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1. 发明申请

WO2009149304A2 PLANT GENE REGULATORY ELEMENTS 审中-公开
标题翻译：植物基因监管元素
公开(公告)号：WO2009149304A2
公开(公告)日：2009-12-10
申请号：PCT/US2009/046328
申请日：2009-06-04
申请人： EDENSPACE SYSTEMS CORPORATION , GAMPALA, Srinivas , NAIR, Ramesh , CHUMLEY, Forrest , PAPPAN, Kirk , KANKANALA, Prasanna
发明人： GAMPALA, Srinivas , NAIR, Ramesh , CHUMLEY, Forrest , PAPPAN, Kirk , KANKANALA, Prasanna
IPC分类号： C12N15/82
CPC分类号： C12N15/8216 , C12N15/8222 , C12N15/8225 , C12N15/8226
摘要： Nucleic acids, vectors, and expression vectors comprising novel plant gene regulatory elements from sorghum. Novel transgenic plants expressing heterologous genes under the control of novel gene regulatory elements.
摘要翻译：核酸，载体和表达载体，其包含来自高粱的新型植物基因调控元件。在新基因调控元件控制下表达异源基因的新型转基因植物。

2. 发明申请

WO2010127313A1 HMG-COA SECONDARY METABOLITES AND USES THEREOF 审中-公开
标题翻译： HMG-COA二次代谢物及其用途
公开(公告)号：WO2010127313A1
公开(公告)日：2010-11-04
申请号：PCT/US2010/033286
申请日：2010-04-30
申请人： EDENSPACE SYSTEMS CORPORATION , PAPPAN, Kirk
发明人： PAPPAN, Kirk
IPC分类号： C12Q1/26 , C12Q1/48 , G01N33/92 , G01N33/50 , A61K31/00
CPC分类号： G01N33/5038 , A61K31/00 , C12Q1/26 , C12Q1/48 , G01N33/92
摘要： The present invention is directed, among other things, to using secondary metabolites in the mevalonate pathway (such as, for example, HMG) and/or structurally related compounds to mediate biological activities (e.g., for therapeutic applications) and/or as diagnostic agents. In some embodiments, the biological activities comprise one or more pleiotropic effects of statins (such as, for example, angiogenesis, promoting vascular function, anti-inflammatory action, immunomodulation, etc.). Also provided are methods of screening for mevalonate pathway secondary metabolites, methods of producing HMG, and methods of diagnosing comprising measuring amount of mevalonate pathway secondary metabolites.
摘要翻译：本发明尤其涉及在甲羟戊酸途径中使用次级代谢物（例如HMG）和/或结构相关化合物来介导生物活性（例如，用于治疗应用）和/或作为诊断剂。在一些实施方案中，生物活性包括他汀类（例如血管发生，促进血管功能，抗炎作用，免疫调节等）的一种或多种多效作用。还提供了筛选甲羟戊酸途径次级代谢物的方法，生产HMG的方法和诊断方法，其包括测量甲羟戊酸途径次级代谢物的量。

3. 发明申请

WO2010096510A2 TEMPERING OF CELLULOSIC BIOMASS 审中-公开
标题翻译：细胞生物质的温度
公开(公告)号：WO2010096510A2
公开(公告)日：2010-08-26
申请号：PCT/US2010/024505
申请日：2010-02-17
申请人： EDENSPACE SYSTEMS CORPORATION , PAPPAN, Kirk , CORRIDOR, Deisy , NAIR, Ramesh , BLAYLOCK, Michael , CHUMLEY, Forrest , LEE, David , FERGUSON, Bruce
发明人： PAPPAN, Kirk , CORRIDOR, Deisy , NAIR, Ramesh , BLAYLOCK, Michael , CHUMLEY, Forrest , LEE, David , FERGUSON, Bruce
IPC分类号： C12N15/82 , C12P7/10
CPC分类号： C12N15/8246 , C12N15/8245 , C12P7/10 , C12P19/02 , C12P19/14 , Y02E50/16
摘要： The present invention is directed to improved systems and methods for reducing costs and increasing yields of cellulosic ethanol. In particular, the present invention provides plants genetically transformed for increased biomass, expression of lignocellulolytic enzyme polypeptides, and/or simplification of harvesting and downstream processing. Also provided are methods for processing biomass from these transgenic plants that involve less severe and/or less expensive pre-treatment protocols that are typically employed. Such methods allow, among other things, reduced costs associated with externally applied lignocellulolytic enzyme polypeptides.
摘要翻译：本发明涉及用于降低纤维素乙醇的成本和提高产率的改进的系统和方法。特别地，本发明提供了遗传转化用于增加生物量，木质纤维素分解酶多肽表达和/或简化收获和下游处理的植物。还提供了用于处理来自这些转基因植物的生物质的方法，其涉及通常使用的较不严格和/或较便宜的预处理方案。除此之外，这样的方法允许降低与外部施用的木质纤维素分解酶多肽相关的成本。

