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1. 发明申请

WO2006003456A2 GLYCOSYLATION OF ANTIBIOTICS 审中-公开
标题翻译：抗生素的糖基化
公开(公告)号：WO2006003456A2
公开(公告)日：2006-01-12
申请号：PCT/GB2005002661
申请日：2005-07-07
申请人： ISIS INNOVATION , DAVID BENJAMIN GUY , GILBERT HARRY JOHN
发明人： DAVID BENJAMIN GUY , GILBERT HARRY JOHN
IPC分类号： C12P19/18 , C12P19/62
CPC分类号： C12P19/62
摘要： It has been demonstrated that macrolide glycosyltransferase enzymes can be recombinantly expressed at high levels. It has also been demonstrated that that these enzymes are able to accept a range of planar, cyclic, hydrophobic molecules in the aglycone binding site such that they may be used to glycosylate a range of substrates. It has been further demonstrated that these enzymes display a plasticity in donor sugar recognition such that they may be utilitised in introducing novel sugar decorations into bioactive molecules. Accordingly, the invention provides a method of attaching a sugar to a substrate comprising contacing the sugar with a macrolide glycosyltransferase enzyme in the presence of a sugar donor. The invention also provides a method of recombinantly expressing a macrolide glycosyltransferase enzyme at a high level comprising expressing a polynucleotide encoding the enzyme in a bacterial host cell.
摘要翻译：已经证明大环内酯糖基转移酶可以以高水平重组表达。还已经证明，这些酶能够接受糖苷配基结合位点中的一系列平面，环状疏水性分子，使得它们可以用于使一系列底物糖基化。已经进一步证明这些酶在供体糖识别中显示出可塑性，使得它们可以用于将新的糖装饰物引入生物活性分子中。因此，本发明提供了将糖附着于底物的方法，包括在糖供体存在下使糖与大环内酯糖基转移酶接触。本发明还提供了以高水平重组表达大环内酯糖基转移酶的方法，包括在细菌宿主细胞中表达编码酶的多核苷酸。

2. 发明申请

WO9846768A3 PHENOLIC ACID ESTERASE AND USE THEREOF 审中-公开
标题翻译：酚醛酸酯酯及其用途
公开(公告)号：WO9846768A3
公开(公告)日：1999-01-21
申请号：PCT/EP9802080
申请日：1998-04-09
申请人： BABRAHAM INST , UNIV NEWCASTLE , FILLINGHAM IAN JOHN , HAZELWOOD GEOFFREY PETER , GILBERT HARRY JOHN
发明人： FILLINGHAM IAN JOHN , HAZELWOOD GEOFFREY PETER , GILBERT HARRY JOHN
IPC分类号： A23K1/165 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/18 , C12N15/09 , C12N15/55 , C12R1/645 , D21C9/00 , C12P7/42 , C12P19/00 , D21H17/00
CPC分类号： C12N9/18 , A23K20/189
摘要： The present invention relates to an enzyme with phenolic acid esterase activity, gene encoding said enzyme as well as a method for the production and use of said enzyme.

3. 发明申请

WO2012112472A3 DIAGNOSTIC TOOL WITH SMART CAMERA 审中-公开
公开(公告)号：WO2012112472A3
公开(公告)日：2012-08-23
申请号：PCT/US2012/024947
申请日：2012-02-14
申请人： SERVICE SOLUTIONS U.S. LLC , GILBERT, Harry , BERTOSA, Thomas
发明人： GILBERT, Harry , BERTOSA, Thomas
IPC分类号： G06F17/30 , G06Q50/28
摘要： A diagnostic tool that includes a smart camera. The smart camera can be used to capture an image of the part that needs to be replaced. The image can also include the bar code that may be attached to the part. The image can be used to search a parts information database for additional parts information such as part number, manuals, pictures, etc. A further search of a parts supplier's database can be conducted using a location of the diagnostic tool to determine the nearest parts supplier that has the part available and the best price.

