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1. 发明申请

WO2011115940A1 SUBSTITUTED PYRIMIDINES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS 审中-公开
标题翻译：取代的吡啶类作为PROSTAGLANDIN D2受体拮抗剂
公开(公告)号：WO2011115940A1
公开(公告)日：2011-09-22
申请号：PCT/US2011/028427
申请日：2011-03-15
申请人： AVENTIS PHARMACEUTICALS INC. , HARRIS, Keith J. , AGUIAR, Joacy C. , SHUM, Patrick Wai-Kwok , ZHAO, Zhicheng , POLI, Gregory B. , STOKLOSA, Gregory , CHOI-SLEDESKI, Yong-Mi , REILING, Stephan , STEFANY, David , GARDNER, Charles
发明人： HARRIS, Keith J. , AGUIAR, Joacy C. , SHUM, Patrick Wai-Kwok , ZHAO, Zhicheng , POLI, Gregory B. , STOKLOSA, Gregory , CHOI-SLEDESKI, Yong-Mi , REILING, Stephan , STEFANY, David , GARDNER, Charles
IPC分类号： C07D403/04 , A61K31/505 , A61P11/00
CPC分类号： C07D403/04
摘要： The present invention is directed to a substituted pyrimidine compound of formula (I) as set forth herein, or an enantiomer thereof, or a prodrug or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising such a compound. The invention also includes a method of treatment of a patient by the administration of a pharmaceutically effective amount of such a compound. Formula (I), wherein m and n, independently of each other, are selected from the integers 0, 1, 2 or 3; X and Y, independently of each other, are selected from CR 1 R 2 , NR 1 or O, wherein X and Y cannot both be O; or X and Y, taken together with the bond between them, form a phenyl group optionally substituted by one to four R 3 groups; each Z, independently of each other, is CR 1 R 2 ; R 1 , R 2 and R 3 , independently of each other, are selected from the group consisting of H, halogen, aryl, amino, optionally substituted alkyl, optionally substituted alkoxy, and carboxy; wherein optionally substituted alkyl, may be substituted by one to three of the same or different of halogen, carboxy, cyano, hydroxy, amino or aryl.
摘要翻译：本发明涉及本文所述的式（I）的取代嘧啶化合物或其对映异构体或其前药或药学上可接受的盐，或包含该化合物的药物组合物。本发明还包括通过施用药学有效量的这种化合物来治疗患者的方法。式（I），其中m和n彼此独立地选自整数0,1,2或3; X和Y彼此独立地选自CR1R2，NR1或O，其中X和Y不能都是O; 或X和Y与它们之间的键连同，形成任选被一至四个R 3基团取代的苯基; 各Z独立地为CR1R2; R 1，R 2和R 3彼此独立地选自H，卤素，芳基，氨基，任选取代的烷基，任选取代的烷氧基和羧基; 其中任选取代的烷基可被一至三个相同或不同的卤素，羧基，氰基，羟基，氨基或芳基取代。

2. 发明申请

WO2007101279A3 METHOD AND APPARATUS FOR COMPACT SPECTROMETER WITH FIBER ARRAY SPECTRAL TRANSLATOR 审中-公开
标题翻译：具有光纤阵列光谱转换器的紧凑光谱仪的方法和装置
公开(公告)号：WO2007101279A3
公开(公告)日：2008-05-08
申请号：PCT/US2007063348
申请日：2007-03-05
申请人： CHEMIMAGE CORP , GARDNER CHARLES W , MAIER JOHN S , NELSON MATTHEW P , SCHWEITZER ROBERT C , TREADO PATRICK J , WANG CHENHUL , VANNI G STEVEN , WOLFE JULIANNE , DEMUTH JOSEPH E , NEISS JASON H
发明人： GARDNER CHARLES W , MAIER JOHN S , NELSON MATTHEW P , SCHWEITZER ROBERT C , TREADO PATRICK J , WANG CHENHUL , VANNI G STEVEN , WOLFE JULIANNE , DEMUTH JOSEPH E , NEISS JASON H
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0224 , G01J3/0237 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/32 , G01J3/36 , G01J3/447 , G01N21/65 , G01N2201/0846
摘要： The disclosure relates to a portable system having a fiber array spectral translator ("FAST") for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.
摘要翻译：本公开涉及一种具有光纤阵列光谱转换器（“FAST”）的便携式系统，用于获得具有第一和第二空间尺寸的样品的空间上准确的波长分辨图像，所述第一和第二空间尺寸可用于通过照射来检测危险物质具有光的样品，使用来自样品的拉曼移动光形成全部或部分样品的图像，并且分析拉曼偏移光以获得一种或多种危险剂的特征。

