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1. 发明申请

WO1995034101A1 METHOD AND APPARATUS FOR DETERMINING DIRECTION 审中-公开
标题翻译：用于确定方向的方法和装置
公开(公告)号：WO1995034101A1
公开(公告)日：1995-12-14
申请号：PCT/GB1995001300
申请日：1995-06-06
申请人： INTERNATIONAL MOBILE SATELLITE ORGANIZATION , FELDMAN, Howard, Ray
发明人： INTERNATIONAL MOBILE SATELLITE ORGANIZATION
IPC分类号： H01Q01/12
CPC分类号： G01C17/04 , G01C1/00 , H01Q1/125
摘要： A map is provided for indicating the direction of a fixed point (S), such as a sub-satellite point, from any point (P) within a specified area which is a substantial fraction of the earth's surface. The map projection is such that the actual direction to the fixed point (S) is the same as the direction shown on the map, when the map is aligned with a reference direction such as magnetic north. Optionally, the distance to the fixed point on the map represents the elevation of the satellite. Apparatus for using the map includes a holder (10) for the map and for a magnetic compass (18). A scale (22) which rotates about the fixed point on the map has a marker (32) which is positioned over the user's location on the map. The azimuthal direction of the satellite is indicated by an arrow (28) on the scale, while the elevation of the satellite is read off the scale by means of a pointer (34) located on the fixed point on the map.
摘要翻译：提供了用于从指定区域内的任何点（P）指示诸如子卫星点的固定点（S）的方向的地图，该点在地球表面的相当大的一部分中。地图投影使得当地图与诸如磁北的参考方向对准时，到固定点（S）的实际方向与图上所示的方向相同。可选地，到地图上固定点的距离表示卫星的高度。用于使用地图的装置包括用于地图和磁罗盘（18）的保持器（10）。围绕地图上的固定点旋转的刻度（22）具有位于地图上用户位置之上的标记（32）。卫星的方位方向由刻度上的箭头（28）表示，而卫星的仰角通过位于地图上的固定点上的指针（34）从比例尺读出。

2. 发明申请

WO1997000561A1 COMMUNICATION METHOD AND APPARATUS USING DATA COMPRESSION 审中-公开
标题翻译：使用数据压缩的通信方法和设备
公开(公告)号：WO1997000561A1
公开(公告)日：1997-01-03
申请号：PCT/GB1996001415
申请日：1996-06-14
申请人： INTERNATIONAL MOBILE SATELLITE ORGANIZATION , OBRADORS, Joan , FELDMAN, Howard, Ray , REMAEL, François-Arnaud
发明人： INTERNATIONAL MOBILE SATELLITE ORGANIZATION
IPC分类号： H04B07/185
CPC分类号： H04B7/18528
摘要： A communications link for data communication via satellite includes interface apparatus (12) comprising a satellite link interface (20) for connection to a satellite link and a PSTN interface (22) for connection to a PSTN (14). The interface apparatus (12) supports different data compression modes in the communications link. Mode A allows data compression over the PSTN (14) but not over the satellite link. Mode B allows data compression over the PSTN (14) and over the satellite link, but enables decompression and recompression of data flowing in each direction through the interface apparatus (12). Mode C allows compressed data to pass transparently between the PSTN (14) and the satellite link, while the interface apparatus performs error correction on the satellite link and on the PSTN (14).
摘要翻译：用于通过卫星进行数据通信的通信链路包括接口设备（12），包括用于连接到卫星链路的卫星链路接口（20）和用于连接到PSTN（14）的PSTN接口（22）。接口装置（12）在通信链路中支持不同的数据压缩模式。模式A允许通过PSTN（14）进行数据压缩，但不能通过卫星链路进行数据压缩。模式B允许通过PSTN（14）和卫星链路上的数据压缩，但是能够通过接口设备（12）对在每个方向上流动的数据进行解压缩和重新压缩。模式C允许压缩数据在PSTN（14）和卫星链路之间透明地通过，而接口装置在卫星链路和PSTN（14）上执行纠错。

