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1. 发明申请

WO2004064702A2 APPARATUS FOR COMBINED APPLICATION OF MASSAGE, ACCUPRESSURE, AND BIOMAGNETIC THERAPY 审中-公开
标题翻译：组合应用按摩，辅助和生物治疗的装置
公开(公告)号：WO2004064702A2
公开(公告)日：2004-08-05
申请号：PCT/US2004/001057
申请日：2004-01-14
申请人： ELYSEE BEAUTY PRODUCTS, LTD , BOUSFIELD, Patrick , LEASON, David , ELLIS, Edward, J. , LEPARIK, Frank
发明人： BOUSFIELD, Patrick , LEASON, David , ELLIS, Edward, J. , LEPARIK, Frank
IPC分类号： A61H
CPC分类号： A61H15/0085 , A61H23/00 , A61H39/04 , A61H2015/0064 , A61H2201/10 , A61N1/40 , A61N2/00
摘要： An apparatus for applying massage, accupressure and biomagnetic therapy to a subject is provided and the apparatus includes a housing having a proximal end and a distal end; a motor disposed within the housing and having a shaft; and a magnet disposed within the housing about the shaft. The apparatus further includes a rotor rotatably supported by the shaft at the distal end of the housing. The rotor has an exterior face which is remote from the magnet and which defines a plurality of entrances, an opposing interior face proximate to the magnet, and a seat more proximate to the magnet than the interior face which is in communication with each of the entrances. Each seat is affixed relative to the rotor at one or more locations proximal to the exterior face. A plurality of metal balls are provided and which are seatable against the seat and retained within the entrances of the rotor by a magnetic field emanating from the magnet. Each ball has a center and is universally rotatable about its center. The seat is constructed and positioned so that it precludes contact of the metal balls with the magnet and counters forces applied to the balls when the apparatus applies therapy to the subject.
摘要翻译：提供了一种用于对受试者施加按摩，按摩和生物磁疗的装置，该装置包括具有近端和远端的壳体; 设置在所述壳体内并具有轴的马达; 以及围绕所述轴设置在所述壳体内的磁体。该装置还包括在壳体的远端处由轴可转动地支撑的转子。转子具有远离磁体并且限定多个入口的外表面，靠近磁体的相对的内表面，以及比与每个入口连通的内表面更靠近磁体的座位。每个座位在靠近外表面的一个或多个位置处相对于转子固定。提供多个金属球，并且能够抵靠座椅而座位并通过从磁体发出的磁场保持在转子的入口内。每个球都有一个中心，它的中心是可以旋转的。座椅的构造和定位使得它防止金属球与磁体接触，并且当设备对受试者施加治疗时，反映施加到球的力。

2. 发明申请

WO2005097157A1 OPHTHALMIC PREPARATION CONTAINING GLYCOMACROPEPTIDE 审中-公开
标题翻译：含有GLYCOMACROPEPTIDE的眼科制剂
公开(公告)号：WO2005097157A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/010157
申请日：2005-03-25
申请人： MILCIN THERAPEUTICS LLC , ELLIS, Edward, J. , LEAHY, Charles, D. , ELLIS, Jeanne, Y.
发明人： ELLIS, Edward, J. , LEAHY, Charles, D. , ELLIS, Jeanne, Y.
IPC分类号： A61K38/00
CPC分类号： A61K38/018 , A61K9/0048 , A61K35/20 , A61K38/1709 , A61L12/14 , A61L12/142
摘要： The present invention relates to an aqueous formulation to be instilled into the eye, or in which to pre soak or store an object to be inserted into the eye, such as a contact lens, an ointment, or a solid device to be inserted into the conjunctiva) sac. The preparations disclosed are utilized for the treatment of a tear film and ocular surface disorder known as keratoconjunctivitis sicca or dry eye syndrome. In general, the preparations of this invention are also effective for the relief of symptoms of eye irritation, such as those caused by dry environmental conditions or by contact lens wear. In accordance with the present invention, the ophthalmic preparation includes a glycomacropeptide component, similar to that found at the normal human ocular surface and in one exemplary and preferred embodiment, the glycomacropeptide is derived from mammalian milk, preferably bovine.
摘要翻译：本发明涉及要滴入眼中的水性制剂，或其中预先浸泡或储存待插入眼睛的物体，例如隐形眼镜，软膏或固体装置，以将其插入到结膜）囊。所公开的制剂用于治疗眼泪膜和称为干眼综合征的眼表症，称为角膜结膜炎。通常，本发明的制剂对于缓解眼睛刺激症状（例如由干燥的环境条件或隐形眼镜磨损引起的）的症状也是有效的。根据本发明，眼科制剂包括类似于在正常人眼表面发现的糖巨肽组分，在一个示例性和优选的实施方案中，糖巨肽衍生自哺乳动物乳，优选牛。

