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1. 发明申请

WO2016022867A2 ELECTRODES AND ELECTRODE POSITIONING SYSTEMS FOR TRANSVASCULAR NEUROMODULATION 审中-公开
标题翻译：电极和电极定位系统用于血管神经修复
公开(公告)号：WO2016022867A2
公开(公告)日：2016-02-11
申请号：PCT/US2015/044112
申请日：2015-08-06
申请人： NERO TRONIK IP HOLDING (JERSEY) LIMITED , MASSON, Stephen, C. , PURCELL, Scott , CUCHIARA, Michael , GLENN, Richard, A.
发明人： MASSON, Stephen, C. , PURCELL, Scott , CUCHIARA, Michael , GLENN, Richard, A.
IPC分类号： A61N1/36
CPC分类号： A61N1/056 , A61N1/0553 , A61N1/0558 , A61N1/3605 , A61N1/36185
摘要： Electrode systems for transvascular stimulation of target nerves include electrode arrays, elements promoting blood flow between electrode surfaces and surrounding vascular walls, electrodes shaped to promote more even current density than electrodes having angular edges, features for retaining the electrode systems with blood vessels, and features for using electrode- carrying elements to asymmetrically distend blood vessel walls towards target nerve structures.
摘要翻译：用于目标神经的经血管刺激的电极系统包括电极阵列，促进电极表面和周围血管壁之间的血液流动的元件，形成为促进比具有角边缘的电极更均匀的电流密度的电极，用于保持具有血管的电极系统的特征，以及特征用于使用电极携带元件将血管壁对称地扩大到目标神经结构。

2. 发明申请

WO2012030393A1 INTRAVASCULAR ELECTRODES AND ANCHORING DEVICES FOR TRANSVASCULAR STIMULATION 审中-公开
标题翻译：用于血管扩张的血管电极和锚固装置
公开(公告)号：WO2012030393A1
公开(公告)日：2012-03-08
申请号：PCT/US2011/001535
申请日：2011-09-01
申请人： SYNECOR LLC , GLENN, Richard, A. , HOLBROOK, Kevin , SMITH, Jeffrey, A. , ORTH, Geoffrey, A. , WILLIAMS, Michael, S.
发明人： GLENN, Richard, A. , HOLBROOK, Kevin , SMITH, Jeffrey, A. , ORTH, Geoffrey, A. , WILLIAMS, Michael, S.
IPC分类号： A61N1/00
CPC分类号： A61N1/056 , A61N1/057
摘要： An intravascular mapping and anchoring assembly is disclosed, comprising: a tubular sheath; an expandable anchor comprising a first portion and a second portion, each having a compressed position and an expanded position, the anchor having a fully compressed position in which the first and second portions are disposed in their compressed positions within the sheath; an array of electrodes mounted to the first portion; wherein the sheath is slidable retractable relative to the anchor to release the anchor from the fully compressed position to a mapping position in which the first portion is released from the sheath to an expanded position while the second portion remains in the compressed position within the sheath; and wherein the sheath is further slidable relative to the anchor to further release the second portion to an expanded position.
摘要翻译：公开了一种血管内映射和锚定组件，包括：管状护套; 可膨胀锚固件，其包括第一部分和第二部分，每个部分具有压缩位置和扩张位置，所述锚具有完全压缩的位置，第一和第二部分设置在其在护套内的压缩位置; 安装到第一部分的电极阵列; 其中所述护套相对于所述锚固件可滑动地缩回，以将所述锚固件从所述完全压缩位置释放到映射位置，在所述映射位置中，所述第一部分从所述护套释放到扩展位置，而所述第二部分保持在所述护套内的压缩位置; 并且其中所述护套可以相对于所述锚固件进一步滑动以进一步将所述第二部分释放到扩张位置。

