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1. 发明申请

WO2011054693A1 TUBING SET HAVING A GATE FOR THE CONNECTION OF VIALS 审中-公开
标题翻译：具有连接门的管道
公开(公告)号：WO2011054693A1
公开(公告)日：2011-05-12
申请号：PCT/EP2010/066056
申请日：2010-10-25
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH , REITER, Reinhold , FINI, Massimo , VENERONI, Alain , BARTHOLOMÄUS, Johannes , WIESEN, Gerhard
发明人： REITER, Reinhold , FINI, Massimo , VENERONI, Alain , BARTHOLOMÄUS, Johannes , WIESEN, Gerhard
IPC分类号： A61M1/34
CPC分类号： A61M1/3672 , A61M1/3621 , A61M1/3627 , A61M2205/07 , A61M2205/3331
摘要： The present invention refers to a tubing set (12) suitable for use in co-operation with a hemodialysis machine (10). The tubing set comprises: an out-tube (14) for supplying the blood from the patient to a filter (16) of the machine; an in-tube (18) for supplying the blood from the filter back to the patient; a drip chamber (20) placed along one of said tubes, adapted to let the blood drip through an air buffer (22); and a vial gate (24) for the connection of vials (26) containing drugs to be delivered into the blood. The vial gate (24) according to the invention comprises a delivery lumen (28), suitable for delivering the drug (30) from the vial to the drip chamber, and a vent lumen (32), suitable for providing air (34) inside the vial in order to replace the delivered drug.
摘要翻译：本发明涉及适用于与血液透析机（10）合作的管组（12）。管组包括：用于将血液从患者提供给机器的过滤器（16）的外管（14）; 用于将来自过滤器的血液提供给患者的管内（18）; 沿着所述管中的一个放置一个适于使血液通过空气缓冲器（22）滴落的滴水室（20）; 以及用于连接含有要输送到血液中的药物的小瓶（26）的小瓶门（24）。根据本发明的小瓶门（24）包括适于将药物（30）从小瓶输送到滴液室的输送腔（28）和适于在内部提供空气（34）的排气腔（32）该小瓶为了更换递送的药物。

2. 发明申请

WO2011015961A1 HEAT EXCHANGE CIRCUIT 审中-公开
标题翻译：热交换电路
公开(公告)号：WO2011015961A1
公开(公告)日：2011-02-10
申请号：PCT/IB2010/053279
申请日：2010-07-19
申请人： SIS-TER SPA , FINI, Massimo
发明人： FINI, Massimo
IPC分类号： A61M5/44 , F28F3/12 , F28F21/06 , F28F3/04
CPC分类号： A61M19/00 , A61M1/166 , A61M1/36 , A61M5/44 , A61M2205/127 , A61M2205/3653 , A61M2205/3673 , A61M2206/20 , F28F3/046 , F28F3/12 , F28F21/065 , Y10T29/4935
摘要： The present invention relates to a heat exchange circuit (30) suitable for promoting heat exchange to/from a physiological fluid. The circuit (30) comprises at least two walls (32 and 34) which rest on each other and are sealed so as to form a duct (36) able to contain a flow of physiological fluid. Each one of the at least two walls comprises, during use, a pattern of corrugations (320 and 340). The corrugations have, at least along sections, a preferential direction. The pattern of corrugations of one wall is positioned so as to be superimposed at least partially on the pattern of corrugations of the other wall so as to form an angle γ between the respective preferential directions, γ ranging between 70° and 110°. Finally at least one of the walls is designed to transfer heat to/from the flow of liquid. The invention relates moreover to a thermal device suitable for use together with the heat exchange circuit. The thermal device (50) comprises two plates (52 and 54), at least one of which is thermally active and which are shaped so as to obtain intimate contact with the walls of the heat exchange circuit, at least in the zones coinciding with the respective patterns of corrugations.
摘要翻译：本发明涉及适于促进与生理液体的热交换的热交换回路（30）。电路（30）包括彼此搁置并被密封以形成能够容纳生理流体流的管道（36）的至少两个壁（32和34）。所述至少两个壁中的每一个在使用期间包括波纹图案（320和340）。这些波纹至少沿着断面具有优先的方向。一个壁的波纹图案被定位成至少部分地叠置在另一个壁的波纹图案上，以便形成一个角度θ 在各自的优先方向之间？范围在70°到110°之间。最后，至少一个壁被设计成将热量传送到/从液体流中。本发明还涉及适合与热交换电路一起使用的热装置。热装置（50）包括两个板（52和54），其中至少一个是热活性的并且其形状被成形为与热交换回路的壁紧密接触，至少在与相应的波纹图案。