3. 发明申请

WO2003028751A1 GLYCOPROTEIN AND/OR GLYCOMACROPEPTIDE CONTAINING OPHTHALMIC PREPARATION 审中-公开
标题翻译：糖蛋白和/或含有眼科准备的糖蛋白
公开(公告)号：WO2003028751A1
公开(公告)日：2003-04-10
申请号：PCT/US2002/031657
申请日：2002-10-03
申请人： VISTA SCIENTIFIC LLC , ELLIS, Edward, J. , TONG, Xiaomi
发明人： ELLIS, Edward, J. , TONG, Xiaomi
IPC分类号： A61K38/16
CPC分类号： A61K35/20 , A61K38/1709
摘要： The present invention relates to an aqueous fonnulation to be instilled into the eye, or in which to pre soak or store an object to be inserted into the eye, such as a contact lens, an ointment, or a solid device to be inserted into the conjunctival sac. The preparations disclosed are utilized for the treatment of a tear film and ocular surface disorder known as keratoconjunctivitis sicca or dry eye syndrome. In general, the preparations of this invention are also effective for the relief of symptoms of eye irritation, such as those caused by dry environmental conditions or by contact lens wear. In accordance with the present invention, the ophthalmic preparation includes a mucin component, similar to that found at the nonnal human ocular surface and in one exemplary and preferred embodiment, the glycoprotein and/or glycomacropeptide is derived from mammalian milk, preferably bovine.
摘要翻译：本发明涉及要灌注到眼睛中的水性制剂，或其中预先浸泡或储存待插入眼睛的物体，例如隐形眼镜，软膏或固体装置，以插入到眼睛中结膜囊所公开的制剂用于治疗称为角结膜炎或干眼综合征的泪膜和眼表疾病。通常，本发明的制剂对于缓解眼睛刺激症状（例如由干燥环境条件引起的或由隐形眼镜磨损引起的）的症状也是有效的。根据本发明，眼用制剂包括粘蛋白组分，类似于在非人眼睛表面发现的粘蛋白组分，在一个示例性和优选的实施方案中，糖蛋白和/或糖巨肽衍生自哺乳动物乳，优选牛。

4. 发明申请

WO2003013477A1 DRUG RELEASE SYSTEM FOR CONTROLLED THERAPY 审中-公开
标题翻译：用于控制治疗的药物释放系统
公开(公告)号：WO2003013477A1
公开(公告)日：2003-02-20
申请号：PCT/US2002/025040
申请日：2002-08-07
申请人： VISTA SCIENTIFIC LLC , ELLIS, Edward, J. , ELLIS, Jeanne, Y.
发明人： ELLIS, Edward, J. , ELLIS, Jeanne, Y.
IPC分类号： A61K9/14
CPC分类号： A61K9/0051 , A61K47/32
摘要： Polymeric compositions containing a high percentage of bound polypropylene glycol provide matrices for the controlled release of drugs and medicinal agents. The compositions are prepared by the polymerization of ethylenically unsaturated polypropylene glycol containing monomers. Copolymers of ethylenically unsaturated polypropylene glycol containing monomers with co-monomers are also disclosed. The drug loaded polymeric compositions of this invention find particular utility as ocular insets for the controlled release of drug(s) into the eye.
摘要翻译：含有高百分比结合的聚丙二醇的聚合物组合物提供用于控释药物和药剂的基质。组合物通过含烯属不饱和聚丙二醇的单体的聚合制备。还公开了含有烯属不饱和聚丙二醇的单体与共聚单体的共聚物。本发明的药物负载的聚合物组合物特别用作用于将药物控制释放到眼睛中的眼睛插图。

