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1. 发明申请

WO2010053610A3 STABLE ANTHRAX VACCINE FORMULATIONS 审中-公开
公开(公告)号：WO2010053610A3
公开(公告)日：2010-05-14
申请号：PCT/US2009/052279
申请日：2009-07-30
申请人： EMERGENT BIOSOLUTIONS, INC. , KAISHEVA, Elizabet
发明人： KAISHEVA, Elizabet
IPC分类号： A61K39/07 , A61K47/00
摘要： Formulations of anthrax protective antigen are provided that are stable in storage for prolonged periods. Methods of using the formulations to prepare vaccine are also provided. Vaccines comprising the formulations are useful, for example, to protect against anthrax infection.

2. 发明申请

WO2010053610A2 STABLE ANTHRAX VACCINE FORMULATIONS 审中-公开
标题翻译：稳定的ANTHRAX疫苗配方
公开(公告)号：WO2010053610A2
公开(公告)日：2010-05-14
申请号：PCT/US2009052279
申请日：2009-07-30
申请人： EMERGENT BIOSOLUTIONS INC , KAISHEVA ELIZABET
发明人： KAISHEVA ELIZABET
IPC分类号： A61K39/07
CPC分类号： A61K39/07 , A61K9/0019 , A61K47/183 , A61K2039/55505 , A61K2039/622
摘要： Formulations of anthrax protective antigen are provided that are stable in storage for prolonged periods. Methods of using the formulations to prepare vaccine are also provided. Vaccines comprising the formulations are useful, for example, to protect against anthrax infection.
摘要翻译：提供了长期保存的稳定的炭疽保护性抗原的制剂。还提供了使用制剂制备疫苗的方法。包含制剂的疫苗可用于例如防止炭疽感染。

3. 发明申请

WO2009047571A1 BOTULINUM NEUROTOXIN VACCINE 审中-公开
标题翻译： BOTULINUM神经毒素疫苗
公开(公告)号：WO2009047571A1
公开(公告)日：2009-04-16
申请号：PCT/GB2008/050937
申请日：2008-10-13
申请人： Health Protection Agency , Emergent BioSolutions Inc. , SHONE, Clifford
发明人： SHONE, Clifford
IPC分类号： A61K39/08
CPC分类号： A61K39/08 , A61K2039/521 , A61K2039/55505 , C07K14/33
摘要： The invention provides compositions comprising an antigenic botulinum neurotoxin serotype E (BoNT/E) peptide, wherein the peptide has improved solubility and thus improved ability to stimulate an immune response against BoNT/E holotoxin. The composition may be used as part of a multivalent vaccine regimen via coordinated use with non-serotype E BoNT peptides, such as one or more BoNT/A and/ or BoNT/B peptides. It further provides processes for manufacturing said BoNT/E peptide. It also provides methods of stimulating an immune response in a mammal, comprising administering to the mammal an effective amount of a BoNT/E and optionally one or more non-serotype E BoNT peptides such as one or more BoNT/A and/ or BoNT/B peptides.
摘要翻译：本发明提供包含抗原性肉毒杆菌神经毒素血清型E（BoNT / E）肽的组合物，其中所述肽具有改善的溶解度并因此改善刺激针对BoNT / E全毒素的免疫应答的能力。组合物可以通过与非血清型E BoNT肽如一种或多种BoNT / A和/或BoNT / B肽的协同使用而用作多价疫苗方案的一部分。它进一步提供了制备所述BoNT / E肽的方法。它还提供刺激哺乳动物免疫应答的方法，包括向哺乳动物施用有效量的BoNT / E和任选的一种或多种非血清型E BoNT肽，例如一种或多种BoNT / A和/或BoNT / B肽。

4. 发明申请

WO2010017383A1 VACCINES AGAINST CLOSTRIDIUM DIFFICILE AND METHODS OF USE 审中-公开
标题翻译：杀虫剂的防腐剂及其使用方法
公开(公告)号：WO2010017383A1
公开(公告)日：2010-02-11
申请号：PCT/US2009/052994
申请日：2009-08-06
申请人： EMERGENT PRODUCT DEVELOPMENT UK LIMITED , EMERGENT BIOSOLUTIONS INC. , TELFER, Jonathan, Lewis , CAPRONI, Lisa
发明人： TELFER, Jonathan, Lewis , CAPRONI, Lisa
IPC分类号： C12N1/21 , C12N1/36
CPC分类号： A61K39/08 , A61K2039/522 , A61K2039/523 , C07K14/33 , C07K2319/01
摘要： Attenuated microorganisms expressing Clostridium difficile antιgen(s), and methods of using the same for vaccination of patients are disclosed The invention provides an attenuated microorganism expressing an immunogenic portion of a C difficile Toxin A C-terminal repeat region and/or a C difficile Toxin B C-terminal repeat region The microorganism is an attenuated Salmonella comprising an integrated gene expression cassette that directs the expression of the immunogenic peptide from an in vivo inducible promoter.
摘要翻译：本发明提供了表达艰难梭菌毒素A C末端重复区和/或C末端重复区的免疫原性部分的减毒微生物，所述微生物表达难辨梭状芽胞杆菌菌种的减毒微生物及其使用方法。艰难梭菌毒素B C-末端重复区微生物是减毒沙门氏菌，其包含整合的基因表达盒，其指导来自体内诱导型启动子的免疫原性肽的表达。

