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1. 发明申请

WO2006132640A3 LIGHT-DRIVEN MICROFLUIDIC DEVICES AND AMPLIFICATION OF STIMULUS-INDUCED WETTING 审中-公开
标题翻译：轻微驱动的微流体装置和刺激性湿润的放大
公开(公告)号：WO2006132640A3
公开(公告)日：2007-04-19
申请号：PCT/US2005020959
申请日：2005-06-14
申请人： UNIV ARIZONA STATE , ROSARIO ROHIT , PICRAUX S THOMAS , HAYES MARK , GUST JOHN DEVENS JR , GARCIA ANTONIO A
发明人： ROSARIO ROHIT , PICRAUX S THOMAS , HAYES MARK , GUST JOHN DEVENS JR , GARCIA ANTONIO A
IPC分类号： G01N27/26
CPC分类号： B01L3/502707 , B01L3/50273 , B01L3/502746 , B01L3/502792 , B01L2300/0819 , B01L2300/089 , B01L2300/166 , B01L2400/0406 , B01L2400/0448 , B01L2400/0454 , B01L2400/082 , Y10T137/2076 , Y10T137/2191 , Y10T137/2224 , Y10T428/24612
摘要： Disclosed are compositions and methods for producing movement of liquid across surfaces.
摘要翻译：公开了用于在表面上产生液体运动的组合物和方法。

2. 发明申请

WO2005072334A2 PHOTORESPONSIVE HYDROGELS 审中-公开
公开(公告)号：WO2005072334A2
公开(公告)日：2005-08-11
申请号：PCT/US2005/002317
申请日：2005-01-24
申请人： ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY , GARCIA, Antonio, A. , ROSARIO, Rohit , GUST, John, Devens, Jr. , HAYES, Mark, A. , MARQUEZ, Manuel , HU, Zhibing , CAI, Tong
发明人： GARCIA, Antonio, A. , ROSARIO, Rohit , GUST, John, Devens, Jr. , HAYES, Mark, A. , MARQUEZ, Manuel , HU, Zhibing , CAI, Tong
IPC分类号： A61K47/34
CPC分类号： C08F2/50 , A61K47/34
摘要： Disclosed are photoresponsive hydrogels. The compositions disclosed herein can be prepared by polymerizing a hydrogel precursor and a spiropyran. The properties of the disclosed compositions can be changed by exposure to light, pH, and temperature. Methods of using the disclosed compositions to deliver pharmaceutical actives are also disclosed.
摘要翻译：公开了光响应水凝胶。本文公开的组合物可以通过聚合水凝胶前体和螺吡喃来制备。所公开的组合物的性质可以通过暴露于光，pH和温度而改变。还公开了使用所公开的组合物递送药物活性物质的方法。

3. 发明申请

WO2004000446A2 METHOD AND ARRANGEMENT OF ROTATING MAGNETICALLY INDUCIBLE PARTICLES 审中-公开
标题翻译：旋转磁性诱导颗粒的方法和布置
公开(公告)号：WO2004000446A2
公开(公告)日：2003-12-31
申请号：PCT/US2003/019257
申请日：2003-06-20
申请人： ARIZONA BOARD OF REGENTS , GARCIA, Antonio, A. , VUPPU, Anil, K.
发明人： GARCIA, Antonio, A. , VUPPU, Anil, K.
IPC分类号： B01F
CPC分类号： B01F13/0809
摘要： This invention provides a device and method for rotating magnetically inducible particles suspended in a fluid by rotating a multidirectional magnetic field through the suspended particles. A rare earth magnet is positioned adjacent to the suspended particles and oriented such that the axis of a magnetic field generated by the magnet passes through the suspension. The magnetic flux lines of the magnet's field radiate in multiple directions through the suspended particles, them to form long multidirectional chains. The magnet and the chains of suspended particles are rotated with respect to one another, the axis of the rotation being approximately parallel to the magnetic axis of the multidirectional magnetic field. This causes the particle chains to rotate about the magnetic axis, thus mixing the fluid.
摘要翻译：本发明提供一种通过使多向磁场通过悬浮颗粒旋转来旋转悬浮在流体中的磁诱导颗粒的装置和方法。稀土磁体定位成与悬浮颗粒相邻并且定向成使得由磁体产生的磁场的轴线通过悬架。磁场的磁通线通过悬浮颗粒沿多个方向辐射，形成长的多向链。磁体和悬浮颗粒的链条相对于彼此旋转，旋转轴线大致平行于多向磁场的磁轴。这使得颗粒链围绕磁轴旋转，从而混合流体。

4. 发明申请

WO2001098785A3 RAPID FLOW-BASED IMMUNOASSAY MICROCHIP 审中-公开
公开(公告)号：WO2001098785A3
公开(公告)日：2001-12-27
申请号：PCT/US2001/041037
申请日：2001-06-19
申请人： ARIZONA BOARD OF REGENTS , HAYES, Mark, A. , POLSON, Nolan, A. , VUPPU, Anil, K. , CROWLEY, Timothy, A. , GARCIA, Antonio, A.
发明人： HAYES, Mark, A. , POLSON, Nolan, A. , VUPPU, Anil, K. , CROWLEY, Timothy, A. , GARCIA, Antonio, A.
IPC分类号： G01N33/543
摘要： A microimmunoassay arrangement including paramagnetic particles having labeled antibody held in a microchannel by an external magnetic field provides rapid analysis using small sample volumes.