3. 发明申请

WO2011134859A1 MEMBRANE FOR A PRESSURE DOME 审中-公开
标题翻译：压力杯的薄膜
公开(公告)号：WO2011134859A1
公开(公告)日：2011-11-03
申请号：PCT/EP2011/056321
申请日：2011-04-20
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GmbH , FINI, Massimo , REITER, Reinhold , DONARINI, Luca
发明人： FINI, Massimo , REITER, Reinhold , DONARINI, Luca
IPC分类号： A61M1/36
CPC分类号： G01L19/14 , A61M1/3639 , A61M1/3641 , G01L7/08
摘要： The present invention relates to a membrane (12) for a pressure dome (10) suitable for cooperation with a pressure sensor (22). The membrane comprises a resilient circular Avail (120) suitable for closing one side of the pressure dome (10) so as to define a partition between the inside of the pressure dome and the outside; and a circular rim (124) suitable for being joined to a main body (16) of the pressure dome. The membrane is characterized in that the resilient circular wall, when there is no difference between the pressures acting respectively on the inner surface (121) and on the outer surface (122), has an outwardly convex form. The invention also relates to a pressure dome comprising the membrane.
摘要翻译：本发明涉及一种用于与压力传感器（22）配合的用于压力圆顶（10）的膜（12）。所述膜包括适于封闭所述压力圆顶（10）的一侧以便限定所述压力圆顶的内部与所述外部之间的间隔的弹性圆形可动（120）; 以及适于连接到压力圆顶的主体（16）的圆形边缘（124）。膜的特征在于，当分别作用在内表面（121）和外表面（122）上的压力之间没有差异时，弹性圆形壁具有向外凸的形式。本发明还涉及包括膜的压力圆顶。

4. 发明申请

WO2010133515A1 SAFETY INSERT FOR EXTRA-CORPOREAL CIRCUITS 审中-公开
标题翻译：安全门禁用于外部电路
公开(公告)号：WO2010133515A1
公开(公告)日：2010-11-25
申请号：PCT/EP2010/056640
申请日：2010-05-14
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH , FINI, Massimo
发明人： FINI, Massimo
IPC分类号： A61M1/36 , G01L19/06
CPC分类号： A61M1/3639 , A61M1/3641 , A61M2205/15 , A61M2205/16 , A61M2205/7536 , G01L19/003 , G01L19/0636 , Y10T428/13
摘要： The present invention relates to a safety insert 20 for an extra-corporeal circuit 19. The safety insert, comprises: a first half-shell 21 and a second half-shell 22 forming a shell 212 defining an inner duct 221, at least part of the second half-shell being made with a translucent or transparent material; a first tubular connector 25 adapted to be connected to a branch pipe 27 from the extra-corporeal circuit, and a second tubular connector 26 defined by the first half-shell and adapted to be connected to a transducer 28; and a first hydrophobic semi-permeable membrane 23 having a first membrane area A 1 and a second hydrophobic semi-permeable membrane 24 having a second membrane area A 2 , said two membranes being arranged in series along said inner duct 221. In a front view, the extent of an overlapping area A 12 of said membranes is comprised between 0% and 50% of the smaller of said two membrane areas A 1 , A 2 . The inventions further relates to an extra-corporeal circuit 19 comprising the above safety insert.
摘要翻译：本发明涉及一种用于体外电路19的安全插入件20.安全插入件包括：第一半壳体21和第二半壳体22，其形成限定内部管道221的壳体212，至少部分第二半壳由半透明或透明材料制成; 第一管状连接器25，适于从额外的体电路连接到分支管27;以及由第一半壳限定并适于连接到换能器28的第二管状连接器26; 以及具有第一膜面积A1的第一疏水性半透膜23和具有第二膜面积A2的第二疏水性半透膜24，所述两个膜沿着所述内管221串联布置。在正视图中，所述膜的重叠区域A12的程度在所述两个膜区域A1，A2中较小者的0％至50％之间。本发明还涉及一种包括上述安全插入件的超体电路19。