5. 发明申请

WO2012058382A3 DEVICES FOR DELIVERING AT LEAST ONE ACTIVE AGENT TO TISSUE 审中-公开
标题翻译：用于将至少一个活性剂递送到组织的装置
公开(公告)号：WO2012058382A3
公开(公告)日：2012-08-16
申请号：PCT/US2011058008
申请日：2011-10-27
申请人： VISTA SCIENT LLC , LEAHY CHARLES D , THOMPSON ROBERT F , ELLIS EDWARD J
发明人： LEAHY CHARLES D , THOMPSON ROBERT F , ELLIS EDWARD J
IPC分类号： A61M35/00 , A61M37/00
CPC分类号： A61F9/0017 , A61M31/002 , A61M37/00
摘要： A device for delivering an active agent to target tissue at a site that includes a bodily fluid includes a body having a first exterior surface including a first section having a local, discrete recessed area formed in the body for holding the active agent. The body includes a surface flow feature in the form of a canal that is formed in the body and is recessed relative to the exterior surface. The surface flow feature interfaces with the first section and the local recessed area and is configured so as to guide or modify flow of the bodily fluid relative to the body such that fluid communication is provided between the bodily fluid and the local recessed area. The local recessed area is recessed relative to at least a portion of the canal. The device can also be in the form of a device that has an erodible member that releases the active agent over a prescribed period of time.
摘要翻译：用于将活性剂递送到包括体液的部位的靶组织的装置包括具有第一外表面的主体，所述第一外表面包括第一部分，所述第一部分具有形成在所述主体中的用于保持活性剂的局部离散凹陷区域。主体包括形成在体内并相对于外表面凹陷的管形式的表面流动特征。表面流动特征与第一部分和局部凹陷区域相接合，并且构造成引导或改变体液相对于身体的流动，从而在体液和局部凹陷区域之间提供流体连通。局部凹陷部分相对于运河的至少一部分凹进。该装置还可以是具有在规定时间段内释放活性剂的可侵蚀构件的装置的形式。

6. 发明申请

WO2005023181A2 POLYMERIC SYSTEMS FOR CONTROLLED DRUG THERAPY 审中-公开
标题翻译：用于控制药物治疗的聚合物系统
公开(公告)号：WO2005023181A2
公开(公告)日：2005-03-17
申请号：PCT/US2004/026775
申请日：2004-08-19
申请人： VISTA SCIENTIFIC , ELLIS, Edward J. , ELLIS, Jeanne Y.
发明人： ELLIS, Edward J. , ELLIS, Jeanne Y.
IPC分类号： A61K
CPC分类号： A61K9/0004 , A61K9/0048 , A61K9/0053 , A61K47/32 , A61K47/34
摘要： Polymeric compositions containing a high percentage of bound alkyl ether segments provide matrices and membranes for the controlled release of drugs and medicinal agents. The polymeric compositions are prepared by the polymerization of ethylenically unsaturated alkyl ether containing monomers. Copolymers of ethylenically unsaturated alkyl ether containing monomers with co-monomers are also disclosed. The drug loaded polymeric compositions of this invention find particular utility in the construction of controlled release devices.
摘要翻译：含有高百分比的结合烷基醚链段的聚合物组合物提供用于药物和药剂的受控释放的基质和膜。聚合物组合物通过聚合含烯属不饱和烷基醚的单体来制备。还公开了烯属不饱和烷基醚单体与共聚单体的共聚物。本发明的载药聚合物组合物在控制释放装置的构造中具有特别的用途。