3. 发明申请

WO2007121280A1 2,6-SUBSTITUTED-4-MONOSUBSTITUTED AMINO-PYRIMIDINE AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS 审中-公开
标题翻译：作为前列腺素D2受体拮抗剂的2,6-取代的4-单核苷酸氨基嘧啶
公开(公告)号：WO2007121280A1
公开(公告)日：2007-10-25
申请号：PCT/US2007/066481
申请日：2007-04-12
申请人： SANOFI-AVENTIS , STEFANY, David , HARRIS, Keith John , GILLESPY, Timothy, Alan , GARDNER, Charles J. , AGUIAR, Joacy C.
发明人： STEFANY, David , HARRIS, Keith John , GILLESPY, Timothy, Alan , GARDNER, Charles J. , AGUIAR, Joacy C.
IPC分类号： C07D239/46 , C07D403/04 , C07D409/04 , A61K31/505 , A61P11/00
CPC分类号： C07D403/04 , C07D239/47 , C07D409/04
摘要： The present invention is directed to a compound of formula (I) wherein R 1 and R 2 are as defined herein, or a pharmaceutically acceptable salt, hydrate, or solvate thereof, a pharmaceutically acceptable prodrug thereof, or a pharmaceutically acceptable salt, hydrate or solvate of the prodrug, a pharmaceutical composition comprising a pharmaceutically effective amount of one or more compounds of the invention in admixture with a pharmaceutically acceptable carrier, a method of treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which are generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like by administering to said patient a pharmaceutically effective amount of a compound of the invention.
摘要翻译：本发明涉及其中R 1和R 2如本文所定义的式（I）化合物或其药学上可接受的盐，水合物或溶剂化物，其药学上可接受的前药，或其药学上可接受的盐，水合物或溶剂化物，药物组合物，其包含药学上有效量的一种或多种本发明化合物与药学上可接受的载体的混合物，治疗患者的方法来自PGD2介导的障碍，包括但不限于过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），全身肥大细胞增多症，伴有全身性肥大细胞活化的病症，过敏性休克，支气管收缩，支气管炎，荨麻疹，湿疹，伴有瘙痒的疾病（如特应性皮炎和荨麻疹），疾病（如白内障，视网膜脱离，炎症，感染和睡眠障碍），其由伴随瘙痒的行为（例如搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿性关节炎，胸膜炎，溃疡性结肠炎等引起。通过向所述患者施用药学有效量的本发明化合物。

