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1. 发明申请

WO2007084141A3 SURFACE-ENHANCED LANTHANIDE CHELATES 审中-公开
标题翻译：表面增强的土耳其语
公开(公告)号：WO2007084141A3
公开(公告)日：2011-05-26
申请号：PCT/US2006002893
申请日：2006-01-24
申请人： STANFORD RES INST INT , FARIS GREGORY W , HAUSHALTER JEANNE P
发明人： FARIS GREGORY W , HAUSHALTER JEANNE P
IPC分类号： G01N33/543 , C12M1/00 , C12M1/34 , C12M3/00 , C12Q1/68 , G01N15/06 , G01N21/00 , G01N33/00 , G01N33/48 , G01N33/544 , G01N33/551 , G01N33/553
CPC分类号： C07C229/76 , Y10T436/143333
摘要： A lanthanide chelate is linked to a noble metal substrate at a proximity wherein the substrate enhances a fluorescent emission of the lanthanide by at least 20-fold when the chelate is illuminated at an excitation wavelength that induces a transition in the lanthanide that results in the fluorescent emission.
摘要翻译：镧系螯合物在邻近处连接到贵金属基底上，其中当螯合物以诱导镧系元素转变的激发波长照射时，底物将镧系元素的荧光发射增强至少20倍，导致荧光排放。

2. 发明申请

WO2005070470A1 OPTICAL VASCULAR FUNCTION IMAGING SYSTEM AND METHOD FOR DETECTION AND DIAGNOSIS OF CANCEROUS TUMORS 审中-公开
标题翻译：光学血管功能成像系统及其诊断与诊断方法
公开(公告)号：WO2005070470A1
公开(公告)日：2005-08-04
申请号：PCT/US2005/003090
申请日：2005-01-21
申请人： SRI INTERNATIONAL , FARIS,Gregory, W.
发明人： FARIS,Gregory, W.
IPC分类号： A61K49/00
CPC分类号： A61B5/4312 , A61B5/0091 , A61B5/14551
摘要： An in vivo optical imaging system and method of identifying unusual vasculature associated with the angiogenic vasculature in tumors. An imaging system acquires images through the breast. Benign, noninvasive oxygen and carbon dioxide are used as vasoactive agents and administered by inhalation to stimulate vascular changes. Images taken before and during inhalation are subtracted. An optical vascular functional imaging system monitors abnormal vasculature through optical measurements on oxy- and deoxyhemoglobin during inhalation of varying levels of O 2 and CO 2 . The increase in contrast between tumor (cancerous) and normal (noncancerous) tissue is dramatic, facilitating accurate early detection of cancerous tumors and improving sensitivity and specificity (lower false negative and false positive rates). The invention is useful in mammography, dermatology, prostate imaging and other optically accessible areas.
摘要翻译：一种体内光学成像系统和识别与肿瘤中血管生成脉管系统相关的异常脉管系统的方法。成像系统通过乳房获取图像。良性的无创氧和二氧化碳被用作血管活性剂并通过吸入给药以刺激血管变化。吸入前和吸入期间拍摄的图像被减去。光学血管功能成像系统通过在吸入不同程度的氧气和二氧化碳期间通过氧化和脱氧血红蛋白的光学测量来监测异常脉管系统。肿瘤（癌性）和正常（非癌性）组织之间的对比度增加是显着的，有助于准确早期检测癌性肿瘤，并提高敏感性和特异性（降低假阴性和假阳性率）。本发明可用于乳房X线照相术，皮肤病学，前列腺成像和其他光学可及区域。

3. 发明申请

WO2007084141A2 SURFACE-ENHANCED LANTHANIDE CHELATES 审中-公开
标题翻译：表面增强的土耳其语
公开(公告)号：WO2007084141A2
公开(公告)日：2007-07-26
申请号：PCT/US2006/002893
申请日：2006-01-24
申请人： SRI INTERNATIONAL , FARIS, Gregory, W. , HAUSHALTER, Jeanne, P.
发明人： FARIS, Gregory, W. , HAUSHALTER, Jeanne, P.
IPC分类号： C12Q1/68
CPC分类号： C07C229/76 , Y10T436/143333
摘要： A lanthanide chelate is linked to a noble metal substrate at a proximity wherein the substrate enhances a fluorescent emission of the lanthanide by at least 20-fold when the chelate is illuminated at an excitation wavelength that induces a transition in the lanthanide that results in the fluorescent emission.
摘要翻译：镧系元素螯合物在邻近处连接到贵金属基底上，其中当螯合物以诱导镧系元素转变的激发波长照射时，底物将镧系元素的荧光发射增强至少20倍，导致荧光排放。

4. 发明申请

WO2004097891A2 DIRECT LIQUID INJECTION INLET TO A LASER PHOTOIONIZATION APPARATUS 审中-公开
标题翻译：直接液体注射入射激光装置
公开(公告)号：WO2004097891A2
公开(公告)日：2004-11-11
申请号：PCT/US2004013821
申请日：2004-04-29
申请人： STANFORD RES INST INT , OSER HARALD , COGGIOLA MICHAEL J , FARIS GREGORY W , YOUNG STEVEN E , CROSLEY DAVID R
发明人： OSER HARALD , COGGIOLA MICHAEL J , FARIS GREGORY W , YOUNG STEVEN E , CROSLEY DAVID R
IPC分类号： H01J49/00 , H01J49/04 , H01J49/16
CPC分类号： H01J49/162 , H01J49/0445
摘要： A method and apparatus are provided for analyzing an analyte at low concentration in a liquid sample by photoionization and mass spectrometry. An inlet system is provided for direct injection of the liquid sample using a capillary tube. The method and apparatus allow for 20 to 2000-fold improvement of the lower detection limit of an analyte in a liquid sample compared to a conventional liquid chromatography/mass spectrometer apparatus.
摘要翻译：提供了一种用于通过光电离和质谱法分析液体样品中低浓度分析物的方法和装置。提供入口系统，用于使用毛细管直接注入液体样品。与常规液相色谱/质谱仪装置相比，该方法和装置允许液体样品中分析物的检测下限提高20至2000倍。

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