7. 发明申请

WO2004014178A9 HAIR WRAPPER 审中-公开
标题翻译：头发包裹
公开(公告)号：WO2004014178A9
公开(公告)日：2004-06-17
申请号：PCT/US0313695
申请日：2003-05-02
申请人： ELISEE BEAUTY PRODUCTS LTD , LEASON DAVID , ELLIS EDWARD J , LATTUGA EUGENE
发明人： LEASON DAVID , ELLIS EDWARD J , LATTUGA EUGENE
IPC分类号： A45D2/00 , A45D7/02
CPC分类号： A45D2/00 , A45D2002/007
摘要： An apparatus for wrapping hair with a cord is provided and includes a housing; a main spindle (190) operatively coupled to the housing and defining a main spindle bore for receiving cord and hair; a rotatable spool carrier (200) and at least one spool (300). The spool carrier (200) has a platform (240) and a drive spindle (230) operatively coupled to the main spindle (190) so that rotation of the main spindle (190) is translated into rotation of the platform (240). The drive spindle (230) has guides for receiving cord and permitting the cord to be disposed through a bore extending through the drive spindle (230). The rotation of the main spindle (230) causes cord to be dispensed through the one guide, the drive spindle bore, and the main spindle bore. Hair is disposed through the drive spindle bore and the main spindle bore. The main spindle is rotated to wrap the hair with cord.
摘要翻译：提供了一种用于用电线缠绕头发的装置，并且包括壳体; 主轴（190），其可操作地联接到所述壳体并且限定用于接收绳索和头发的主轴孔; 可旋转的卷轴托架（200）和至少一个卷轴（300）。卷筒支架（200）具有可操作地联接到主轴（190）的平台（240）和驱动轴（230），使得主轴（190）的旋转被转换成平台（240）的旋转。驱动主轴（230）具有用于接收绳索的引导件，并允许绳索通过延伸穿过驱动轴（230）的孔设置。主轴（230）的旋转使得通过一个导向器，驱动主轴孔和主轴孔分配线。头发通过驱动主轴孔和主轴孔设置。主轴旋转以用电线包裹头发。

8. 发明申请

WO2012058382A2 DEVICES FOR DELIVERING AT LEAST ONE ACTIVE AGENT TO TISSUE 审中-公开
标题翻译：用于将至少一种活性剂递送至组织的装置
公开(公告)号：WO2012058382A2
公开(公告)日：2012-05-03
申请号：PCT/US2011/058008
申请日：2011-10-27
申请人： VISTA SCIENTIFIC LLC , LEAHY, Charles, D. , THOMPSON, Robert, F. , ELLIS, Edward, J.
发明人： LEAHY, Charles, D. , THOMPSON, Robert, F. , ELLIS, Edward, J.
IPC分类号： A61M35/00 , A61M37/00
CPC分类号： A61F9/0017 , A61M31/002 , A61M37/00
摘要： A device for delivering an active agent to target tissue at a site that includes a bodily fluid includes a body having a first exterior surface including a first section having a local, discrete recessed area formed in the body for holding the active agent. The body includes a surface flow feature in the form of a canal that is formed in the body and is recessed relative to the exterior surface. The surface flow feature interfaces with the first section and the local recessed area and is configured so as to guide or modify flow of the bodily fluid relative to the body such that fluid communication is provided between the bodily fluid and the local recessed area. The local recessed area is recessed relative to at least a portion of the canal. The device can also be in the form of a device that has an erodible member that releases the active agent over a prescribed period of time.
摘要翻译：用于递送活性剂以在包括体液的部位处靶向组织的装置包括具有第一外表面的主体，所述第一外表面包括第一部分，所述第一部分具有形成在所述主体中的局部离散凹陷区域，用于持有活性剂。该主体包括呈管道形式的表面流动特征，该管道形成在主体中并且相对于外表面凹陷。表面流动特征与第一部分和局部凹陷区域接合并且被配置为引导或改变体液相对于身体的流动，使得在体液和局部凹陷区域之间提供流体连通。局部凹陷区域相对于运河的至少一部分凹陷。该装置也可以是具有在预定时间段内释放活性剂的易蚀成员的装置。