4. 发明申请

WO2007103897A2 METHOD AND APPARATUS FOR COMPACT SPECTROMETER FOR MULTIPOINT SAMPLING OF AN OBJECT 审中-公开
标题翻译：用于多目标采样的紧凑型光谱仪的方法和装置
公开(公告)号：WO2007103897A2
公开(公告)日：2007-09-13
申请号：PCT/US2007/063346
申请日：2007-03-05
申请人： CHEMIMAGE CORPORATION , GARDNER, Charles, W., JR. , MAIER, John, S. , NELSON, Matthew, P. , SCHWEITZER, Robert, C. , TREADO, Patrick, J. , VANNI, G., Steven , WOLFE, Julianne , DEMUTH, Joseph, E. , NEISS, Jason, H. , WANG, Chenhui
发明人： GARDNER, Charles, W., JR. , MAIER, John, S. , NELSON, Matthew, P. , SCHWEITZER, Robert, C. , TREADO, Patrick, J. , VANNI, G., Steven , WOLFE, Julianne , DEMUTH, Joseph, E. , NEISS, Jason, H. , WANG, Chenhui
IPC分类号： G06F19/00
CPC分类号： G01N21/65 , G01N21/6456 , G01N2021/6421 , G01N2201/0221
摘要： The disclosure relates to methods and apparatus for assessing occurrence of one or more hazardous agents in a sample by performing multipoint spectral analysis of the sample using a portable or hand-held device. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.
摘要翻译：本公开涉及通过使用便携式或手持式装置对样品进行多点光谱分析来评估样品中一种或多种危险剂的发生的方法和装置。公开了采用拉曼光谱法和其他分光光度法的方法。还公开了适于执行这种多点方法的设备和系统。

5. 发明申请

WO2007092009A2 SYSTEM AND METHOD FOR THE DEPOSITION, DETECTION AND IDENTIFICATION OF THREAT AGENTS 审中-公开
标题翻译：沉积物的系统和方法，威胁剂的检测和鉴定
公开(公告)号：WO2007092009A2
公开(公告)日：2007-08-16
申请号：PCT/US2006/004561
申请日：2006-02-09
申请人： CHEMIMAGE CORPORATION , TREADO, Patrick, J. , GARDNER, Charles, W., Jr. , MAIER, John, S.
发明人： TREADO, Patrick, J. , GARDNER, Charles, W., Jr. , MAIER, John, S.
CPC分类号： G01J3/44 , G01N21/65
摘要： A system and method for depositing a sample of a threat agent is deposited onto a substrate. The threat agent is identified substantially coincident in time with the depositing of the sample of the threat agent onto the substrate. A system and method for depositing a sample of a threat agent onto a substrate. A single illumination source illuminates the threat agent deposited on the substrate with a plurality of photons to thereby produce elastic scattered photons and Raman scattered photons. The threat agent on the substrate is identified. The system and method operate in a trigger mode that detects the presence or absence of the threat agent, and an identification mode that identifies the threat agent.
摘要翻译：将用于沉积威胁剂的样品的系统和方法沉积在基底上。识别威胁剂与威胁剂的样品沉积在基材上基本一致。一种用于将威胁剂的样品沉积到基底上的系统和方法。单个照明源用多个光子照射沉积在基板上的威胁剂，从而产生弹性散射光子和拉曼散射光子。识别基质上的威胁剂。系统和方法在检测威胁代理的存在或不存在的触发模式下操作，以及识别威胁代理的识别模式。

6. 发明申请

WO2005060380A3 WIDE FIELD METHOD FOR DETECTING PATHOGENIC MICROORGANISMS 审中-公开
标题翻译：用于检测病原微生物的广义方法
公开(公告)号：WO2005060380A3
公开(公告)日：2005-12-01
申请号：PCT/US2004020266
申请日：2004-06-24
申请人： CHEMIMAGE CORP , GARDNER CHARLES W JR , MAIER JOHN S , NELSON MATTHEW P , SCHWEITZER ROBERT C , TREADO PATRICK J , VANNI G STEVEN , WOLFE JULIANNE
发明人： GARDNER CHARLES W JR , MAIER JOHN S , NELSON MATTHEW P , SCHWEITZER ROBERT C , TREADO PATRICK J , VANNI G STEVEN , WOLFE JULIANNE
IPC分类号： G01J3/02 , G01J3/10 , G01J3/44 , G01N21/35 , G01N21/64 , G01N21/65
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0272 , G01J3/10 , G01N21/35 , G01N21/3577 , G01N21/6458 , G01N21/6486 , G01N21/65 , G01N2021/6417 , G01N2021/6423 , G01N2021/656 , G01N2201/0221
摘要： Pathogenic microorganisms are detected in a wide field of view and classified by Raman light scattered light from these organisms together with digital pattern recognition of their spectral patterns.
摘要翻译：在广泛的视野中检测致病微生物，并通过来自这些生物的拉曼光散射光以及它们的光谱图案的数字图案识别来分类病原微生物。