5. 发明申请

WO2012168211A1 HEAT EXCHANGE DEVICE 审中-公开
标题翻译：热交换装置
公开(公告)号：WO2012168211A1
公开(公告)日：2012-12-13
申请号：PCT/EP2012/060549
申请日：2012-06-05
申请人： SIS-TER S.P.A. , FINI, Massimo , REITER, Reinhold
发明人： FINI, Massimo , REITER, Reinhold
IPC分类号： F28F3/04 , A61M1/28 , A61M5/44
CPC分类号： A61M1/28 , A61M1/166 , A61M5/44 , A61M2205/127 , A61M2205/3653 , A61M2205/366 , F24H1/102 , F28F3/02 , F28F3/048
摘要： The present invention relates to a device 20 designed to promote heat exchange to/from a medical liquid ML. The device comprises an inlet 21, an outlet 22 and a duct 23 adapted to contain a flow of the medical liquid ML. The duct is enclosed between two walls 230, 231, has a planar development defining a mean plane π, and comprises means 24 for promoting turbulence in the flow of the liquid ML. At least one wall 230 of the duct is suitable to allow a heat exchange with the flow of the liquid ML. The means for promoting turbulence comprises a plurality of fins 240, wherein each fin 240 n , has a lenticular cross section and defines its own mean plane t n substantially perpendicular to plane π. The invention also relates to a disposable cassette 30 for use in a PD/APD treatment, comprising a polymeric structure defining a first part 31, suitable for pumping and distributing the medical liquid ML, SML, and a second part 32 comprising a device (20) similar to the one described above.
摘要翻译：本发明涉及设计用于促进与医用液体ML的热交换的装置20。该装置包括入口21，出口22和适于容纳医用液体ML流的管道23。管道封闭在两个壁230,231之间，具有限定平均平面p的平面展开，并且包括用于促进液体ML流动中的湍流的装置24。管道的至少一个壁230适于允许与液体ML的流动进行热交换。用于促进湍流的装置包括多个翅片240，其中每个翅片240n具有透镜横截面并且限定其自身的平均平面tn，其基本上垂直于平面p。本发明还涉及用于PD / APD处理的一次性盒30，其包括限定适于泵送和分配医用液体ML，SML的第一部分31的聚合物结构以及包括装置（20）的第二部分32 ）与上述相似。

6. 发明申请

WO2012076386A1 INSERT AND VIAL FOR THE INFUSION OF LIQUIDS 审中-公开
标题翻译：插入和渗透液体渗透
公开(公告)号：WO2012076386A1
公开(公告)日：2012-06-14
申请号：PCT/EP2011/071452
申请日：2011-12-01
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH , FINI, Massimo , VENERONI, Alain , WEHMEYER, Wolfgang , HOFMANN, Wolfgang
发明人： FINI, Massimo , VENERONI, Alain , WEHMEYER, Wolfgang , HOFMANN, Wolfgang
IPC分类号： A61J1/14 , A61J1/20 , A61M5/162
CPC分类号： A61M5/162 , A61J1/1406 , A61J1/20 , A61J1/2031 , A61J1/2065 , A61J1/2089 , B65B3/003
摘要： The present invention relates to an insert (40) and a vial (30) for the infusion of a liquid (80). The vial (30) comprises a hollow body (31) for storing the liquid (80), a grasp portion (38) and a head (32). The head comprises a delivery opening (33) defining an axis (X), a closing septum (34) suitable for closing the delivery opening; and at least one circumferential push surface (35) defined next to the head by a protrusion. The circumferential push surface is firmly connected to the grasp portion. The insert (40) according to the invention is suitable to delivery the liquid (80) and to receive the insertion along axis (X) of the vial. The insert comprises a main body (41) and an inner part (42). The main body comprises a lateral wall (410) and a lower delivery portion (411) defining a first lower duct (511) and a second lower duct (521). The inner part comprises an inner wall (420) and a piercing spike (421). The inner wall (420) defines a seat (422) suitable to receive the head of the vial, and comprises at least one slit (423) suitable to engage a radially inner portion (350) of the at least one circumferential push surface of the vial. The piercing spike is suitable to pierce the closing septum of the vial and defines a first upper duct (510) and a second upper duct (520). The inner part is housed inside the main body so as to be able to rotate with respect to the latter around axis (X). In particular, the inner part is able to rotate between: a fluidly open configuration A wherein the upper ducts are in fluid communication with the lower ducts; and a fluidly closed configuration (B) wherein the upper ducts are not in fluid communication with the lower ducts.
摘要翻译：本发明涉及用于液体（80）的注入的插入件（40）和小瓶（30）。小瓶（30）包括用于储存液体（80）的空心体（31），把持部分（38）和头部（32）。头部包括限定轴线（X）的输送开口（33），适于关闭输送口的闭合隔膜（34）; 以及至少一个周向推动表面（35），该周向推动表面（35）由突出部限定在头部附近。周向推动表面牢固地连接到抓握部分。根据本发明的插入件（40）适于输送液体（80）并且沿着小瓶的轴线（X）接收插入物。插入件包括主体（41）和内部部件（42）。主体包括限定第一下部管道（511）和第二下部管道（521）的侧壁（410）和下部输送部分（411）。内部部分包括内壁（420）和穿刺尖（421）。所述内壁（420）限定适于容纳所述小瓶的头部的座（422），并且包括适于接合所述至少一个周向推动表面的径向内部（350）的至少一个狭缝（423）小瓶。穿刺尖端适于刺穿小瓶的闭合隔膜并且限定第一上部管道（510）和第二上部管道（520）。内部容纳在主体内，以能够相对于主体绕轴线（X）旋转。特别地，内部部分能够在以下方面之间旋转：流体打开构型A，其中上部管道与下部管道流体连通; 以及流体关闭的构造（B），其中上部管道不与下部管道流体连通。

