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1. 发明申请

WO2010105130A2 OPTHALMIC DRUG DELIVERY SYSTEM AND APPLICATIONS 审中-公开
标题翻译： OPALALMIC药物递送系统和应用
公开(公告)号：WO2010105130A2
公开(公告)日：2010-09-16
申请号：PCT/US2010027097
申请日：2010-03-12
申请人： VISTA SCIENT LLC , LEAHY CHARLES , ELLIS EDWARD , ELLIS JEANNE Y
发明人： LEAHY CHARLES , ELLIS EDWARD , ELLIS JEANNE Y
IPC分类号： A61F9/00 , A61L27/14 , A61L27/54 , A61M37/00
CPC分类号： A61F9/0017 , A61L27/54 , A61L2300/22 , A61L2300/45 , A61L2300/452 , A61L2300/602 , A61L2430/16
摘要： An ocular device for insertion into an eye is provided and includes a body having an anterior surface and a posterior surface for placement on one of superior sclera and inferior sclera of the eye. The posterior surface is defined by a base curve that is substantially identical to a radius of curvature of the one of the superior sclera and inferior sclera of the eye. In one embodiment, the ocular device serves as an ocular drug delivery system and contains an active pharmaceutical agent, a lubricant, etc. In a second embodiment the ocular device can be constructed in such a manner to treat a wide variety of ocular conditions and diseases.
摘要翻译：提供用于插入眼睛的眼部装置，并且包括具有前表面和后表面的主体，用于放置在眼睛的巩膜和下巩膜中的一个上。后表面由基本曲线限定，其基本上与眼睛的上巩膜和下巩膜中的一个的曲率半径相同。在一个实施方案中，眼睛装置用作眼部药物递送系统并且含有活性药剂，润滑剂等。在第二实施方案中，眼睛装置可以以治疗各种眼部病症和疾病的方式构造。

2. 发明申请

WO2010105130A3 OPTHALMIC DRUG DELIVERY SYSTEM AND APPLICATIONS 审中-公开
公开(公告)号：WO2010105130A3
公开(公告)日：2010-09-16
申请号：PCT/US2010/027097
申请日：2010-03-12
申请人： VISTA SCIENTIFIC LLC , LEAHY, Charles , ELLIS, Edward , ELLIS, Jeanne, Y.
发明人： LEAHY, Charles , ELLIS, Edward , ELLIS, Jeanne, Y.
IPC分类号： A61F9/00 , A61M37/00 , A61L27/14 , A61L27/54
摘要： An ocular device for insertion into an eye is provided and includes a body having an anterior surface and a posterior surface for placement on one of superior sclera and inferior sclera of the eye. The posterior surface is defined by a base curve that is substantially identical to a radius of curvature of the one of the superior sclera and inferior sclera of the eye. In one embodiment, the ocular device serves as an ocular drug delivery system and contains an active pharmaceutical agent, a lubricant, etc. In a second embodiment the ocular device can be constructed in such a manner to treat a wide variety of ocular conditions and diseases.

3. 发明申请

WO2005097157A1 OPHTHALMIC PREPARATION CONTAINING GLYCOMACROPEPTIDE 审中-公开
标题翻译：含有GLYCOMACROPEPTIDE的眼科制剂
公开(公告)号：WO2005097157A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/010157
申请日：2005-03-25
申请人： MILCIN THERAPEUTICS LLC , ELLIS, Edward, J. , LEAHY, Charles, D. , ELLIS, Jeanne, Y.
发明人： ELLIS, Edward, J. , LEAHY, Charles, D. , ELLIS, Jeanne, Y.
IPC分类号： A61K38/00
CPC分类号： A61K38/018 , A61K9/0048 , A61K35/20 , A61K38/1709 , A61L12/14 , A61L12/142
摘要： The present invention relates to an aqueous formulation to be instilled into the eye, or in which to pre soak or store an object to be inserted into the eye, such as a contact lens, an ointment, or a solid device to be inserted into the conjunctiva) sac. The preparations disclosed are utilized for the treatment of a tear film and ocular surface disorder known as keratoconjunctivitis sicca or dry eye syndrome. In general, the preparations of this invention are also effective for the relief of symptoms of eye irritation, such as those caused by dry environmental conditions or by contact lens wear. In accordance with the present invention, the ophthalmic preparation includes a glycomacropeptide component, similar to that found at the normal human ocular surface and in one exemplary and preferred embodiment, the glycomacropeptide is derived from mammalian milk, preferably bovine.
摘要翻译：本发明涉及要滴入眼中的水性制剂，或其中预先浸泡或储存待插入眼睛的物体，例如隐形眼镜，软膏或固体装置，以将其插入到结膜）囊。所公开的制剂用于治疗眼泪膜和称为干眼综合征的眼表症，称为角膜结膜炎。通常，本发明的制剂对于缓解眼睛刺激症状（例如由干燥的环境条件或隐形眼镜磨损引起的）的症状也是有效的。根据本发明，眼科制剂包括类似于在正常人眼表面发现的糖巨肽组分，在一个示例性和优选的实施方案中，糖巨肽衍生自哺乳动物乳，优选牛。