4. 发明申请

WO2009155601A2 PROCESSING CELLULOSIC BIOMASS 审中-公开
标题翻译：加工细胞生物量
公开(公告)号：WO2009155601A2
公开(公告)日：2009-12-23
申请号：PCT/US2009/048153
申请日：2009-06-22
申请人： EDENSPACE SYSTEMS CORPORATION , ALLIANCE FOR SUSTAINABLE ENERGY, LLC , DECKER, Stephen, R. , SELIG, Michael, K. , BRUNECKY, Roman , VINZANT, Todd , HIMMELL, Michael , LEE, David , BLAYLOCK, Michael
发明人： DECKER, Stephen, R. , SELIG, Michael, K. , BRUNECKY, Roman , VINZANT, Todd , HIMMELL, Michael , LEE, David , BLAYLOCK, Michael
IPC分类号： C12P19/02
CPC分类号： C12P7/06 , C12N9/2437 , C12N15/8221 , C12N15/8245 , C12N15/8246 , C12N15/8261 , Y02A40/146 , Y02E50/17
摘要： Improved systems and methods for reducing costs and increasing yields of cellulosic ethanol are disclosed herein, along with plants genetically transformed for increased biomass, expression of lignocellulolytic enzyme polypeptides, and/or simplification of harvesting and downstream processing. Methods for processing biomass from these transgenic plants that involve less severe and/or less expensive pre-treatment protocols than are typically employed are also disclosed.
摘要翻译：本文公开了用于降低成本和提高纤维素乙醇产量的改进的系统和方法，以及遗传转化用于增加生物量，木质纤维素分解酶多肽表达和/或简化收获和下游处理的植物。还公开了处理来自这些转基因植物的生物质的方法，其涉及比通常使用的不太严格和/或更便宜的预处理方案。

5. 发明申请

WO2011160050A2 SYSTEMS TO REDUCE RECALCITRANCE OF CELLULOSIC BIOMASS AND INCREASE YIELDS OF FERMENTABLE SUGARS 审中-公开
标题翻译：减少细胞生物量回收和增加可食用糖的系统
公开(公告)号：WO2011160050A2
公开(公告)日：2011-12-22
申请号：PCT/US2011/040928
申请日：2011-06-17
申请人： EDENSPACE SYSTEMS CORPORATION , PAPPAN, Kirk , BLAYLOCK, Michael , LEE, David , FERGUSON, Bruce
发明人： PAPPAN, Kirk , BLAYLOCK, Michael , LEE, David , FERGUSON, Bruce
IPC分类号： A01H5/00 , C12N15/55 , C12N15/82 , C12P19/12
CPC分类号： C12N9/00 , C12N9/18 , C12N9/2437 , C12N15/8255 , C12P19/02 , C12P19/14 , C12P2201/00 , C12Y302/01091
摘要： Described herein are methods to reduce the resistance of the plant cell wall to hydrolysis, methods to enhance the conversion of plant biomass into fermentable sugars, methods to increase yields of fermentable sugars from corn grain hydrolysis, and techniques to harvest both the grain and stover from the field simultaneously for hydrolysis. In certain embodiments, the invention provides transgenic plants transformed with expression vectors containing a DNA sequence encoding plant cell wall-modifying enzymes from microbial and animal sources. In certain embodiments, the invention provides methods of improving enzyme performance by creating variants of the parental enzyme. In certain embodiments, the invention provides methods of using stay-green varieties as biomass feedstocks for cellulosic biofuel production. Uses of this invention include, but are not limited to, enhanced biomass conversion, cost-effective lignocellulosic biomass conversion and biofuel production, reduced biomass recalcitrance, enhanced forage digestibility by animals, improved fiber qualities, and enhanced fiber processing properties.
摘要翻译：本文描述的是减少植物细胞壁对水解的抗性的方法，增强植物生物质转化为可发酵糖的方法，从玉米粒水解中提高可发酵糖产量的方法，以及收获谷物和秸秆两者的技术该领域同时进行水解。在某些实施方案中，本发明提供用含有编码来自微生物和动物来源的植物细胞壁修饰酶的DNA序列的表达载体转化的转基因植物。在某些实施方案中，本发明提供了通过产生亲本酶的变体来提高酶性能的方法。在某些实施方案中，本发明提供了使用保留绿色品种作为纤维素生物燃料生产的生物质原料的方法。本发明的用途包括但不限于增强的生物质转化率，成本有效的木质纤维素生物质转化和生物燃料生产，降低的生物质耐受性，动物提高的饲料消化率，改进的纤维品质和增强的纤维加工性能。