7. 发明申请

WO2011092068A1 INSERT FOR THE INFUSION OF DRUGS 审中-公开
标题翻译：插入药物输注
公开(公告)号：WO2011092068A1
公开(公告)日：2011-08-04
申请号：PCT/EP2011/050517
申请日：2011-01-17
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH , VENERONI, Alain , FINI, Massimo
发明人： VENERONI, Alain , FINI, Massimo
IPC分类号： A61M39/26 , A61J1/20
CPC分类号： A61M39/26 , A61M5/162 , A61M2039/267 , A61M2039/268
摘要： The present invention relates to an insert 20 for the infusion of drugs. The insert 20 is suitable for connection Io a vial 18 and preferably to a circuit 16 or an infusion line. Moreover the insert comprises a main body 22, a resilient element 24 and a piercing spike 26, The piercing spike has an axis X and defines a first channel 261 and a second channel 262 and is movable relative to the main body along the axis X between a first closed position A and a second open position B. Moreover the resilient element presses against the piercing spike so as to keep it in the first closed position A when no external forces are applied.
摘要翻译：本发明涉及用于输注药物的插入件20。插入件20适于连接到小瓶18并且优选地连接到电路16或输注线。此外，插入件包括主体22，弹性元件24和刺穿尖钉26.刺穿尖钉具有轴线X并且限定第一通道261和第二通道262，并且可相对于主体沿轴线X相对于主体第一关闭位置A和第二打开位置B.此外，弹性元件压靠刺穿尖钉，以便当不施加外力时将其保持在第一关闭位置A。

8. 发明申请

WO2013079160A1 CONNECTOR WITH DOUBLE LUMEN TUBE 审中-公开
标题翻译：双管连接器
公开(公告)号：WO2013079160A1
公开(公告)日：2013-06-06
申请号：PCT/EP2012/004718
申请日：2012-11-14
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH , VENERONI, Alain , FINI, Massimo
发明人： VENERONI, Alain , FINI, Massimo
IPC分类号： A61M39/08 , A61M39/10
CPC分类号： F16L9/19 , A61M39/08 , A61M39/105 , A61M2039/082 , Y10T137/0318 , Y10T156/10
摘要： The present invention relates to the invention relates to an assembly of a dual lumen tubing as described above and a dual bore connector as described above having a first flow conduit along the first lumen and the first bore, and having a second flow conduit from the second bore, via a circumferential groove and along the second lumen. Such an assembly may be used in connection with an extracorporeal circuit of a haemodialysis machine or an infusion set.
摘要翻译：本发明涉及如上所述的双腔管组件和如上所述的双孔连接器，其具有沿着第一内腔和第一孔的第一流动管道，并且具有来自第二管腔的第二流动管道通过周向凹槽并沿着第二内腔。这样的组件可以与血液透析机或输液器的体外回路结合使用。