3. 发明申请

WO2011057210A2 METHODS AND SYSTEMS FOR REMOVAL OF IMPLANTABLE INTRAVASCULAR DEVICES 审中-公开
标题翻译：用于移除可植入的血管内装置的方法和系统
公开(公告)号：WO2011057210A2
公开(公告)日：2011-05-12
申请号：PCT/US2010055863
申请日：2010-11-08
申请人： INNERPULSE , FIFER DANIEL , GLENN RICHARD , SMITH JEFFREY , ORTH GEOFF , WILLIAMS MICHAEL , SANDERS WILLIAM M D , BARDSLEY EARL , GRACZYK WENDY
发明人： FIFER DANIEL , GLENN RICHARD , SMITH JEFFREY , ORTH GEOFF , WILLIAMS MICHAEL , SANDERS WILLIAM M D , BARDSLEY EARL , GRACZYK WENDY
IPC分类号： A61B17/3205 , A61B17/22 , A61B17/32 , A61N1/36 , A61N1/372
CPC分类号： A61B17/320016 , A61B17/29 , A61B2017/00358 , A61B2017/32006 , A61N1/37205 , A61N2001/0578
摘要： Improved methods, systems and apparatuses for extracting devices implanted within the vasculature of a patient are provided, including a method of extracting an intravascular device anchored in a vasculature of a patient, the device including a device body and a lead coupled to the device body, the lead having a distal end including an electrode, the distal end being fixed in a heart of the patient, the method comprising forming an incision in the vasculature, disconnecting the lead from the device body, removing the distal end of the lead from the heart, withdrawing the lead from the patient, disconnecting the device body from an anchor, and withdrawing the device body from the patient via the incision.
摘要翻译：提供了用于提取植入患者的脉管系统内的装置的改进的方法，系统和设备，包括提取锚定在患者的脉管系统中的血管内装置的方法，所述装置包括装置主体和联接到装置主体的引线，所述引线具有包括电极的远端，所述远端固定在患者的心脏中，所述方法包括在所述脉管系统中形成切口，将所述引线从所述装置主体断开，从所述心脏移除所述引线的所述远端，从患者身上抽出导线，将装置主体与锚定件分离，并且经由切口从患者身上抽出装置主体。

4. 发明申请

WO2010091282A2 FLEXIBLE STRUCTURAL APPARATUS, SPRING, WOUND COVERING, AND METHODS 审中-公开
标题翻译：柔性结构设备，弹簧，绕线和方法
公开(公告)号：WO2010091282A2
公开(公告)日：2010-08-12
申请号：PCT/US2010/023362
申请日：2010-02-05
申请人： THT CONSULTING, LLC , TURNLUND, Todd, H. , LAYMAN, Ted, W. , GLENN, Richard, A.
发明人： TURNLUND, Todd, H. , LAYMAN, Ted, W. , GLENN, Richard, A.
CPC分类号： A61F15/008
摘要： A flexible structural apparatus which may be used as a wound covering which extends above the wound such that the wound covering does not contact the wound and also protects the wound from contact. The apparatus provides a high degree of flexibility while retaining structural strength and resisting collapse, for example, so as to adequately protect the wound. Various embodiments include parallel beams and connections between beams that alternate in location along the beams to provide flexibility. Some embodiments may be used as springs and may have attachment features, such as holes, which may be located at the end beams, for example.
摘要翻译：一种柔性结构设备，其可用作在伤口上方延伸的伤口覆盖物，使得伤口覆盖物不接触伤口并且还保护伤口免受接触。该设备提供高度的灵活性，同时保持结构强度和抵抗塌陷，例如以充分保护伤口。各种实施例包括平行光束和沿着光束位置交替的光束之间的连接，以提供灵活性。一些实施例可以用作弹簧，并且可以具有例如可以位于端部梁处的附接特征，例如孔。

