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1. 发明申请

WO2016115028A1 SAMPLE PLATE FOR SLIDING MAGNETIC PARTICLE SEPARATION 审中-公开
标题翻译：用于滑动磁颗粒分离的样品板
公开(公告)号：WO2016115028A1
公开(公告)日：2016-07-21
申请号：PCT/US2016/012827
申请日：2016-01-11
申请人： GILSON, INC.
发明人： FAWCETT, Kevin , ROBINSON, Gregory J. , GUCKENBERGER, David John , BERRY, Scott
IPC分类号： B01L3/00
CPC分类号： G01N1/38 , B01L3/5085 , B01L2200/141 , B01L2300/0829 , B01L2300/0854 , B01L2300/0858 , G01N2001/386
摘要： A sample plate includes a top surface, a plurality of wells, and a plurality of reservoirs. The plurality of wells is mounted to the top surface. Each well includes a well bottom surface and a well wall extending up from the well bottom surface. The plurality of reservoirs is mounted to the top surface. Each reservoir includes a reservoir bottom surface, a reservoir wall extending from a first side of the reservoir bottom surface, and the well wall extending from a second side of the reservoir bottom surface. Each reservoir of the plurality of reservoirs surrounds a corresponding well of the plurality of wells.
摘要翻译：样品板包括顶表面，多个孔和多个储存器。多个井被安装到顶部表面。每个井包括井底表面和从井底表面向上延伸的井壁。多个储存器安装到顶表面。每个储存器包括储存器底部表面，从储存器底部表面的第一侧延伸的储存器壁以及从储存器底部表面的第二侧延伸的井壁。多个储存器中的每个储存器围绕多个孔的对应的井。

2. 发明申请

WO2002059570A1 PROBE TIP ALIGNMENT FOR PRECISION LIQUID HANDLER 审中-公开
标题翻译：用于精密液体处理器的探针提升对准
公开(公告)号：WO2002059570A1
公开(公告)日：2002-08-01
申请号：PCT/US2001/050800
申请日：2001-12-31
申请人： GILSON, INC. , GILSON, Robert, E. , NORTON, Robert
发明人： GILSON, Robert, E. , NORTON, Robert
IPC分类号： G01N1/00
CPC分类号： G01N35/10 , G01N35/028 , G01N35/1002 , G01N35/1011 , G01N2035/00237 , G01N2035/0494
摘要： A probe drive system (24) of a precision liquid handler (20) sequentially inserts probe tips (36) of a multiple probe array (30) into a locator well (76) at a known position on a locator bed (28). The position of each probe tip (36) is determined by driving the probe tip (36) into contact with points on the side wall (88) of the locator well (76) and sensing the contacts. The positions of the probe tips (36) are mapped and checked for skew of the probe array (30). The probe tip positions ae overlaid to determine probe tip scatter. If a probe tip (36) is excessively misaligned, it is inserted into the locator well (76) and driven against the side wall (88) to bend the probe and reduce the misalignment of the probe tip (36). The center of the probe tip scatter is determined and is used by the probe drive system (24) as a global correction factor. Probe tips (36) with known positions are inserted into spaced apart locator wells (78,80) to detect skew of the locator bed.
摘要翻译：精密液体处理器（20）的探针驱动系统（24）在定位器床（28）上的已知位置处依次将多个探针阵列（30）的探针尖端（36）插入到定位器井（76）中。通过驱动探针尖端（36）与定位器孔（76）的侧壁（88）上的点接触并感测触点来确定每个探针尖端（36）的位置。对探针尖端（36）的位置进行映射并检查探针阵列（30）的偏斜。探针尖端位置ae重叠以确定探针尖端散射。如果探针尖端（36）过度不对准，则将其插入定位器孔（76）并被驱动抵靠侧壁（88）以弯曲探针并减小探针尖端（36）的未对准。探针尖端散射的中心被确定并被探针驱动系统（24）用作全局校正因子。具有已知位置的探针尖端（36）插入到间隔开的定位孔（78,80）中以检测定位器床的偏斜。

