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1. 发明申请

WO2005062340A3 HIGH THROUGHPUT SYSTEMS AND METHODS FOR PARALLEL SAMPLE ANALYSIS 审中-公开
标题翻译：高通量系统和并行样品分析方法
公开(公告)号：WO2005062340A3
公开(公告)日：2006-07-06
申请号：PCT/US2004023980
申请日：2004-07-23
申请人： NANOSTREAM INC , HOBBS STEVEN E , O'CONNOR STEPHEN D , GAMBLE RONALD C
发明人： HOBBS STEVEN E , O'CONNOR STEPHEN D , GAMBLE RONALD C
IPC分类号： H01J49/00 , B01J19/00 , B01L3/00 , G01N30/60 , G01N30/72 , H01J49/02 , H01J49/04
CPC分类号： G01N30/6043 , B01L3/5027 , G01N30/6095 , G01N30/72 , H01J49/009 , H01J49/04
摘要： Systems and methods for analyzing multiple samples in parallel using mass spectrometry preferably coupled with fluid phase separation techniques are provided. A modular mass spectrometer includes a vacuum enclosure, multiple sample inlets, multiple common vacuum pumping elements, and multiple mass analysis modules disposed substantially within the enclosure, with each module preferably including a mass analyzer and a transducer. In one embodiment, the modules mate with the vacuum enclosure to define multiple sequential vacuum regions, with each vacuum region having an associated common vacuum pumping element. At least one multi-pole ion transfer optic element is preferably associated with each module. Fluid phase separation devices for use with a multi-analyzer spectrometer may include microfluidic devices utilizing chromatographic, electrophoretic, or other separation methods to process raw samples into prepared samples to be ionized and injected into a multi-channel mass spectrometer.
摘要翻译：提供了使用优选与流体相分离技术结合的质谱分析多个样品并行的系统和方法。模块化质谱仪包括真空外壳，多个样品入口，多个共同的真空抽吸元件和基本上设置在外壳内的多个质量分析模块，每个模块优选地包括质量分析器和换能器。在一个实施例中，模块与真空外壳配合以限定多个连续的真空区域，每个真空区域具有相关联的共同真空泵送元件。至少一个多极离子转移光学元件优选地与每个模块相关联。用于多分析仪光谱仪的流体相分离装置可以包括利用色谱，电泳或其它分离方法的微流体装置，以将原始样品处理成待离子化并注入多通道质谱仪的制备样品。

2. 发明申请

WO2005062340A2 HIGH THROUGHPUT SYSTEMS AND METHODS FOR PARALLEL SAMPLE ANALYSIS 审中-公开
标题翻译：高通量系统和并行样品分析方法
公开(公告)号：WO2005062340A2
公开(公告)日：2005-07-07
申请号：PCT/US2004/023980
申请日：2004-07-23
申请人： NANOSTREAM, INC.? , HOBBS, Steven, E? , O'CONNOR, Stephen, D.? , GAMBLE, Ronald, C.?
发明人： HOBBS, Steven, E? , O'CONNOR, Stephen, D.? , GAMBLE, Ronald, C.?
IPC分类号： H01J49/04
CPC分类号： G01N30/6043 , B01L3/5027 , G01N30/6095 , G01N30/72 , H01J49/009 , H01J49/04
摘要： Systems and methods for analyzing multiple samples in parallel using mass spectrometry preferably coupled with fluid phase separation techniques are provided. A modular mass spectrometer includes a vacuum enclosure, multiple sample inlets, multiple common vacuum pumping elements, and multiple mass analysis modules disposed substantially within the enclosure, with each module preferably including a mass analyzer and a transducer. In one embodiment, the modules mate with the vacuum enclosure to define multiple sequential vacuum regions, with each vacuum region having an associated common vacuum pumping element. At least one multi-pole ion transfer optic element is preferably associated with each module. Fluid phase separation devices for use with a multi-analyzer spectrometer may include microfluidic devices utilizing chromatographic, electrophoretic, or other separation methods to process raw samples into prepared samples to be ionized and injected into a multi-channel mass spectrometer.
摘要翻译：提供了使用优选与流体相分离技术结合的质谱分析多个样品并行的系统和方法。模块化质谱仪包括真空外壳，多个样品入口，多个共同的真空抽吸元件和基本上设置在外壳内的多个质量分析模块，每个模块优选地包括质量分析器和换能器。在一个实施例中，模块与真空外壳配合以限定多个连续的真空区域，每个真空区域具有相关联的共同真空泵送元件。至少一个多极离子转移光学元件优选地与每个模块相关联。用于多分析仪光谱仪的流体相分离装置可以包括利用色谱，电泳或其它分离方法的微流体装置，以将原始样品处理成待离子化并注入多通道质谱仪的制备样品。