9. 发明申请

WO2011141200A1 TUBING SET HAVING AN IMPROVED GATE FOR THE CONNECTION OF VIALS 审中-公开
标题翻译：管道设有一个改进的门，用于连接六角形
公开(公告)号：WO2011141200A1
公开(公告)日：2011-11-17
申请号：PCT/EP2011/053936
申请日：2011-03-16
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GmbH , FINI, Massimo , VENERONI, Alain
发明人： FINI, Massimo , VENERONI, Alain
IPC分类号： A61M5/162
CPC分类号： A61M5/162 , A61M2005/1623
摘要： The present invention refers to a tubing set (12) suitable for use in co-operation with a medical liquid delivery device (10). The tubing set comprises: a delivery tube (68) suitable for supplying a medical liquid or blood to a patient; and a vial gate (24) for the connection of vials (26) containing drugs to be delivered into the medical liquid or blood. The vial gate comprises a delivery lumen (28), suitable for delivering the drug (30) from the vial to the delivery tube; and a vent lumen (32), suitable for providing a replacement fluid (34, 60) from a location (20, 64) inside the tubing set (12) to the inside of the vial in order to replace the delivered drug. The vial gate according to the invention further comprises at least one one-way valve (70, 72) placed along said vent lumen or said delivery lumen.
摘要翻译：本发明涉及一种适用于与医用液体输送装置（10）配合使用的管道组件（12）。管组包括：适于向患者供应医用液体或血液的输送管（68）以及用于连接含有要输送到医用液体或血液中的药物的小瓶（26）的小瓶门（24）。小瓶门包括适于将药物（30）从小瓶输送到输送管的递送腔（28）; 和排气腔（32），其适于从所述管组（12）内部的位置（20,64）提供到所述小瓶内部的替换流体（34,60），以便替换所递送的药物。根据本发明的小瓶门还包括沿着所述通气腔或所述输送腔放置的至少一个单向阀（70,72）。

10. 发明申请

WO2006069737A1 REAKTOR UND REAKTOREINHEIT MIT HOHLFASERN 审中-公开
标题翻译：反应器和核电机组中空纤维
公开(公告)号：WO2006069737A1
公开(公告)日：2006-07-06
申请号：PCT/EP2005/013906
申请日：2005-12-22
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH , KUGELMANN, Franz , HENGSTER, Paul , MARGREITER, Raimund , NEDERLOF, Bernd , FINI, Massimo , TETTA, Ciro , WILD, Thomas , YAKUBOVICH, Micaela , PAUL, Michael , CARONNA, Marco
发明人： KUGELMANN, Franz , HENGSTER, Paul , MARGREITER, Raimund , NEDERLOF, Bernd , FINI, Massimo , TETTA, Ciro , WILD, Thomas , YAKUBOVICH, Micaela , PAUL, Michael , CARONNA, Marco
IPC分类号： C12M3/06
CPC分类号： C12M23/24 , C12M23/28 , C12M25/10 , C12M27/10 , C12M27/14
摘要： Die Erfindung betrifft eine Reaktoreinheit mit einer ersten Kammer und einer zweiten Kammer, wobei die erste Kammer durch den Innenraum eines Gehäuses gebildet wird und wobei die zweite Kammer durch den Innenraum mehrerer in dem Gehäuse angeordneter Hohlfasern gebildet wird. Die Hohlfasern sind in dem Gehäuse derart angeordnet, dass ihre auf die Querschnittsfläche der ersten Kammer bezogene Dichte in wenigstens einem Bereich der ersten Kammer (10) Fasern/mm 2 nicht übersteigt. Gemäss einer weiteren Ausgestaltung der Erfindung ist vorgesehen, dass in der Reaktoreinheit zwei Vergussmassen angeordnet sind, in denen ein Abschnitt der Hohlfasern eingebettet ist und zwischen denen sich ein weiterer Abschnitt der Hohlfasern erstreckt, wobei die Länge wenigstens einiger oder aller Hohlfasern mindestens 0,5 % über dem Abstand der Vergussmassen liegt.
摘要翻译：本发明涉及一种具有第一腔室和第二腔室中的反应器单元，所述第一腔室由壳体的内部和形成，其中所述第二腔室由多个布置在壳体中的中空纤维的内部形成。中空纤维被布置在壳体中，使得它们在第一腔室中的至少一个区域与所述第一腔室密度的截面积（10）纤维/毫米2 不超过^{。根据本发明的另一个实施例，提供两个密封剂被布置在所述反应器单元，其中，所述中空纤维的一部分被嵌入，并且所述中空纤维的另一部分之间，所述的至少一些或所有的中空纤维长度至少为0.5％是比浇铸化合物的间距。}

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