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1. 发明申请

WO2009091933A2 SYSTEMS, METHODS, AND COMPUTER-READABLE MEDIUM FOR DETERMINING COMPOSITION OF CHEMICAL CONSTITUENTS IN A COMPLEX MIXTURE 审中-公开
标题翻译：确定复合混合物中化学成分组成的系统，方法和计算机可读介质
公开(公告)号：WO2009091933A2
公开(公告)日：2009-07-23
申请号：PCT/US2009031168
申请日：2009-01-15
申请人： METABOLON INC , MILGRAM K ERIC , BARRETT THOMAS , EVANS ANNE M
发明人： MILGRAM K ERIC , BARRETT THOMAS , EVANS ANNE M
IPC分类号： G01N30/72 , G01N30/88
CPC分类号： G01N30/8675 , G01N30/7233 , G01N30/8651 , G01N30/8665 , G06F19/703 , H01J49/0036
摘要： Systems, methods, and computer-readable media for determining composition of chemical constituents in a complex mixture are disclosed. According to one aspect, a method for determining composition of chemical constituents in a complex mixture includes generating, using a separation tool and a mass spectrometer, separation and mass spectrometry data of a sample, wherein the separation data includes peak information and wherein the mass spectrometry data includes primary and secondary mass spectrometry data. The analysis results, including the generated separation and mass spectrometry data, are collected and stored. A chemical constituent of the sample is determined by comparing the analysis results to a library of information indicating characteristics of chemical entities, where the comparison is based on the separation and mass spectrometry information. The library of information includes data generated by the separation tool and mass spectrometer, and also includes separation and mass spectrometry data for both identified and unidentified chemical entities. An indication of the chemical constituent of the sample is made available in human-accessible form.
摘要翻译：公开了用于确定复杂混合物中化学成分组成的系统，方法和计算机可读介质。根据一个方面，用于确定复杂混合物中化学成分的组成的方法包括使用分离工具和质谱仪产生样品的分离和质谱数据，其中分离数据包括峰值信息，并且其中质谱法数据包括主要和次要质谱数据。收集并存储分析结果，包括生成的分离和质谱数据。通过将分析结果与指示化学实体特征的信息库比较来确定样品的化学成分，其中比较基于分离和质谱信息。信息库包括由分离工具和质谱仪生成的数据，还包括识别和未识别化学实体的分离和质谱数据。样品的化学成分指示以人类可及的形式提供。

2. 发明申请

WO2009091933A3 SYSTEMS, METHODS, AND COMPUTER-READABLE MEDIUM FOR DETERMINING COMPOSITION OF CHEMICAL CONSTITUENTS IN A COMPLEX MIXTURE 审中-公开
公开(公告)号：WO2009091933A3
公开(公告)日：2009-07-23
申请号：PCT/US2009/031168
申请日：2009-01-15
申请人： METABOLON INC. , MILGRAM, K. Eric , BARRETT, Thomas , EVANS, Anne, M.
发明人： MILGRAM, K. Eric , BARRETT, Thomas , EVANS, Anne, M.
IPC分类号： G01N30/72 , G01N30/88
摘要： Systems, methods, and computer-readable media for determining composition of chemical constituents in a complex mixture are disclosed. According to one aspect, a method for determining composition of chemical constituents in a complex mixture includes generating, using a separation tool and a mass spectrometer, separation and mass spectrometry data of a sample, wherein the separation data includes peak information and wherein the mass spectrometry data includes primary and secondary mass spectrometry data. The analysis results, including the generated separation and mass spectrometry data, are collected and stored. A chemical constituent of the sample is determined by comparing the analysis results to a library of information indicating characteristics of chemical entities, where the comparison is based on the separation and mass spectrometry information. The library of information includes data generated by the separation tool and mass spectrometer, and also includes separation and mass spectrometry data for both identified and unidentified chemical entities. An indication of the chemical constituent of the sample is made available in human-accessible form.