5. 发明申请

WO2010005915A2 ENERGY HARVESTING FOR IMPLANTED MEDICAL DEVICES 审中-公开
标题翻译：用于植入医疗器械的能量收集
公开(公告)号：WO2010005915A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/049727
申请日：2009-07-06
申请人： SYNECOR LLC , FIFER, Daniel, W. , GLENN, Richard, A. , WILLIAMS, Michael, W.
发明人： FIFER, Daniel, W. , GLENN, Richard, A. , WILLIAMS, Michael, W.
IPC分类号： A61N1/375
CPC分类号： A61N1/372 , A61N1/37205 , A61N1/375 , A61N1/3785 , H02N2/18 , H02N2/185
摘要： An energy harvesting device positionable within a blood vessel for use in generating energy for powering all or a portion of the functions of a diagnostic or therapeutic medical implant. The energy harvesting device includes piezoelectric elements arranged to generate a voltage in response to mechanical blood vessel activity such as bending, expansion or contraction of the blood vessel, or flow of blood through the blood vessel. The electrical energy generated by the piezoelectric elements may be used to recharge a battery, stored in a capacitor, and/or used in real time to generate the energy used for operation of the implant.
摘要翻译：可在血管内定位的能量收集装置，用于产生用于为诊断或治疗性医用植入物的全部或一部分功能供电的能量。能量收集装置包括压电元件，其被布置成响应于诸如血管的弯曲，膨胀或收缩的机械血管活动或血液通过血管的流动而产生电压。由压电元件产生的电能可以用于对存储在电容器中的电池进行充电和/或实时使用以产生用于植入物的操作的能量。

6. 发明申请

WO2008036384A3 STOMACH WALL CLOSURE DEVICES 审中-公开
标题翻译： STOMACH墙关闭装置
公开(公告)号：WO2008036384A3
公开(公告)日：2008-07-24
申请号：PCT/US2007020440
申请日：2007-09-21
申请人： SYNECOR LLC , WILLIAMS MICHAEL S , ORTH GEOFFREY A , GLENN RICHARD A , SMITH JEFFREY A
发明人： WILLIAMS MICHAEL S , ORTH GEOFFREY A , GLENN RICHARD A , SMITH JEFFREY A
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00278 , A61B2017/00292 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623 , A61B2017/00637
摘要： In a method for sealing an incision in an interior body wall such as a gastrotomy opening in a stomach, a closure device (10) is positioned within the incision. The closure device includes a seal (12b) and an anchor (12a) coupled to the seal. The seal is positioned in sealing contact against a first surface surface of the body wall, and the anchor is positioned against the second surface of the body wall such that a portion of the closure device is positioned. The closure device seals the incision while healing takes place. Once the incision is significantly healed, the closure device bioerodes.
摘要翻译：在用于密封内部体壁（例如胃中的胃切口）的切口的方法中，闭合装置（10）位于切口内。闭合装置包括密封件（12b）和联接到密封件的锚固件（12a）。密封件被定位成与主体壁的第一表面表面密封接触，并且锚定件抵靠主体壁的第二表面定位，使得封闭装置的一部分被定位。闭合装置在愈合发生时密封切口。一旦切口明显愈合，关闭装置就会生物反应。