3. 发明申请

WO9631040A2 DATA COMMUNICATION METHOD AND APPARATUS 审中-公开
标题翻译：数据通信方法和设备
公开(公告)号：WO9631040A2
公开(公告)日：1996-10-03
申请号：PCT/GB9600751
申请日：1996-03-29
申请人： INT MOBILE SATELLITE ORG , FELDMAN HOWARD RAY , KAWAI NOBUYUKI , SMITH RICHARD DOUGLAS LANE , REMAEL FRANCOIS ARNAUD
发明人： FELDMAN HOWARD RAY , KAWAI NOBUYUKI , SMITH RICHARD DOUGLAS LANE , REMAEL FRANCOIS-ARNAUD
IPC分类号： H04L29/08 , H04B7/15 , H04B7/185 , H04L1/18 , H04L12/54 , H04L12/861 , H04L29/06 , H04M11/00 , H04M11/06
CPC分类号： H04L49/9078 , H04B7/18532 , H04B7/1858 , H04L1/18 , H04L12/5601 , H04L29/06 , H04L49/90 , H04L67/14 , H04L69/08 , H04L69/324 , H04M11/06
摘要： An interface (4; 12) between a data terminal (2; 18) and a digital communications link (6, 8, 10) implements protocols and frame formats designed to reduce delays in a data communication with a remote terminal (18; 2). The interface (4; 12) overcomes the need to send or receive an HDLC SABME or UA control signal, and allows data to be sent over the digital communications link (6, 8, 10) as soon as the communication parameters are established. In a non-ARQ (error correction) mode, the interface (4; 12) sends control signals and data over the communications link (6, 8, 10) in frames subdivided into many small subframes of fixed length, each subframe having a length code. The interface (12), when arranged for connection to the data terminal (18) through a telephone network (14), encodes call progress signals from the telephone network (14) for sending over the digital communications link (6, 8, 10). The interface (4; 12) encodes and decodes interrupt signals for sending between the data terminal (2; 18) and the digital communications link (6, 8, 10) when an interrupt signal is detected.
摘要翻译：在数据终端（2; 18）和数字通信链路（6,8,10）之间的接口（4; 12）实现被设计为减少与远程终端（18; 2）进行数据通信的延迟的协议和帧格式，。接口（4; 12）克服了发送或接收HDLC SABME或UA控制信号的需要，并且一旦建立通信参数就允许数据通过数字通信链路（6,8,10）发送。在非ARQ（纠错）模式中，接口（4; 12）通过通信链路（6,8,10）发送控制信号和数据，该帧分成许多固定长度的小子帧，每个子帧的长度码。接口（12）当被布置为通过电话网络（14）连接到数据终端（18）时，对来自电话网络（14）的呼叫进程信号进行编码，以通过数字通信链路（6,8,10）发送，。当检测到中断信号时，接口（4; 12）编码和解码用于在数据终端（2; 18）和数字通信链路（6,8,10）之间发送的中断信号。

4. 发明申请

WO1997002697A1 COMMUNICATION METHOD AND APPARATUS 审中-公开
标题翻译：通信方法和设备
公开(公告)号：WO1997002697A1
公开(公告)日：1997-01-23
申请号：PCT/GB1995001548
申请日：1995-06-30
申请人： INTERNATIONAL MOBILE SATELLITE ORGANIZATION , GARSTANG, Brian , FELDMAN, Howard, Ray
发明人： INTERNATIONAL MOBILE SATELLITE ORGANIZATION
IPC分类号： H04N01/32
CPC分类号： H04N1/32069 , H04N1/00103 , H04N1/00281 , H04N1/00315 , H04N1/32037 , H04N2201/0034
摘要： A broadcast facsimile interface unit (FIU) (4) and broadcast receiving facsimile interface units (FIU) (16a, 16b, 16c) enable facsimile data to be broadcast from a transmitting facsimile terminal (2) via a satellite (10) to more than one receiving facsimile terminals (18a, 18b, 18c) simultaneously. The broadcast FIU (4) simulates a facsimile terminal connected to the transmitting facsimile terminal (2) and sends broadcast signals (8) through a land earth station (6), and the broadcast receiving FIU's (16a, 16b, 16c) receive the broadcast signals (12) and simulate facsimile terminals connected to their respective receiving facsimile terminals (18a, 18b, 18c) according to protocols which enable the receiving terminals to receive the facsimile data successfully.
摘要翻译：广播传真接口单元（FIU）（4）和广播接收传真接口单元（FIU）（16a，16b，16c）使得传真数据能够通过卫星（10）从发送传真终端（2）广播到多于一个接收传真终端（18a，18b，18c）。广播FIU（4）模拟连接到发送传真终端（2）的传真终端，并通过地面站（6）发送广播信号（8），并且广播接收FIU（16a，16b，16c）接收广播信号（12），并且根据允许接收终端成功接收传真数据的协议来模拟连接到它们各自的接收传真终端（18a，18b，18c）的传真终端。