4. 发明申请

WO2003013477A1 DRUG RELEASE SYSTEM FOR CONTROLLED THERAPY 审中-公开
标题翻译：用于控制治疗的药物释放系统
公开(公告)号：WO2003013477A1
公开(公告)日：2003-02-20
申请号：PCT/US2002/025040
申请日：2002-08-07
申请人： VISTA SCIENTIFIC LLC , ELLIS, Edward, J. , ELLIS, Jeanne, Y.
发明人： ELLIS, Edward, J. , ELLIS, Jeanne, Y.
IPC分类号： A61K9/14
CPC分类号： A61K9/0051 , A61K47/32
摘要： Polymeric compositions containing a high percentage of bound polypropylene glycol provide matrices for the controlled release of drugs and medicinal agents. The compositions are prepared by the polymerization of ethylenically unsaturated polypropylene glycol containing monomers. Copolymers of ethylenically unsaturated polypropylene glycol containing monomers with co-monomers are also disclosed. The drug loaded polymeric compositions of this invention find particular utility as ocular insets for the controlled release of drug(s) into the eye.
摘要翻译：含有高百分比结合的聚丙二醇的聚合物组合物提供用于控释药物和药剂的基质。组合物通过含烯属不饱和聚丙二醇的单体的聚合制备。还公开了含有烯属不饱和聚丙二醇的单体与共聚单体的共聚物。本发明的药物负载的聚合物组合物特别用作用于将药物控制释放到眼睛中的眼睛插图。

5. 发明申请

WO0124837A8 PRESERVATIVE SYSTEM FOR OPHTHALMIC SOLUTIONS 审中-公开
标题翻译：防水系统
公开(公告)号：WO0124837A8
公开(公告)日：2001-07-19
申请号：PCT/US0027524
申请日：2000-10-06
申请人： VISTA SCIENT LLC , ELLIS JEANNE Y
发明人： ELLIS JEANNE Y
IPC分类号： A61L12/14 , A61L2/16
CPC分类号： A61L12/141
摘要： Multi-use ophthalmic solutions require a preservative system designed to kill microbes that come in contact with the solution. Failure of the preservative system can pose potential ocular infection hazard to the solution user. Preservative systems must be both efficacious and non-irritating, a balance which is often difficult to achieve. The present invention describes a three-component preservative system for ophthalmic solutions which is both effective in preventing microbial growth and is compatible with the ocular environment.
摘要翻译：多用眼科溶液需要设计用于杀死与溶液接触的微生物的防腐剂系统。防腐系统的故障可能会给解决方案使用者造成潜在的眼部感染危害。防腐剂体系必须既有效又无刺激性，这是一种常常难以达到的平衡。本发明描述了用于眼用溶液的三组分防腐剂体系，其既有效防止微生物生长又与眼部环境相容。