3. 发明申请

WO2005123229A3 MIXING CHAMBER PROBE ADAPTOR 审中-公开
标题翻译：混合室探头适配器
公开(公告)号：WO2005123229A3
公开(公告)日：2006-12-14
申请号：PCT/US2005020743
申请日：2005-06-10
申请人： GILSON INC , ROENNEBURG LUCAS D , FAWCETT KEVIN R
发明人： ROENNEBURG LUCAS D , FAWCETT KEVIN R
IPC分类号： B01D59/44 , B01F13/00 , B01F15/00 , B01L3/02 , G01N35/10 , H01J49/00 , H01J49/16
CPC分类号： H01J49/0418 , B01F13/0059 , B01F15/00824 , B01F15/00935 , B01L3/0241 , B01L2200/04 , B01L2300/0838 , B01L2300/0867 , G01N2035/1039 , H01J49/0431
摘要： A mixing chamber probe adaptor comprising a chamber connector and a probe connector is provided. The mixing chamber probe adaptor imparts a fixed spatial joining of a chamber to a probe and allows a mixing chamber to be received by the chamber connector. In some embodiments, the mixing chamber probe adaptor will be adapted to connect to a spring-loaded probe and receive a micro mixing tee. In other embodiments, the mixing chamber probe adaptor may be used with other types of chambers and probes.
摘要翻译：提供了包括室连接器和探针连接器的混合室探针适配器。混合室探针适配器将腔室固定空间连接到探针，并允许混合室由腔室连接器容纳。在一些实施例中，混合室探针适配器将适于连接到弹簧加载的探针并接收微混合发球体。在其他实施例中，混合室探针适配器可以与其它类型的腔室和探针一起使用。

4. 发明申请

WO2006029330A3 FRACTION COLLECTOR WITH ADJUSTABLE TRAY 审中-公开
标题翻译：具有可调节托盘的分类收集器
公开(公告)号：WO2006029330A3
公开(公告)日：2006-10-05
申请号：PCT/US2005032178
申请日：2005-09-08
申请人： GILSON INC , ROENNEBURG LUCAS D , ACKER JEFFREY L
发明人： ROENNEBURG LUCAS D , ACKER JEFFREY L
IPC分类号： B01D15/08
CPC分类号： B01D15/247 , B01J2219/00351 , G01N30/80 , G01N30/82
摘要： A fraction collector (100) comprising a movable tray (102) is provided. The movable tray (102) may be attached to the fraction collector support system in a variety of ways and provides for a method of adjusting the tray without adjusting the parts of the fraction collector support system. The moveable tray (102) may be stably attached to the fraction collector support system by either fixed or removable pegs, as well as by channels.
摘要翻译：提供包括可移动托盘（102）的级分收集器（100）。可移动托盘（102）可以以各种方式附接到馏分收集器支撑系统，并且提供了一种在不调节馏分收集器支撑系统的部分的情况下调节托盘的方法。可移动托盘（102）可以通过固定的或可移除的钉以及通道被稳定地附接到级分收集器支撑系统。

5. 发明申请

WO2005062776A3 METHOD AND APPARATUS FOR LIQUID CHROMATOGRAPHY AUTOMATED SAMPLE LOADING 审中-公开
公开(公告)号：WO2005062776A3
公开(公告)日：2005-07-14
申请号：PCT/US2004/042356
申请日：2004-12-17
申请人： GILSON, INC. , STAPLES, Kary , ROENNEBURG, Luke
发明人： STAPLES, Kary , ROENNEBURG, Luke
IPC分类号： G01N1/00
摘要： A method for automated loading of liquid sample to a liquid chromatography testing device is provided including installing a disposable tip on a probe, moving the probe with an automated liquid handler to a loading position proximate to a sample, and drawing a sample into the disposable tip. The probe is then moved to an injection position proximate an injection port, and the sample is injected from the disposable tip into the injection port. Also provided are the novel injection ports. After injection of the sample, the disposable tip is then removed from the probe. These steps may be repeated a plurality of times to sequentially load a plurality of samples. An exemplary method of the invention is directed to use with a liquid chromatography apparatus. An apparatus for assisting in the removal of the disposable tip is also provided.