5. 发明申请

WO1996031040A3 DATA COMMUNICATION METHOD AND APPARATUS 审中-公开
公开(公告)号：WO1996031040A3
公开(公告)日：1996-10-03
申请号：PCT/GB1996000751
申请日：1996-03-29
申请人： INTERNATIONAL MOBILE SATELLITE ORGANIZATION , FELDMAN, Howard, Ray , KAWAI, Nobuyuki , SMITH, Richard, Douglas, Lane , REMAEL, François-Arnaud
发明人： INTERNATIONAL MOBILE SATELLITE ORGANIZATION
IPC分类号： H04L29/06

6. 发明申请

WO2008019187A3 DETECTING AND TREATING DEMENTIA 审中-公开
标题翻译：检测和治疗痴呆症
公开(公告)号：WO2008019187A3
公开(公告)日：2008-04-17
申请号：PCT/US2007070008
申请日：2007-05-30
申请人： MAYO FOUNDATION , UNIV MANCHESTER , UNIV BRITISH COLUMBIA , VIB VZW , UNIV ANTWERPEN , HUTTON MICHAEL L , BAKER MATTHEW COLIN , GASS JENNIFER MAE , RADEMAKERS ROSA , ERIKSEN JASON , PICKERING-BROWN STUART M , MACKENZIE IAN REID ALEXANDER , FELDMAN HOWARD , KUMAR-SINGH SAMIR , VAN BROECKHOVEN CHRISTINE , CRUTS MARC
发明人： HUTTON MICHAEL L , BAKER MATTHEW COLIN , GASS JENNIFER MAE , RADEMAKERS ROSA , ERIKSEN JASON , PICKERING-BROWN STUART M , MACKENZIE IAN REID ALEXANDER , FELDMAN HOWARD , KUMAR-SINGH SAMIR , VAN BROECKHOVEN CHRISTINE , CRUTS MARC
IPC分类号： A61K38/16
CPC分类号： A61K48/005 , C07K14/435 , C12Q1/6809 , C12Q1/6883 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172
摘要： This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.
摘要翻译：本文件涉及检测可能与痴呆相关的突变的方法和材料。例如，提供了用于检测PGRN核酸内的一个或多个突变的方法和材料。本文件还提供了检测颗粒体蛋白前体表达水平的方法和材料。另外，该文献涉及用于治疗患有神经退行性病症（例如痴呆）的哺乳动物的方法和材料。例如，提供了用于增加哺乳动物中PGRN多肽水平的方法和材料，以及用于鉴定可用于增加哺乳动物中PGRN多肽水平的试剂的方法和材料。

7. 发明申请

WO1996013916A1 COMMUNICATION METHOD AND APPARATUS WITH TRANSMISSION OF A SECOND SIGNAL DURING ABSENCE OF A FIRST ONE 审中-公开
标题翻译：第一信号传输第二信号传输方法与装置
公开(公告)号：WO1996013916A1
公开(公告)日：1996-05-09
申请号：PCT/GB1995002533
申请日：1995-10-27
申请人： INTERNATIONAL MOBILE SATELLITE ORGANIZATION , FELDMAN, Howard, Ray
发明人： INTERNATIONAL MOBILE SATELLITE ORGANIZATION
IPC分类号： H04J03/17
CPC分类号： H04B7/18532 , H04J3/17
摘要： A network station (4) receives a principal signal (S) and data (D). When the principal signal (S) is present or contains information, it is transmitted to a receiving station (6) through a communication channel. When the principal signal (S) is absent or does not have a significant information content, the network station (4) transmits the data (D) through the same communication channel in a format such that the data (D) is received and output by a further receiving station (8).
摘要翻译：网络站（4）接收主信号（S）和数据（D）。当主信号（S）存在或包含信息时，通过通信信道将其发送到接收站（6）。当主信号（S）不存在或不具有重要的信息内容时，网络站（4）通过相同的通信信道以如下格式发送数据（D），使得数据（D）被接收并由另一接收站（8）。