6. 发明申请

WO2005023181A2 POLYMERIC SYSTEMS FOR CONTROLLED DRUG THERAPY 审中-公开
标题翻译：用于控制药物治疗的聚合物系统
公开(公告)号：WO2005023181A2
公开(公告)日：2005-03-17
申请号：PCT/US2004/026775
申请日：2004-08-19
申请人： VISTA SCIENTIFIC , ELLIS, Edward J. , ELLIS, Jeanne Y.
发明人： ELLIS, Edward J. , ELLIS, Jeanne Y.
IPC分类号： A61K
CPC分类号： A61K9/0004 , A61K9/0048 , A61K9/0053 , A61K47/32 , A61K47/34
摘要： Polymeric compositions containing a high percentage of bound alkyl ether segments provide matrices and membranes for the controlled release of drugs and medicinal agents. The polymeric compositions are prepared by the polymerization of ethylenically unsaturated alkyl ether containing monomers. Copolymers of ethylenically unsaturated alkyl ether containing monomers with co-monomers are also disclosed. The drug loaded polymeric compositions of this invention find particular utility in the construction of controlled release devices.
摘要翻译：含有高百分比的结合烷基醚链段的聚合物组合物提供用于药物和药剂的受控释放的基质和膜。聚合物组合物通过聚合含烯属不饱和烷基醚的单体来制备。还公开了烯属不饱和烷基醚单体与共聚单体的共聚物。本发明的载药聚合物组合物在控制释放装置的构造中具有特别的用途。

7. 发明申请

WO2005097159A1 OPHTHALMIC PREPARATION CONTAINING GLYCOPROTEIN 审中-公开
标题翻译：含有GLYCOPROTEIN的眼科制剂
公开(公告)号：WO2005097159A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/010237
申请日：2005-03-25
申请人： MILCIN THERAPEUTICS LLC , ELLIS, Edward, J. , LEAHY, Charles, D. , ELLIS, Jeanne, Y.
发明人： ELLIS, Edward, J. , LEAHY, Charles, D. , ELLIS, Jeanne, Y.
IPC分类号： A61K38/00
CPC分类号： A61K38/1709 , A61K9/0048 , A61K35/20
摘要： The present invention relates to an aqueous formulation to be instilled into the eye, or in which to pre soak or store an object to be inserted into the eye, such as a contact lens, an ointment, or a solid device to be inserted into the conjunctiva) sac. The preparations disclosed are utilized for the treatment of a tear film and ocular surface disorder known as keratoconjunctivitis sicca or dry eye syndrome. In general, the preparations of this invention are also effective for the relief of symptoms of eye irritation, such as those caused by dry environmental conditions or by contact lens wear. In accordance with the present invention, the ophthalmic preparation includes a glycoprotein component, similar to that found at the normal human ocular surface and in one exemplary and preferred embodiment, the glycoproteins are derived from mammalian milk, preferably bovine
摘要翻译：本发明涉及要滴入眼中的水性制剂，或其中预先浸泡或储存待插入眼睛的物体，例如隐形眼镜，软膏或固体装置，以插入到眼睛中结膜）囊。所公开的制剂用于治疗称为角结膜炎或干眼综合征的泪膜和眼表疾病。通常，本发明的制剂对于缓解眼睛刺激症状（例如由干燥环境条件引起的或由隐形眼镜磨损引起的）的症状也是有效的。根据本发明，眼用制剂包括类似于在正常人眼表面发现的糖蛋白组分，在一个示例性和优选实施方案中，糖蛋白衍生自哺乳动物乳，优选牛

8. 发明申请

WO2005023181B1 POLYMERIC SYSTEMS FOR CONTROLLED DRUG THERAPY 审中-公开
标题翻译：用于控制药物治疗的聚合物系统
公开(公告)号：WO2005023181B1
公开(公告)日：2005-09-15
申请号：PCT/US2004026775
申请日：2004-08-19
申请人： VISTA SCIENT , ELLIS EDWARD J , ELLIS JEANNE Y
发明人： ELLIS EDWARD J , ELLIS JEANNE Y
IPC分类号： A61K20060101 , A61K9/00 , A61K9/14 , A61K47/34
CPC分类号： A61K9/0004 , A61K9/0048 , A61K9/0053 , A61K47/32 , A61K47/34
摘要： Polymeric compositions containing a high percentage of bound alkyl ether segments provide matrices and membranes for the controlled release of drugs and medicinal agents. The polymeric compositions are prepared by the polymerization of ethylenically unsaturated alkyl ether containing monomers. Copolymers of ethylenically unsaturated alkyl ether containing monomers with co-monomers are also disclosed. The drug loaded polymeric compositions of this invention find particular utility in the construction of controlled release devices.
摘要翻译：含有高百分比的结合烷基醚链段的聚合物组合物提供用于药物和药剂的控制释放的基质和膜。聚合物组合物通过聚合含烯属不饱和烷基醚的单体来制备。还公开了烯属不饱和烷基醚单体与共聚单体的共聚物。本发明的载药聚合物组合物在控释装置的构造中具有特别的用途。