5. 发明申请

WO2007079173A2 NOVEL 2-HETEROARYLOXY-PHENOL DERIVATIVES AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译：新型2-杂芳氧基 - 苯酚衍生物作为抗菌剂
公开(公告)号：WO2007079173A2
公开(公告)日：2007-07-12
申请号：PCT/US2006/049473
申请日：2006-12-29
申请人： EMERGENT BIOSOLUTIONS INC. , HUANG, Liren , CLANCY, Joanna , TAYLOR, Christopher , PAN, Weitao , TOMAZIC, Alenka , JACKSON, W., James
发明人： HUANG, Liren , CLANCY, Joanna , TAYLOR, Christopher , PAN, Weitao , TOMAZIC, Alenka , JACKSON, W., James
IPC分类号： A61K31/4166 , A61K31/381
CPC分类号： C07D495/04 , C07D209/08 , C07D213/65 , C07D231/18 , C07D237/14 , C07D239/34 , C07D241/18 , C07D333/32
摘要： Antimicrobial compounds, compositions and methods of treatment administering same, of 2-heteroaryloxyphenol, as well as methods for their preparation and formation, wherein the compounds are generally of Formula 1.
摘要翻译：抗微生物化合物，组合物和施用其的2-杂芳基氧基苯酚的治疗方法以及其制备和形成的方法，其中所述化合物通常为式1的化合物。

6. 发明申请

WO2010048322A1 USE OF E. COLI SURFACE ANTIGEN 3 SEQUENCES FOR THE EXPORT OF HETEROLOGOUS ANTIGENS 审中-公开
标题翻译：大肠杆菌表面抗原3序列用于出血异位抗原
公开(公告)号：WO2010048322A1
公开(公告)日：2010-04-29
申请号：PCT/US2009/061528
申请日：2009-10-21
申请人： EMERGENT PRODUCT DEVELOPMENT UNITED KINGDOM , EMERGENT BIOSOLUTIONS, INC. , TELFER, Jonathan, Lewis , REDFERN, Mark, Richard
发明人： TELFER, Jonathan, Lewis , REDFERN, Mark, Richard
IPC分类号： C07H21/04 , C12N15/00
CPC分类号： C12N15/74 , C07K14/245 , C07K2319/02
摘要： The present invention provides an export signal system based on E. coli CS3 antigen for directing the secretion of foreign antigens from host cells. In particular, the invention describes genetic constructs encoding fusion proteins that contain a CS3 export signal fused to at least one heterologous amino acid sequence. Attenuated microorganisms expressing the fusion proteins and pharmaceutical compositions comprising such attenuated microorganisms are also disclosed.
摘要翻译：本发明提供了一种基于大肠杆菌CS3抗原的导出信号系统，用于引导来自宿主细胞的外源抗原的分泌。特别地，本发明描述了编码融合蛋白的遗传构建体，其含有与至少一个异源氨基酸序列融合的CS3输出信号。还公开了表达融合蛋白的减毒微生物和包含这种减毒微生物的药物组合物。

7. 发明申请

WO2008152429A1 CHEMICALLY MODIFIED PEPTIDES WITH IMPROVED IMMUNOGENICITY 审中-公开
标题翻译：具有改善免疫原性的化学修饰的肽
公开(公告)号：WO2008152429A1
公开(公告)日：2008-12-18
申请号：PCT/GB2008/050449
申请日：2008-06-13
申请人： HEALTH PROTECTION AGENCY , EMERGENT BIOSOLUTIONS, INC. , SHONE, Clifford , XIAOMI, Tong , CLANCY, Joanna , GU, Mili
发明人： SHONE, Clifford , XIAOMI, Tong , CLANCY, Joanna , GU, Mili
IPC分类号： A61K39/02 , A61K39/07 , A61K39/08
CPC分类号： A61K39/07 , A61K39/08 , A61K2039/55505
摘要： The invention provides processes for improving the ability of a peptide to stimulate an immune response, comprising exposing the peptide to a chemical modifying agent. It further provides compositions comprising an antigenic peptide, wherein the peptide has been treated with a chemical modifying agent to improve its ability to stimulate an immune response. It also provides methods of stimulating an immune response in a mammal, comprising administering to the mammal an effective amount of a vaccine.
摘要翻译：本发明提供了改善肽刺激免疫应答能力的方法，包括将肽暴露于化学改性剂。它进一步提供包含抗原肽的组合物，其中肽已用化学改性剂处理以改善其刺激免疫应答的能力。它还提供刺激哺乳动物免疫应答的方法，包括向哺乳动物施用有效量的疫苗。

8. 发明申请

WO2007079173A3 NOVEL 2-HETEROARYLOXY-PHENOL DERIVATIVES AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译：新型2-杂环基酚衍生物作为抗菌剂
公开(公告)号：WO2007079173A3
公开(公告)日：2007-11-15
申请号：PCT/US2006049473
申请日：2006-12-29
申请人： EMERGENT BIOSOLUTIONS INC , HUANG LIREN , CLANCY JOANNA , TAYLOR CHRISTOPHER , PAN WEITAO , TOMAZIC ALENKA , JACKSON W JAMES
发明人： HUANG LIREN , CLANCY JOANNA , TAYLOR CHRISTOPHER , PAN WEITAO , TOMAZIC ALENKA , JACKSON W JAMES
IPC分类号： A61K31/085 , A61K31/075
CPC分类号： C07D495/04 , C07D209/08 , C07D213/65 , C07D231/18 , C07D237/14 , C07D239/34 , C07D241/18 , C07D333/32
摘要： Antimicrobial compounds, compositions and methods of treatment administering same, of 2-heteroaryloxyphenol, as well as methods for their preparation and formation, wherein the compounds are generally of Formula 1.
摘要翻译：抗微生物化合物，施用其的组合物和处理方法，2-杂芳基氧基苯酚，以及其制备和形成方法，其中所述化合物通常为式1。

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