7. 发明申请

WO2008020421A2 COMPOSITIONS COMPRISING CALCIUM CITRATE MALATE AND METHODS FOR MAKING THE SAME 审中-公开
标题翻译：包含钙柠檬酸钙的组合物及其制备方法
公开(公告)号：WO2008020421A2
公开(公告)日：2008-02-21
申请号：PCT/IB2007/053296
申请日：2007-08-17
申请人： THE PROCTER & GAMBLE COMPANY , LUHADIYA, Ashok, Premchand , DAKE, Timothy, William , HUDEPOHL, Glenn, Richard , COMPTON, Donald, Brown
发明人： LUHADIYA, Ashok, Premchand , DAKE, Timothy, William , HUDEPOHL, Glenn, Richard , COMPTON, Donald, Brown
IPC分类号： A61K9/14 , A61K33/06
CPC分类号： A61K33/06 , A61K9/1688 , A61K31/19 , A61K31/194 , C07C59/245 , C07C59/265
摘要： A process for producing a calcium citrate malate composition by the steps of: combining a calcium source, a citrate source, a malate source and water to form a calcium citrate malate mixture. The mixture is reacted until reaching a peak temperature of from about 45°C to about 700C, and then cooled at a rate of from about l°C/minute to about 4°C/minute to reach a final temperature of less than about 400C. A calcium citrate malate precipitate is formed and then dried to obtain the calcium citrate malate composition.
摘要翻译：一种通过以下步骤生产柠檬酸柠檬酸苹果酸组合物的方法：将钙源，柠檬酸盐源，苹果酸盐和水混合以形成柠檬酸柠檬酸苹果酸盐混合物。使混合物反应直到达到约45℃至约70℃的峰值温度，然后以约1℃/分钟至约4℃/分钟的速率冷却至达到小于约40℃的最终温度。形成柠檬酸苹果酸钙沉淀物，然后干燥，得到柠檬酸苹果酸钙组合物。

8. 发明申请

WO2007038715A1 TRANSGASTRIC SURGICAL DEVICES AND PROCEDURES 审中-公开
标题翻译：转移性外科手术和手术
公开(公告)号：WO2007038715A1
公开(公告)日：2007-04-05
申请号：PCT/US2006/037978
申请日：2006-09-27
申请人： SYNECOR, LLC , WILLIAMS, Michael, S. , STACK, Richard, S. , ORTH, Geoff , SMITH, Jeff , GLENN, Richard, A. , ATHAS, William, S. , PRYOR, Aurora
发明人： WILLIAMS, Michael, S. , STACK, Richard, S. , ORTH, Geoff , SMITH, Jeff , GLENN, Richard, A. , ATHAS, William, S. , PRYOR, Aurora
IPC分类号： A61B17/34
CPC分类号： A61B17/3421 , A61B17/0057 , A61B17/3417 , A61B17/3423 , A61B17/3478 , A61B17/3496 , A61B46/10 , A61B90/40 , A61B2017/00278 , A61B2017/00867 , A61B2017/00871 , A61B2017/3484 , A61B2017/3486 , A61B2017/3488 , A61B2017/349 , A61B2017/3492
摘要： Embodiments of surgical access cannulas and access systems for use in gaining access to a body cavity of a patient via a natural orifice are disclosed. A distal end of an access cannula is advanced through a natural orifice into a hollow organ. Instruments passed through the cannula are used to form an incision in the wall of the hollow organ. The access cannula is anchored in the incision with its distal opening giving access to a body cavity outside the hollow organ. Surgical instruments are passed through the access cannula and used to perform procedures in the body cavity.
摘要翻译：公开了用于通过自然孔口进入患者体腔的外科手术插管和进入系统的实施例。进入插管的远端通过自然孔进入中空器官。通过插管的仪器用于在中空器官的壁上形成切口。进入插管锚定在切口中，其远端开口进入中空器官外部的体腔。手术器械通过入口插管并用于在体腔中执行程序。