7. 发明申请

WO2007103897A3 METHOD AND APPARATUS FOR COMPACT SPECTROMETER FOR MULTIPOINT SAMPLING OF AN OBJECT 审中-公开
标题翻译：用于多目标采样的紧凑型光谱仪的方法和装置
公开(公告)号：WO2007103897A3
公开(公告)日：2008-07-10
申请号：PCT/US2007063346
申请日：2007-03-05
申请人： CHEMIMAGE CORP , GARDNER CHARLES W JR , MAIER JOHN S , NELSON MATTHEW P , SCHWEITZER ROBERT C , TREADO PATRICK J , VANNI G STEVEN , WOLFE JULIANNE , DEMUTH JOSEPH E , NEISS JASON H , WANG CHENHUI
发明人： GARDNER CHARLES W JR , MAIER JOHN S , NELSON MATTHEW P , SCHWEITZER ROBERT C , TREADO PATRICK J , VANNI G STEVEN , WOLFE JULIANNE , DEMUTH JOSEPH E , NEISS JASON H , WANG CHENHUI
IPC分类号： G01J3/44 , G01J3/28
CPC分类号： G01N21/65 , G01N21/6456 , G01N2021/6421 , G01N2201/0221
摘要： The disclosure relates to methods and apparatus for assessing occurrence of one or more hazardous agents in a sample by performing multipoint spectral analysis of the sample using a portable or hand-held device. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.
摘要翻译：本公开涉及通过使用便携式或手持式装置对样品进行多点光谱分析来评估样品中一种或多种危险剂的发生的方法和装置。公开了采用拉曼光谱法和其他分光光度法的方法。还公开了适于执行这种多点方法的设备和系统。

8. 发明申请

WO2008042766A1 SPECTRAL IMAGING SYSTEM 审中-公开
标题翻译：光谱成像系统
公开(公告)号：WO2008042766A1
公开(公告)日：2008-04-10
申请号：PCT/US2007/079880
申请日：2007-09-28
申请人： CHEMIMAGE CORPORATION , WANG, Xinghua , TREADO, Patrick, J. , GARDNER, Charles, W. , TUSCHELL, David , ZHANG, Jingyun
发明人： WANG, Xinghua , TREADO, Patrick, J. , GARDNER, Charles, W. , TUSCHELL, David , ZHANG, Jingyun
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0218 , G01J3/10 , G01J3/32 , G01J3/36 , G01J3/447
摘要： Macroscopic and microscopic samples are imaged through a spectral filter operable into the short wave infrared, e.g., to approximately 3200nm. The sample is iliuminated for reflective, transmissive, fluorescent and/or Raman imaging by a laser or metal-halide arc beam. The filter has tunable birefringent retarders distributed rotationally and stacked in stages leading up to a selection polarizer. Image forming optics and CCD cameras collect the luminance of each pixel in the spatially resolved image, at multiple wavelengths to which the filter is tuned successively. The filter stages have comb shaped transmission characteristics. Two filter stages with distinctly different characteristics can be cascaded, one or both being tunable. The combined transmission characteristic has narrow passbands where the bandpass peaks of the stages coincide and wide free spectral range where the peaks do not coincide. Embodiments are disclosed for forensic analysis, material composition and morphology, chemical compound identification and detection of biological species.
摘要翻译：宏观和微观样品通过可操作成短波红外光谱的光谱滤光片成像，例如达到约3200nm。样品通过激光或金属卤化物弧光束进行反射，透射，荧光和/或拉曼成像。滤光器具有可调谐的双折射延迟器，其分级旋转并且分级地分层导向选择偏振器。图像形成光学器件和CCD照相机在多个波长下收集空间分辨图像中每个像素的亮度，其中滤波器依次被调谐到这些波长。过滤器级具有梳状传动特性。可以级联具有明显不同特性的两个过滤器级，一个或两个可调谐。组合传输特性具有窄通带，其中级的带通峰重合，峰的自由光谱范围不一致。公开了用于法医分析，材料组成和形态，化学化合物鉴定和生物物种检测的实施例。

