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1. 发明申请

WO0240706A3 METHOD AND MEDIUM FOR DETECTING/IDENTIFYING MICRO-ORGANISMS 审中-公开
标题翻译：用于检测/鉴定微量有机物的方法和介质
公开(公告)号：WO0240706A3
公开(公告)日：2003-01-03
申请号：PCT/FR0103611
申请日：2001-11-16
申请人： BIO MERIEUX , GILBERT SANDRA , ROGER-DALBERT CELINE , ORENGA SYLVAIN
发明人： GILBERT SANDRA , ROGER-DALBERT CELINE , ORENGA SYLVAIN
IPC分类号： C12N1/00 , C12N1/20 , C12Q1/04 , C12Q1/10 , C12Q1/26 , C12Q1/34 , C12Q1/37 , C12Q1/42 , C12Q1/44 , C12R1/01
CPC分类号： C12Q1/44 , C12N1/20 , C12Q1/045 , C12Q1/10 , C12Q1/34 , C12Q1/37 , C12Q1/42 , G01N2333/255 , G01N2496/25
摘要： The invention concerns a medium for biological analysis by biochemical process comprising chromogenic and fluorogenic substrates reactive to enzymes specific (esterases and/or osidases and/or peptidases and/or sulphatases and/or phosphatases) of the searched strains. The invention aims at improving the sensitivity, initial translucency, stability and ease of use of such identification/detection media. This is achieved by the inventive medium which is in ready-to-use stable, liquid or gel form comprising at least an emulsifying stabilising agent such as ester of Sorbitan or of fatty acids/fatty acids and at least a solvent (dimethylsulphoxide). Said medium is obtained by mixing a stock solution of esterase and/or osidase and/or peptidase and/or sulphatase and/or phosphatase substrates, in the solvent and the emulsifying stabilising agent, with part of the constituents of the culture medium. The invention also concerns the preparation of such a medium and the use of ester of Sorbitan and of fatty acids/fatty acids as emulsifying stabiliser in a micro-organism detection/identification medium, in particular bacteria or yeasts, with esterase and/or osidase and/or peptidase and/or sulphatase and/or phosphatase activity.
摘要翻译：本发明涉及通过生物化学方法进行生物分析的培养基，其包括对所搜索菌株的酶特异性（酯酶和/或糖苷酶和/或肽酶和/或硫酸酯酶和/或磷酸酶）具有反应性的显色和荧光底物。本发明旨在提高这种识别/检测介质的灵敏度，初始半透明度，稳定性和易用性。这是通过本发明的介质实现的，该介质是即用型稳定的液体或凝胶形式，其包含至少一种乳化稳定剂，例如脱水山梨糖醇或脂肪酸/脂肪酸的酯和至少一种溶剂（二甲基亚砜）。所述培养基通过在溶剂和乳化稳定剂中与培养基的一部分成分混合酯酶和/或氧化酶和/或肽酶和/或硫酸酯酶和/或磷酸酶底物的原液而获得。本发明还涉及这样一种培养基的制备，以及使用脱水山梨糖醇和脂肪酸/脂肪酸的酯作为微生物检测/鉴定培养基，特别是细菌或酵母中的乳化稳定剂与酯酶和/或糖苷酶和 /或肽酶和/或硫酸酯酶和/或磷酸酶活性。

2. 发明申请

WO2003076424A1 MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS 审中-公开
标题翻译：大环化合物作为药物有用
公开(公告)号：WO2003076424A1
公开(公告)日：2003-09-18
申请号：PCT/US2003/007377
申请日：2003-03-07
申请人： EISAI CO. LTD. , BOIVIN, Roch , CHIBA, Kenichi , DAVIS, Heather, A. , DIEPITRO, Lucian , DU, Hong , EGUCHI, Yoshihito , FUJITA, Masanori , GILBERT, Sandra , GOTO, Masaki , HARMANGE, Jean, Christophe , INOUE, Atsushi , JIANG, Yimin , KAWADA, Megumi , KAWAI, Takatoshi , KAWAKAMI, Yoshiyuki , KIMURA, Akifumi , KOTAKE, Makoto , KUBOI, Yoshikazu , LEMELIN, Charles , LI, Xiang-Yi , MATSUSHIMA, Tomohiro , MIZUI, Yoshiharu , SAKURAI, Hideki , SCHILLER, Shawn , SHEN, Yongchun , SPYVEE, Mark , TANAKA, Isao , WANG, Yuan , YAMAMOTO, Satoshi , YONEDA, Naoki , KOBAYASHI, Seiichi
发明人： BOIVIN, Roch , CHIBA, Kenichi , DAVIS, Heather, A. , DIEPITRO, Lucian , DU, Hong , EGUCHI, Yoshihito , FUJITA, Masanori , GILBERT, Sandra , GOTO, Masaki , HARMANGE, Jean, Christophe , INOUE, Atsushi , JIANG, Yimin , KAWADA, Megumi , KAWAI, Takatoshi , KAWAKAMI, Yoshiyuki , KIMURA, Akifumi , KOTAKE, Makoto , KUBOI, Yoshikazu , LEMELIN, Charles , LI, Xiang-Yi , MATSUSHIMA, Tomohiro , MIZUI, Yoshiharu , SAKURAI, Hideki , SCHILLER, Shawn , SHEN, Yongchun , SPYVEE, Mark , TANAKA, Isao , WANG, Yuan , YAMAMOTO, Satoshi , YONEDA, Naoki , KOBAYASHI, Seiichi
IPC分类号： C07D313/00
CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要： The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R 1 -R 11 , t, X, Y, Z, and n are as defined herein.
摘要翻译：本发明提供具有式（I）的化合物，另外提供其合成方法及其用于治疗各种疾病（包括炎性或自身免疫性疾病）以及涉及恶性或增加血管发生的疾病的方法，其中R1-R1， t，X，Y，Z和n如本文所定义。

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