5. 发明申请

WO0021665A9 IMMOBILIZED SILVER IMMUNOASSAY SYSTEM 审中-公开
标题翻译：免疫银免疫系统
公开(公告)号：WO0021665A9
公开(公告)日：2000-08-24
申请号：PCT/US9923902
申请日：1999-10-14
申请人： UNIV ARIZONA , GARCIA ANTONIO A , BONEN MATTHEW R
发明人： GARCIA ANTONIO A , BONEN MATTHEW R
IPC分类号： G01N33/53 , G01N33/543 , B01L3/00 , B05D5/12 , C12Q1/68 , G01N33/549 , G01N33/553
CPC分类号： G01N33/54393 , G01N33/5304
摘要： The present invention provides bioassay plates having silver ions immobilized thereon, which are useful in immunoassays for detection of antibodies or antigens. Methods of making and using the biossay plates are also provided, as well as an apparatus for making activated bioassay plates.
摘要翻译：本发明提供了其上固定有银离子的生物测定板，其可用于检测抗体或抗原的免疫测定。还提供制造和使用生物测定板的方法，以及用于制备活性生物测定板的装置。

6. 发明申请

WO2004000446A3 METHOD AND ARRANGEMENT OF ROTATING MAGNETICALLY INDUCIBLE PARTICLES 审中-公开
标题翻译：旋转磁性诱导颗粒的方法和布置
公开(公告)号：WO2004000446A3
公开(公告)日：2004-03-25
申请号：PCT/US0319257
申请日：2003-06-20
申请人： UNIV ARIZONA , GARCIA ANTONIO A , VUPPU ANIL K
发明人： GARCIA ANTONIO A , VUPPU ANIL K
IPC分类号： B01F20060101 , B01F13/08
CPC分类号： B01F13/0809
摘要： A device and method for rotating magnetically inducible particles (204) suspended in a fluid by rotating a multidirectional magnetic field through the suspended particles. A rare earth magnet (502) is positioned adjacent to the suspended particles and oriented such that the axis of a magnetic field generated by the magnet passes through the suspension. The magnetic flux lines of the magnet's field radiate in multiple directions through the suspended particles, them to form long multidirectional chains (601). The magnet and the chains of suspended particles (601) are rotated with respect to one another, the axis of the rotation (503) being approximately parallel to the magnetic axis of the multidirectional magnetic field. This causes the particle chains (601) to rotate about the magnetic axis, thus mixing the fluid.
摘要翻译：一种用于通过旋转多向磁场通过悬浮颗粒旋转悬浮在流体中的磁诱导颗粒（204）的装置和方法。稀土磁体（502）定位成与悬浮颗粒相邻并且定向成使得由磁体产生的磁场的轴线穿过悬架。磁场的磁通线通过悬浮颗粒沿多个方向辐射，形成长的多向链（601）。磁体和悬浮颗粒链（601）相对于彼此旋转，旋转轴（503）大致平行于多方向磁场的磁轴。这使得颗粒链（601）围绕磁轴旋转，从而混合流体。

7. 发明申请

WO0189985A3 NOVEL METHOD OF CREATING MICRO-STRUCTURES FOR MICRO-FLUIDIC APPLICATIONS 审中-公开
标题翻译：微流体应用微创结构的新方法
公开(公告)号：WO0189985A3
公开(公告)日：2002-03-28
申请号：PCT/US0116764
申请日：2001-05-23
申请人： UNIV ARIZONA , HAYES MARK A , GARCIA ANTONIO A , POLSON NOLAN A
发明人： HAYES MARK A , GARCIA ANTONIO A , POLSON NOLAN A
IPC分类号： B81B1/00 , H01F1/00 , H01F1/44 , B03C1/00
CPC分类号： H01F1/44 , B81B1/00 , H01F1/0018 , Y10T137/2191
摘要： A method for assembling a pattern of structures in a microchannel comprises providing a colloid of paramagnetic particles in a microchannel and applying an axially uniform magnetic field thereto.
摘要翻译：在微通道中组装结构图案的方法包括在微通道中提供顺磁性粒子的胶体并向其施加轴向均匀的磁场。

