剂 |
| --------A61K47/48 | .非有效成分被化学键键合到有效成分上，例如聚合物药物轭合物 |