6. 发明申请

WO2010138971A1 PLANT GENE REGULATORY ELEMENTS 审中-公开
标题翻译：植物基因监管元素
公开(公告)号：WO2010138971A1
公开(公告)日：2010-12-02
申请号：PCT/US2010/036945
申请日：2010-06-01
申请人： EDENSPACE SYSTEMS CORPORATION , GAMPALA, Srinivas , KANKANALA, Prasanna , LEE, David , PULLEY, Emily , NAIR, Ramesh , CHUMLEY, Forrest
发明人： GAMPALA, Srinivas , KANKANALA, Prasanna , LEE, David , PULLEY, Emily , NAIR, Ramesh , CHUMLEY, Forrest
IPC分类号： C12N15/82
CPC分类号： C12N15/8216
摘要： Nucleic acids, vectors, and expression vectors comprising novel plant gene regulatory elements from poplar that can drive heterologous gene expression in plants. Novel transgenic plants expressing heterologous genes under the control of novel gene regulatory elements.
摘要翻译：核酸，载体和表达载体，其包含可以驱动植物中异源基因表达的来自杨树的新型植物基因调控元件。在新基因调控元件控制下表达异源基因的新型转基因植物。

7. 发明申请

WO2010002548A3 MULTI-GENE EXPRESSION VECTORS 审中-公开
公开(公告)号：WO2010002548A3
公开(公告)日：2010-01-07
申请号：PCT/US2009/046649
申请日：2009-06-08
申请人： EDENSPACE SYSTEMS CORPORATION , LEE, David, A. , WANG, Yueju
发明人： LEE, David, A. , WANG, Yueju
IPC分类号： C12N15/90
摘要： Technologies for stacking multiple genes into a single vector, such as an expression vector. Stacked vectors, cells expressing multiple genes from such vectors, and organisms with stacked traits.

8. 发明申请

WO2009146464A9 SYSTEMS FOR REDUCING BIOMASS RECALCITRANCE 审中-公开
公开(公告)号：WO2009146464A9
公开(公告)日：2009-12-03
申请号：PCT/US2009/045883
申请日：2009-06-01
申请人： EDENSPACE SYSTEMS CORPORATION , PAPPAN, Kirk , NAIR, Ramesh , CHUMLEY, Forrest
发明人： PAPPAN, Kirk , NAIR, Ramesh , CHUMLEY, Forrest
IPC分类号： C12N15/55 , C12N15/56 , C12N15/82 , C12N9/18 , C12N9/24 , C12N9/42
摘要： Improved systems and methods for reducing costs and increasing yields of cellulosic ethanol including compositions of matter comprising plant biomass and cell wall-modifying enzyme polypeptides and transgenic plants expression cell wall- modifying enzyme polypeptides.

9. 发明申请

WO2012009106A2 BIOMASS EXTRACTS AND USES THEREOF 审中-公开
标题翻译：生物质提取物及其用途
公开(公告)号：WO2012009106A2
公开(公告)日：2012-01-19
申请号：PCT/US2011/041109
申请日：2011-06-20
申请人： EDENSPACE SYSTEMS CORPORATION , PAPPAN, Kirk , CORRIDOR, Deisy , LEE, David , NAIR, Ramesh , FERGUSON, Bruce , BLAYLOCK, Michael
发明人： PAPPAN, Kirk , CORRIDOR, Deisy , LEE, David , NAIR, Ramesh , FERGUSON, Bruce , BLAYLOCK, Michael
IPC分类号： C08B1/00 , C12P19/02 , C12N9/14
CPC分类号： C12P19/14 , C08H8/00 , C12P19/02 , C12P2201/00 , C13K1/02
摘要： Methods of using plant biomass extracts to improve glucan conversion, to increase fermentation yields, to reduce biomass recalcitrance, to improve silage quality, to increase starch hydrolysis, and/or to bleach cellulosic material.
摘要翻译：使用植物生物质提取物以改善葡聚糖转化率，增加发酵产量，减少生物量不顺应性，改善青贮品质，增加淀粉水解和/或漂白纤维素材料的方法。

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