4. 发明申请

WO2012112472A2 DIAGNOSTIC TOOL WITH SMART CAMERA 审中-公开
标题翻译：具有SMART CAMERA的诊断工具
公开(公告)号：WO2012112472A2
公开(公告)日：2012-08-23
申请号：PCT/US2012024947
申请日：2012-02-14
申请人： SPX CORP , GILBERT HARRY , BERTOSA THOMAS
发明人： GILBERT HARRY , BERTOSA THOMAS
IPC分类号： G06F17/00 , G06F17/30
CPC分类号： G07C5/008 , G06F17/30047 , G06Q10/087 , G07C2205/02
摘要： A diagnostic tool that includes a smart camera. The smart camera can be used to capture an image of the part that needs to be replaced. The image can also include the bar code that may be attached to the part. The image can be used to search a parts information database for additional parts information such as part number, manuals, pictures, etc. A further search of a parts supplier's database can be conducted using a location of the diagnostic tool to determine the nearest parts supplier that has the part available and the best price.
摘要翻译：包括智能相机的诊断工具。智能相机可用于捕获需要更换的部件的图像。该图像还可以包括可能附加到零件的条形码。该图像可以用于搜索零件信息数据库中的附加零件信息，例如零件号，手册，图片等。可以使用诊断工具的位置进一步搜索零件供应商的数据库，以确定最近的零件供应商该部分可用和最优惠的价格。

5. 发明申请

WO1993025693A1 RECOMBINANT XYLANASES 审中-公开
标题翻译：重构XYLANASES
公开(公告)号：WO1993025693A1
公开(公告)日：1993-12-23
申请号：PCT/GB1993001283
申请日：1993-06-17
申请人： HAZLEWOOD, Geoffrey, Peter , GILBERT, Harry, John
IPC分类号： C12N15/56
CPC分类号： C12Y302/01032 , C12N9/248 , C12Y302/01008
摘要： Recombinant xylanases are derived from anaerobic fungi, particularly Neocallimastix patriciarum. The enzymes are highly specific for xylans and have industrial value, particularly in the pulp and paper industries. Certain truncated forms of the enzymes, and enzymes encoded by truncated DNA sequences, are preferred for their high expression levels.
摘要翻译：重组木聚糖酶来源于厌氧真菌，特别是新西兰白僵菌（Neocallimastix patriciarum）。这些酶对木聚糖具有高度的特异性，具有工业价值，特别是在纸浆和造纸工业中。由于其高表达水平，某些截短形式的酶和由截短的DNA序列编码的酶是优选的。

6. 发明申请

WO2006003456A3 GLYCOSYLATION OF ANTIBIOTICS 审中-公开
公开(公告)号：WO2006003456A3
公开(公告)日：2006-01-12
申请号：PCT/GB2005/002661
申请日：2005-07-07
申请人： ISIS INNOVATION LIMITED , DAVID, Benjamin, Guy , GILBERT, Harry, John
发明人： DAVID, Benjamin, Guy , GILBERT, Harry, John
IPC分类号： C12P19/18 , C12P19/62
摘要： It has been demonstrated that macrolide glycosyltransferase enzymes can be recombinantly expressed at high levels. It has also been demonstrated that that these enzymes are able to accept a range of planar, cyclic, hydrophobic molecules in the aglycone binding site such that they may be used to glycosylate a range of substrates. It has been further demonstrated that these enzymes display a plasticity in donor sugar recognition such that they may be utilitised in introducing novel sugar decorations into bioactive molecules. Accordingly, the invention provides a method of attaching a sugar to a substrate comprising contacing the sugar with a macrolide glycosyltransferase enzyme in the presence of a sugar donor. The invention also provides a method of recombinantly expressing a macrolide glycosyltransferase enzyme at a high level comprising expressing a polynucleotide encoding the enzyme in a bacterial host cell.

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