9. 发明申请

WO2005097159A1 OPHTHALMIC PREPARATION CONTAINING GLYCOPROTEIN 审中-公开
标题翻译：含有GLYCOPROTEIN的眼科制剂
公开(公告)号：WO2005097159A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/010237
申请日：2005-03-25
申请人： MILCIN THERAPEUTICS LLC , ELLIS, Edward, J. , LEAHY, Charles, D. , ELLIS, Jeanne, Y.
发明人： ELLIS, Edward, J. , LEAHY, Charles, D. , ELLIS, Jeanne, Y.
IPC分类号： A61K38/00
CPC分类号： A61K38/1709 , A61K9/0048 , A61K35/20
摘要： The present invention relates to an aqueous formulation to be instilled into the eye, or in which to pre soak or store an object to be inserted into the eye, such as a contact lens, an ointment, or a solid device to be inserted into the conjunctiva) sac. The preparations disclosed are utilized for the treatment of a tear film and ocular surface disorder known as keratoconjunctivitis sicca or dry eye syndrome. In general, the preparations of this invention are also effective for the relief of symptoms of eye irritation, such as those caused by dry environmental conditions or by contact lens wear. In accordance with the present invention, the ophthalmic preparation includes a glycoprotein component, similar to that found at the normal human ocular surface and in one exemplary and preferred embodiment, the glycoproteins are derived from mammalian milk, preferably bovine
摘要翻译：本发明涉及要滴入眼中的水性制剂，或其中预先浸泡或储存待插入眼睛的物体，例如隐形眼镜，软膏或固体装置，以插入到眼睛中结膜）囊。所公开的制剂用于治疗称为角结膜炎或干眼综合征的泪膜和眼表疾病。通常，本发明的制剂对于缓解眼睛刺激症状（例如由干燥环境条件引起的或由隐形眼镜磨损引起的）的症状也是有效的。根据本发明，眼用制剂包括类似于在正常人眼表面发现的糖蛋白组分，在一个示例性和优选实施方案中，糖蛋白衍生自哺乳动物乳，优选牛

10. 发明申请

WO2005023181B1 POLYMERIC SYSTEMS FOR CONTROLLED DRUG THERAPY 审中-公开
标题翻译：用于控制药物治疗的聚合物系统
公开(公告)号：WO2005023181B1
公开(公告)日：2005-09-15
申请号：PCT/US2004026775
申请日：2004-08-19
申请人： VISTA SCIENT , ELLIS EDWARD J , ELLIS JEANNE Y
发明人： ELLIS EDWARD J , ELLIS JEANNE Y
IPC分类号： A61K20060101 , A61K9/00 , A61K9/14 , A61K47/34
CPC分类号： A61K9/0004 , A61K9/0048 , A61K9/0053 , A61K47/32 , A61K47/34
摘要： Polymeric compositions containing a high percentage of bound alkyl ether segments provide matrices and membranes for the controlled release of drugs and medicinal agents. The polymeric compositions are prepared by the polymerization of ethylenically unsaturated alkyl ether containing monomers. Copolymers of ethylenically unsaturated alkyl ether containing monomers with co-monomers are also disclosed. The drug loaded polymeric compositions of this invention find particular utility in the construction of controlled release devices.
摘要翻译：含有高百分比的结合烷基醚链段的聚合物组合物提供用于药物和药剂的控制释放的基质和膜。聚合物组合物通过聚合含烯属不饱和烷基醚的单体来制备。还公开了烯属不饱和烷基醚单体与共聚单体的共聚物。本发明的载药聚合物组合物在控释装置的构造中具有特别的用途。

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