9. 发明申请

WO2005081878A3 POLYMERIC ENDOPROSTHESES WITH ENHANCED STRENGTH AND FLEXIBILITY AND METHODS OF MANUFACTURE 审中-公开
标题翻译：具有增强强度和柔韧性的制备聚合物的方法及制备方法
公开(公告)号：WO2005081878A3
公开(公告)日：2005-11-24
申请号：PCT/US2005005299
申请日：2005-02-22
申请人： SYNECOR LLC , WILLIAMS MICHAEL S , HOLBROOK KEVIN D , GLENN RICHARD A
发明人： WILLIAMS MICHAEL S , HOLBROOK KEVIN D , GLENN RICHARD A
IPC分类号： A61F2/02 , A61F2/82 , A61L29/12 , A61L29/18 , A61L31/12 , A61L31/18 , B32B1/08 , F16L11/00 , A61F2/04 , A61F2/06
CPC分类号： A61F2/82 , A61L29/126 , A61L29/18 , A61L31/128 , A61L31/18
摘要： Improved polymeric endoprostheses and methods of manufacturing endoprostheses are disclosed herein. The endoprostheses may comprise one or more polymers wherein the polymer chains are substantially aligned circumferentially, and comprising increased radial strength and flexibility. An endoprosthesis according to the invention may comprise a smooth surface. Endoprostheses disclosed herein may be used in the treatment of strictures in lumens of the body. Alternatively, endoprostheses disclosed herein may be used as anchors to secure medical devices within lumens of the body. The endoprostheses disclosed herein may comprise one or more erodible polymer.
摘要翻译：本文公开了改进的聚合物内用假体和制造内用假体的方法。内用假体可以包含一种或多种聚合物，其中聚合物链基本上对齐地对齐，并且包括增加的径向强度和柔性。根据本发明的内用假体可以包括光滑表面。本文公开的内假体可以用于治疗身体内腔的狭窄。或者，本文公开的假体可以用作锚固件以将身体内腔内的医疗装置固定。本文公开的内用假体可以包含一种或多种可侵蚀的聚合物。

10. 发明申请

WO2005027734A3 METHOD AND APPARATUS FOR TREATING DISEASED OR FRACTURED BONE 审中-公开
标题翻译：用于治疗疾病或骨折的方法和设备
公开(公告)号：WO2005027734A3
公开(公告)日：2005-05-26
申请号：PCT/US2004030771
申请日：2004-09-17
申请人： SYNECOR LLC , WILLIAMS MICHAEL S , SMITH JEFFERY A , STACK RICHARD S , HOLBROOK KEVIN D , GLENN RICHARD A
发明人： WILLIAMS MICHAEL S , SMITH JEFFERY A , STACK RICHARD S , HOLBROOK KEVIN D , GLENN RICHARD A
IPC分类号： A61B20060101 , A61B17/00 , A61B17/70 , A61F2/00 , A61F2/44
CPC分类号： A61B17/8858 , A61B17/70 , A61B2017/00867
摘要： An apparatus according to the invention may comprise one or more expandable structural support pylons (140), means for deploying said one or more structural support pylons (138, 141), and one or more therapeutic substances. Structural support pylons (20) may comprise an elastomeric core (22), or may comprise one or more suitable metals, and may be deployed by shortening the length and increasing the height of the pylon. Alternatively, scaffold (200) may comprise a delivery configuration in which first unit (202) and second unit (204) he generally end to end, and a deployed configuration in which superior surfaces (216) and (218) exert an upward force and inferior surfaces (220) and (222) exert a downward force on superior and inferior vertebral surfaces respectively. A method according to the invention may comprise accessing an interior of a diseased or injured bone in a minimally invasive manner, creating a semi-circular path within said bone, deploying one or more structural support pylons within said interior, introducing structural reinforcement material, and if desired, repeating with one or more subsequent structural support pylons.
摘要翻译：根据本发明的装置可以包括一个或多个可膨胀结构支撑塔架（140），用于展开所述一个或多个结构支撑塔架（138,141）以及一种或多种治疗物质的装置。结构支撑塔架（20）可以包括弹性体芯（22），或者可以包括一种或多种适合的金属，并且可以通过缩短长度并增加塔架的高度来展开。或者，支架（200）可以包括输送构造，其中第一单元（202）和第二单元（204）通常首尾相接，以及展开构造，其中上表面（216）和（218）施加向上的力，并且下表面（220）和（222）分别向上和下椎骨表面施加向下的力。根据本发明的方法可以包括以微创方式进入患病或受损骨骼的内部，在所述骨内创建半圆形路径，在所述内部中布置一个或多个结构支撑柱，引入结构增强材料，以及如果需要，用一个或多个随后的结构支撑塔重复。

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