6. 发明申请

WO2002048582A1 HIGH PRESSURE LOW VOLUME PUMP 审中-公开
标题翻译：高压低容量泵
公开(公告)号：WO2002048582A1
公开(公告)日：2002-06-20
申请号：PCT/US2001/044927
申请日：2001-11-30
申请人： GILSON, INC. , CAUTENET, Etienne , DE TALHOUET, Philippe
发明人： CAUTENET, Etienne , DE TALHOUET, Philippe
IPC分类号： F16J1/14
CPC分类号： F04B53/22 , F04B53/144 , F04B53/147 , F05C2203/0852 , F05C2203/0873
摘要： A piston carrier (46) supports an elongated, slender piston rod (2) for reciprocation in a pump cylinder (30) to pump fluid into and out of the cylinder (30). The piston rod (12) is made of a material such as sapphire or zircon and has a diameter less than about ten millimeters, and the pump can provide flows of from about 50 nanoliters to about 250 microliters per minute at pressures of several hundred bars. A drive motor (18) rotates a threaded screw (58) and a drive nut (70) of a drive system (26) applies a linear drive force to the piston carrier (46). A ball and socket connection (74) between the drive system (26) and the piston carrier (46) avoids the need for precise alignment to prevent breakage of the fragile piston (12). A magnet (80) in the socket (78) holds the ball (76) in place and avoids the need for a spring or other mechanical holder. The socket (78) also includes a ring (88) of a low reluctance material surrounding the ball (76) to increase the magnetic retention force.
摘要翻译：活塞架（46）支撑用于在泵缸（30）中往复运动的细长活塞杆（2），以将流体泵入和泵出缸（30）。活塞杆（12）由诸如蓝宝石或锆石的材料制成并且具有小于约十毫米的直径，并且泵可以在几百巴的压力下提供约50纳升至约250微升/分钟的流量。驱动马达（18）旋转螺杆（58），并且驱动系统（26）的驱动螺母（70）将线性驱动力施加到活塞架（46）。驱动系统（26）和活塞架（46）之间的球窝连接（74）避免了精确对准的需要，以防止易碎活塞（12）的损坏。插座（78）中的磁体（80）将球（76）保持在适当位置并避免需要弹簧或其他机械支架。插座（78）还包括围绕球（76）的低磁阻材料的环（88），以增加磁保持力。

7. 发明申请

WO2006029330A2 FRACTION COLLECTOR WITH ADJUSTABLE TRAY 审中-公开
标题翻译：具有可调节托盘的分类收集器
公开(公告)号：WO2006029330A2
公开(公告)日：2006-03-16
申请号：PCT/US2005/032178
申请日：2005-09-08
申请人： GILSON, INC. , ROENNEBURG, Lucas D. , ACKER, Jeffrey L.
发明人： ROENNEBURG, Lucas D. , ACKER, Jeffrey L.
IPC分类号： B01D15/08
CPC分类号： B01D15/247 , B01J2219/00351 , G01N30/80 , G01N30/82
摘要： A fraction collector comprising a movable tray is provided. The movable tray may be attached to the fraction collector support system in a variety of ways and provides for a method of adjusting the tray without adjusting the parts of the fraction collector support system. The moveable tray may be stably attached to the fraction collector support system by either fixed or removable pegs, as well as by channels.
摘要翻译：提供了包括活动托盘的馏分收集器。可移动托盘可以以各种方式附接到级分收集器支撑系统，并且提供了一种在不调节馏分收集器支撑系统的部件的情况下调节托盘的方法。可移动托盘可以通过固定或可移除的钉以及通道稳定地附接到馏分收集器支撑系统。

8. 发明申请

WO2005062776A2 METHOD AND APPARATUS FOR LIQUID CHROMATOGRAPHY AUTOMATED SAMPLE LOADING 审中-公开
标题翻译：用于液相色谱自动样品加载的方法和设备
公开(公告)号：WO2005062776A2
公开(公告)日：2005-07-14
申请号：PCT/US2004042356
申请日：2004-12-17
申请人： GILSON INC , STAPLES KARY , ROENNEBURG LUKE
发明人： STAPLES KARY , ROENNEBURG LUKE
IPC分类号： B01L3/02 , G01N1/00 , G01N35/10
CPC分类号： G01N35/10 , G01N30/24 , G01N35/1095 , G01N2035/103
摘要： A method for automated loading of liquid sample to a liquid chromatography testing device is provided including installing a disposable tip on a probe, moving the probe with an automated liquid handler to a loading position proximate to a sample, and drawing a sample into the disposable tip. The probe is then moved to an injection position proximate an injection port, and the sample is injected from the disposable tip into the injection port. Also provided are the novel injection ports. After injection of the sample, the disposable tip is then removed from the probe. These steps may be repeated a plurality of times to sequentially load a plurality of samples. An exemplary method of the invention is directed to use with a liquid chromatography apparatus. An apparatus for assisting in the removal of the disposable tip is also provided.
摘要翻译：提供了用于将液体样品自动加载到液相色谱测试装置的方法，包括将一次性尖端安装在探针上，用自动化液体处理器将探针移动到接近样品的装载位置，并将样品拉入一次性尖端。然后将探针移动到靠近注射端口的注射位置，并且将样品从一次性尖端注射到注射端口中。还提供了新颖的注射口。注入样品后，一次性吸头从探头上取下。这些步骤可以重复多次以顺序加载多个样本。本发明的示例性方法涉及与液相色谱装置一起使用。还提供了一种用于辅助去除一次性尖端的设备。