9. 发明申请

WO2007032814A3 SYSTEM AND METHOD FOR ROBOT MOUNTED SENSOR 审中-公开
标题翻译：机器人安装传感器的系统和方法
公开(公告)号：WO2007032814A3
公开(公告)日：2008-01-10
申请号：PCT/US2006027172
申请日：2006-07-12
申请人： CHEMIMAGE CORP , TREADO PATRICK J , GARDNER CHARLES W
发明人： TREADO PATRICK J , GARDNER CHARLES W
IPC分类号： G01N21/00 , G01J3/28 , G01J3/44
CPC分类号： G01N21/474 , G01J3/02 , G01J3/0208 , G01J3/0218 , G01J3/0227 , G01J3/027 , G01J3/0278 , G01J3/0291 , G01J3/44
摘要： An apparatus and method for the remote analysis and identification of unknown compounds. A robotic arm positions a sensor on a surface. The sensor unit has a monitoring mechanism to monitor separation between the sensor unit and the surface when placed in contact with the surface to maintain the separation substantially constant. An illumination source illuminates the region of interest to produce scattered photons from an unknown compound. The scattered photons are collected by an optical system and delivered to a spectroscopic detector for analysis and identification. An algorithm is applied to the data generated by the spectroscopic detector to identify the unknown compound.
摘要翻译：用于远程分析和鉴定未知化合物的装置和方法。机器手臂将传感器定位在表面上。传感器单元具有监测机构，用于在放置与表面接触时监测传感器单元与表面之间的分离，以保持分离基本恒定。照明源照亮感兴趣的区域以产生来自未知化合物的散射光子。散射的光子被光学系统收集并传送到光谱检测器进行分析和识别。将一种算法应用于由光谱检测器产生的数据，以识别未知化合物。

10. 发明申请

WO2007032814A2 SYSTEM AND METHOD FOR ROBOT MOUNTED SENSOR 审中-公开
标题翻译：机器人安装传感器的系统和方法
公开(公告)号：WO2007032814A2
公开(公告)日：2007-03-22
申请号：PCT/US2006/027172
申请日：2006-07-12
申请人： CHEMIMAGE CORPORATION , TREADO, Patrick, J. , GARDNER, Charles, W.
发明人： TREADO, Patrick, J. , GARDNER, Charles, W.
IPC分类号： G01B11/16
CPC分类号： G01N21/474 , G01J3/02 , G01J3/0208 , G01J3/0218 , G01J3/0227 , G01J3/027 , G01J3/0278 , G01J3/0291 , G01J3/44
摘要： An apparatus and method for the remote analysis and identification of unknown compounds. A robotic arm positions a sensor on a surface. The sensor unit has a monitoring mechanism to monitor separation between the sensor unit and the surface when placed in contact with the surface to maintain the separation substantially constant. An illumination source illuminates the region of interest to produce scattered photons from an unknown compound. The scattered photons are collected by an optical system and delivered to a spectroscopic detector for analysis and identification. An algorithm is applied to the data generated by the spectroscopic detector to identify the unknown compound.
摘要翻译：用于远程分析和鉴定未知化合物的装置和方法。机器手臂将传感器定位在表面上。传感器单元具有监测机构，用于在放置与表面接触时监测传感器单元与表面之间的分离，以保持分离基本恒定。照明源照亮感兴趣的区域以产生来自未知化合物的散射光子。散射的光子被光学系统收集并传送到光谱检测器进行分析和识别。将一种算法应用于由光谱检测器产生的数据，以识别未知化合物。

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