3. 发明申请

WO2010048036A2 SYSTEMS AND METHODS FOR MANAGING UTILITY CONSUMPTION 审中-公开
标题翻译：用于管理公用事业消费的系统和方法
公开(公告)号：WO2010048036A2
公开(公告)日：2010-04-29
申请号：PCT/US2009/060925
申请日：2009-10-15
申请人： TERRATRIM, INC. , O'CONNOR, Stephen, D. , GAMBLE, Ronald, C. , SUCHTER, Richard, A.
发明人： O'CONNOR, Stephen, D. , GAMBLE, Ronald, C. , SUCHTER, Richard, A.
IPC分类号： G06Q50/00
CPC分类号： G06Q10/06
摘要： A system and method for monitoring and managing utility consumption includes use of (A) one or more sensors arranged to monitor an operating condition and/or utility consumption of at least one segment or appliance of a first facility; (B) a memory including at least one of (i) stored utility consumption information correlated or normalized to at least one designated parameter affecting utility consumption or (ii) hypothetical utility consumption; (C) a processor to compare the monitored information with the stored information, and (D) an output medium to store and/or display the comparison information. Stored consumption information may relate to the first facility or a second facility. Hypothetical utility consumption information may relate to a segment or appliance of the first facility operated according to optimized conditions, or an upgraded segment or appliance.
摘要翻译：用于监测和管理公用设施消耗的系统和方法包括使用（A）一个或多个传感器，所述一个或多个传感器被布置成监测第一设施的至少一个区段或设备的操作状况和/或公用设施消耗 ; （B）包括以下中的至少一个的存储器：（i）与影响公共设施消耗的至少一个指定参数相关或归一化的所存储的公用设施消耗信息或（ii）假设公用设施消耗; （C）处理器，将监视的信息与存储的信息进行比较，以及（D）存储和/或显示比较信息的输出介质。存储的消耗信息可能与第一设施或第二设施有关。假想的公用设施消耗信息可以涉及根据优化的条件操作的第一设施的区段或设备，或升级的区段或设备。

4. 发明申请

WO2010048036A3 SYSTEMS AND METHODS FOR MANAGING UTILITY CONSUMPTION 审中-公开
标题翻译：用于管理实用消费的系统和方法
公开(公告)号：WO2010048036A3
公开(公告)日：2010-07-22
申请号：PCT/US2009060925
申请日：2009-10-15
申请人： TERRATRIM INC , O'CONNOR STEPHEN D , GAMBLE RONALD C , SUCHTER RICHARD A
发明人： O'CONNOR STEPHEN D , GAMBLE RONALD C , SUCHTER RICHARD A
IPC分类号： G06Q10/00
CPC分类号： G06Q10/06
摘要： A system and method for monitoring and managing utility consumption includes use of (A) one or more sensors arranged to monitor an operating condition and/or utility consumption of at least one segment or appliance of a first facility; (B) a memory including at least one of (i) stored utility consumption information correlated or normalized to at least one designated parameter affecting utility consumption or (ii) hypothetical utility consumption; (C) a processor to compare the monitored information with the stored information, and (D) an output medium to store and/or display the comparison information. Stored consumption information may relate to the first facility or a second facility. Hypothetical utility consumption information may relate to a segment or appliance of the first facility operated according to optimized conditions, or an upgraded segment or appliance.
摘要翻译：一种用于监测和管理公用事业消耗的系统和方法包括使用（A）布置成监测第一设施的至少一个段或设备的运行状况和/或公用事业消耗的一个或多个传感器; （B）存储器，其包括以下中的至少一个：（i）与影响公用事业消耗的至少一个指定参数相关联或归一化的存储的公用设施消耗信息;（ii）假设的公用事业消费; （C）处理器，用于将所监视的信息与存储的信息进行比较，以及（D）存储和/或显示比较信息的输出介质。存储的消费信息可能与第一设施或第二设施有关。假设效用消耗信息可以涉及根据优化条件操作的第一设施的段或设备，或升级的段或设备。

5. 发明申请

WO1998010858A1 APPARATUS FOR THE CHEMICAL SYNTHESIS OF MOLECULAR ARRAYS 审中-公开
标题翻译：化学合成分子阵列的装置
公开(公告)号：WO1998010858A1
公开(公告)日：1998-03-19
申请号：PCT/US1997016594
申请日：1997-09-16
申请人： INCYTE PHARMACEUTICALS, INC. , GAMBLE, Ronald, C. , THERIAULT, Thomas, P. , BALDESCHWIELER, John, D.
发明人： INCYTE PHARMACEUTICALS, INC.
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00378 , B01J2219/00391 , B01J2219/00475 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00722 , C40B40/06 , C40B60/14 , Y02P20/582
摘要： An apparatus for the automated synthesis of molecular arrays. A jetting device (24) is employed along with a reaction chamber (26) to dispense reagents used in the synthesis onto the substrate (20). A positioning system (30) moves the substrate (20, 20') from the jet (24) to the reaction chamber (26). A controller (44) controls the movement of the substrate (20, 20') and the application of the reagents so that the synthesis is carried out according to a pre-determined procedure. The apparatus will synthesize nucleotides in an array of micron-size spots according to a pattern selected by the operator immediately prior to synthesis.
摘要翻译：用于自动合成分子阵列的装置。喷射装置（24）与反应室（26）一起被用于将合成中使用的试剂分配到基材（20）上。定位系统（30）将基板（20,20'）从射流（24）移动到反应室（26）。控制器（44）控制衬底（20,20'）的移动和试剂的施加，使得根据预定程序进行合成。该装置将根据在合成前立即由操作者选择的图案在微米级斑点的阵列中合成核苷酸。