8. 发明申请

WO2012040444A3 TREATMENT OF PATIENTS WITH INCIPIENT ALZHEIMER'S DISEASE 审中-公开
标题翻译：治疗患有阿尔茨海默病的患者
公开(公告)号：WO2012040444A3
公开(公告)日：2012-06-28
申请号：PCT/US2011052731
申请日：2011-09-22
申请人： SQUIBB BRISTOL MYERS CO , ALBRIGHT CHARLES F , BERMAN ROBERT MARK , CORIC VLADIMIR , FELDMAN HOWARD , MARCUS RONALD N
发明人： ALBRIGHT CHARLES F , BERMAN ROBERT MARK , CORIC VLADIMIR , FELDMAN HOWARD , MARCUS RONALD N
IPC分类号： A61K38/00 , A61P3/04 , A61P25/00
CPC分类号： A61K31/55
摘要： Disclosed are methods for the treatment of patients with incipient Alzheimer's disease and the use of compounds that may be inhibitors of the enzymes that form ß -amyloid (A ß), e.g., A ß 42, in particular ?-secretase.
摘要翻译：公开了用于治疗患有早期阿尔茨海默病的患者的方法，以及使用可能是形成β-淀粉样蛋白（Aβ）的酶的抑制剂的化合物，例如Aβ42，特别是γ-分泌酶。

9. 发明申请

WO2012040444A2 TREATMENT OF PATIENTS WITH INCIPIENT ALZHEIMER'S DISEASE 审中-公开
标题翻译：治疗患有先天性阿尔茨海默病的患者
公开(公告)号：WO2012040444A2
公开(公告)日：2012-03-29
申请号：PCT/US2011/052731
申请日：2011-09-22
申请人： BRISTOL-MYERS SQUIBB COMPANY , ALBRIGHT, Charles, F. , BERMAN, Robert, Mark , CORIC, Vladimir , FELDMAN, Howard , MARCUS, Ronald, N.
发明人： ALBRIGHT, Charles, F. , BERMAN, Robert, Mark , CORIC, Vladimir , FELDMAN, Howard , MARCUS, Ronald, N.
IPC分类号： A61K31/55
CPC分类号： A61K31/55
摘要： Disclosed are methods for the treatment of patients with incipient Alzheimer's disease and the use of compounds that may be inhibitors of the enzymes that form β -amyloid (A β ), e.g., A β 42, in particular γ -secretase.
摘要翻译：公开了用于治疗患有早期阿尔茨海默病的患者的方法和使用可能是形成β淀粉样蛋白酶（ββ ），例如Aβ42，特别是γ-分泌酶。

10. 发明申请

WO2008019187A9 DETECTING AND TREATING DEMENTIA 审中-公开
标题翻译：检测和治疗DEMENTIA
公开(公告)号：WO2008019187A9
公开(公告)日：2008-05-29
申请号：PCT/US2007070008
申请日：2007-05-30
申请人： MAYO FOUNDATION , UNIV MANCHESTER , UNIV BRITISH COLUMBIA , VIB VZW , UNIV ANTWERPEN , HUTTON MICHAEL L , BAKER MATTHEW COLIN , GASS JENNIFER MAE , RADEMAKERS ROSA , ERIKSEN JASON , PICKERING-BROWN STUART M , MACKENZIE IAN REID ALEXANDER , FELDMAN HOWARD , KUMAR-SINGH SAMIR , VAN BROECKHOVEN CHRISTINE , CRUTS MARC
发明人： HUTTON MICHAEL L , BAKER MATTHEW COLIN , GASS JENNIFER MAE , RADEMAKERS ROSA , ERIKSEN JASON , PICKERING-BROWN STUART M , MACKENZIE IAN REID ALEXANDER , FELDMAN HOWARD , KUMAR-SINGH SAMIR , VAN BROECKHOVEN CHRISTINE , CRUTS MARC
IPC分类号： A61K38/16
CPC分类号： A61K48/005 , C07K14/435 , C12Q1/6809 , C12Q1/6883 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172
摘要： This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.
摘要翻译：本文件涉及用于检测可与痴呆相关的突变的方法和材料。例如，提供了用于检测PGRN核酸内的一个或多个突变的方法和材料。本文件还提供了检测颗粒体蛋白前体表达水平的方法和材料。此外，本文件涉及用于治疗具有神经变性疾病（例如痴呆）的哺乳动物的方法和材料。例如，提供用于增加哺乳动物中PGRN多肽水平的方法和材料，以及用于鉴定可用于增加哺乳动物中PGRN多肽水平的试剂的方法和材料。

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