8. 发明申请

WO2011034678A1 USE OF SUPERHYDROPHOBIC SURFACES FOR LIQUID AGGLUTINATION ASSAYS 审中-公开
标题翻译：超声波表面用于液体分析测定
公开(公告)号：WO2011034678A1
公开(公告)日：2011-03-24
申请号：PCT/US2010/045692
申请日：2010-08-17
申请人： ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA , GARCIA, Antonio, A. , SCHNEIDER, John
发明人： GARCIA, Antonio, A. , SCHNEIDER, John
IPC分类号： G01N21/00
CPC分类号： G01N21/82 , G01N21/49 , G01N33/5304 , G01N33/536 , G01N33/54346 , G01N2021/035
摘要： This invention relates to the use of thermodynamically incompatible surfaces in agglutination assays for the express purpose of using the sample as a key component of the detection instrument. Specifically, the invention relates to formation of a lense and a virtual container for rapid mixing via thermal energy by a sample liquid disposed on a superhydrophobic surfaces, and a subsequent specific analyte or overall protein concentration assay using particles agglutination for use in the industrial, environmental, and clinical laboratory test fields.
摘要翻译：本发明涉及在凝集测定中使用热力学不相容的表面，以便将样品用作检测仪器的关键组分。具体地说，本发明涉及用于通过设置在超疏水表面上的样品液体通过热能快速混合的透镜和虚拟容器的形成，以及随后使用用于工业环境中的颗粒凝集物的特定分析物或总体蛋白质浓度测定，临床实验室检测领域。

9. 发明申请

WO2007101174A3 DIGITAL MAGNETOFLUIDIC DEVICES AND METHODS 审中-公开
公开(公告)号：WO2007101174A3
公开(公告)日：2007-09-07
申请号：PCT/US2007/062842
申请日：2007-02-27
申请人： ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY , HERNANDEZ, Sonia, Melle , GOMEZ, Ana, N. , PICRAUX, S., Thomas , GUST, John, Devens , HAYES, Mark , LINDSAY, Solitaire , GARCIA, Antonio, A. , WANG, Joseph , VAZQUEZ-ALVAREZ, Terannie
发明人： HERNANDEZ, Sonia, Melle , GOMEZ, Ana, N. , PICRAUX, S., Thomas , GUST, John, Devens , HAYES, Mark , LINDSAY, Solitaire , GARCIA, Antonio, A. , WANG, Joseph , VAZQUEZ-ALVAREZ, Terannie
IPC分类号： B32B9/00
摘要： Disclosed are devices and methods for moving and controlling droplets of fluids on hydrophobic surfaces through the use of magnetic fields. For example, droplets can be moved, immobilized, dispensed, coalesced, and/or divided. Also disclosed is a digital magnetofluidic device comprising a hydrophobic surface; a magnetically active fluid droplet in contact with the surface; and a magnetic field coupled with at least a portion of the droplet. Also disclosed is a digital isoelectric focusing method using the devices and methods. Also disclosed are digital microelectrochemical detection methods and digital microelectrochemical reaction methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

10. 发明申请

WO2007101174A2 DIGITAL MAGNETOFLUIDIC DEVICES AND METHODS 审中-公开
标题翻译：数字磁阻器件及方法
公开(公告)号：WO2007101174A2
公开(公告)日：2007-09-07
申请号：PCT/US2007062842
申请日：2007-02-27
申请人： UNIV ARIZONA STATE , HERNANDEZ SONIA MELLE , GOMEZ ANA N , PICRAUX S THOMAS , GUST JOHN DEVENS , HAYES MARK , LINDSAY SOLITAIRE , GARCIA ANTONIO A , WANG JOSEPH , VAZQUEZ-ALVAREZ TERANNIE
发明人： HERNANDEZ SONIA MELLE , GOMEZ ANA N , PICRAUX S THOMAS , GUST JOHN DEVENS , HAYES MARK , LINDSAY SOLITAIRE , GARCIA ANTONIO A , WANG JOSEPH , VAZQUEZ-ALVAREZ TERANNIE
CPC分类号： B01F13/0071 , B01F13/0077 , B01L3/502792 , B01L2300/0822 , B01L2300/166 , B01L2400/043 , B01L2400/0448
摘要： Disclosed are devices and methods for moving and controlling droplets of fluids on hydrophobic surfaces through the use of magnetic fields. For example, droplets can be moved, immobilized, dispensed, coalesced, and/or divided. Also disclosed is a digital magnetofluidic device comprising a hydrophobic surface; a magnetically active fluid droplet in contact with the surface; and a magnetic field coupled with at least a portion of the droplet. Also disclosed is a digital isoelectric focusing method using the devices and methods. Also disclosed are digital microelectrochemical detection methods and digital microelectrochemical reaction methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译：公开了通过使用磁场来移动和控制疏水表面上的流体液滴的装置和方法。例如，液滴可以被移动，固定，分配，聚结和/或分割。还公开了包括疏水表面的数字磁流体装置; 与表面接触的磁性活性流体液滴; 以及与液滴的至少一部分耦合的磁场。还公开了使用这些装置和方法的数字等电聚焦方法。还公开了数字微电化学检测方法和数字微电化学反应方法。该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

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