6. 发明申请

WO1998025944A1 SOLVENT VEHICLES FOR REAGENT DELIVERY IN OLIGONUCLEOTIDE SYNTHESIS USING AUTOMATED PULSE JETTING DEVICES 审中-公开
标题翻译：在使用自动脉冲喷射装置的寡核苷酸合成中用于试剂递送的溶剂车辆
公开(公告)号：WO1998025944A1
公开(公告)日：1998-06-18
申请号：PCT/US1997023318
申请日：1997-12-12
申请人： INCYTE PHARMACEUTICALS, INC. , GAMBLE, Ronald, C. , THERIAULT, Thomas, P. , WINDER, Scott, C.
发明人： INCYTE PHARMACEUTICALS, INC.
IPC分类号： C07H21/00
CPC分类号： C07H21/00 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00722 , C40B40/06 , C40B60/14
摘要： Solvent vehicles and methods of their use in the pulse jet delivery of reagents in automated oligonucleotide synthesis by the solid-phase phosphoramidite method are provided. For pulse jet delivery of the activated monomer, acetonitrile in combination with at least one stabilizer co-solvent is employed as the solvent vehicle, where the stabilizer co-solvent is an inert, organic solvent having a boiling point of at least 100 DEG C. For pulse jet delivery of the detritylation reagent, a mono- or disubstituted methane is employed as the solvent vehicle, where substituents have a molecular weight greater than 36 daltons. Use of the solvent vehicles according to the subject invention provides for reduced reagent precipitation in the pulse jet tubes and improved results.
摘要翻译：提供溶剂车辆及其在通过固相亚磷酰胺方法的自动寡核苷酸合成中脉冲喷射输送试剂中的方法。对于活化单体的脉冲喷射输送，使用乙腈与至少一种稳定剂助溶剂组合作为溶剂载体，其中稳定剂助溶剂是沸点至少为100℃的惰性有机溶剂。对于去离子试剂的脉冲喷射输送，使用单取代或二取代的甲烷作为溶剂载体，其中取代基的分子量大于36道尔顿。根据本发明的溶剂载体的使用提供了脉冲喷射管中减少的试剂沉淀和改进的结果。

7. 发明申请

WO1997044134A1 JET DROPLET DEVICE AND METHOD 审中-公开
标题翻译：喷射装置和方法
公开(公告)号：WO1997044134A1
公开(公告)日：1997-11-27
申请号：PCT/US1997008135
申请日：1997-05-13
申请人： INCYTE PHARMACEUTICALS, INC. , GAMBLE, Ronald, C. , THERIAULT, Thomas, P. , BALDESCHWIELER, John
发明人： INCYTE PHARMACEUTICALS, INC.
IPC分类号： B01L03/02
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00531 , B01J2219/00533 , B01J2219/00536 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00691 , B01L2200/04 , B82Y30/00 , C40B50/14 , C40B60/14 , G01N2001/282 , G01N2035/1041
摘要： Devices and method are provided for precise reduction of arrays of microspots. A pulse jetting device is employed having a capillary (16) of micron dimensions, with a portion of the capillary proximal to the jetting orifice (60) circumferentially surrounded by a piezoelectric transducer (56). By appropriate design of the capillary (16), orifice (60) and piezoelectric transducer (56), droplets can be formed on a surface, separated by as little as 80 microns center-to-center, and having at least about a 15 micron spacing at the border. The subject subtrate arrays can be used for providing miniaturized arrays of reagents, such as nucleic acids, for detecting the presence of homologous sequences in a sample.
摘要翻译：提供了设备和方法来精确地减少微阵列阵列。使用脉冲喷射装置具有微米尺寸的毛细管（16），毛细管的一部分靠近喷射孔（60），周向地被压电换能器（56）包围。通过毛细管（16），孔口（60）和压电换能器（56）的适当设计，可以在表面上形成液滴，中心至中心分开少至80微米，并具有至少约15微米边界间距。主题减滴阵列可用于提供用于检测样品中同源序列存在的试剂例如核酸的小型化阵列。

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