9. 发明申请

WO2017120156A1 BASE FOR COLLECTION AND RELEASE OF PARAMAGNETIC PARTICLES 审中-公开
标题翻译：收集和释放参数粒子的基础
公开(公告)号：WO2017120156A1
公开(公告)日：2017-07-13
申请号：PCT/US2017/012082
申请日：2017-01-04
申请人： GILSON, INC. , SALUS DISCOVERY LLC
发明人： GUCKENBERGER, David John , REGIER, Mary Christin
IPC分类号： G01N35/00 , G01N33/543
CPC分类号： G01N1/40 , B01L3/502 , B01L2300/06 , B01L2300/0609 , B01L2300/0829 , B03C1/32 , B03C2201/18 , G01N35/0098 , G01N2001/4038 , G01N2035/00564
摘要： A magnetic base for a sample plate of a sample processing system is provided comprising a first plate comprising a first top surface; a bottom surface; and a sample plate mounting cavity wall mounted to the first top surface, wherein the first plate and the sample plate mounting cavity wall define a sample plate mounting cavity configured to accommodate a sample plate of a sample processing system. The magnetic base further comprises a second plate extending parallel to the first plate, the second plate comprising a second top surface; and a magnet mounting cavity wall extending between the bottom surface of the first plate and the second top surface of the second plate, wherein the first plate, the second plate, and the magnet mounting cavity wall define a magnet mounting cavity configured to accommodate a free floating magnet.
摘要翻译：提供了一种用于样品处理系统的样品板的磁性基座，其包括：第一板，其包括第一顶面; 底面; 以及安装到所述第一顶表面的样品板安装腔壁，其中所述第一板和所述样品板安装腔壁限定样品板安装腔，所述样品板安装腔配置为容纳样品处理系统的样品板。磁性基座还包括平行于第一板延伸的第二板，第二板包括第二顶部表面; 以及在所述第一板的所述底表面与所述第二板的所述第二顶表面之间延伸的磁体安装腔壁，其中所述第一板，所述第二板和所述磁体安装腔壁限定磁体安装腔，所述磁体安装腔配置为容纳自由浮动磁铁。

10. 发明申请

WO2016115025A1 ADAPTER FOR SLIDING MAGNETIC PARTICLE SEPARATION 审中-公开
标题翻译：适用于滑动磁颗粒分离
公开(公告)号：WO2016115025A1
公开(公告)日：2016-07-21
申请号：PCT/US2016/012822
申请日：2016-01-11
申请人： GILSON, INC.
发明人： FAWCETT, Kevin , ROBINSON, Gregory, J. , GUCKENBERGER, David, John , BERRY, Scott , BEEBE, David, J.
IPC分类号： G01N35/00
CPC分类号： G01N1/4077 , G01N35/00029 , G01N35/0098
摘要： An adapter for a sliding head of a sample processing system is provided that includes a plate and a magnet mounting recess wall. The plate includes a top surface, a bottom surface, a front wall extending between the top surface and the bottom surface, and a back wall extending between the top surface and the bottom surface. The magnet mounting recess wall is mounted to the top surface. The magnet mounting recess wall is configured to accommodate a magnet of a sliding head of a sample processing system. At least a portion of the bottom surface is curved in a first direction from the front wall to the back wall and is concave relative to the top surface.
摘要翻译：提供了一种用于样品处理系统的滑动头的适配器，其包括板和磁体安装凹槽。板包括顶表面，底表面，在顶表面和底表面之间延伸的前壁，以及在顶表面和底表面之间延伸的后壁。磁铁安装凹槽安装在顶面上。磁体安装凹部壁构造成容纳样品处理系统的滑动头的磁体。底表面的至少一部分在从前壁到后壁的第一方向上弯曲，并且相对于顶表面是凹的。

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