9. 发明申请

WO2005037248A1 GLYCOPROTEIN AND/OR GLYCOMACROPEPTIDE CONTAINING PREPARATIONS FOR MEDICAL USES 审中-公开
标题翻译：含有医药用途的糖精和/或谷丙转氨酶
公开(公告)号：WO2005037248A1
公开(公告)日：2005-04-28
申请号：PCT/US2004/034493
申请日：2004-10-15
申请人： MILCIN THERAPEUTICS LLC , LEAHY, Charles, D. , ELLIS, Edward, J. , ELLIS, Jeanne, Y.
发明人： LEAHY, Charles, D. , ELLIS, Edward, J. , ELLIS, Jeanne, Y.
IPC分类号： A61K9/00
CPC分类号： A61K35/20 , A61K9/0014 , A61K38/1709 , A61K47/46
摘要： The present invention relates to preparations for use in the treatment of certain medical conditions involving non keratinized tissues. More specifically, this invention relates to preparations containing at least one of a glycoprotein and/or a glycomacropeptide. The preparations disclosed can be utilized to treat certain medical conditions such as wound and mucosal surface disorders, and to assist and enhance the normal wound healing process. Furthermore, the disclosed preparations are particularly well suited in the treatment of conditions involving compromised mucusal surfaces, such as those found in the eye, nose, mouth, vagina and rectum. The compositions of this invention are also well suited to enhance the application and delivery of drugs at such surfaces.
摘要翻译：本发明涉及用于治疗涉及非角化组织的某些医学病症的制剂。更具体地，本发明涉及含有糖蛋白和/或糖巨肽中的至少一种的制剂。所公开的制剂可用于治疗诸如伤口和粘膜表面疾病的某些医学病症，并且有助于和增强正常伤口愈合过程。此外，所公开的制剂特别适用于治疗涉及受损的粘液表面的病症，例如在眼睛，鼻子，口腔，阴道和直肠中发现的那些。本发明的组合物也非常适合于增强药物在这些表面的应用和递送。

10. 发明申请

WO2013040238A3 SUSTAINED RELEASE OCULAR DRUG DELIVERY DEVICES AND METHODS OF MANUFACTURE 审中-公开
标题翻译：持续发布OCULAR DRUG DELIVERY DEVICES AND METHODS OF MANUFACTURE
公开(公告)号：WO2013040238A3
公开(公告)日：2015-07-16
申请号：PCT/US2012055202
申请日：2012-09-13
申请人： VISTA SCIENT LLC , ELLIS EDWARD J , ELLIS JEANNE Y
发明人： ELLIS EDWARD J , ELLIS JEANNE Y
IPC分类号： A61F9/00 , A61K31/557 , A61M37/00 , A61P27/02
CPC分类号： B29C70/70 , B29L2031/753
摘要： A method for forming an ocular drug delivery device includes the steps of: (1) forming a drug core containing an active agent, wherein the drug core has a barrier disposed all surfaces thereof except for a drug release surface which is left free of the barrier; (2) forming a drug release membrane over the drug release surface; and (3) forming the remaining portion of the device body by an overcast (overmold) process.
摘要翻译：用于形成眼药物递送装置的方法包括以下步骤：（1）形成含有活性剂的药物核心，其中所述药物核心具有除了不存在所述屏障的药物释放表面以外的所有表面的阻挡层 ; （2）在药物释放表面上形成药物释放膜; 和（3）通过阴影（包覆模制）工艺形成装置主体的剩余部分。

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