3. 发明申请

WO2005033267A3 ANTIGENS TARGETED BY PREVALENT PATHOGENIC T CELLS IN TYPE 1 DIABETES AND USES THEREOF 审中-公开
标题翻译： 1型糖尿病中预防性致病性T细胞靶向的抗原及其用途
公开(公告)号：WO2005033267A3
公开(公告)日：2005-12-15
申请号：PCT/US2004015752
申请日：2004-05-20
申请人： EINSTEIN COLL MED , DILORENZO TERESA P , EVANS ANNE M , HUNT DONALD F , LIEBERMAN SCOTT M , NATHENSON STANLEY G , SANTAMARIA PERE , SHABANOWITZ JEFFREY
发明人： DILORENZO TERESA P , EVANS ANNE M , HUNT DONALD F , LIEBERMAN SCOTT M , NATHENSON STANLEY G , SANTAMARIA PERE , SHABANOWITZ JEFFREY
IPC分类号： A61K38/04 , A61K39/00 , A61K39/38 , C07K5/00 , C07K14/47 , C07K16/00 , C07K17/00 , C12N20060101 , G01N33/53
CPC分类号： C07K14/4711
摘要： The present invention is based on the identification of a predominant ligand of CD8 T cells that are responsible for type 1 diabetes. That ligand is islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP). Several CD8 T cell-binding peptides from IGRP are identified, including the peptide comprising amino acids 206-214 of the IGRP sequence, which has high avidity to the most prevalent T cell receptor of pathogenic CD8 T cells in autoimmune diabetes. The invention thus provides oligopeptide and polypeptide compositions comprising YLKTN/A/I/L/V)FL, FLWSVFWLI, (T/A)YY/G/T)FLNFM, LR(L/V)(F/L)(G/N)IDLL, KWCANPDWI, and SFCKSASIP. Also provided are oligopeptide compositions 8-10 amino acids in length and completely homologous with a mammalian IGRP, where the oligopeptide is capable of binding a human MHC class I molecule. Additionally, various methods of treating a mammal using the above compositions are provided, where the mammal is at risk for or has type 1 diabetes. Also provided are methods of preventing a CD8 T cell that is cytotoxic to pancreatic islet beta-cells from destroying a mammalian beta-cell, where the methods also use the above compositions. Further provided are methods for determining whether a mammal is at risk for or has type 1 diabetes, where the methods use the above compositions.
摘要翻译：本发明基于鉴定负责1型糖尿病的CD8 + T细胞的主要配体。该配体是胰岛特异性葡萄糖-6-磷酸酶催化亚单位相关蛋白（IGRP）。鉴定了来自IGRP的几种CD8 + T细胞结合肽，包括含有IGRP序列的氨基酸206-214的肽，其与自身免疫中病原性CD8 + T细胞最流行的T细胞受体具有高亲合力糖尿病。因此，本发明提供包含YLKTN / A / I / L / V）FL，FLWSVFWLI，（T / A）YY / G / T）FLNFM，LR（L / V）（F / L）（G / N）IDLL，KWCANPDWI和SFCKSASIP。还提供了长度为8-10个氨基酸且与哺乳动物IGRP完全同源的寡肽组合物，其中寡肽能够结合人MHC I类分子。此外，提供使用上述组合物治疗哺乳动物的各种方法，其中哺乳动物处于或具有1型糖尿病的风险。还提供了防止对胰岛β细胞具有细胞毒性的CD8 + T细胞破坏哺乳动物β细胞的方法，其中该方法也使用上述组合物。还提供了用于确定哺乳动物是否处于或患有1型糖尿病的风险的方法，其中所述方法使用上述组合物。

4. 发明申请

WO2005033267A2 ANTIGENS TARGETED BY PREVALENT PATHOGENIC T CELLS IN TYPE 1 DIABETES AND USES THEREOF 审中-公开
标题翻译：预防性1型糖尿病致病T细胞靶向抗原及其应用
公开(公告)号：WO2005033267A2
公开(公告)日：2005-04-14
申请号：PCT/US2004/015752
申请日：2004-05-20
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY , DILORENZO, Teresa, P. , EVANS, Anne, M. , HUNT, Donald, F. , LIEBERMAN, Scott, M. , NATHENSON, Stanley, G. , SANTAMARIA, Pere , SHABANOWITZ, Jeffrey
发明人： DILORENZO, Teresa, P. , EVANS, Anne, M. , HUNT, Donald, F. , LIEBERMAN, Scott, M. , NATHENSON, Stanley, G. , SANTAMARIA, Pere , SHABANOWITZ, Jeffrey
IPC分类号： C12N
CPC分类号： C07K14/4711
摘要： The present invention is based on the identification of a predominant ligand of CD8 + T cells that are responsible for type 1 diabetes. That ligand is islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP). Several CD8 + T cell-binding peptides from IGRP are identified, including the peptide comprising amino acids 206-214 of the IGRP sequence, which has high avidity to the most prevalent T cell receptor of pathogenic CD8 + T cells in autoimmune diabetes. The invention thus provides oligopeptide and polypeptide compositions comprising YLKTN/A/I/L/V)FL, FLWSVFWLI, (T/A)YY/G/T)FLNFM, LR(L/V)(F/L)(G/N)IDLL, KWCANPDWI, and SFCKSASIP. Also provided are oligopeptide compositions 8-10 amino acids in length and completely homologous with a mammalian IGRP, where the oligopeptide is capable of binding a human MHC class I molecule. Additionally, various methods of treating a mammal using the above compositions are provided, where the mammal is at risk for or has type 1 diabetes. Also provided are methods of preventing a CD8 + T cell that is cytotoxic to pancreatic islet β-cells from destroying a mammalian β-cell, where the methods also use the above compositions. Further provided are methods for determining whether a mammal is at risk for or has type 1 diabetes, where the methods use the above compositions.
摘要翻译：本发明基于鉴定负责1型糖尿病的CD8 + T细胞的主要配体。该配体是胰岛特异性葡萄糖-6-磷酸酶催化亚基相关蛋白（IGRP）。鉴定了来自IGRP的几种CD8 + T细胞结合肽，包括含有IGRP序列的氨基酸206-214的肽，其对致病性CD8 ^{的最普遍的T细胞受体具有高亲和力 > + T细胞在自身免疫性糖尿病中的作用。本发明因此提供了包含YLKTN / A / I / L / V）FL，FLWSVFWLI，（T / A）YY / G / T）FLNFM，LR（L / V）（F / L） N）IDLL，KWCANPDWI和SFCKSASIP。还提供长度为8-10个氨基酸并与哺乳动物IGRP完全同源的寡肽组合物，其中寡肽能够结合人类MHC I类分子。另外，提供了使用上述组合物治疗哺乳动物的各种方法，其中哺乳动物有患1型糖尿病的风险或具有1型糖尿病。还提供了防止对胰岛β-细胞具有细胞毒性的CD8 + T细胞破坏哺乳动物β-细胞的方法，其中所述方法也使用上述组合物。还提供了用于确定哺乳动物是否有患1型糖尿病或患有1型糖尿病的方法，其中所述方法使用上述组合物。}

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