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    • 3. 发明申请
    • USE OF CBX CANNABINOID RECEPTOR MODULATORS AS POTASSIUM CHANNEL MODULATORS
    • CBX CANNABINOID受体调节剂作为钾通道调节剂的使用
    • WO2007125049A1
    • 2007-11-08
    • PCT/EP2007/053915
    • 2007-04-20
    • SOLVAY PHARMACEUTICALS GMBHANTEL, JochenGREGORY, Peter-ColinLANGE, Josephus Hubertus MariaFIRNGES, MichaelREICHE, Dania
    • ANTEL, JochenGREGORY, Peter-ColinLANGE, Josephus Hubertus MariaFIRNGES, MichaelREICHE, Dania
    • A61K31/353A61K31/425A61K31/415A61K31/454A61K31/09A61K31/542A61K31/5415A61P3/04A61P3/10A61P9/06A61P9/10A61P13/10A61P15/10A61P17/14A61P25/28
    • A61K31/09A61K31/353A61K31/415A61K31/425A61K31/454A61K31/5415A61K31/542
    • The invention is directed to the use of at least one CB x modulator wherein the CB x modulator is selected from the group consisting of CB 1 agonists; CB 2 agonists; CB 2 partial agonists; CB 2 antagonists; CB 2 inverse agonists; and dually acting compounds which are both a CB 1 agonist and a CB 2 agonist; and mixtures thereof, as K ATP channel modulator for the prophylaxis, treatment, delayed progression, delayed onset and/or inhibition of a variety of disease conditions including obesity, diabetes mellitus, metabolic syndrome, syndrome X, insulinoma, familial hyperinsulemic hypoglycemia, male pattern baldness, detrusor hyperreactivity, asthma, neuroprotection, epilepsy, analgesia, cardioprotection, angina, cardioplegia, arrhythmia, coronary spasm, peripheral vascular disease, cerebral vasospasm, appetite regulation, neurodegeneration, pain - including neuropathic pain and chronic pain - and impotence in mammals and humans. The invention further relates to methods of treating, preventing, delaying progression of, delaying onset of and/or inhibiting a variety of disease conditions including obesity, diabetes mellitus, metabolic syndrome, syndrome X, insulinoma, familial hyperinsulemic hypoglycemia, male pattern baldness, detrusor hyperreactivity, asthma, neuroprotection, epilepsy, analgesia, cardioprotection, angina, cardioplegia, arrhythmia, coronary spasm, peripheral vascular disease, cerebral vasospasm, appetite regulation, neurodegeneration, pain - including neuropathic pain and chronic pain - and impotence in mammals and humans comprising administering to a subject in need thereof an effective amount of at least one CB x modulator having K ATP channel modulating properties.
    • 本发明涉及使用至少一种CB-X调节剂,其中CB调节剂选自CB 1激动剂 ; CB 2激动剂; CB 2/2部分激动剂; CB 2拮抗剂; CB 2反向激动剂; 和作为CB 1激动剂和CB 2 N 2激动剂的双作用化合物; 和其混合物,作为用于预防,治疗,延迟进展,延迟发作和/或抑制多种疾病状况(包括肥胖症,糖尿病,代谢综合征,综合征X,胰岛素瘤)的K ATP通道调节剂 ,家族性高胰岛素低血糖,男性型秃发,逼尿肌反应性过高,哮喘,神经保护,癫痫,镇痛,心脏保护,心绞痛,心跳停搏,心律失常,冠状动脉痉挛,外周血管疾病,脑血管痉挛,食欲调节,神经变性,疼痛 - 包括神经性疼痛和慢性 疼痛和哺乳动物和人类的阳。。 本发明还涉及治疗,预防,延缓发病和/或抑制各种疾病状况(包括肥胖症,糖尿病,代谢综合征,综合征X,胰岛素瘤,家族性高胰岛素低血糖,男性型秃发,逼尿肌)的进展, 高反应性,哮喘,神经保护,癫痫,止痛,心脏保护,心绞痛,心脏停跳,心律失常,冠状动脉痉挛,外周血管疾病,脑血管痉挛,食欲调节,神经变性,疼痛 - 包括神经性疼痛和慢性疼痛 - 以及哺乳动物和人的阳humans 涉及有需要的受试者有效量的至少一种具有K ATP通道调节特性的CB调节剂。